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- Lane GuideWoodward, Amanda.Lane Medical Library and the Diversity CORE celebrate Banned Books Week
- ArticleLiu F, Shen C, He Q, Zhang A, Liu Y, Kong F.Sensors (Basel). 2014 May 05;14(5):8096-125.A fault diagnosis strategy based on the wayside acoustic monitoring technique is investigated for locomotive bearing fault diagnosis. Inspired by the transient modeling analysis method based on correlation filtering analysis, a so-called Parametric-Mother-Doppler-Wavelet (PMDW) is constructed with six parameters, including a center characteristic frequency and five kinematic model parameters. A Doppler effect eliminator containing a PMDW generator, a correlation filtering analysis module, and a signal resampler is invented to eliminate the Doppler effect embedded in the acoustic signal of the recorded bearing. Through the Doppler effect eliminator, the five kinematic model parameters can be identified based on the signal itself. Then, the signal resampler is applied to eliminate the Doppler effect using the identified parameters. With the ability to detect early bearing faults, the transient model analysis method is employed to detect localized bearing faults after the embedded Doppler effect is eliminated. The effectiveness of the proposed fault diagnosis strategy is verified via simulation studies and applications to diagnose locomotive roller bearing defects.
- ArticleZhang H, Zou J, Yin Y, Zhang B, Hu Y, Wang J, Mu H.PeerJ. 2019;7:e8096.Clear cell renal cell carcinoma (ccRCC) is one of the most common and lethal types of cancer within the urinary system. Great efforts have been made to elucidate the pathogeny. However, the molecular mechanism of ccRCC is still not well understood. The aim of this study is to identify key genes in the carcinogenesis and progression of ccRCC. The mRNA microarray dataset GSE53757 was downloaded from the Gene Expression Omnibus database. The GSE53757 dataset contains tumor and matched paracancerous specimens from 72 ccRCC patients with clinical stage I to IV. The linear model of microarray data (limma) package in R language was used to identify differentially expressed genes (DEGs). The protein-protein interaction (PPI) network of the DEGs was constructed using the search tool for the retrieval of interacting genes (STRING). Subsequently, we visualized molecular interaction networks by Cytoscape software and analyzed modules with MCODE. A total of 1,284, 1,416, 1,610 and 1,185 up-regulated genes, and 932, 1,236, 1,006 and 929 down-regulated genes were identified from clinical stage I to IV ccRCC patients, respectively. The overlapping DEGs among the four clinical stages contain 870 up-regulated and 645 down-regulated genes. The enrichment analysis of DEGs in the top module was carried out with DAVID. The results showed the DEGs of the top module were mainly enriched in microtubule-based movement, mitotic cytokinesis and mitotic chromosome condensation. Eleven up-regulated genes and one down-regulated gene were identified as hub genes. Survival analysis showed the high expression of CENPE, KIF20A, KIF4A, MELK, NCAPG, NDC80, NUF2, TOP2A, TPX2 and UBE2C, and low expression of ACADM gene could be involved in the carcinogenesis, invasion or recurrence of ccRCC. Literature retrieval results showed the hub gene NDC80, CENPE and ACADM might be novel targets for the diagnosis, clinical treatment and prognosis of ccRCC. In conclusion, the findings of present study may help us understand the molecular mechanisms underlying the carcinogenesis and progression of ccRCC, and provide potential diagnostic, therapeutic and prognostic biomarkers.
- ArticleRao N, Vance J, Walters D, Burns B.Cureus. 2020 May 13;12(5):e8096.A global surgical rotation program has been developed at La Loma Luz Adventist Hospital in San Ignacio, Belize, by the Department of Surgery at East Tennessee State University in 2014. It encompasses a one-month rotation for surgery residents to travel to Belize, accompanied by a senior surgical attending, to participate in direct patient care. Residents are able to operate under supervision and practice both perioperative and medical management. Practitioners often collaborate with permanent facility surgeons and internists in order to assist with cases, discuss different practice strategies, and, ultimately, tailor patient care. In addition to providing residents with surgical experience, this rotation aims to advance the overall standard of medical care available to the community. Additional aims include healthcare promotion and education of patients. While this rotation was developed to provide residents surgical experience in an underserved country, we hope that it will further cultivate volunteerism and foster future participation.
