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  • Article
    Li Y, Liao Y, Schleyer Pv, Chen Z.
    Nanoscale. 2014 Sep 21;6(18):10784-91.
    Inspired by our theoretical finding that C₂Al₆(2-) has a planar D₂h minimum with two planar tetracoordinate carbons (ptCs), we computationally designed a new two-dimensional (2D) inorganic material, an Al₂C monolayer. All carbons in this monolayer are ptC's, stabilized inductively by binding to four electropositive Al atoms in the same plane. The Al₂C monolayer is semiconducting with an indirect minimum band gap and a slightly larger direct band gap. Good persistence of the Al₂C monolayer is indicated by its moderate cohesive energy, the absence of imaginary modes in its phonon spectrum, and the high melting point predicted by molecular dynamics (MD) simulations. Moreover, a particle-swarm optimization (PSO) global minimum search found the Al₂C monolayer to be the lowest-energy 2D structure compared to other Al₂C alternatives. Dividing the Al₂C monolayer results in one-dimensional (1D) Al₂C nanoribbons, which are computed to have quite rich characteristics such as direct or indirect band gaps with various values, depending on the direction of the division and the resulting edge configuration.
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  • Article
    Pérez-Rodríguez R, Esquivel-Bobadilla S, Orozco-Ruíz AM, Olivas-Hernández JL, García-De León FJ.
    PeerJ. 2021;9:e10784.
    BACKGROUND: Astyanax mexicanus from the river basins of the Gulf of Mexico slope are small freshwater fish that usually live in large groups in different freshwater environments. The group is considered successful due to its high capacity for dispersal and adaptation to different habitats, and the species present high morphological variability throughout their distribution in Mexico. This has produced the most extreme morphotype of the group; the hypogeous or troglobite, which has no eyes or coloration, and is probably the cause of taxonomic uncertainty in the recognition of species across the entire range. Most studies of A. mexicanus have mainly focused on cave individuals, as well as their adjacent surface locations, providing an incomplete evolutionary history, particularly in terms of factors related to dispersal and the potential corridors used, barriers to gene flow, and distribution of genetic variability. The aim of the present study is to determine the population structure and the degree and direction of genetic flow in this complex taxonomic group, incorporating geographic locations not previously included in analyses using microsatellite loci. Our aim is to contribute to the knowledge of the intricate evolutionary history of A. mexicanus throughout most of its range.
    METHODS: The present study included a set of several cave and surface locations of A. mexicanus, which have been widely sampled along the Gulf of Mexico slope, in a genetic population analysis using 10 microsatellite loci.
    RESULTS: Ten genetic populations or lineages were identified. In these populations, gene flow was recorded at two time periods. Historical gene flow, both inter and intra-basin, was observed among surface populations, from surface to cave populations, and among cave populations, whereas recording of contemporary gene flow was limited to intra-basin exchanges and observed among surface populations, surface to cave populations, and cave populations.
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  • Article
    Lima CG, Ali A, van Berkel SS, Westermann B, Paixão MW.
    Chem Commun (Camb). 2015 Jul 11;51(54):10784-96.
    Metal-free 1,3-dipolar cycloaddition reactions have proven to be a powerful tool for the assembly of key heterocycles, in particular diversely functionalized 1,2,3-triazoles. A number of metal-free (3+2)-cycloaddition approaches have been developed up to date with the aim to circumvent the use of metal catalysts allowing these reactions to take place in biological systems without perturbation of the naturally occurring processes. This feature article specifically provides an overview of emerging metal-free synthetic routes, and their mechanistic features, in the formation of functionalized 1,2,3-triazoles.
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  • Article
    Weng YT, Wu NL.
    Chem Commun (Camb). 2013 Nov 28;49(92):10784-6.
    A unique nanostructure consisting of a TiC nanoparticle core and a conformal polypyrrole shell doped with p-toluene sulfonate has been synthesized by a controlled heterogeneous nucleation process. As an electrode material in a Li-ion containing organic electrolyte, the nanocomposite exhibits remarkable high-rate (up to 400 C-rate) charge-discharge capability and cycling stability even at 50 °C.
