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  • Book
    Kalevi Kairemo, Homer A. Macapinlac, editors.
    Read Full Description
    Summary: This pocket book is the first of its kind on sodium fluoride (18F-NaF)-PET and addresses skeletal as well as cardiovascular applications. In malignant metastatic diseases 18F-NaF-PET has already demonstrated its benefits in cancer staging, re-staging, follow-up and response evaluation. It also has an emerging diagnostic role in the calcified soft-tissue metastases of primary bone tumours, and can be applied to evaluate cardiovascular diseases, such as calcifications in heart valves and peripheral vascular disease. The book is divided into 11 chapters: five on oncology, four addressing the general aspects of skeletal conditions, and two on cardiovascular diseases. It offers a valuable guide for referring colleagues, nuclear medicine physicians/radiologists and aid clinicians, and highlights the main applications and limitations of 18F-NaF-PET hybrid imaging (PET/CT).

    Contents:
    18F-Fluoride Imaging: Tracer and Technique
    18F-Fluoride Imaging: Normal variants and artefacts
    Sodium fluoride imaging in oncology
    18F-Fluoride Imaging: Monitoring therapy
    Determination of Skeletal Tumor Burden on 18F-Fluoride PET/CT
    18F-Fluoride: Benign Bone Disease
    Dynamic 18F-Fluoride Imaging
    18F-Fluoride Imaging: Atlas of interesting images (images with specific teaching points, tracer, technique and pitfalls)
    Role of Sodium Fluoride-PET in Primary Bone Tumors
    18F-Sodium Fluoride Positron Emission Tomography in Cardiac Disease
    18F-Sodium Fluoride positron emission tomography / computed tomography imaging of the peripheral vasculature.
    Digital Access Springer 2020
  • Article
    Bolton WK, Atuk NO.
    Kidney Int. 1978 Apr;13(4):263-70.
    Abstract
    Shock and the generalized Shwartzman reaction are well known features of endotoxin which have been shown to involve the sympathetic nervous system. The mechanism of sympathetic nervous system involvement with endotoxin injection was studied in rabbits chemically sympathectomized with 6-hydroxydopamine. Endotoxin, in doses producing a spectrum of morbidity and mortality in normal rabbits, was administered i.v. to chemically sympathectomized, normal, and unilateral renal surgically sympathectomized animals. Chemical sympathectomy produced a significant depletion of tissue norepinephrine which, in endotoxin recipient animals, was associated with a significantly lower mortality rate and greatly decreased fibrin deposition in the lungs and kidneys, despite intravascular coagulation. Unilateral renal sympathectomy afforded protection to the ipsilateral kidney, but data on mortality and systemic fibrin deposition were similar to those reported for normal rabbits given endotoxin. Six-hydroxydopamine prevents significant tissue injury secondary to endotoxin in this experimental model. In addition, the data provide direct evidence that an intact reactive sympathetic nervous system is essential for development of lethal toxicity and generalized Shwartzman reaction due to endotoxin.
    Digital Access Access Options
doi:10.1038/ki.1978.39