BookAlexey Moskalev, editor.
Summary: This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging. In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function). The book goes on to describe DNA methylation, known as the "epigenetic clock," as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education. Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging. Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.
Contents:
Chapter 1: Introduction
Alexey Moskalev Section-1: BIOMARKERS OF AGING AND HEALTH Chapter 2: Practical Detection of Biological Age: Why it is not a trivial task
Ancha Baranova Tiange Cui, Boris Veytsman Chapter 3: Biological age is a universal marker of aging, stress, and frailty
Timothy V. Pyrkov, Peter O. Fedichev Chapter 4: Biomarkers of health and healthy ageing from the outside-in
Jonathan Sholl, Suresh Rattan Chapter 5: Biomarkers of aging
Yizhen Yan, Yonglin Mu, Weiyang Chen, Jing-Dong J. Han Chapter 6: Review of molecular and cellular biomarkers of aging
Ilya Solovyev, Mikhail Shaposhnikov, Alexey Moskalev Section-2: PROTEOMICS AND GLYCOMICS BIOMARKERS OF AGING Chapter 7: IgG glycans as a biomarker of biological age
Vilaj M, Gudelj I, Trbojević-Akmačić I, Lauc G, Pezer M Chapter 8: Oxidatively modified proteins and maintenance systems as biomarkers of aging
Bertrand Friguet, Martin Baraibar Chapter 9: Is impaired proteodynamics a key to understand the biomarkers of cellular aging?
Jacek M. Witkowski, Tamas Fulop Section-3: GENETICS AND EPIGENETICS AGING MARKERS Chapter 10: Genetic markers of extreme human longevity
Paola Sebastiani, Anastasia Gurinovich, Harold Bae, Thomas T Perls Chapter 11: Epigenetic biomarkers of aging
Morgan E. Levine Chapter 12: DNA methylation biomarkers to assess biological age -Dmitiriy Podolskiy, Vadim Gladyshev Chapter 13: Epigenetics of brain aging: lessons from chemo brain and tumor brain
Anna Kovalchuk, Bryan Kolb, Olga Kovalchuk Chapter 14: Approaches and methods for variant analysis in a cell
Alexej Abyzov, Flora M. Vaccarino, Alexander E. Urban, Vivekananda Sarangi Section-4: IMMUNOSENESCENCE AND INFLAMMAGING MARKERS Chapter 15: Is there any reliable biomarker for immunosenescence and inflammaging?
Tamas Fulop, Alan Cohen, Glenn Wong, Jacek M Witkowski, Anis Larbi. Chapter 16: Immune parameters associated with mortality in longitudinal studies of very old people can be markedly dissimilar even in apparently similar populations
Graham Pawelec, David Goldeck Chapter 17: Gut microbiota and aging
Kashtanova DA, Tkacheva ON, Strazhesko ID, Dudinskaya EN, Kotovskaya YuV, Popenko AS, Tyaht AV, Alexeev DG Section-5: SYSTEMS BIOLOGY OF AGING, BIOLOGICAL AGE AND MORTALITY MARKERS Chapter 18: Deep integrated biomarkers of aging
Polina Mamoshina, Alex Zhavoronkov Chapter 19: Quantification of the biological age of the brain using neuroimaging
James Cole, Katja Franke, Nic Cherbuin Chapter 20: Arterial aging: the role of hormonal and metabolic status and telomere biology
Irina D. Strazhesko, Daria A. Kashtanova, Ekaterina N. Dudinskaya, Olga N. Tkacheva Chapter 21: Circulating Biomarkers of Aging
Hongxia Zhang, Brian Wang, Kunlin Jin Chapter 22: Molecular signature of aging driven by Wnt signaling pathway: Lessons from nematodes
Marco Lezzerini, Yelena V. Budovskaya. Chapter 23: The problem of integrating of biological and clinical markers of aging
Arnold Mitnitski Index.