- ArticleNi L, Yamada T, Nakatani K.Sci Rep. 2024 04 06;14(1):8096.Circular RNAs (circRNAs), are a covalently closed, single-stranded RNA without 5'- and 3'-termini, commonly stem from the exons of precursor mRNAs (pre-mRNAs). They have recently garnered interest, with studies uncovering their pivotal roles in regulating various aspects of cell functions and disease progressions. A notable feature of circRNA lies in the mechanism of its biogenesis involving a specialized form of splicing: back-splicing. A splicing process that relies on interactions between introns flanking the circularizing exon to bring the up and downstream splice sites in proximity through the formation of a prerequisite hairpin structure, allowing the spliceosomes to join the two splice sites together to produce a circular RNA molecule. Based on this mechanism, we explored the feasibility of facilitating the formation of such a prerequisite hairpin structure by utilizing a newly designed oligonucleotide, CircuLarIzation Promoting OligoNucleotide (CLIP-ON), to promote the production of circRNA in cells. CLIP-ON was designed to hybridize with and physically bridge two distal sequences in the flanking introns of the circularizing exons. The feasibility of CLIP-ON was confirmed in HeLa cells using a model pre-mRNA, demonstrating the applicability of CLIP-ON as a trans-acting modulator to upregulate the production of circRNAs in a cellular environment.
- ArticleBogati S, Kunwar SR, Amgain LP.Heliyon. 2021 Oct;7(10):e08096.Inadequate, unscientific, and lack of optimum utilization of fertilizer management devoid of site-specific nutrient management have been the significant constraints of maize (Zea mays L.) production in Nepal. Therefore, a multi-locational farmers' field was planned and executed at two VDCs of Morang district in the Terai region of Nepal from December 2015 to May 2016. Nutrient Expert (NE) and Farmer's Fertilizer Practices (FFP) treatments were imposed in a randomized complete block design (RCBD) with twenty replications. The research explored highly significant results in terms of plant number m -2, cob numbers m -2 , cob length, kernel rows cob -1 , kernels kernel row -1 , test weight, grain, stover, and biological yields and harvest index. NE showed the highest yield (8.06 tons ha -1) among the two treatments tested than FFP (4.52 tons ha -1). While comparing net revenue, NE-based fertilizer recommendation gave the significantly higher (NRs.151.116 thousand ha -1 equivalent to $1281 ha -1) result than FFP (NRs.84.834 thousand ha-1 equivalents to $707). The result suggests adopting NE practices to minimize the yield gaps and increase the productivity of maize in Morang and adjoining agro-climatic conditions of eastern Terai, Nepal.
- ArticlePark SW, Yeo NY, Kim Y, Byeon G, Jang JW.Sci Rep. 2023 05 19;13(1):8096.The positron emission tomography (PET) with 18F-flortaucipir can distinguish individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) from cognitively unimpaired (CU) individuals. This study aimed to evaluate the utility of 18F-flortaucipir-PET images and multimodal data integration in the differentiation of CU from MCI or AD through DL. We used cross-sectional data (18F-flortaucipir-PET images, demographic and neuropsychological score) from the ADNI. All data for subjects (138 CU, 75 MCI, 63 AD) were acquired at baseline. The 2D convolutional neural network (CNN)-long short-term memory (LSTM) and 3D CNN were conducted. Multimodal learning was conducted by adding the clinical data with imaging data. Transfer learning was performed for classification between CU and MCI. The AUC for AD classification from CU was 0.964 and 0.947 in 2D CNN-LSTM and multimodal learning. The AUC of 3D CNN showed 0.947, and 0.976 in multimodal learning. The AUC for MCI classification from CU had 0.840 and 0.923 in 2D CNN-LSTM and multimodal learning. The AUC of 3D CNN showed 0.845, and 0.850 in multimodal learning. The 18F-flortaucipir PET is effective for the classification of AD stage. Furthermore, the effect of combination images with clinical data increased the performance of AD classification.
- ArticleCosta SV, Gonçalves AS, Zaguete MA, Mazon T, Nogueira AF.Chem Commun (Camb). 2013 Sep 21;49(73):8096-8.In this report, hierarchical ZnO nano- and microstructures were directly grown for the first time on a bacterial cellulose substrate and on two additional different papers by hydrothermal synthesis without any surface modification layer. Compactness and smoothness of the substrates are two important parameters that allow the growth of oriented structures.