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  • Article
    Everett J, Druyor K, Krasinski C, Obaid M, Li Y.
    Heliyon. 2022 Oct;8(10):e10784.
    Several studies have aimed to describe associated demographic and psychiatric risk factors that would lead to readmission to a behavioral health unit within 30 days of discharge. Here we considered 1,095 patients that were discharged from Millcreek Community Hospital (MCH) in Erie, Pennsylvania between June 2018 and June 2019. We extracted electronic medical data and analyzed various risk factors using a SPSS software and performed Chi square analysis to determine significance. We determined that patients between the age 30-39 that were diagnosed with major depressive disorder or bipolar disorder, and patients that had 12 or more previous behavioral health admissions were significantly more likely to be readmitted within 30 days of discharge. By analyzing risk factors that lead to a higher percentage of readmission rates, physicians can be more readily equipped and prepared while treating inpatient psychiatric patients. These physicians can take more precautionary measures when discharging patients with specific characteristic profiles to prevent the risk of being readmitted within 30 days of discharge.
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  • Article
    Tadokoro T, Tani J, Manabe T, Takuma K, Nakahara M, Oura K, Mimura S, Fujita K, Nomura T, Morishita A, Kobara H, Himoto T, Ono M, Masaki T.
    Sci Rep. 2024 05 11;14(1):10784.
    Portal vein thrombosis (PVT) worsens the long-term prognosis of patients with cirrhosis; however, the optimal treatment remains to be determined. Reports on the efficacy of direct oral anticoagulants are increasing, and further evidence is needed. Therefore, we investigated the effectiveness of treatment with edoxaban in patients with PVT. We retrospectively reviewed the outcomes of edoxaban and warfarin as antithrombotic therapies for PVT. The median overall survival time was 4.2 years in patients with PVT, with a 1-year survival rate of 70.7% and a 5-year survival rate of 47.9%. The leading cause of death was hepatocellular carcinoma. The overall response rate for thrombolysis in the edoxaban group was 76.7% compared to 29.4% in the warfarin group, and edoxaban significantly improved PVT compared to warfarin. In addition, edoxaban provided long-term improvement of PVT. Warfarin, on the other hand, was temporarily effective but did not provide long-term benefits. The Child-Pugh and albumin-bilirubin scores did not change after edoxaban or warfarin use. No deaths occurred due to adverse events associated with edoxaban or warfarin. Edoxaban as a single agent can achieve long-term recanalization without compromising the hepatic reserves. Edoxaban is easy to initiate, even in an outpatient setting, and could become a major therapeutic agent for the treatment of PVT.
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  • Article
    Xu P, Yu H, Li X.
    Chem Commun (Camb). 2012 Nov 11;48(87):10784-6.
    Noble metal nanoparticles are directly and homogeneously grown onto graphene-oxide (GO) sheets in oleylamine. After the oleylamine is removed, the GO sheets are exfoliated by the nanoparticle pillars to further form hierarchical GO nanostructures with molecule accessible nanopores. With specific sensing-groups modified, the porous-layered nanostructure can be constructed onto resonant microcantilevers for chemical sensing.
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  • Article
    Zhao J, Yang C, Guo S, Wu Y.
    Int J Clin Exp Pathol. 2015;8(9):10784-91.
    Gastric cancer is one of the most common causes of digestive tract tumor. Despite of recent advances in surgical techniques and development of adjuvant therapy, the underlying mechanisms of gastric cancer remain poorly understood and relevant insight into novel treatment strategies using gene target remains incomplete. Recently, several studies report that epithelial to mesenchymal transition (EMT) is a crucial process for the invasion and metastasis of epithelial tumors; however, the molecular mechanisms underlying this transition are unknown. As a cis-Golgi matrix protein, GM130 plays an important role in cell cycle progression and transport of protein in the secretory pathway. In this study, we found that GM130 expression has a positive correlation with the pathological differentiation and tumor node metastasis (TNM) stage of gastric cancer. High GM130 expression levels also predict shorter overall survival of gastric cancer patients. RNA interference-mediated knockdown of GM130 expression increased epithelial marker (E-cadherin) and decreased mesenchymal marker (N-cadherin and vimentin) expression in gastric cancer cells, suppressing cell invasion, and tumor formation. Furthermore, we found that GM130 upregulated expression of the key EMT regulator Snail (SNAI1), which mediated EMT activation and cell invasion by GM130. Taken together, our study indicates GM130 may be a promising therapeutic biomarker for gastric cancer.
