BookAna C. Xavier, Mitchell S. Cairo, editors.
Summary: This volume will review different classes of "target" drugs that have been developed, approved, or are under investigation in the field of lymphoma therapy. The discussion will not only be on the understanding of the mechanisms of action or clinical response of those agents, but also help the reader to understand the nature of lymphoma biology in patients who relapse or are refractor after exposure to those drugs. Contributors will discuss what is currently known about mechanisms of tumor-related or host-related resistance, and how to overcome this resistance. This understanding is crucial given the dismal outcomes of patients with relapsed or refractory lymphomas. The book provides a unique opportunity to review and reflect on the recent successes and pitfalls of the modern lymphoma therapy era.
Contents:
Mechanisms of Glucocorticoid Response and Resistance in Lymphoid Malignancies
Resistance to Monoclonal Antibody Therapeutics in Lymphoma
Resistance to Antibody-Drug Conjugate
Resistance to Proteasome Inhibitor Therapy in Non-Hodgkin Lymphoma
Resistance to Histone Deacetylase Inhibitors in the Treatment of Lymphoma
Resistance to Brutons Tyrosine Kinase Signaling Pathway Targeted Therapies
Resistance to Checkpoint Blockade Inhibitors and Immunomodulatory Drugs
Resistance to Bispecific T-cell Engagers and Bispecific Antibodies
Resistance to Chimeric antigen receptor T-cell therapy
Index.