BookDirk Lange, Kymora B. Scotland, editors.
Summary: This updated volume provides a concise guide to the pathogenic, therapeutic, and preventative roles of bacteria in urology. New chapters discussing the involvement of the microbiome in the areas of recurrent kidney stone disease, female urology, and prostate cancer are included. The treatment of urosepsis, stone management, genitourinary malignancy, stone sequencing, and the role of microbiome and virome in urology are also covered. The Role of Bacteria in Urology is relevant to both clinicians and scientists interested in the infection of the genitourinary system.
Contents:
Intro; Preface; Contents;
1: Bacteria in the Genitourinary Tract: The Microbiota and Efforts to Address Infection; Introduction; The Microbiome and Its Significance in Urology; Probiotics and Urological Diseases; Cranberry Juice; References;
2: Overview of Urinary Tract Infections; Cystitis; Pathogenesis; Uropathogenic E. coli; Staphylococcus saprophyticus; Enterococcus faecalis; Streptococcus agalactiae (GBS); Clinical Management, Treatment, and Preventive Measures; Pyelonephritis; Mechanisms of Bacterial Pathogenesis; Differences Between E. coli Strains in Pyelonephritis and Cystitis Clinical Management, Treatment, and Preventive MeasuresUrethritis; Clinical Management, Treatment, and Preventive Measures; Microbiome of the Urinary Tract; References;
3: Pathogenic Mechanisms of Uropathogens; Introduction; Bacterial Adhesion; Type 1 Fimbriae; P Fimbriae; S Fimbriae and F1C Fimbriae; Non-fimbriated Adhesins; Biofilms and Related Communities; Biofilms; Intracellular Biofilm Communities (IBCs); Quiescent Intracellular Reservoirs (QIRs); Toxins and Nutrient Acquisition; Hemolysin A; Cytotoxic Necrotizing Factor; Iron Acquisition; Urease; Surviving Antimicrobials; References
4: Urosepsis: Pathogenesis and TreatmentClinical Introduction; Sources and Pathogenesis of Urosepsis; Management; Prior Sepsis Scoring; Conclusion; References;
5: The Microbiome in the Testis: Epididymitis and Orchitis; Introduction; Epidemiology; Epididymitis; Definition and Classification; Presentation; Pathogenesis and Etiology; Investigations; Complications; Management; Orchitis; Epidemiology; Definition and Classification; Presentation; Pathogenesis and Etiology; Investigations; Complications; Management; Chronic Scrotal Pain; Testis Microbiome: Future Directions of Research; References
6: Struvite Stone Formation by Ureolytic BiofilmsFormation of Struvite Stones by Ureolytic Microorganisms; Biofilm Development and Struvite Precipitation; Investigation of Struvite Stone Formation Using In Vitro and In Silico Techniques; Summary; References;
7: Management of Infection Stones; Introduction; References;
8: The Use of Probiotics and Other Microbiota Therapies to Mitigate Recurrent Calcium Oxalate Stone Formation; Introduction; The Role of CaOx in Stone Disease; Treatment of CaOx Stone Disease; Microbiome Damage and Stone Formation; Environmental Damage to the Microbiota Microbiome Restoration TherapiesProbiotics; O. formigenes; the Bacterial Proto-oxalate Utilizer in Humans; Oxalobacter Replacement; Lactic Acid Bacteria-Based Probiotics; Engineered Microbial Solutions; Fecal Microbiome Transplantation (FMT); Conclusion; References;
9: Role of Oxalobacter formigenes Colonization in Calcium Oxalate Kidney Stone Disease; Microbiology of O. formigenes; O. formigenes in the Human Gut; O. formigenes Colonization; O. formigenes Colonization and Risk of Calcium Oxalate Stone Disease; Conclusions; References