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  • Article
    Sikora A, Devlin JW, Yu M, Zhang T, Chen X, Smith SE, Murray B, Buckley MS, Rowe S, Murphy DJ.
    Sci Rep. 2023 07 04;13(1):10784.
    While medication regimen complexity, as measured by a novel medication regimen complexity-intensive care unit (MRC-ICU) score, correlates with baseline severity of illness and mortality, whether the MRC-ICU improves hospital mortality prediction is not known. After characterizing the association between MRC-ICU, severity of illness and hospital mortality we sought to evaluate the incremental benefit of adding MRC-ICU to illness severity-based hospital mortality prediction models. This was a single-center, observational cohort study of adult intensive care units (ICUs). A random sample of 991 adults admitted ≥ 24 h to the ICU from 10/2015 to 10/2020 were included. The logistic regression models for the primary outcome of mortality were assessed via area under the receiver operating characteristic (AUROC). Medication regimen complexity was evaluated daily using the MRC-ICU. This previously validated index is a weighted summation of medications prescribed in the first 24 h of ICU stay [e.g., a patient prescribed insulin (1 point) and vancomycin (3 points) has a MRC-ICU = 4 points]. Baseline demographic features (e.g., age, sex, ICU type) were collected and severity of illness (based on worst values within the first 24 h of ICU admission) was characterized using both the Acute Physiology and Chronic Health Evaluation (APACHE II) and the Sequential Organ Failure Assessment (SOFA) score. Univariate analysis of 991 patients revealed every one-point increase in the average 24-h MRC-ICU score was associated with a 5% increase in hospital mortality [Odds Ratio (OR) 1.05, 95% confidence interval 1.02-1.08, p = 0.002]. The model including MRC-ICU, APACHE II and SOFA had a AUROC for mortality of 0.81 whereas the model including only APACHE-II and SOFA had a AUROC for mortality of 0.76. Medication regimen complexity is associated with increased hospital mortality. A prediction model including medication regimen complexity only modestly improves hospital mortality prediction.
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  • Article
    Park GY, Rak Kwon D, Gil Kwon D.
    Medicine (Baltimore). 2018 05;97(20):e10784.
    RATIONALE: We report a case of a 61-year-old patient who developed complex regional pain syndrome (CRPS) type II after a cervical transforaminal epidural steroid injection (CTESI).
    PATIENT CONCERNS: The patient developed sudden-onset severe pain and swelling of his upper right limb after a cervical transforaminal epidural injection.
    DIAGNOSES: On physical examination, the patient's symptoms and signs corresponded to the Budapest criteria for CRPS. Cervical magnetic resonance imaging and laboratory tests were performed to rule out other causes. An electrodiagnostic study revealed right C6/7 radiculopathies. A three-phase bone scan showed increased uptake in the right wrist in all phases. Thus, he was diagnosed with CRPS type II due to a cervical nerve root injury caused by the transforaminal epidural injection.
    INTERVENTIONS: He received oral methylprednisolone and gabapentin, and underwent physical therapy for 9 days.
    OUTCOMES: The pain and swelling of his right upper limb disappeared and he returned to his previous functional activities.
    LESSONS: CRPS type II due to cervical root injury is rare but can develop during CTESI. Early comprehensive physical therapy and oral medications might result in good outcomes.
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  • Article
    Denard J, Marolleau B, Jenny C, Rao TN, Fehling HJ, Voit T, Svinartchouk F.
    J Virol. 2013 Oct;87(19):10784-91.
