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  • Book
    [edited by] Michael Valente, L. Maureen Valente.
    Contents:
    Hearing disorders
    Diagnostic examination auditory function
    Diagnostic examination vestibular function
    Amplification : hearing devices
    Cochlear implants
    Hearing assistive technology
    Tinnitus management
    Other rehabilitative strategies.
    Digital Access Thieme MedOne ComSci [2015]
  • Article
    Ekka NM, Kujur AD, Guria R, Mundu M, Mishra B, Sekhar S, Kumar A, Prakash J, Birua H.
    Cureus. 2023 Feb;15(2):e35618.
    A lipase/amylase (L/A) ratio of more than three may be a tool for differentiating alcoholic pancreatitis from non-alcoholic pancreatitis. We conducted a systematic literature review to identify published studies. A thorough data search of various databases was conducted using keywords. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 survey. Data were extracted under the following headings: country, sample size, baseline characteristics, specificity, and sensitivity of the L/A ratio. Studies were analyzed using a bivariate random-effects model, and the sensitivity and specificity of the L/A ratio were pooled separately. Summary receiver operating characteristic (SROC) curves were plotted using the hierarchical method. A total of nine studies with 1,825 patients were identified for inclusion. SROC showed estimates of the area under the curve to be 0.75 (confidence interval (CI) = 0.71-0.79). Forest plots for sensitivity and specificity showed pooled estimates of sensitivity to be 74% (95% CI = 62-83%) while that of specificity was 63% (95% CI = 47-77%). The pooled diagnostic odds ratio was estimated to be 5 (95% CI = 3-9), the pooled positive likelihood ratio was estimated at 2.0, and the pooled negative likelihood ratio was estimated to be 0.41. We concluded that an L/A ratio of more than 3 has moderate accuracy for the diagnosis of alcoholic pancreatitis.
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  • Article
    Lee HW, Park SH.
    Oncotarget. 2017 May 30;8(22):35609-35618.
    Multiple causes are associated with the complex mechanism of pathogenesis of pulmonary arterial hypertension (PAH), but the molecular pathway in the pathogenesis of PAH is still insufficiently understood. In this study, we investigated epigenetic changes that cause PAH induced by exposure to combined Th2 antigen (Ovalbumin, OVA) and urban particulate matter (PM) in mice. To address that, we focused on the epigenetic mechanism, linked to microRNA (miR)-135a. We found that miR-135a levels were significantly increased, and levels of bone morphogenetic protein receptor type II (BMPR2) which is the target of miR-135a, were significantly decreased in this experimental PAH mouse model. Therefore to evaluate the role of miR-135a, we injected AntagomiR-135a into this mouse model. AntagomiR-135a injected mice showed decreased right ventricular systolic pressures (RVSPs), right ventricular hypertrophy (RVH), and the percentage of severely thickened pulmonary arteries compared to control scrambled miRNA injected mice. Both mRNA and protein expression of BMPR2 were recovered in the AntagomiR-135a injected mice compared to control mice. Our study understands if miR-135a could serve as a biomarker helping to manage PAH. The blocking of miR-135a could lead to new therapeutic modalities to alleviate exacerbation of PAH caused by exposure to Th2 antigen and urban air pollution.
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  • Article
    Hassanzadeh-Barforoushi A, Shemesh J, Farbehi N, Asadnia M, Yeoh GH, Harvey RP, Nordon RE, Warkiani ME.
    Sci Rep. 2016 10 18;6:35618.
    Regulation of tissue development and repair depends on communication between neighbouring cells. Recent advances in cell micro-contact printing and microfluidics have facilitated the in-vitro study of homotypic and heterotypic cell-cell interaction. Nonetheless, these techniques are still complicated to perform and as a result, are seldom used by biologists. We report here development of a temporarily sealed microfluidic stamping device which utilizes a novel valve design for patterning two adherent cell lines with well-defined interlacing configurations to study cell-cell interactions. We demonstrate post-stamping cell viability of >95%, the stamping of multiple adherent cell types, and the ability to control the seeded cell density. We also show viability, proliferation and migration of cultured cells, enabling analysis of co-culture boundary conditions on cell fate. We also developed an in-vitro model of endothelial and cardiac stem cell interactions, which are thought to regulate coronary repair after myocardial injury. The stamp is fabricated using microfabrication techniques, is operated with a lab pipettor and uses very low reagent volumes of 20 μl with cell injection efficiency of >70%. This easy-to-use device provides a general strategy for micro-patterning of multiple cell types and will be important for studying cell-cell interactions in a multitude of applications.