- ArticleStokes EC, Román MO.Sci Rep. 2022 05 16;12(1):8096.In response to the COVID-19 pandemic, governments around the world have enacted widespread physical distancing measures to prevent and control virus transmission. Quantitative, spatially-disaggregated information about the population-scale shifts in activity that have resulted from these measures is extremely scarce, particularly for regions outside of Europe and the US. Public health institutions often must make decisions about control measures with limited region-specific data about how they will affect societal behavior, patterns of exposure, and infection outcomes. The Visible Infrared Imaging Radiometer Suite Day/Night Band (VIIRS DNB), a new-generation space-borne low-light imager, has the potential to track changes in human activity, but the capability has not yet been applied to a cross-country analysis of COVID-19 responses. Here, we examine multi-year (2015-2020) daily time-series data derived from NASA's Black Marble VIIRS nighttime lights product (VNP46A2) covering 584 urban areas, in 17 countries in the Middle East to understand how communities have adhered to COVID-19 measures in the first 4 months of the pandemic. Nighttime lights capture the onset of national curfews and lockdowns well, but also expose the inconsistent response to control measures both across and within countries. In conflict-afflicted countries, low adherence to lockdowns and curfews was observed, highlighting the compound health and security threats that fragile states face. Our findings show how satellite measurements can aid in assessing the public response to physical distancing policies and the socio-cultural factors that shape their success, especially in fragile and data-sparse regions.
- ArticleFan Y, Li T, Li B, Hu A, Li D, Li K, Yang B, Pan Y, Liu J, Long J.Nanoscale. 2024 Apr 25;16(16):8096-8107.Metal single-atom catalysts have attracted widespread attention in the field of lithium-oxygen batteries due to their unique active sites, high catalytic selectivity, and near total atomic utilization efficiency. Isolated metal atoms not only serve as the active sites themselves, but also function as modulators, reversely regulating the surface electronic structure of the support to enhance its inherent electrocatalytic activities. Despite the potential of isolated metal atom-driven active sites, understanding the structure-activity relationship remains a challenge. In this study, we present a ruthenium single-atom doping-driven cost-effective and durable tricobalt tetroxide electrocatalyst with excellent oxygen electrode electrocatalytic activity. The lithium-oxygen battery with this catalyst as the oxygen electrode demonstrates high performance, achieving a capacity of up to 25 000 mA h g-1 and maintaining good stability over 400 cycles at a current density of 100 mA g-1. This improvement is attributed to the exquisite control of the morphology and structure of the discharge product, lithium peroxide. The aresults of physical characterization and theoretical calculations reveal that isolated ruthenium atoms bond with the tetrahedral cobalt site, resulting in spin polarization enhancement and rearrangement of d orbital energy levels in cobalt. This rearrangement reduces the dz2 orbital occupancy and promotes their transfer to the octahedral cobalt site, thereby enhancing its adsorption capacity for the oxygen-containing intermediates, and ultimately increasing the electrocatalytic activity of the oxygen evolution reaction. This work presents an innovative strategy to regulate the catalytic activity of metal oxides by introducing another metal single atom.
- ArticleZhang X, Dang Y, Li P, Rong M, Chen G.Int J Clin Exp Pathol. 2014;7(11):8096-104.The interleukin-1 receptor associated kinases 1 (IRAK1) is a down stream effector molecule of the toll like receptor (TLR) signaling pathway, which is involved in inflammation, autoimmunity and cancer. However, the role of IRAK1 in lung cancer remains unclarified. Herein, we investigated the protein expression and the clinicopathological significance of IRAK1 in 3 formalin-fixed paraffin-embedded lung cancer tissue microarrays by using immunohistochemistry, which included 365 tumor and 30 normal lung tissues. We found that the expression of IRAK1 in lung cancer was significantly higher compared with that in normal lung tissues (P=0.002). Receiver operating characteristic (ROC) curves were generated to evaluate the power of IRAK1 to distinguish lung cancer from non-cancerous lung tissue. The area under curve (AUC) of ROC of IRAK1 was 0.643 (95% CI 0.550~0.735, P=0.009). Additionally, IRAK1 expression was related to clinical TNM stage (r=0.241, P < 0.001), lymph node metastasis (r=0.279, P < 0.001) and tumor size (r=0.299, P < 0.001) in lung cancer. In the subgroup of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), the positive rates of IRAK1 were both higher than that in the normal lung tissues (P=0.003, P=0.002, respectively). Further spearman analysis showed that IRAK1 protein in NSCLC was positive correlated with clinical TNM stage (r=0.222, P < 0.001), lymph node metastasis (r=0.277, P < 0.001), tumor size (r=0.292, P < 0.001) and distal metastasis (r=0.110, P=0.043). In conclusion, the expression of IRAK1 protein might be valuable in identifying patients with increased risks of lung cancer and might act as a target for diagnosis and gene therapy for lung cancer.