    The clinical relevance of gene therapy using the recombinant adeno-associated virus (rAAV) vectors often requires widespread distribution of the vector, and in this case, systemic delivery is the optimal route of administration. Humoral blood factors, such as antibodies or complement, are the first barriers met by the vectors administered systemically. We have found that other blood proteins, galectin 3 binding protein (G3BP) and C-reactive protein (CRP), can interact with different AAV serotypes in a species-specific manner. While interactions of rAAV vectors with G3BP, antibodies, or complement lead to a decrease in vector efficacy, systemic transduction of the CRP-deficient mouse and its respective control clearly established that binding to mouse CRP (mCRP) boosts rAAV vector 1 (rAAV-1) and rAAV-6 transduction efficiency in skeletal muscles over 10 times. Notably, the high efficacy of rAAV-6 in CRP-deficient mice can be restored by reconstitution of the CRP-deficient mouse with mCRP. Human CRP (hCRP) does not interact with either rAAV-1 or rAAV-6, and, consequently, the high efficiency of mCRP-mediated muscle transduction by these serotypes in mice cannot be translated to humans. No interaction of mCRP or hCRP was observed with rAAV-8 and rAAV-9. We show, for the first time, that serum components can significantly enhance rAAV-mediated tissue transduction in a serotype- and species-specific manner. Bioprocessing in body fluids should be considered when transfer of a preclinical proof of concept for AAV-based gene therapy to humans is planned.
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  • Article
    Ekvall MT, Hedberg J, Odnevall Wallinder I, Malmendal A, Hansson LA, Cedervall T.
    Sci Rep. 2021 05 24;11(1):10784.
    As the use of engineered nanomaterials increases, so does the risk of them spreading to natural ecosystems. Hitherto, knowledge regarding the toxic properties of nanoparticles (NP's) and their potential interactions with natural bio-organic molecules adsorbed to them, and thereby forming surface coronas, is limited. However, we show here that the toxic effect of NPs of tungsten carbide cobalt (WC-Co) and cobalt (Co) on the crustacean Daphnia magna is postponed in the presence of natural biological degradation products (eco-corona biomolecules). For Daphnia exposed to WC-Co NPs the survival time increased with 20-25% and for Co NPs with 30-47% after mixing the particles with a solution of eco-corona biomolecules before exposure. This suggests that an eco-corona, composed of biomolecules always present in natural ecosystems, reduces the toxic potency of both studied NPs. Further, the eco-coronas did not affect the particle uptake, suggesting that the reduction in toxicity was related to the particle-organism interaction after eco-corona formation. In a broader context, this implies that although the increasing use and production of NPs may constitute a novel, global environmental threat, the acute toxicity and long-term effects of some NPs will, at least under certain conditions, be reduced as they enter natural ecosystems.
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  • Article
    González-Castellano I, González-López J, González-Tizón AM, Martínez-Lage A.
    Sci Rep. 2020 07 01;10(1):10784.
    The rockpool shrimp Palaemon elegans is an ecologically important crustacean species within the European coastline fauna. In the present study, genetic diversity and population structure and connectivity were assessed by examining 21 polymorphic microsatellite loci at 13 sampling sites located along the natural distribution range. All localities showed similar levels of genetic variability. Significant deficits of heterozygosity were recorded, most likely due to the presence of null alleles. Genetic structure analyses revealed two clearly genetically distinct groups within P. elegans but without following any geographical or oceanographic basis. Thus, our results provided nuclear evidence for the existence of a Mediterranean cryptic species within P. elegans, highlighting the need to revise its taxonomic status. Regarding P. elegans sensu stricto, population structuring was reported across the Atlantic-Mediterranean transition area, where the Almería-Orán Front restricts the gene flow between the Atlantic and the Mediterranean population. Moreover, while population connectivity was suggested between all Mediterranean localities, some substructure was found within the Atlantic group. Canary Islands exhibited a weak but significant genetic differentiation from all Atlantic mainland localities, consistent with the isolation-by-distance pattern detected throughout the Atlantic population. Overall, all these findings provided new insights into the population biology of P. elegans complex.
