Today's Hours: 10:00am - 6:00pm

Search

Filter Applied Clear All

Did You Mean:

Search Results

  • Article
    Ohl CD, Wolfrum B.
    Biochim Biophys Acta. 2003 Dec 05;1624(1-3):131-8.
    The interaction of lithotripter-generated shock waves with adherent cells is investigated using high-speed optical techniques. We show that shock waves permeabilize adherent cells in vitro through the action of cavitation bubbles. The bubbles are formed in the trailing tensile pulse of a lithotripter-generated shock wave where the pressure drops below the vapor pressure. Upon collapse of cavitation bubbles, a strong flow field is generated which accounts for two effects: first, detachment of cells from the substrate; and second, the temporary opening of cell membranes followed by molecular uptake, a process called sonoporation. Comparison of observed cell detachment with results from a theoretical model considering peeling cell detachment by a wall jet-induced shear stress shows reasonable agreement.
    Digital Access Direct to PDF
doi:10.1016/j.bbagen.2003.10.005