Live Chat
Today's Hours: 10:00am - 6:00pm
Lane Medical Library

Search

Filter Results

Did You Mean:

Search Results

Sort by
relevance
  • Article
    Kumari PB, Singh YK, Mandal J, Shambhavi S, Sadhu SK, Kumar R, Ghosh M, Raj A, Singh M.
    Chemosphere. 2021 May;270:128630.
    Abstract
    Irrigation water contaminated with arsenic acts as a potent source of contamination to humans through water-soil-crop-food transfer so quantification of safe limit for irrigation water is also critical. A pot experiment was conducted to determine the safe limit for As contaminated irrigation water with two soil types (alluvial and red) using ten levels of contaminated irrigation water (0, 0.25, 0.5, 0.75, 1.0, 1.25, 1.50, 1.75, 2.0, 2.25 mg L-1), applied 5 times in rice (Variety: Sushak Samrat),used as a test crop. The results reveal that the different fractions of arsenic in terms of its profusion followed the order F4 > F2 > F5 > F3 > F1 and F4 > F3 > F2 > F5 > F1 across all the doses of As for alluvial soil and red soil respectively. The safe limit of irrigation water in terms of risk assessment expressed as Hazard Quotient (HQ) was at 0.75 mg L-1 and the solubility FIAM can effectively predict the As content in rice grain in both the soils. The Tobit Regression Model in alluvial soil quantified the safe limit for As in irrigation water from 1.20 to 0.10 mg L-1 for available soil As 0.25-3.0 mg kg-1 and in red soil, the range was from 0.10 to 0.40 mg L-1 for soil As 1.0 to 0.25 mg kg-1 provided that the As content in rice grain is < 0.4 mg kg-1. This proved to be an effective protocol for estimation of safe limits after proper validation and calibration.
    Digital Access Direct to PDF
  • Article
    Malunga LN, Ames N, Khorshidi AS, Thandapilly SJ, Yan W, Dyck A, Waterer J, Malcolmson L, Cuthbert R, Sopiwnyk E, Scanlon MG.
    Food Chem. 2021 May 15;344:128630.
    Abstract
    The need to produce wheat with low asparagine concentration is of great importance as a measure to mitigate acrylamide concentration in wheat-based products. The association of asparagine concentration in Canadian bread wheat with cultivar, growing location, fertilizer and their interaction were investigated. Wheat cultivars (8) were grown in 2 locations under 4 fertilizer treatments in triplicate (which consisted of two nitrogen rates (90 or 120 lbs/acre) with or without 15 lbs sulphur per acre). The asparagine concentration ranged from 168.9 to 1050 µg/g and was significantly affected by cultivar, location, and their interaction but not fertilizer treatment. Location and cultivar were responsible for 80% and 14% of the variation, respectively. Some cultivars were not affected by location and maintained their low asparagine accumulation trait. Thus, breeding strategies should aim to identify cultivars that are low asparagine accumulating and are stable across different growing environments.
    Digital Access Access Options
  • Article
    Kuo CS, Kuo DTF, Chang A, Wang K, Chou PH, Shih YH.
    J Hazard Mater. 2022 06 15;432:128630.
    Abstract
    Tetrabromobisphenol A (TBBPA), a widely used brominated flame retardants, has been detected in various environmental matrices and is known to cause various adverse effects on human bodies. This study examined the feasibility and effectiveness of remediating TBBPA using Cu/Fe bimetallic nanoparticles (Cu/Fe BNPs) at various environmental and operational conditions. In general, TBBPA removal rate and debromination efficiency increased with higher Cu doping, higher Cu/Fe BNPs loading, higher temperature, and lower pH. At optimal conditions, TBBPA was completed removed at a rate constant > 0.2 min-1 where over 90% TBBPA was transformed to BPA within 30 min. The activation energy was found to be 35.6 kJ/mol, indicating that TBBPA was predominantly removed via surface-controlled reactions. Under pH 3-7 and ≥ 25 °C, debromination was the dominant removal mechanism compared to adsorption. The complete debromination pathway and the time-evolution of intermediates byproducts at different pHs were also presented. Cu/Fe BNPs can be reused for more than 6 times with performance constancy. Genotoxic tests showed that the treated solution did not find a significant hazardous potential. The byproducts can be further degraded by additional H2O2 through Fenton reaction. These results demonstrated the efficacy of Cu/Fe BNPs for treating TBBPA and its potential for degrading other halogenated organic compounds.
    Digital Access Access Options
  • Article
    Jia Y, Maitra S, Singh V.
    Bioresour Technol. 2023 Mar;371:128630.
    Abstract
    Bioenergy crops have potential for being a sustainable and renewable feedstock for biofuels and various value-added bioproducts. The study utilizes recently developed transgenic sugarcane ('oilcane') bagasse for chemical-free coproduction of high-value bioproducts, i.e., furfurals, HMF, acetic acid, cellulosic sugars, and vegetative lipids. Hydrothermal pretreatment was optimized at 210 °C for 5 min to coproduce 6.91%, 2.67%, 5.07%, 2.42% and 37.82% (w/w) furfurals, HMF, acetic acid, vegetative lipids, and cellulosic sugars, respectively from lignocellulosic biomass. Additionally, nanofiltration system in-series was successfully established to recover sugars, furfurals, HMF, and acetic acid from the pretreatment liquor. 1st nanofiltration with Duracid NF membrane rejected ∼99% sugars. Concentrated sugars with significantly reduced inhibitory products were obtained in retentate for fermentation. 2nd nanofiltration with NF90 membrane used permeate of 1st nanofiltration as feed and rejected ∼ 86% furfurals. The work demonstrates the feasibility of coproducing and recovering multiple biochemicals from lignocellulosic biomass.
    Digital Access Access Options
  • Article
    Shao B, Liu X, Zhang D, Wu J, Ouyang Q.
    PLoS One. 2015;10(6):e0128630.
    Abstract
