Books
- Dacie and Lewis Practical haematology. Twelfth edition. [12th ed.] — Designing urban food policies : concepts and approaches (190)
- Designing your life : how to build a well-lived, joyful life. First edition. — Diagnostic ultrasound. 5th edition. (190)
- Diagnostic ultrasound : physics and equipment. Third edition. — Disruptive behavior : development, psychopathology, crime, and treatment (190)
- Disruptive cooperation in digital health — Dystonia and dystonic syndromes (188)
- DigitalJody Ranck, editor.Contents:
Chapter 1: Introduction to Digital Health
Chapter 2: Overview of the Digital Health Ecosystem
Chapter 3: Diabetes and the Telcare Solution (Jonathan Javitt, Telcare)
Chapter 4: Cooperation in Aging Services Technologies
Chapter 5: The Quantified Self, Wearables, and the Tracking Revolution
Chapter 6: Beyond Silos to Data Analytics for Population Health: Case Study of HealthBank and Citizen Coops for Health Data Transactions
Chapter 7: Healthcare Lessons From the Telecommunications Sector (Sven Schuchardt, Detecon)
Chapter 8: Smart Healthy Cities: Public-Private Partnerships, a Case From Telefonica in Brazil [Jody Ranck, Katia Galvane (Telefonica), Washington Tavares (ISPM)]
Chapter 9: Smart Digital Health Policies (Ticia Gerber, HL7)
Chapter 10: Cooperation for Building Secure Standards for Health Data (Cem Senturk, Detecon)
Chapter 11: Peer to Peer Platforms for Physicians in Underserved Areas: A Human Rights Approach to Social Media in Medicine: The Case of Tabeeb (Osama Alshaykh).Digital Access Springer 2016 - DigitalRade B. Vukmir.Summary: This book explores a rapidly growing area of discussion in the health care industry, disruptive behavior in medical providers. The presence of disruptive behavior adversely impacts the providers of all disciplines: paraprofessional personnel, nurses, physicians and administrators. But more importantly, there may be a greater detrimental effect on quality and patient safety. This has led to mandated regulatory requirements that assist healthcare institutions in developing programs to address the problem. The book presents an evidence-based analysis of the disruptive provider behavior that defines the incidence, demographics, and profile of the behavior; discusses the specialties and work locations predisposed, as well as the interface with residents and nurses. The importance of patient safety, economic, and legal issues are addressed by a comprehensive, management strategy to effect positive, sustainable culture change in healthcare.
Contents:
Introduction
Scope of the Problem
Organizational Approach
Maturation of the Analysis
Profile of the Behavior
Location at Risk
Specialty at Risk
Physicians in Training
Etiology
Nursing Interface
Patient Safety
Policy and Guidelines
Economic Issues
Legal Interface
Regulatory Interventions
Strategies for Improvement
Educational Process
Management's Responsibility
Conclusion
Appendix: Situational Analysis and Approach: Case Scenarios.Digital Access Springer 2016 - DigitalXue Han, Yuanyuan Wu, Jie Zheng.Summary: The book addresses the prevalent digital transformation and focuses on its significant disruption in healthcare. In light of the distinctive characteristics and evolution of the Chinese healthcare industry, private multi-sided platform (MSP) companies emerge to offer novel values and explore the industry value chain. Drawing on the management and economics literature of MSPs, this book examines the selected Chinese MSPs and compares them with the counterpart MSPs in the U.S. This analysis highlights how the unfolding healthcare disruption is valuable for both scholars and practitioners to understand the trends and to take effective actions. "Disruptive Innovation through Digital Transformation: Multi-Sided Platforms of E-Health in China" provides readers in the developing and developed countries with insights on how to approach the current multi-sided platform and to resolve the current problems to better serve customers and patients in the healthcare market.
Contents:
Intro
Acknowledgements
About This Book
Contents
List of Figures
List of Tables
1 Demands for Healthcare Industry Changes Provide the Soil for Digital Transformation
1.1 Problems in the Healthcare Industry and the Impact of Digital Transformation
1.2 The Transformation Scenario in E-Health
1.3 Distinctive Chinese Healthcare Evolution Surpassing Typical Digital Transformation Developments
1.4 Overview of the Book
1.4.1 Starting Point
1.4.2 Theoretical Approach
1.4.3 Research Methodologies
1.4.4 Research Route
1.5 Structure of the Book 2 Digital Transformation, Multi-sided Platforms, and Analytical Framework
2.1 Transformation by Business Model Innovation
2.1.1 Disruption in Initially Serving the New Market: The Ignored Low-End Market or Non-existing Market
2.1.2 Disruption in Serving Complementary Markets
2.1.3 Disruption in Integrating and Serving the Whole Value Chain
2.2 Multi-sided Platforms (MSPs)
2.2.1 Characteristics of MSPs
2.2.2 The Importance of MSP Governance
2.2.3 Two-Stage Management of MSPs
2.2.4 Solving Chicken-and-Egg Problems
2.3 Analysis Model Suggested 3 Distinctive Characteristics of the Chinese Healthcare Industry
3.1 Ongoing Reforms in the Chinese Healthcare System
3.2 The Current E-Health Ecosystem in China
3.2.1 Key Players in the Chinese E-Health Ecosystem
