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  • Article
    Abdallah MM, Yahia M, Tagelsir Ahmed Y, Alfaki M.
    Cureus. 2024 Jul;16(7):e65190.
    BACKGROUND AND OBJECTIVE: The wingless-related integration site family (WNT) signaling pathway is critical for tumor progression and development. It is associated with various neoplasms produced by WNT pathway deregulation; WNT5A, a member of the WNT family, has been linked to carcinogenesis, exhibiting either oncogenic or tumor-suppressive effects. The study investigates how the gene affects certain types of cancer. The study aimed to evaluate the potential prognostic significance of WNT5A genes as diagnostic biomarkers for various types of cancer.
    METHODOLOGY: We investigated WNT5A gene expression in a pan-cancer analysis using various bioinformatics databases, including GEPIA (Gene Expression Profiling Interactive Analysis), TIMER2 (Tumor Immune Estimation Resource, Version 2), the University of Alabama at Birmingham Cancer Data Analysis Portal UACLAN databases, the Kaplan-Meier (K-M) plotter, cBioPortal, and Gene Set Cancer Analysis (GSCA). We aimed to gain insight into the expression of WNT5A in various tumors and its relationship with immune infiltration, overall survival, and genetic changes. Public datasets validated WNT5A expression in lung squamous cell carcinoma (LUSC) and stomach adenocarcinoma (STAD) samples.
    RESULTS: WNT5A pan-cancer analysis was highly expressed in two cancer types, including STAD and LUSC. Additionally, TIMER results showed a positive association of WNT5A with immune cell infiltration in LUSC and STAD. Survival analysis indicated that LUSC cancer exhibits better overall survival, while STAD has lower overall survival levels, which means a poor prognosis in the STAD cancer type. Furthermore, mutation analysis revealed that the WNT5A gene was mutated in 1.4% of cases, with most alterations being deletions followed by amplifications.
    CONCLUSIONS: The WNT5A gene's high expression in many malignancies, including LUSC and STAD, suggests it could be used as a diagnostic biomarker. This study shows a relationship between WNT5A expression and immune cell abundance in LUSC and STAD. Our pan-cancer analysis of this gene is the first of its type, and it will inform future research, comprehensive investigation, and wet lab experiments.
    Digital Access Access Options
  • Article
    Essack M, Radovanovic A, Bajic VB.
    PLoS One. 2013;8(6):e65190.
    BACKGROUND: Sickle cell disease (SCD) is a fatal monogenic disorder with no effective cure and thus high rates of morbidity and sequelae. Efforts toward discovery of disease modifying drugs and curative strategies can be augmented by leveraging the plethora of information contained in available biomedical literature. To facilitate research in this direction we have developed a resource, Dragon Exploration System for Sickle Cell Disease (DESSCD) (http://cbrc.kaust.edu.sa/desscd/) that aims to promote the easy exploration of SCD-related data.
    DESCRIPTION: The Dragon Exploration System (DES), developed based on text mining and complemented by data mining, processed 419,612 MEDLINE abstracts retrieved from a PubMed query using SCD-related keywords. The processed SCD-related data has been made available via the DESSCD web query interface that enables: a/information retrieval using specified concepts, keywords and phrases, and b/the generation of inferred association networks and hypotheses. The usefulness of the system is demonstrated by: a/reproducing a known scientific fact, the "Sickle_Cell_Anemia-Hydroxyurea" association, and b/generating novel and plausible "Sickle_Cell_Anemia-Hydroxyfasudil" hypothesis. A PCT patent (PCT/US12/55042) has been filed for the latter drug repurposing for SCD treatment.
    CONCLUSION: We developed the DESSCD resource dedicated to exploration of text-mined and data-mined information about SCD. No similar SCD-related resource exists. Thus, we anticipate that DESSCD will serve as a valuable tool for physicians and researchers interested in SCD.
    Digital Access Access Options
  • Book
    Susan C. Helm-Murtagh, Paul C. Erwin, editors.
    Summary: "Today's public health and healthcare leaders face an array of leadership contexts presenting formidable challenges, including the syndemics of COVID-19 and structural racism; an ageing population; unhealthy lifestyles; the rapid spread of infectious pathogens; national disasters, conflicts, and mass population movements; antimicrobial resistance; injuries; and the health impacts of climate change and environmental pollution"-- Provided by publisher.

    Contents:
    Part I: Leadership basics : skills, traits, and behaviors. Dialogue : a foundational skill for effective health leadership / Daniel Martin and Edward L. Baker
    Moral courage in public health leadership / James C. Thomas
    Systems thinking in public health / Kaye Bender
    Strategic thinking : rationale, process, and behaviors / Peter M. Ginter and W. Jack Duncan
    Emotional intelligence / Susan C. Helm-Murtagh
    Part II: Key leadership theories and their application. The situational approach to leadership / Eduardo Sanchez and John Wiesman
    Transformational leadership / Donna J. Petersen
    Authentic leadership / Paul C. Erwin, Stephanie B. C. Bailey, and Susan C. Helm-Murtagh
    Servant leadership / Paul C. Erwin
    Adaptive leadership / Laura Magaña-Valladares, Sandro Galea, and Angelina Casazza
    Part III: The context and challenges of leadership practice. Leading change / Suzanne M. Babich
    Diversity, equity, inclusion, and intercultural competence in leadership / Katherine L. Turner
    Managing and resolving conflict / Michael R. Fraser
    Crisis leadership / J. Bennet Waters and Claude A. Jacob
    Building and leading teams : essential approaches and practical tools for improving the health of populations / Kathleen Colville and Trissa Torres
    Talent management : a leadership imperative / Lynn "Stevie" Sesslar McNeal
    Creating effective public health messengers / Barbara Alvarez Martin and Gene W. Matthews
    Part IV: Putting it all together : your leadership practice. The evolution and development of a leader / Susan C. Helm-Murtagh
    Mentoring and trusted advisors / Cynthia D. Lamberth, F. Douglas Scutchfield, and C. William Keck
    Leadership intangibles / Paul C. Erwin
    Creating your leadership framework / Susan C. Helm-Murtagh
    Learning from experience / Karen DeSalvo, Kushal Kadakia, Ross C. Brownson, Stephanie Watson-Grant, David Adler, Elizabeth (Liz) Maguire, Dave Chang, Alyson Rose-Wood, Innocent Ndubuisi Ibergbunam, Nancy McGhee, Max Michael, Katie Kaney, Ugbede Abu, and Lisa M. Koonin.
    Digital Access R2Library [2023]
    Limited to 1 simultaneous user