    Computational circuit design with desired functions in a living cell is a challenging task in synthetic biology. To achieve this task, numerous methods that either focus on small scale networks or use evolutionary algorithms have been developed. Here, we propose a two-step approach to facilitate the design of functional circuits. In the first step, the search space of possible topologies for target functions is reduced by reverse engineering using a Boolean network model. In the second step, continuous simulation is applied to evaluate the performance of these topologies. We demonstrate the usefulness of this method by designing an example biological function: the SOS response of E. coli. Our numerical results show that the desired function can be faithfully reproduced by candidate networks with different parameters and initial conditions. Possible circuits are ranked according to their robustness against perturbations in parameter and gene expressions. The biological network is among the candidate networks, yet novel designs can be generated. Our method provides a scalable way to design robust circuits that can achieve complex functions, and makes it possible to uncover design principles of biological networks.
    Digital Access Access Options
  • Article
    Ji L, Fang Y, Tang J, Liu C, Huang C, Hu Q, Li Q, Chen Z.
    Bioorg Med Chem Lett. 2022 04 15;62:128630.
    Abstract
    The dopamine D3 receptor (D3R) is highly expressed in the limbic regions of the brain and closely related to a variety of neurological disorders including Parkinson's disease, schizophrenia and drug-seeking behavior. In vivo imaging of D3R with radio-labelled tracers and positron emission tomography (PET) has become a powerful technique in related disorders. In this study, we synthesized three novel aromatically 18F-labelled phenylpiperazine-like D3R selective radioactive ligands ([18F]5b, [18F]8b and [18F]11b) and developed a simple, rapid and efficient 18F-labelling method by condition optimization. Radiosynthesis of [18F]5b, [18F]8b and [18F]11b was achieved by 18F-fluorination from nitroarene precursors. Final radiochemical purities of [18F]5b, [18F]8b and [18F]11b solution were > 99% and remained good stability (> 98% for up to 6 h) in PBS and FBS. PET imaging and cellular binding studies revealed that [18F]8b had a higher D3R affinity than [18F]5b and [18F]11b. Autoradiography and biodistribution studies of the brain showed that [18F]8b had medium intensity specific accumulation in the striatum and cortex. Meanwhile, the low skeletal uptake of [18F]8b revealed a good in vivo stability with negligible defluorination. These results indicated that [18F]8b might be a potential 18F-labelled D3R PET imaging agent.
    Digital Access Access Options
  • Article
    Xu R, Zheng L, Huang M, Zhao M.
    Int J Biol Macromol. 2024 Feb;257(Pt 2):128630.
    Abstract
    Previously, we prepared a chondroitin sulfate-soluble undenatured type II collagen complex (CS-SC II) with low salt content. This paper further explored the differences between CS-SC II and SC II in terms of gastrointestinal digestive characteristics and osteoarthritis (OA) improvement. In vitro and in vivo experiments showed that the gastric digestive stability of CS-SC II was high under both pH 2.0 and pH 3.0, the α1 chain and triple helix structure of type II collagen retained >60 %. However, SC II had high gastric digestive stability only under pH 3.0. Furthermore, intestinal digestion had little effect on α1 chains of CS-SC II and SC II, and distribution experiments showed that they might exert their biological activities in the intestine. CS-SC II had obvious improvement in OA rats at 1.0 mg/kg/d, that is, the joint swelling was significantly reduced and the weight-bearing ratio of the right hind limb was increased to 49 %, which was close to that of 4.0 mg/kg/d SC II. The wear of articular cartilage, Mankin and OARSI scores of rats in CS-SC II group were significantly reduced. The effects of low-dose CS-SC II on the proportion of regulatory T cells (Treg), mRNA expression of OA key biomarkers (Il6, Ccl7, MMP-3 and MMP13) and signaling pathway genes (NF-κB, AKT or AMPKα) were comparable to those of high-dose SC II. These results showed that CS-SC II might have greater potential to improve OA at a lower dose than SC II due to its high gastrointestinal digestive stability at a wide range of pH conditions.
    Digital Access Access Options
  • Book
    David G. Hunter, Michael J. Wan, Constance E. West.
    Read Full Description
    Summary: "Learn and review clinical optics and refraction with the newly revised edition of this popular resource! Last-Minute Optics, 3rd Edition, distills a vast amount of complex information into an easy-to-read, engaging text that makes the most of your limited study time. Now in full color for the first time, this clear and concise review manual features a unique question-and-answer format that allows for self-assessment and easy identification of areas where more study is needed"-- publisher's description.

    Contents:
    Refraction and reflection
    Vergence, lenses, objects, and images
    Mirrors
    Principles of light and lasers
    The model eye
    Visual acuity testing
    Refraction and optical dispensing
    Lens effectivity and vertex distance
    Accommodation, presbyopia, and bifocals
    Cylinders, crosses (axis and power), and spherocylindrical notation
    Astigmatism
    Aberrations, distortions, and irregularities
    Contact lenses
    Intraocular lenses
    Refractive surgery
    Prisms and diplopia
    Instruments
    Low vision
    Good people, bad optics: the dissatisfied patient
    Summary of important optics formulas.
    Digital Access Clinical Key [2024]
doi:10.1016/j.chemosphere.2020.128630 doi:10.1016/j.foodchem.2020.128630 doi:10.1016/j.jhazmat.2022.128630 doi:10.1016/j.biortech.2023.128630 doi:10.1371/journal.pone.0128630 doi:10.1016/j.bmcl.2022.128630 doi:10.1016/j.ijbiomac.2023.128630