Bookeditors, Kenneth Kaushansky, Marshall A. Lichtman, Josef T. Prchal, Marcel Levi, Oliver W. Press, Linda J. Burns, Michael A. Caligiuri.
Contents:
Part I: Clinical evaluation of the patient. Initial approach to the patient: history and physical examination
Examination of the marrow
Consultative hematology
Part II: The organization of the lymphohematopoietic tissues. Structure of the marrow and the hematopoietic microenvironment
The organization and structure of lymphoid tissues
Part III: Epochal hematology. Hematology of the fetus and newborn
Hematology during pregnancy
Hematology in older persons
Part IV: Molecular and cellular hematology. Genetic principles and molecular biology
Genomics
Cytogenetics and genetic abnormalities
Metabolism of hematologic neoplastic cells
Signal transduction pathways
Hematopoietic stem cells, progenitors, and cytokines
The inflammatory response
Dendritic cells and adaptive immunity
Part V: Therapeutic principles. Principles of antithrombotic therapy
Immune cell therapy
Therapeutic apheresis: indications, efficacy, and complications
Regenerative medicine: multipotential cell therapy for tissue repair
Part VI: The erythrocyte. Structure and composition of the erythrocyte
Erythropoiesis
Erythrocyte turnover
Clinical manifestations and classification of erythrocyte disorders
Aplastic anemia: acquired and inherited
Pure red cell aplasia
Anemia of chronic disease
Erythropoietic effects of endocrine disorders
The congenital dyserythropoietic anemias
Iron deficiency and overload
Anemia resulting from other nutritional deficiencies
Anemia associated with marrow infiltration
Erythrocyte membrane disorders
Erythrocyte enzyme disorders
The thalassemias: disorders of globin synthesis
Fragmentation hemolytic anemia
Erythrocyte disorders as a result of chemical and physical agents
Hemolytic anemia resulting from infections with microorganisms
Hemolytic anemia resulting from immune injury
Alloimmune hemolytic disease of the fetus and newborn
Hypersplenism and hyposplenism
Primary and secondary erythrocytoses.