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  • Book
    Giuseppe Micali, Francesco Lacarrubba, Giuseppe Stinco, Giuseppe Argenziano, Iria Neri, editors.
    Summary: This atlas, containing a wealth of clinical and dermoscopic images, describes and illustrates the applications of dermoscopy in a wide variety of skin disorders that may be encountered in the pediatric population. Key features and other salient aspects are highlighted with the aim of enabling the clinician to reach a fast and reliable diagnosis in all cases. Dermoscopy is a non-invasive technique that allows rapid and magnified in vivo observation of the skin, with visualization of morphologic features imperceptible to the naked eye. Dermoscopy has revolutionized the approach to pigmented skin lesions, greatly improving diagnostic accuracy. Furthermore, over the past few years it has been demonstrated to be very useful in the diagnosis, follow-up, and therapeutic monitoring of a range of other skin disorders, including cutaneous/mucosal infections, ectoparasitoses, inflammatory diseases, and hair and nail abnormalities. Being non-invasive, dermoscopy is particularly suitable for use in the pediatric population, in which invasive diagnostic procedures may be problematic.
    Digital Access Springer 2018
  • Article
    Stalder H.
    Yale J Biol Med. 1977 Sep-Oct;50(5):507-32.
    The current status of antiviral therapy is reviewed, including discussion of older approaches together with more recently developed chemotherapy. Following the introduction dealing with pathophysiological aspects of virus disease, the different approaches to antiviral therapy are presented. The reasons for the slow progress in antiviral therapy are discussed. These include: 1. the necessity of intracellular penetration of drugs acting on viral replication; 2. the severe toxicity of most antiviral drugs; 3. the narrow antiviral spectrum of most of these agents; 4. the difficulty of making a rapid etiological diagnosis in view of the necessity of starting (specific?) treatment early in the course of the disease; 5. the difficult evaluation of beneficial as compared with deleterious effects of antiviral therapy. After a detailed review of clinically tested substances, including immunoglobulins, synthetic antiviral drugs (amantadine, nucleoside analogs, thiosemicarbazones and photodynamic dyes) and interferon, a guide concerning indications and application of specific antiviral therapy is presented. Although at present there are few indications, clinicians should be aware of the (present and future) possibilities of antiviral therapy.
    Digital Access Access Options