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- ArticlePennington SN, Smith CP, Tapscott EB.Alcohol Clin Exp Res. 1978 Jul;2(3):311-6.The lipid composition of rat liver microsomes was not altered in response to a single acute dose of ethanol relative to isocaloric glycerol-treated controls. Microsomal cytochrome P-450 was transiently elevated, the elevation paralleling blood ethanol levels. Microsomal NADPH oxidase was transiently elevated relative to the activity in isocaloric glycerol-treated controls.