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  • Article
    Al Shubbar MD, Bojabara LM, Al Qunais AA, Huldar AS, Alamro S, Alameer MH, Alameer FH.
    Cureus. 2024 Aug;16(8):e66842.
    This narrative review meticulously examines the intricate landscape of poisoning incidents within Saudi Arabia, delineating the prevalence and characteristics across three main categories: pharmaceutical, illicit, and chemical substances. Pharmaceutical agents, particularly analgesics and antipsychotics, are identified as leading causes of acute adult poisoning, highlighting the paramount role of their widespread accessibility and the potential risks associated with over-the-counter availability. The review underscores the alarming prevalence of over-the-counter analgesics, such as paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs), as the most frequent culprits in poisoning cases, with a significant correlation observed between analgesic poisoning and gender, notably affecting the female population. Additionally, the study delves into the burgeoning issue of illicit drug use, with opioids and amphetamines emerging as substantial contributors to the poisoning landscape, reflecting a broader global trend of increasing substance misuse and its associated health risks. Chemical poisoning, encompassing a range of substances from household cleaners to industrial chemicals, presents another critical area of concern, with specific emphasis on the dangers posed by antiseptics, detergents, and organophosphates. The review identifies a pressing need for targeted public health interventions and policy reforms aimed at mitigating the risks associated with these diverse types of poisoning. By offering a comprehensive overview of the poisoning epidemiology in Saudi Arabia, the study contributes valuable insights into the multifaceted nature of this public health challenge, advocating for enhanced regulatory measures, public awareness campaigns, and improved access to mental health services to address the underlying factors contributing to poisoning incidents.
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  • Article
    Yang IP, Tsai HL, Huang CW, Huang MY, Hou MF, Juo SH, Wang JY.
    PLoS One. 2013;8(6):e66842.
    BACKGROUND: The recurrence of colorectal cancer (CRC) is frequent within the first year of curative resection surgery and may be unavoidable. microRNAs have been suggested to play roles in carcinogenesis and cancer recurrence. We recently identified microRNA-29c (miRNA-29c) as a predictor of early recurrence in CRC. In the present study, we further investigated the functions and serum level of miRNA-29c in relation to early recurrence of CRC.
    METHODS: First we further confirmed overexpression of miRNA-29c in non-early relapse subjects. Gain-of-function in vitro studies were used to evaluate the effect of miRNA-29c on cell proliferation, migration, invasion, and cell cycle progression. The colon cancer cell line Caco2 and a stable clone overexpressing miRNA-29c were xenografted to evaluate the in vivo effect of miRNA-29c in null mice. Finally, circulating miRNA-29c was investigated as a potential biomarker for identifying early relapse.
    RESULTS: miRNA-29c expression significantly decreased during early relapse compared to non-early relapse in UICC stage II and III CRC patients (P = 0.021). In vitro studies showed that overexpression of miRNA-29c inhibited cell proliferation and migration. The cell cycle studies also revealed that miRNA-29c caused an accumulation of the G1 and G2 population. In vivo, miRNA-29c suppressed tumor growth in null mice. The serum miRNA-29c increased significantly in early relapsed patients compared to non-early elapsed patients (P = 0.012).
    CONCLUSIONS: miRNA-29c shows anti-tumorigenesis activity, and preoperative circulating miRNA-29c levels can be used to predict postoperative early relapse of CRC.
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  • Article
    Behera D, Panigrahi K, Rout JR.
    Environ Sci Pollut Res Int. 2024 Dec;31(59):66842-66853.
    Nowadays organophosphate-based chemicals are most commonly used insecticides worldwide which are applicable to a wide range of crop plants. In this study, the effect of organophosphate insecticides, dimethoate (DM) and malathion (MT), was investigated on Solanum lycopersicum L. The seeds were germinated under in vivo conditions and after 1 month of germination, they were transferred to separate pots. Insecticides were applied in three different concentrations (X, 2X, and 4X) using a nozzle spray at 7-day intervals for 21 days where X was the recommended dose. After 21 days of treatment, the toxicological responses of plants were confirmed by evaluating the growth patterns, anatomical, photosynthetic pigments, expression of proteins, and antioxidant enzymes catalase (CAT), guaiacol peroxidase (GPX), and ascorbate peroxidase (APX). The study findings demonstrated that both DM and MT treatment resulted in adverse growth effects even at the initial recommended dose (X) of application. However, compared to MT, at 4X concentrations of DM, maximum decrease in plant height (43.43%), leaf length (43.16%), leaf width (41.09%), and total numbers of leaves per plant (50.57%) was observed. Plants subjected to higher doses of DM and MT showed a gradual reduction in chlorophyll a, chlorophyll b, total chlorophyll, and carotenoids (67.25, 50.00, 62.03, and 41.04%, respectively, for DM and 61.75, 55.72, 59.87, and 41.04%, respectively, for MT). In addition, higher doses of these insecticides greatly disturbed micromorphology and protein contents. At high dose (4X) of treatment, the activities of CAT, GPX, and APX were found to increase by 14.01, 3.62, and 2.21 times the control value, respectively, for DM and 5.17, 2.53, and 1.46 times, respectively, for MT. Additionally, increased isoenzymes of CAT, GPX, and APX were demonstrated by nondenaturing PAGE and were also dependent on the concentrations of DM and MT. These results suggest that the isoforms of the antioxidant enzymes newly developed due to DM and MT excess may be used as biochemical markers for other crop plants grown under insecticide stress. This study provides insights into the biochemical mechanism associated with the toxicity caused to plants by the test insecticides.
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  • Book
    Jacqueline M. Loversidge, Joyce Zurmehly.
    Summary: "What happens in health policy at local, state, and federal levels directly affects patients, nurses, and nursing practice. Some healthcare professionals, though, are intimidated by the complex and often nonlinear policy process or simply don't know how to take the first step toward implementing policy change. In the second edition of Evidence-Informed Health Policy, authors Jacqueline M. Loversidge and Joyce Zurmehly demystify health policymaking and equip nurses and other healthcare professionals with the knowledge, tools, and confidence to navigate the first of many steps into health policy. This book translates the EBP language of clinical decision-making into an evidence-informed health policy (EIHP) model-a foundation for integrating evidence into health policymaking and leveraging dialogue with stakeholders. Readers will develop a stronger understanding of policymaking and its role within government, learn strategies for influencing policymakers, and help shape future healthcare policy that makes the best use of evidence. This new edition includes: Fresh perspectives on the use of evidence to inform smart health policy, learned knowledge of the COVID-19 pandemic and global crisis to more effectively strategize for sound policy informed by the best science, a new visual graphic representation of the EIHP Model with added descriptions of the EIHP process, and additional breadth and depth on policymaking theories and models"-- Provided by publisher.
    Digital Access R2Library [2023]