Search Results

• Book

  Group Practice Development : a Practical Handbook

  John W. Field.

  Print Access Request

  Location

  Version

  Call Number

  Items

  General Collection: Downstairs

  1976

  R729.5.G6 F53 1976

  1
  Get Shareable Link

  View Details
• Article

  Effects of phosvitin on the ecg changes induced under hypoxia in the rat.

  Caprino L, Falchetti R, Borrelli F.

  J Pharm Pharmacol. 1976 Feb;28(2):127-32.

  The effect of phosvitin (1 g kg(-1), i.p.) on ecg changes induced in rats by a reduction of partial oxygen pressure in the respiratory mixture was studied. Phosphocreatine, phosphoserine, ATP and Na2HPO42H2O were also administered intraperitoneally for comparison. Phosvitin alone was found to prevent the hypoxia-induced T-wave changes (flattening or disappearance), which were also temporarily aggravated by injection of noradrenaline. As to the metabolic, hypoxia-induced myocardial changes, two hypotheses are discussed: a release of phosvitin phosphate radicals ready for immediate utilization or a drug action mediated via a membrane-bound intrinsic proteinkinase system.

  Digital Access Access Options
  Get Shareable Link

  PubMed