- ArticleKuss S, Trinh D, Danis L, Mauzeroll J.Anal Chem. 2015 Aug 18;87(16):8096-101.Scanning electrochemical microscopy (SECM) allows imaging and analysis of a variety of biological samples, such as living cells. Up to now, it still remains a challenge to successfully decouple signals related to topography and reactivity. Furthermore, such delicate samples require careful adjustment of experimental parameters, such as scan velocity. The present study proposes a method to extract a substrate's kinetic rate by numerical modeling and experimental high speed constant height SECM imaging. This is especially useful for the determination of substrates with unknown surface reaction kinetics and large topographical features. To make this approach applicable to soft cell samples, which cannot be imaged at high velocity, a nonlinear fit strategy is presented to obtain kinetic rate values also under slow scan velocity conditions.
- ArticleGriffin DO, Goff SP.J Virol. 2015 Aug;89(15):8096-100.Certain cells have the ability to block retroviral infection at specific stages of the viral cycle by the activities of well-characterized factors and transcriptional silencing machinery. Infection of murine stem cells (MSCs) by the murine leukemia viruses (MLVs) is profoundly blocked postintegration by transcriptional silencing. Here, we show that a dominant point of restriction of HIV-1 in human CD34+ cells is prior to integration of viral DNA and that HIV-1 restriction by human CD34+ cells is fundamentally different from MLV restriction by mouse cells.
- ArticleTang CY, Phillips N, Bates JI, Thompson AL, Gutmann MJ, Aldridge S.Chem Commun (Camb). 2012 Aug 21;48(65):8096-8.The reactions of Me(2)NH·BH(3) with cationic Rh(III) and Ir(III) complexes have been shown to generate the 18-electron aminoborane adduct [Ir(IMes)(2)(H)(2){κ(2)-H(2)BNMe(2))](+) and the remarkable 14-electron aminoboryl complex [Rh(IMes)(2)(H)-{B(H)NMe(2))](+). Neutron diffraction studies have been used for the first time to define H-atom locations in metal complexes of this type formed under catalytic conditions.
- ArticleChua P, Lim WK.Sci Rep. 2021 04 14;11(1):8096.Stroke causes death and disability globally but no neuroprotectant is approved for post-stroke neuronal injury. Neuroprotective compounds can be identified using oxygen glucose deprivation (OGD) of neuronal cells as an in vitro stroke model. Nerve growth factor (NGF)-differentiated PC12 pheochromocytoma cells are frequently used. However, investigators often find their clonal variant undifferentiable and are uncertain of optimal culture conditions. Hence we studied 3 commonly used PC12 variants: PC12 Adh, PC12 from Riken Cell Bank (PC12 Riken) and Neuroscreen-1 (NS-1) cells. We found DMEM the optimal media for PC12 Riken and NS-1 cells. Using a novel serum-free media approach, we identified collagen IV as the preferred adhesive substrate for both cell lines. We found PC12 Adh cells cannot attach without serum and is unable to differentiate using NGF. NS-1 cells differentiated to a maximal 72.7 ± 5.2% %, with substantial basal differentiation. We optimised differentiated NS-1 cells for an in vitro stroke model using 3 h of OGD resulting in ~ 70% viable cells. We screened 5 reported neuroprotectants and provide the first report that serotonin is antiapoptotic in a stroke model and the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) is neuroprotective in PC12 cells. Thus we demonstrate the optimisation and validation for a PC12 cell-based in vitro stroke model.