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  • Article
    Liu Z, Li N, Xu L, Huang R, Xu Z, Liu G, Liang X, Yang X.
    Heliyon. 2024 Aug 30;10(16):e35618.
    Neonicotinoid insecticides (NEOs) are a widely used type of insecticide found globally, leading to broad human exposure. However, there is limited research on how internal exposure levels of NEOs and their metabolites impact in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes. A study was conducted at the Sixth Affiliated Hospital of Sun Yat-sen University between 2017 and 2020 involving 436 women undergoing IVF/ICSI treatment. Data on demographics and clinical history were collected from medical records. The concentrations of 11 NEOs and 4 NEO metabolites in follicular fluid and serum were measured using a salting-out assisted liquid-liquid extraction method and liquid chromatography-tandem mass spectrometry. Our findings indicated that NEOs were prevalent in women with infertility. One NEO metabolite, N-dm-ACE, was detected in all samples with median concentrations of 0.221 ng/mL in follicular fluid and 0.228 ng/mL in serum. The study showed a decrease in the number of retrieved oocytes, mature oocytes, 2 PN zygotes, and high-quality embryos as the number of exposed NEOs in follicular fluid increased. Women in the highest tertile of N-dm-ACE exposure had fewer mature oocytes, 2 PN zygotes, and lower oocyte maturity rates compared to those in the lowest tertile. The findings suggest that exposure to NEOs may negatively impact reproductive outcomes in IVF/ICSI pregnancies, particularly affecting oocyte retrieval and embryo quality. This study highlights the potential adverse effects of environmental NEO exposure on IVF/ICSI outcomes, emphasizing the importance of considering such exposures in preconception care.
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  • Article
    Gao Q, Jin H, Xu W, Wang Y.
    Medicine (Baltimore). 2023 Oct 27;102(43):e35618.
    The present study was designed to identify potential diagnostic markers for diabetic kidney disease (DKD). Two publicly available gene expression profiles (GSE142153 and GSE30528 datasets) from human DKD and control samples were downloaded from the GEO database. Differentially expressed genes (DEGs) were screened between 23 DKD and 10 control samples using the gene data from GSE142153. Weighted gene co expression network analysis was used to find the modules related to DKD. The overlapping genes of DEGs and Turquoise modules were narrowed down and using the least absolute shrinkage and selection operator regression model and support vector machine-recursive feature elimination analysis to identify candidate biomarkers. The area under the receiver operating characteristic curve value was obtained and used to evaluate discriminatory ability using the gene data from GSE30528. A total of 110 DEGs were obtained: 64 genes were significantly upregulated and 46 genes were significantly downregulated. Weighted gene co expression network analysis found that the turquoise module had the strongest correlation with DKD (R = -0.58, P = 4 × 10-4). Thirty-eight overlapping genes of DEGs and turquoise modules were extracted. The identified DEGs were mainly involved in p53 signaling pathway, HIF-1 signaling pathway, JAK - STAT signaling pathway and FoxO signaling pathway between and the control. C-X-C motif chemokine ligand 3 was identified as diagnostic markers of DKD with an area under the receiver operating characteristic curve of 0.735 (95% CI 0.487-0.932). C-X-C motif chemokine ligand 3 was identified as diagnostic biomarkers of DKD and can provide new insights for future studies on the occurrence and the molecular mechanisms of DKD.
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  • Article
    Qin WD, Liu GL, Wang J, Wang H, Zhang JN, Zhang F, Ma Y, Ji XY, Li C, Zhang MX.
    Oncotarget. 2016 Jun 14;7(24):35618-35631.
