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  • Book
    Mohd Sayeed Akhtar, Mallappa Kumara Swamy, editors.
    Summary: This book summarizes the application of plant derived anticancer compounds as chemopreventives to treat several cancer types, focusing on the molecular mechanisms of action of phytocompounds and providing an overview of the basic processes at the cellular and molecular level that are involved in the progression of the cancer and can be employed in targeted preventive therapies. In addition, it highlights the development of novel anticancer drugs from plant sources using bioinformatics approaches. The compiled chapter data aids readers understanding of issues related to bioavailability, toxic effects and mechanisms of action of phytocompounds, and helps them identify the leads and utilize them against various cancer types effectively. Furthermore, it promotes the use of bioinformatics tools in medicinal plants to expedite their use in plant breeding programs to develop molecular markers to distinguish disease subtypes and predicting mutation, which in turn improves cancer diagnosis and prognosis, and to develop new lead compounds computationally. Thebook provides scientific verifications of plant compounds mechanisms of action against various cancers and offers useful information for students, teachers, and healthcare professionals involved in drug discovery, and clinical and therapeutic research.

    Contents:
    Chapter 1. Omics- a holistic approach in cancer treatment
    Chapter 2. Plant miRNAs and phytomolecules as anticancer therapeutics
    Chapter 3. Potential of herbal medicines in colorectal carcinoma and their mechanism of action
    Chapter 4. Elucidation of mechanisms of anticancer plant compounds against the tumor cells
    Chapter 5. Computational approach towards exploring interaction of target protein-phytocompounds in drug development for breast cancer
    Chapter 6. Anticancer Potential of Andrographolide, a diterpenoid lactone from Andrographis paniculata: A nature's treasure for chemoprevention and therapeutics
    Chapter 7. Anticancer activity of herbal medicine: Mechanism of action
    Chapter 8. Metabolomic study of chemo-preventive phytochemicals and their therapeutic prospects
    Chapter 9. CADD studies applied to secondary metabolites in the anticancer drug research
    Chapter 10. Anticancerous plant compounds affecting the power house of cancerous cells: A possible herbal mitocan
    Chapter 11. Phytoestrogens as a natural source for the possible colon cancer treatment
    Chapter 12. Bioinformatics approaches for genomics and post genomics applications of anticancer plants
    Chapter 13. Fruits of Rosaceae family as a source of anticancer compounds and molecular innovations
    Chapter 14. Mechanism of action of anticancer herbal medicines.
    Digital Access Springer 2018
  • Article
    Hardham AR, Gunning BE.
    J Cell Biol. 1978 Apr;77(1):14-34.
    Serial sectioning was used to track the position and measure the lengths of cortical microtubules in glutaraldehyde-osmium tetroxide-fixed root tip cells. Microtubules lying against the longitudinal walls during interphase, those overlying developing xylem thickenings, and those in pre-prophase bands are oriented circumferentially but on average are only about one-eighth of the cell circumference in length, i.e., 2-4 micrometer. The arrays consist of overlapping component microtubules, interconnected by cross bridges where they are grouped and also connected to the plasma membrane. Microtubule lengths vary greatly in any given array, but the probability that any pass right around the cell is extremely low. The majority of the microtubule terminations lie in statistically random positions in the arrays, but nonrandomness in the form of groups of terminations and terminations in short lines parallel to the axis of cell elongation has been observed. Low temperature induces microtubule shortening and increases the frequency of C-shaped terminations over the 1.7% found under normal conditions; colchicine and high pressures produce abnormally large proportions of very short microtubules amongst those that survive the treatments. Deuterium oxide (D2O) treatment probably induces the formation of additional microtubules as distinct from increasing the length of those already present. The distribution of C-shaped terminations provides evidence for at least local polarity in the arrays. The validity of the findings is discussed, along with implications for the development, maintenance, and orientation of the arrays and their possible relationship to the orientation of cellulose deposition.
    Digital Access Access Options
  • Journal
    Print 1965-1970.