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  • Article
    Velvizhi G, Mohan SV.
    Bioresour Technol. 2011 Dec;102(23):10784-93.
    Biocatalyst behavior was comparatively evaluated under diverse microenvironments viz., self-induced electrogenic (bioelectrochemical treatment, BET) and anaerobic treatment (AnT) microenvironments, with real-field pharmaceutical wastewater. Relatively higher treatment efficiency was observed with BET (COD removal, 78.70%) over AnT (32%) along with the power output. Voltammetric profiles of AnT showed persistent reduction behavior, while BET depicted simultaneous redox behavior. BET operation documented significantly higher bio-electrocatalytic activity (kapp, 245.22 s(-1)) than AnT (kapp, 7.35 s(-1)). The electron accepting conditions due to the presence of electrode in the BET might contributed to higher electrogenesis leading to enhanced substrate degradation along with the removal of multiple pollutants accounting for the effective reduction of toxicity levels of wastewater. Even at higher organic loads, BET operation showed good treatment efficiency without process inhibition. Introduction of electrode-membrane assembly in anaerobic microenvironment showed significant change in the electrocatalytic behavior of biocatalyst resulting in enhanced treatment of complex wastewater.
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  • Article
    Cox R, O'Boyle L, Cytrynbaum J.
    Sci Rep. 2019 07 25;9(1):10784.
    Coastal boulder deposits (CBD) are archives of extreme wave events. They are emplaced well above high tide, and may include megagravel clasts weighing tens or even hundreds of tonnes. But do they represent storms or tsunami? Many are interpreted as tsunami deposits based simply on clast size and inferences about transport, despite the fact that there are no direct observations documenting formation of these inbricated boulder clusters and ridges. In this study, we use force-balanced, dynamically scaled wave-tank experiments to model storm wave interactions with boulders, and show that storm waves can produce all the features of imbricated CBD. This means that CBD, even when containing megagravel, cannot be used as de facto tsunami indicators. On the contrary, CBD should be evaluated for inclusion in long-term storminess analysis.
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  • Article
    Wang Q, Hou K, Yang J, Li H, Li C, Zhang Y, Tian J, Li C, Guo B, Jia S, Luo Y.
    Aging (Albany NY). 2023 10 12;15(19):10767-10784.
    The G-rich DNA, such as telomere, tends to form G-quadruplex (G4) structure, which slows down the replication fork progression, induces replication stress, and becomes the chromosome fragile sites. Here we described a molecular strategy that cells developed to overcome the DNA replication stress via DNA helicase regulation. The p53N236S (p53S) mutation has been found in the Werner syndrome mouse embryo fibroblast (MEFs) escaped from senescence, could be the driving force for cell escaping senescence. We revealed that the p53S could transcriptionally up-regulate DNA helicases expression, including Wrn, Blm, Timeless, Ddx, Mcm, Gins, Fanc, as well as telomere specific proteins Terf1, Pot1, through which p53S promoted the unwinding of G4 structures, and protected the cells from DNA replication stress induced by G4 stabilizer. By modified iPOND (isolation of proteins on nascent DNA) assay and telomere assay, we demonstrated that the p53S could promote the recruitment of those helicases to the DNA replication forks, facilitated the maintenance of telomere, and prevent the telomere dysfunction induced by G4 stabilizer. Interestingly, we did not observe the function of promoting G4 resolving and facilitating telomere lengthening in the cells with Li-Fraumeni Syndrome mutation-p53R172H (p53H), which suggests that this is the specific gain of function for p53S. Together our data suggest that the p53S could gain the new function of releasing the replication stress via regulating the helicase function and G4 structure, which benefits telomere lengthening. This strategy could be applied to the treatment of diseases caused by telomere replication stress.
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  • Article
    Huang J, Burke P, Yang Y, Seiss K, Beamon J, Cung T, Toth I, Pereyra F, Lichterfeld M, Yu XG.
    J Virol. 2010 Oct;84(20):10784-91.