    Diabetic cardiomyopathy (DCM) is characterized by structural alterations such as cardiomyocyte hypertrophy, necrosis and focal fibrosis. Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear enzyme which can be activated by DNA damage and plays a critical role in various diseases. We hypothesized that PARP-1 may play an important role in DCM and that its inhibition may protect cardiomyocytes from inflammation and apoptosis in DCM. H9c2 cardiomyocytes were treated with normal glucose, mannitol or high glucose (HG). Male C57BL/6 mice or PARP-1-/- mice were treated with streptozotocin (STZ) by intraperitoneal injection for 5 consecutive days to induce diabetes. In vitro, HG stimulation induced oxidative stress and DNA damage and increased PARP-1 expression and activity. Compared with the control, pretreatment with PARP-1 siRNA significantly reduced HG-induced inflammatory response, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and IL-6 secretion, and intercellular adhesion molecule-1 (ICAM-1) and inducible nitric oxide synthase (iNOS) expression. PARP-1 inhibition reduced HG-induced cardiomyocyte apoptosis through downregulation of cleaved caspases and activation of IGF-1R/Akt pathway. In vivo, hyperglycemia increased the protein expression of nitrotyrosine and PARP-1 as well as PARP-1 activity. PARP-1 gene deletion significantly improved cardiac dysfunction and reduced inflammatory response and apoptosis. This work demonstrated the critical role of PARP-1 in diabetic heart injury, and suggested that PARP-1 inhibition may be a feasible strategy for the treatment of DCM.
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  • Article
    Selvaraj B, G LP, Balasubramanian S.
    RSC Adv. 2024 Nov 04;14(48):35618-35627.
    Heavy metal ions are hazardous pollutants that pose serious threats to ecosystems and human health, making it imperative to detect and monitor their presence in water for environmental protection. This paper highlights the synthesis of the UiO-67 Metal-Organic Framework (MOF) without any dopants, offering a novel approach specifically for the detection of cadmium ions (Cd2+) in aqueous environments. Following solvothermal synthesis, Powder X-ray Diffraction (PXRD), BET nitrogen adsorption-desorption analysis, X-ray Photoelectron Spectroscopy (XPS), and Scanning Electron Microscopy (SEM) were used to characterize the structural and morphological features of UiO-67. The MOF exhibited a high pore volume and surface area, which are essential for enhancing its detection capabilities for Cd2+ ions. Based on experimental findings, the proposed sensor exhibits excellent selectivity towards Cd2+ ions and a sensitivity of 3.008 μA nM-1. Further, it achieves a low Limit of Detection (LoD) of 1.43 nM μA-1 and a Limit of Quantification (LoQ) of 4.34 nM μA-1. The sensitivity and reliability of the UiO-67-modified electrode are demonstrated by these values, which qualify it for trace-level cadmium ion detection. The ground-breaking potential of undoped UiO-67 serves as a cutting-edge and effective tool for environmental monitoring, particularly in the detection of toxic metal ions in water bodies.
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  • Article
    Ivliev AE, 't Hoen PA, van Roon-Mom WM, Peters DJ, Sergeeva MG.
    PLoS One. 2012;7(4):e35618.
    Cilia are cell organelles that play important roles in cell motility, sensory and developmental functions and are involved in a range of human diseases, known as ciliopathies. Here, we search for novel human genes related to cilia using a strategy that exploits the previously reported tendency of cell type-specific genes to be coexpressed in the transcriptome of complex tissues. Gene coexpression networks were constructed using the noise-resistant WGCNA algorithm in 12 publicly available microarray datasets from human tissues rich in motile cilia: airways, fallopian tubes and brain. A cilia-related coexpression module was detected in 10 out of the 12 datasets. A consensus analysis of this module's gene composition recapitulated 297 known and predicted 74 novel cilia-related genes. 82% of the novel candidates were supported by tissue-specificity expression data from GEO and/or proteomic data from the Human Protein Atlas. The novel findings included a set of genes (DCDC2, DYX1C1, KIAA0319) related to a neurological disease dyslexia suggesting their potential involvement in ciliary functions. Furthermore, we searched for differences in gene composition of the ciliary module between the tissues. A multidrug-and-toxin extrusion transporter MATE2 (SLC47A2) was found as a brain-specific central gene in the ciliary module. We confirm the localization of MATE2 in cilia by immunofluorescence staining using MDCK cells as a model. While MATE2 has previously gained attention as a pharmacologically relevant transporter, its potential relation to cilia is suggested for the first time. Taken together, our large-scale analysis of gene coexpression networks identifies novel genes related to human cell cilia.
