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  • Journal
    Summary: "Acta Neuropathologica Communications publishes experimental and descriptive articles on the pathology of nervous system and skeletal muscle disorders and on mechanisms of neurological disease using morphological, molecular and cell biology methods."
    Digital Access
    Provider
    Version
    PubMed Central
    v. 1-, 2013-
    BioMed Central
    v. 1-, 2013-
  • Article
    Howard MC, Fidler JM.
    Aust J Exp Biol Med Sci. 1977 Oct;55(5):501-7.
    While the virgin AFC-progenitors for an adoptive immune response in neonatal germ-free CBA mouse spleen are small, dense cells, the equivalent cells in the adult are a larger, lighter density population. The effects of injections of unrelated antigens on the physical properties of the AFC-progenitors in neonatal spleen were investigated to test the postulate that the physically distinct "virgin" AFC-progenitors in the adult arose by a process of non-specific activation. Spleen cells from 7-day-old germ-free CBA mice were separated by sedimentation at unit gravity or by density on continuous albumin gradients, and the fractions were tested for NIP-specific AFC-progenitor activity using an adoptive immune assay which gave a direct linear measure of B cell activity. If the donor neonatal animals were injected one day previously with POL or PPD, the NIP-specific AFC-progenitor activity shifted from the typical small, dense lymphocytes to larger, lighter cells. The physical properties of these stimulated AFC-progenitors resembled those of IgM AFC-progenitors in normal adult mice. These results experimentally confirm the theory that environmental stimuli induce a non-specific "activation" of a particular subset of "virgin" B cells.
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