    Dendritic cells represent a specialized class of professional antigen-presenting cells that are responsible for priming and maintaining antigen-specific effector cell responses and regulating immune activation by cytokine secretion. In HIV-1 infection, myeloid dendritic cells are highly dysfunctional, but mechanisms contributing to their functional alterations are not well defined. Here, we show that soluble molecules of the nonclassical major histocompatibility complex class Ib (MHC-Ib) antigen HLA-G are highly upregulated in the plasma during progressive HIV-1 infection, while levels of membrane-bound HLA-G surface expression on dendritic cells, monocytes, and T cells only slightly differ among HIV-1 progressors, HIV-1 elite controllers, and HIV-1-negative persons. These elevated levels of soluble HLA-G in progressive HIV-1 infection likely result from increased secretion of intracellularly stored HLA-G molecules in monocytes and dendritic cells and contribute to a functional disarray of dendritic cells by inhibiting their antigen-presenting properties, while simultaneously enhancing their secretion of proinflammatory cytokines. Interestingly, we observed that these immunoregulatory effects of soluble HLA-G were mainly mediated by interactions with the myelomonocytic HLA class I receptor leukocyte immunoglobulin-like receptor B2 (LILRB2; ILT4), while binding of soluble HLA-G to its alternative high-affinity receptor, LILRB1 (ILT2), appeared to be less relevant for its immunomodulatory functions on dendritic cells. Overall, these results demonstrate a critical role for soluble HLA-G in modulating the functional characteristics of professional antigen-presenting cells in progressive HIV-1 infection and suggest that soluble HLA-G might represent a possible target for immunotherapeutic interventions in HIV-1-infected persons.
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  • Article
    Hopkins AJ, Schrödle S, Richmond GL.
    Langmuir. 2010 Jul 06;26(13):10784-90.
    Calcium fluoride is a slightly soluble compound commonly extracted from ores via flotation at elevated pH, where surfactant molecules bind with hydroxylated surface sites. The addition of F-(aq) suppresses surfactant adsorption by replacing these sites. In this paper, we look at the effects of aqueous Cl-, Br-, F-, and SO4(2-) on the water structure at the CaF2/H2O interface at a pH where surface hydroxylation has not yet occurred. Using static and time-resolved vibrational sum-frequency spectroscopy (VSFS), we find that aqueous Cl- and Br- have only electrostatic screening effects on the interface and do not perturb the interfacial water or surface structure. Sulfate, which we find to be strongly attracted to the interface, affects the interfacial water more than Cl- or Br-. This is in contrast to F- ions that directly interact with the surface and alter the water structure and bonding at the CaF2 surface in addition to screening the surface charge.
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  • Article
    Haider A, Siddiqa A, Ali N, Dhallu M.
    Cureus. 2020 Oct 03;12(10):e10784.
    Central nervous system (CNS) viral infections result in the clinical syndromes of aseptic meningitis or encephalitis. Although the primary target of coronavirus disease 2019 (COVID-19) is the respiratory system, it is increasingly being recognized as a neuropathogen. The hallmark clinical feature is altered mental status, ranging from mild confusion to deep coma. Most patients with encephalopathy or encephalitis are critically ill. We present a case of COVID-19-related encephalitis who presented with acute delirium and new-onset seizures. The patient responded well to treatment with intravenous immunoglobulins and rituximab.
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  • Article
    Aw Yong KM, Li Z, Merajver SD, Fu J.
    Sci Rep. 2017 09 07;7(1):10784.
    The analysis of invading leader cells at the tumor invasion front is of significant interest as these cells may possess a coordinated functional and molecular phenotype which can be targeted for therapy. However, such analyses are currently limited by available technologies. Here, we report a fluidic device for long-term three-dimensional tumoroid culture which recapitulated the tumor invasion front, allowing for both quantification of invasive potential and molecular characterization of invasive leader cells. Preliminary analysis of the invasion front indicated an association with cell proliferation and higher expression of growth differentiation factor 15 (GDF15). This device makes real-time tracking of invading leader cell phenotypes possible and has potential for use with patient material for clinical risk stratification and personalized medicine.
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