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  • Article
    Cao Q, Lin Y, Li Y, Tian J, Liu H, Zhu T, Wang J.
    ACS Omega. 2023 Oct 03;8(39):35608-35618.
    A carbonyl sulfide (COS) hydrolysis catalyst can play an efficient role in blast furnace gas (BFG), but the life of the catalyst is greatly shortened due to the presence of O2 and H2S in the atmosphere, so improving the sulfur resistance of the catalyst is the key to application. In this work, alkali metals Na and K modified γ-Al2O3 catalysts to improve COS hydrolysis efficiency and sulfur resistance by adding an alkaline center. Compared with γ-Al2O3 catalysts, the COS hydrolysis efficiency of the modified catalysts in the experiment was improved by 12% in the presence of H2S and O2. The main cause of catalyst sulfur poisoning is the presence of O2, which intensifies both the total amount of sulfur deposition and the proportion of sulfate. It is found that the NaOH/Al2O3 catalyst shows better sulfur resistance than the KOH/Al2O3 catalyst for two reasons: first, the support of Na can significantly improve the medium-strong alkaline site, which is the adsorption site of H2S. This is equivalent to increasing the "sulfur capacity" of H2S adsorption and reducing the impact of sulfur deposition on the main reaction. Second, the elemental sulfur is more easily produced on the NaOH/Al2O3 catalyst, but the sulfur is further oxidized to sulfate and sulfite on the KOH/Al2O3 catalyst. The molecular diameter of elemental sulfur is smaller than that of sulfate. Therefore, the NaOH/Al2O3 catalyst has better sulfur resistance.
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  • Article
    Hassen W, Selimefendigil F, Ben Khedher N, Kolsi L, Borjini MN, Alresheedi F.
    ACS Omega. 2021 Dec 28;6(51):35607-35618.
    In this work, mixed convection and entropy generation analyses in a partitioned porous cavity with double inner rotating cylinders are explored under magnetic field effects. A curved partition shape is considered with identical rotating cylinders and an inclined magnetic field, while the right vertical wall moves with a constant speed in the y-direction. Numerical simulations are performed by considering various values of Rayleigh number, Hartman number, Darcy number, inclination of the magnetic field, size of the curved partitions, and rotational speeds of the inner cylinders and their vertical locations with the cavity. Complicated flow field with multicellular structures are observed due to the complex interaction between the natural convection, moving wall, and rotational effects of inner cylinders. Improved heat-transfer performance is obtained with higher values of magnetic field inclination, higher values of permeability/porosity of the medium, and higher rotational speeds of the cylinders. Almost doubling of the average Nu number is obtained by decreasing the value of the Hartmann number from 25 to 0 or varying the magnetic field inclination from 90 to 0. When rotational effects of the cylinders are considered, average heat-transfer improvements by a factor of 5 and 5.9 are obtained for nondimensional rotational speeds of 5 and -5 in comparison with the case of motionless cylinders. An optimum length of the porous layer is achieved for which the best heat-transfer performance is achieved. As the curvature size of the partition is increased, better heat transfer of the hot wall is obtained and up to 138% enhancement is achieved. Significant increments of entropy generation are observed for left and right domains including the rotating cylinders. The magnetic field parameter also affects the entropy generation and contributions of different domains including the curved porous partition.
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  • Article
    Xie Z, Ramakrishnam Raju MV, Stewart AC, Nantz MH, Fu XA.
    RSC Adv. 2018 Oct 21;8(62):35618-35624.
    Chemiresistor-based gas sensors for detection of target volatile organic compounds (VOCs) in air face common challenges of poor sensitivity and selectivity as well as suffering from interference by other constituent gases and/or humidity. This work demonstrates that functionalizing gold nanoparticles (AuNPs) with a designed thiol monolayer improves sensitivity and selectivity of the derived AuNPs gas sensor. We report the synthesis and application of a thiol ligand fitted with both a urea motif and a tert-butyl end group for functionalizing AuNPs. The AuNPs sensor prepared using the urea thiol ligand demonstrated significantly increased acetone sensing in comparison with tested commercially available thiol-functionalized AuNPs. The sensor worked under ambient temperature and high humidity conditions, and demonstrated a linear relationship between the sensor response and the common logarithm of analyte concentration.
