Bookedited by Ajaykumar Vishwakarma, Jeffrey M. Karp.
Contents:
I. Biology of stem cell niches and molecular mechanisms
The need to study, mimic, and target stem cell niches
Harnessing the biology of stem cells' niche
Pluripotent stem cell microenvironment
Regulation of hematopoietic stem cell dynamics by molecular niche signaling
HSC niche: regulation of mobilization and homing
Neuronal stem cells niches of the brain
Cardiovascular stem cell niche
Intestinal epithelial Lgr5+ stem cell niche and organoids
The epithelial stem cell niche in skin
The satellite cell niche in skeletal muscle
The cancer stem cell niche
Cellular senescence and stem cell niche
Biochemical and physical cues in the stem cell niche directing cell fate
Matrix chemistry controlling stem cell behavior
Matrix growth factor and surface ligand presentation
Effects of matrix mechanical forces and geometry on stem cell behavior
Wettability effect on stem cell behavior
Fluid flow control of stem cells with investigation of mechanotransduction pathways
Hypoxia regulation of stem cell: mechanisms, biological properties, and applications
III. Designing smart biomaterials to mimic and control stem cell niche
Polymer design and development
Design and development of ceramics and glasses
Surface functionalization of biomaterials
Biofunctional hydrogels for three-dimensional stem cell culture
Technologies to engineer cell substrate mechanics in hydrogels
Micro- and nanosurface patterning technologies
Self-assembled nanostructures (SANs)
Biometric nanofibers as artificial stem cell niche
IV. Bioengineering strategies to model synthetic stem cell niches
Employing microfluidic devices to induce concentration gradients
Engineering niches for embryonic and induced pluripotent stem cells
Engineering niches for cardiovascular tissue regeneration
Engineering niches for blood vessel regeneration
Engineering niches for bone tissue regeneration
Engineering vascular niche for bone tissue regeneration
Engineering niches for cartilage tissue regeneration
Engineering niches for stem and progenitor cell differentiation into immune cells
Engineering niches for skin and wound healing
Designing stem cell niche for liver development and regeneration
Engineering the niche for intestinal regeneration.