BookSusan H. Fox, Jonathan M. Brotchie, editors.
Summary: This book aims to provide a single reference source on levodopa-induced dyskinesias (LID) from ?bench to bedside?. Initial chapters review the clinical features and phenomenology of LID with video examples; epidemiology and genetic risk factors for LID are covered as a background to understanding risk factors for developing LID. The following chapters cover the latest preclinical studies aiming to understand the pathophysiology of LID at the cellular, neurochemical, neurophysiological and circuitry level with detailed discussion of mechanisms and future directions to take the field forward; clinical studies from phase II to phase IV; ongoing RCTs in LID; and evidence-based medicine reviews of treatment options. Levodopa-Induced Dyskinesia in Parkinson?s Disease is aimed at an international audience of movement disorder neurologists; neuroscientists; trainees; and graduate and post-graduate students.
Contents:
Phenomenology of Levodopa-Induced Dyskinesia
Dyskinesia Rating Scales in Parkinson's Disease
Epidemiology of Levodopa-Induced Dyskinesia
Risk Factors for Levodopa-Induced Dyskinesia
Pharmacological Treatment Options for Levodopa-Induced Dyskinesia
Surgical Options for Levodopa-Induced Dyskinesia in Parkinson?s Disease
Basal Ganglia Circuitry Models of L-DOPA-Induced Dyskinesia
Basal Ganglia Circuitry Models of L-DOPA-Induced Dyskinesia
Pharmacological Properties of Levodopa
Dopamine Receptors and LID
The Serotonergic System In Levodopa-Induced Dyskinesia
The Opioid System in Levodopa-Induced Dyskinesia
Glutamate Receptors and Levodopa-Induced Dyskinesia
Cannabinoids and Levodopa-Induced Dyskinesia
The Role of the Noradrenergic System and its Receptors In Levodopa-Induced Dyskinesia
Involvement of the Cholinergic System in Levodopa-Induced Dyskinesia
New Clinical Trials for Levodopa-Induced Dyskinesia
Preclinical Models of Levodopa-Induced Dyskinesia
Final Thoughts: Summary and Future Therapeutic Strategies in LID.