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  • Article
    Sun X, Sun J, Guo L, Hou L, Yuan C.
    RSC Adv. 2020 Sep 28;10(59):35611-35618.
    The spinel NiCo2O4 and rock-salt NiCoO2 have been well established as attractive electrodes for supercapacitors. However, what is the intrinsic role of the congenital aspect, i.e., crystal structure and the surface and/or near-surface controlled electrochemical redox behaviors, if the acquired features (i.e., morphology, specific surface area, pore structure, and so on) are wholly ignored? Herein, we purposefully elucidated the underlying influences of unique crystal structures of NiCo2O4 and NiCoO2 on their pseudocapacitance from mechanism analysis through the density function theory based first-principles calculations, along with the experimental validation. Systematic theoretical calculation and analysis revealed that more charge carriers near the Fermi-level, stronger affinity with OH- in the electrolyte, easier deprotonation process, and the site-enriched characteristic for low-index surfaces of NiCoO2 enable its faster redox reaction kinetics and greater charge transfer, when compared to the spinel NiCo2O4. The in-depth understanding of crystal structure-property relationship here will guide rational optimization and selection of appropriate electrodes for advanced supercapacitors.
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  • Article
    Lima MRP, McCallum CA, Menezes GMS.
    Cad Saude Publica. 2020;36Suppl 1(Suppl 1):e00035618.
    This article aims to analyze the practices and meanings involved in obstetric ultrasound (USG) in women undergoing abortion at public maternity hospital in Salvador, Bahia, Brazil. This is a qualitative ethnographic study that included three months of participant observation in the interactions between these women and medical and non-medical staff in the USG room of a public maternity hospital. USG has a central place in women's abortion itinerary, and its practice is incorporated into the institution's routine and the definition of approaches to abortion care at the maternity hospital studied here. In this context, distinct categories of "women with abortion" are produced and mobilized according to the interpretation of the USG images. The way the health condition and moral status of a woman with suspected abortion are defined depends on the presence or absence of a live fetus in her uterus, in addition to the gestational age at which the attempted or completed abortion occurred. We conclude that when the USG evidence indicates that there was (probably) an abortion in the initial stages of a pregnancy, the health professionals themselves help the women by disconnecting the semiotic process that would result in assigning a sense of human nature to the embryo. The later a pregnancy is terminated, the more likely the process of defining the images will sustain the idea that there was a person there. The hegemonic morals on abortion and its criminalization in Brazil modulate the symbolic constructions and practices involved in the USG test in women experiencing abortion.
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  • Article
    Cai Y, Bi Y, Tian B, Cheng L, Zhou S, Qi Q.
    Environ Sci Pollut Res Int. 2024 May;31(24):35609-35618.
    The water crisis may be solved by utilizing reclaimed water. Three reclaimed water sources have restored the lower sections of the Licun River, forming a landscaped river. In this paper, the river's water quality was monitored for a year, and the ecological concerns were analyzed using luminescent bacteria, chlorella, and zebrafish. The results indicated that although basic water quality indicators like COD and ammonia fluctuated along the river, the classification of water quality was primarily affected by factors such as flow rate and water depth. Under experimental conditions, the toxic inhibitory effect of river water on luminescent bacteria, chlorella, and zebrafish was related to the treatment process of reclaimed water. It was found that the reclaimed water produced by the MBR, along with the UV disinfection process, showed no detectable toxicity. In contrast, the MBBR process, when combined with coagulation, sedimentation, filtration, ozonation, and chlorination, seemed to be the source of this toxicity. Along the river, the results of water quality assessments and ecological risk assessments were different, indicating that both should be conducted to evaluate rivers replenished with reclaimed water.
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  • Article
    Deng J, Gao X, Xiao C, Xu S, Ma Y, Yang J, Wu M, Pan F.
