Bookedited by Shuu-Jiun Wang, Chi Ieong Lau.
Contents:
Chapter 1: Update in migraine preventive treatment
1. Introduction
2. Preventive medications for migraine
2.1. Beta-blockers
2.2. Antiepileptic drugs
2.3. Calcium channel blockers
2.4. Antidepressants
2.5. Non-steroid anti-inflammatory drugs (NSAIDs)
2.6. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs)
2.7. Miscellaneous
3. Preventive medications for chronic migraine
3.1. OnabotulinumtoxinA
3.2. Topiramate
4. Calcitonin gene-related peptide monoclonal antibodies
4.1. Erenumab
4.2. Galcanezumab
4.3. Fremanezumab
4.4. Eptinezumab
5. Special considerations
5.1. Menstrual-related migraine
5.2. Pregnancy and breastfeeding
5.3. Children and adolescents
6. Conclusion
References
Chapter 2: Therapeutic implications of cortical spreading depression models in migraine
1. Migraine
2. Cortical spreading depression
3. Basics on in vivo experimental models of CSD
4. Consequences of CSD
4.1. Trigeminovascular activation
4.2. Cortical inflammation
4.3. Disruption of blood-brain barrier and impaired glymphatic flow
5. Migraine modulators affect CSD susceptibility
5.1. Genetic factors
5.2. Sex and age
5.3. Stress, sleep deprivation and hypoglycemia
6. CSD inhibition reflecting clinical responsiveness
7. CSD inhibitors that inhibit migraine aura but not headache
7.1. Ketamine
7.2. Lamotrigine
7.3. Tonabersat
8. Novel targets for migraine therapeutics
8.1. Calcitonin gene-related peptide
8.2. Ion channels
8.2.1. Pannexin-1 channels and P2X7 receptors
8.2.2. Acid-sensing ion channels (ASICs)
8.2.3. Transient receptor potential (TRP) channels
8.2.4. TWIK-related spinal cord potassium channel (TRESK)
8.3. Insulin-like growth factor-1 (IGF-1)
8.4. Neuromodulation
8.4.1. Vagus nerve stimulation
8.4.2. Transcranial magnetic stimulation
8.4.3. Transcranial direct current stimulation
9. Future directions and potentials for CSD models
10. Conclusion
Funding
References
Chapter 3: Electrophysiological basis for antiepileptic drugs in migraine prevention
Abstract
Keywords
1. Introduction --2. Basic concepts of electrophysiological studies in migraine
3. The visual cortex
3.1. Steady-state visual evoked potential (SSVEP)
3.2. Pattern reversal visual evoked potential (PRVEP)
3.3. Phosphene induced by transcranial magnetic stimulation
3.4. Magnetic suppression of perceptual accuracy (MSPA)
4. The somatosensory cortex
4.1. Standard (broad-band) somatosensory evoked potential
4.2. High-frequency oscillations of the somatosensory evoked potential
5. The motor cortex
5.1. Motor threshold (MTh) and motor evoked potentials (MEPs)
5.2. Silent period (SP).