- ArticleCheltsov A, Nomura N, Yenugonda VM, Roper J, Mukthavaram R, Jiang P, Her NG, Babic I, Kesari S, Nurmemmedov E.Sci Rep. 2020 05 15;10(1):8096.Abnormal regulation of β-catenin initiates an oncogenic program that serves as a main driver of many cancers. Albeit challenging, β-catenin is an attractive drug target due to its role in maintenance of cancer stem cells and potential to eliminate cancer relapse. We have identified C2, a novel β-catenin inhibitor, which is a small molecule that binds to a novel allosteric site on the surface of β-catenin. C2 selectively inhibits β-catenin, lowers its cellular load and significantly reduces viability of β-catenin-driven cancer cells. Through direct binding to β-catenin, C2 renders the target inactive that eventually activates proteasome system for its removal. Here we report a novel pharmacologic approach for selective inhibition of β-catenin via targeting a cryptic allosteric modulation site. Our findings may provide a new perspective for therapeutic targeting of β-catenin.
- ArticleLama RD, Charlson K, Anantharam A, Hashemi P.Anal Chem. 2012 Oct 02;84(19):8096-101.Carbon fiber microelectrodes provide the ideal platform for performing ultrafast, selective measurements of electroactive brain molecules. This article highlights the current status of the use of carbon fiber microelectrodes in neurochemical measurements, outlining the most cutting edge findings and technological advances in amperometry and fast-scan cyclic voltammetry.
- ArticleMuriel C, Blanco-Romero E, Trampari E, Arrebola E, Durán D, Redondo-Nieto M, Malone JG, Martín M, Rivilla R.Sci Rep. 2019 05 30;9(1):8096.Flagellum mediated motility is an essential trait for rhizosphere colonization by pseudomonads. Flagella synthesis is a complex and energetically expensive process that is tightly regulated. In Pseudomonas fluorescens, the regulatory cascade starts with the master regulatory protein FleQ that is in turn regulated by environmental signals through the Gac/Rsm and SadB pathways, which converge in the sigma factor AlgU. AlgU is required for the expression of amrZ, encoding a FleQ repressor. AmrZ itself has been shown to modulate c-di-GMP levels through the control of many genes encoding enzymes implicated in c-di-GMP turnover. This cyclic nucleotide regulates flagellar function and besides, the master regulator of the flagellar synthesis signaling pathway, FleQ, has been shown to bind c-di-GMP. Here we show that AdrA, a diguanylate cyclase regulated by AmrZ participates in this signaling pathway. Epistasis analysis has shown that AdrA acts upstream of SadB, linking SadB with environmental signaling. We also show that SadB binds c-di-GMP with higher affinity than FleQ and propose that c-di-GMP produced by AdrA modulates flagella synthesis through SadB.
- ArticleYao L, Wang Z, Zhao H, Cheng C, Fu X, Liu J, Yang X.Int J Mol Sci. 2011;12(11):8096-104.The aim of this study was to investigate radioprotective effect of the polysaccharides from soybean meal (SMP) against X-ray radiation-induced damage in mouse spleen lymphocytes. MTT and comet assay were performed to evaluate SMP's ability to prevent cell death and DNA damage induced by radiation. The results show that, X-ray radiation (30 KV, 10 mA, 8 min (4 Gy)) can significantly increase cell death and DNA fragmentation of mouse spleen lymphocytes. Pretreatment with SMP for 2 h before radiation could increase cell viability, moreover, the SMP can reduce X-ray radiation-induced DNA damage. The percentage of tail DNA and the tail moment of the SMP groups were significantly lower than those of the radiation alone group (p < 0.05). These results suggest SMP may be a good candidate as a radioprotective agent.
- ArticleMartin DDO, Kay C, Collins JA, Nguyen YT, Slama RA, Hayden MR.Sci Rep. 2018 05 25;8(1):8096.Post-translational modifications (PTMs) are key modulators of protein function. Huntington disease (HD) is a dominantly inherited neurodegenerative disorder caused by an expanded CAG trinucleotide repeat in the huntingtin (HTT) gene. A spectrum of PTMs have been shown to modify the normal functions of HTT, including proteolysis, phosphorylation and lipidation, but the full contribution of these PTMs to the molecular pathogenesis of HD remains unclear. In this study, we examine all commonly occurring missense mutations in HTT to identify potential human modifiers of HTT PTMs relevant to HD biology. We reveal a SNP that modifies post-translational myristoylation of HTT, resulting in downstream alterations to toxic HTT proteolysis in human cells. This is the first SNP shown to functionally modify a PTM in HD and the first validated genetic modifier of post-translational myristoylation. This SNP is a high-priority candidate modifier of HD phenotypes and may illuminate HD biology in human studies.