    Environ Sci Pollut Res Int. 2020 Oct;27(28):35618-35625.
    We aimed to quantify the relationship between the outpatient visits of hand, foot, and mouth disease (HFMD) and diurnal temperature range (DTR). The data of daily HFMD outpatient visits and meteorological parameters were obtained. A distributed lag nonlinear model combined with generalized linear model was used to estimate simultaneously nonlinear and delayed effects between DTR and daily HFMD outpatient visits after controlling confounding factors. A total of 15,275 HFMD visits were enrolled. DTR was significantly associated with HFMD outpatient visits in children. High DTR (P75: 11.4 °C) and extreme DTR (P95: 15.3 °C) were compared with 8.5 °C, and HFMD visits increased by a maximum of 3.93% (95% CI: 1.82 to 6.07%) and 4.47% (95% CI: 0.45 to 8.65%) in single-day lag effect, respectively. Furthermore, the extreme DTR effect decreased with the lag time and lasted for 10 days. Cumulative lag effects with markedly increasing percent of visits are over 64.88%. Furthermore, the effects were most pronounced among female children and children aged 0-2 years. Our study suggested that DTR changes were associated with HFMD outpatient visits, and populations of female and aged 0-2 years were more sensitive.
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  • Article
    Rodríguez-Arbolí E, Rodríguez-Veiga R, Soria-Saldise E, Bergua JM, Caballero-Velázquez T, ... Show More Arnán M, Vives S, Serrano J, Bernal T, Martínez-Sánchez P, Tormo M, Rodríguez-Medina C, Herrera-Puente P, Lavilla-Rubira E, Boluda B, Acuña-Cruz E, Cano I, Cáceres S, Ballesteros J, Falantes J, Martínez-Cuadrón D, Pérez-Simón JA, Montesinos P, PETHEMA Group.
    Cancer. 2025 Jan 01;131(1):e35618.
    BACKGROUND: LAMVYX was a multicenter, single-arm, phase 2 trial designed to validate the safety and efficacy of CPX-351 in patients aged 60-75 years with newly diagnosed, secondary acute myeloid leukemia and to generate evidence on key issues not addressed in the preceding regulatory pivotal trial.
    METHODS: The primary end point of the study was the complete remission (CR)/CR with incomplete hematologic recovery (CRi) rate after induction. Eligible patients were recommended to undergo allogeneic hematopoietic stem cell transplantation after the first consolidation cycle. Alternatively, patients could undergo up to six maintenance cycles with CPX-351.
    RESULTS: Twenty-nine patients (49%; 95% exact confidence interval [CI], 37%-62%) patients achieved a CR/CRi after one or two cycles of induction, with a measurable residual disease negativity rate of 67% as assessed by centralized, multiparameter flow cytometry. Among patients who had serial next-generation sequencing analyses available, clearance of somatic mutations that were present at diagnosis was achieved in 7 (35%). The median follow-up among survivors was 16.8 months (range, 8.7-24.3 months). The median event-free survival was 3.0 months (95% CI, 1.4-7.3 months), and the median overall survival was 7.4 months (95% CI, 3.7-12.7 months). In landmark analyses at day +100 from diagnosis, the 1-year overall and event-free survival rate among patients who underwent allogeneic hematopoietic stem cell transplantation was 70% (95% CI, 47%-100%) and 70% (95% CI, 47%-100%), respectively. The corresponding values were 89% (95% CI, 71%-100%) and 44% (95% CI, 21%-92%), respectively, for patients who entered the maintenance phase. No significant longitudinal changes were observed in severity index or quality-of-life visual analog scale scores.
    CONCLUSIONS: The current data provide novel insights that might inform the clinical positioning and optimal use of CPX-351, complementing previous results (ClinicalTrials.gov identifier NCT04230239).
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  • Book
    [edited by] Michael Valente, L. Maureen Valente.
    Contents:
    Hearing disorders
    Diagnostic examination : auditory function
    Diagnostic examination : vestibular function
    Amplification : hearing devices
    Cochlear implants
    Hearing assistive technology
    Tinnitus and misophonia management.
    Digital Access Thieme MedOne ComSci 2020