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  • Book
    Esen Özkaya, Kurtuluş Didem Yazganoğlu.
    Summary: This book describes adverse cutaneous drug reactions as among the most frequent events in patients receiving drug therapy. Cardiovascular drugs are an important group as there are a greater number of indications for the use of new drugs and their prescription continues to increase. The exact incidence of cutaneous side effects from cardiovascular drugs is difficult to estimate due to sporadic reporting. Moreover, a reliable connection between a certain drug and a certain type of reaction can only rarely be made, aside from the well-known angioedema/urticaria from angiotensin-converting enzyme inhibitors, lichen planus/lichenoid reaction from beta adrenergic blockers, and photosensitivity from thiazid diuretics. These reactions can extend to rare but life-threatening conditions such as erythroderma, Stevens-Johnson syndrome, toxic epidermal necrolysis and drug hypersensitivity syndrome. Adverse Cutaneous Drug Reactions To Cardiovascular Drugs reviews the reported types of reactions to cardiovascular drugs. Each is discussed according to drug class and the type of dermatologic reaction with special emphasize on cross-reactions and the role of patch testing in diagnosis. A total of 116 images are included featuring clinical appearance of common adverse cutaneous drug reactions and diagnostic procedures such as patch and photopatch testing with the suspected drugs. Complementary tables may allow to scan the most common cutaneous reactions and the related cardiovascular drugs along with the possible cross reactions at first glance. It will thus be of considerable importance to all dermatologists and medical professionals who manage the skin, while being an important reference resource for cardiologists in terms of identifying potential adverse reactions to the drugs they prescribe.

    Contents:
    Introduction (General information on different types of ACDR)
    Angiotensin converting enzyme inhibitors
    Angiotensin II receptor blockers
    Alpha-2 adrenergic receptor agonists
    Alpha-adrenergic receptor blockers
    Adrenergic neuron blockers
    Class I antiarrhythmic drugs (sodium channel blockers)
    Beta adrenergic receptor blockers (class II antiarrhythmics)
    Class III antiarrhythmics
    Calcium channel blockers (class IV antiarrhythmics)
    Diuretics
    Sympathomimetics
    Vasodilatory drugs
    Lipid lowering drugs
    Platelet inhibitors
    Thrombolytics
    Anticoagulants
    Miscellaneous drugs
    Diagnostic procedure: The role of patch. .
    Digital Access Springer 2014
  • Article
    Watkins WB, Choy VJ.
    Cell Tissue Res. 1979 Mar 19;197(2):337-46.
    Transverse sections of the median eminence from fetal and neonatal rats were examined by the immunoperoxidase technique to detect the presence of oxytocin, vasopressin and neurophysin. Neurophysin was observed in the 18-day fetus. Vasopressin and oxytocin were not detected until after birth, on the 4th and 8th days respectively. There was an accumulation of material crossreactive with neurophysin and vasopressin antibodies in the palisade layer of the median eminence between the 4th and 9th days after birth. This distribution of immunoreactive material in the palisade layer was suggestive of neurosecretory substances localized in two fibre tracts on either side of the median eminence. The data are consistent with the accumulation of corticotropin releasing factor and an associated neurophysin in this area. It is suggested that the accumulation of material occurs because of the relative immaturity of the capillary loops that constitute the primary plexus of the hypophysial portal system.
    Digital Access Access Options