Search

Search Results

• Book

  Data Mining with R : Learning with Case Studies. Second edition. [2nd ed.]

  Luís Torgo.

  Read Full Description

  Contents:
  I. R and data mining
  II. Case studies.

  Digital Access TandFonline 2017
  
  Get Shareable Link

  View Details
• Article

  Relationships of quantum mechanical calculations, relative mutagenicity of benzo[a]anthracene diol epoxides, and "bay region" concept of aromatic hydrocarbon carcinogenicity.

  Lehr RE, Jerina DM.

  J Toxicol Environ Health. 1977 Jul;2(6):1259-65.

  Abstract

  Evidence supporting the conclusion that 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrenes are ultimate mutagenic and carcinogenic forms of benzo[a]pyrene (BP) is summarized. Qauntum mechanical calculations that predict reactivity of diol epoxides derived from BP and other polycyclic aromatic hydrocarbons are described. The calculations predict that diol epoxides in which the oxirane ring forms part of a "bay region" of a tetrahydrobenzo ring should be the most reactive for a given aromatic hydrocarbon. Experiments with dihydrodiols and diol epoxides from benzo[a]anthracene (BA) are described. The ability to metabolically activate BA 3,4-dihydrodiol to species much more mutagenic that those obtained from other BA dihydrodiols ant the much greater mutagenicity of the diastereoisomeric 3,4-diol 1,2-epoxides of 1,2,3,4-tetrahydro BA relative to other diol epoxides of BA are in accord with predictions of the quantum mechanical calculations.

  Digital Access Access Options
  Get Shareable Link

  PubMed