BookSami Shousha.
Summary: This book provides a concise, step-by-step guide to accurate microscopic diagnosis for clinicians who deal with patients with breast lesions. The emphasis is on a practical approach to dealing with breast biopsies and reaching a diagnosis. It outlines the procedures used for the microscopic diagnosis of various breast lesions and the significance of the nomenclature and terms used in pathology reports, including those dealing with uncommon or rare lesions. Ample illustrations of the lesions discussed are included, particularly those dealing with uncommon and border-line lesions. There is a special emphasis on breast cancer and on the fact that not all breast cancers are the same. The different ways by which breast cancers are classified are discussed including recent classifications which lead to personalized therapy. The book is aimed at pathologists of all grades who deal with breast biopsies including those in training. It would be also useful for practicing and trainee surgeons and oncologists as well as other health professionals dealing with patients with breast diseases and scientists carrying out research on breast problems.
Contents:
Intro
Contents
1: Introduction
References
2: Core Biopsy
The Patient
The Lesion
The Doctor
The Needle
Type of Biopsies
The Sample
The Request Form
The Laboratory
The Pathologist
The Multi-disciplinary Team Meeting (MDT)
References
3: Reporting Core Biopsies: Benign (B2) Lesions
Introduction: Is the Lesion Benign or Malignant?
Benign Lesions That Do Not Usually Need Further Intervention (B2 Lesions)
Fibroadenoma
Special Types of Fibroadenomas
Hamartoma
Fibrocystic Change
Ductal Hyperplasia Differentiating Regular Hyperplasia (B2) from Atypical Hyperplasia (B3) and Low Grade DCIS (B5a)
Columnar Cell Change and Columnar Cell Hyperplasia
Sclerosing Adenosis and Apocrine Adenosis
Duct Ectasia
Granulomatous Mastitis
Other Inflammatory Conditions
Other Less Common Benign Conditions
References
4: Reporting Core Biopsies: Benign Lesions That Usually Need Further Intervention (B3 Lesions)
Introduction
Atypical Epithelial Hyperplasia (ADH)
Flat Epithelial Atypia (FEA)
In Situ Lobular Neoplasia
Radial Scar/Complex Sclerosing Lesions Intraduct Papillomas
Cellular Fibro-Epithelial Lesions
Spindle Cell Lesions
Mucocele Like Lesions
Microglandular Adenosis
Benign and Atypical Vascular Lesions
Granular Cell Tumour
Collagenous Spherulosis
Epithelial Myoepithelial Benign Lesions
General Remark: Risk of Malignancy in Benign Breast Lesions Discovered During Mammography
References
5: Reporting Core Biopsies: Lesions That Are Highly Suspicious of Malignancy (B4) or Definitely Malignant (B5)
B4 Lesions
B5 Lesions
B5a (Non-invasive Lesions)
In Situ Carcinoma
Ductal Carcinoma In Situ (DCIS) Incidence of Metastasis and Death After Diagnosing DCIS
Lobular Carcinoma In Situ (LCIS)
Paget's Disease of the Nipple
Intracystic and Solid Papillary Carcinomas
Invasive Lesions (B5b)
Primary Invasive Breast Carcinoma
Morphological Types
Invasive Ductal Carcinoma
Pleomorphic Invasive Ductal Carcinoma
Invasive Lobular Carcinoma
Invasive Tubular Carcinoma
Invasive Cribriform Carcinoma
Invasive Mucinous Carcinoma
Lympho-Epithelioma-Like Carcinoma
Invasive Apocrine Carcinoma
Invasive Papillary Carcinoma
Invasive Micropapillary Carcinoma Neuroendocrine Tumours of the Breast
Glycogen-Rich Clear Cell Carcinoma
Lipid-Rich Carcinoma
Triple Negative Invasive Breast Carcinoma
Grading of Primary Invasive Breast Carcinoma
Other Additional Features That Should Be Mentioned in the Core Biopsy Report
ER and PR Assessment
HER2 Assessment [75]
Other Immunohistological Studies
Molecular Classification of Breast Carcinoma
Complete Removal of Lesions
Primary Sarcomas of the Breast
Angiosarcoma
Mammary Sarcoma with CD10 Expression (Fig. 5.60)
Stromal Sarcoma
Primary Osteogenic Sarcoma