BookAndrew Emili, Jack Greenblatt, Shoshana Wodak, editors.
Summary: Epigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic "code" is considered a key challenge in biomedical research. Chromatin structure and function are modified by protein complexes, causing genes to be turned on or off and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field, human chromatin-modifying machines have only recently started to be characterized. To meet this challenge, our book explores complementary experimental tracks, pursued by expert international research groups, aimed at the physical and functional characterization of the diverse repertoire of chromatin protein machines - namely, the "readers, writers and erasers" of epigenomic marks. These studies include the identification of RNA molecules and drugs that interact selectively with components of the chromatin machinery. What makes this book distinctive is its emphasis on the systematic exploration of chromatin protein complexes in the context of human development and disease networks.
Contents:
Systematic proteomic analysis of histone demethylating enzymes linked to cancer
Histone methylating protein complexes in cancer
Chromatin protein-protein interaction networks linked to cancer
Structural genomics and drug discovery for chromatin-related protein complexes involved in histone tail recognition
Transcription factories and global chromatin (enhancer) interactions in cancer
Long ncRNAs associated with chromatin complexes and their role in cancer
Familial and somatic mutations of histone modifying enzymes in cancer
Chromatin regulators arising from RNAi screens of transformed cancer cell lines
Chromatin complexes in cancer
Exploring dynamics of chromatin complexes in cancer based on quantitative proteomics
Regulatory ncRNAs and their targets
ncRNA regulatory networks in cancer
Decoding BAF remodelling complexes in cancer
Mediator/cohesin complex in cancer
miRNAs targeting chromatin-related protein complexes regulate epigenetic states in cancer
Polycomb group protein complexes in cancer stem cells
Genetic interactions between chromatin factors in cancer cell lines
Chromatin complexes in DNA repair
Chromatin complexes in chromosome segregation
Evolution, co-expression and domain architecture of CM complexes linked to cancer.