3.2.2 Dominant Players in the Chinese E-Health Ecosystem
3.2.3 Interactions Between Players in the E-Health Ecosystem
3.3 Distinctive Characteristics of the Chinese Healthcare System
3.3.1 The Huge Medical Demands and Significant Imbalances
3.3.2 The Improving Medical Insurance System and Higher Percentage of Out-of-Pocket Payment 3.3.3 High Concentration of Visits in Comprehensive Hospitals
3.3.4 Ongoing Reform on the Multi-site License of Certified Physicians
3.3.5 Pressures of Career Advancement for Physicians
3.4 Great Opportunities for E-Health and MSP to Disrupt the Traditional Chinese Healthcare Market
4 Emerging E-Health MSPs in China
4.1 www.chunyuyisheng.com
4.1.1 The Involved Sides
4.1.2 Services and Advantages
4.1.3 The Chicken-Egg Solution
4.1.4 Cooperation-Competition with Other Practitioners
4.2 www.dxy.cn
4.2.1 The Involved Sides
4.2.2 Services and Advantages 4.2.3 The Chicken-Egg Solution
4.2.4 Cooperation-Competition with Other Practitioners
4.3 www.xingren.com
4.3.1 The Involved Sides
4.3.2 Services and Advantages
4.3.3 The Chicken-Egg Solution
4.3.4 Cooperation-Competition with Other Practitioners
4.4 www.guahao.com
4.4.1 The Involved Sides
4.4.2 Services and Advantages
4.4.3 The Chicken-Egg Solution
4.4.4 Cooperation-Competition with Other Practitioners
4.5 www.manyoubang.com (Manyoubang)
4.5.1 The Involved Sides
4.5.2 Services and Advantages
4.5.3 The Chicken-Egg Solution - Printedited by Ross C. Brownson, Graham A. Colditz, Enola K. Proctor.Summary: In the past twenty years, dissemination and implementation (D&I) research has sought to narrow the gap between the discovery of new knowledge and its application in public health, mental health, and health care settings. The challenges of moving research to practice and policy are universal, and future progress calls for collaborative partnerships and cross-country research. The fundamental tenet of D&I research - taking what we know about improving health and putting it into practice - must be the highest priority. This book presents a roadmap to effecting change in health and science from today's leading D&I researchers. With insights from around the globe, these scholars collectively address key issues in the field including how to evaluate evidence based on effective interventions, how to design an appropriate study, and how to track a set of essential outcomes.Digital Access Oxford [2023]
- Digitaledited by Ross C. Brownson, Graham A. Colditz, Enola K. Proctor.Contents:
The promise and challenges of dissemination and implementation research / Graham A. Colditz and Karen M. Emmons
Terminology for dissemination and implementation research / Borsika A. Rabin and Ross C. Brownson
Historical roots of dissemination and implementation science / James W. Dearing, Kerk F. Kee, and Tai-Quan Peng
Ethical issues in dissemination and implementation research / James M. Dubois and Beth Prusaczyk
The conceptual basis for dissemination and implementation research: lessons from existing models and frameworks / Rachel G. Tabak, David A. Chambers, Mary Hook, and Ross C. Brownson
The role of economic evaluation in dissemination and implementation research / Ramesh Raghavan
Designing for dissemination in chronic disease prevention and management / Neville Owen, Ana Goode, Takemi Sugiyama, Mohammad Javad Koohsari, Genevieve Healy, Brianna Fjeldsoe, and Elizabeth Eakin
The role of organizational processes in dissemination and implementation research
Gregory A. Aarons, Joanna C. Moullin, and Mark G. Ehrhart
Systems thinking and dissemination and implementation research / Barbara L. Riley, Cameron D. Willis, Bev Holmes, Diane T. Finegood, Allan Best, and Jessie-Lee D. McIsaac
Systems science methods in dissemination and implementation research / Douglas A. Luke, Alexandra B. Morshed, Virginia R. McKay, and Todd B. Combs
Participatory approaches for study design and analysis in dissemination and implementation research / Meredith Minkler, Alicia L. Salvatore, and Charlotte Chang
Enhancing dissemination through marketing and distribution systems: a vision for public health / Joseph T. Steensma, Matthew W. Kreuter, Christopher M. Casey, and Jay M. Bernhardt
Design and analysis in dissemination and implementation research / John Landsverk, C. Hendricks Brown, Justin D. Smith, Patricia Chamberlain, Geoffrey M. Curran, Lawrence Palinkas, Mitsunori Ogihara, Sara Czaja, Jeremy D. Goldhaber-Fiebert, Wouter Vermeer, Lisa Saldana, Jennifer A. Rolls Reutz, and Sarah McCue Horwitz
Measurement issues in dissemination and implementation research / Cara C. Lewis, Enola K. Proctor, and Ross C. Brownson
Implementation strategies / Joann E. Kirchner, Thomas J. Waltz, Byron J. Powell, Jeffrey L. Smith, and Enola K. Proctor
Fidelity and its relationship to implementation effectiveness, adaptation, and dissemination / Jennifer D. Allen, Rachel C. Shelton, Karen M. Emmons, and Laura A. Linnan
Adaptation in dissemination and implementation science / Ana A. Baumann, Leopoldo J. Cabassa, and Shannon Wiltsey Stirman
Furthering dissemination and implementation research: the need for more attention to external validity / Lawrence W. Green and Mona Nasser
Evaluation approaches for dissemination and implementation research / Bridget Gaglio and Russell E. Glasgow
Mixed methods evaluation in dissemination and implementation science / Lawrence A. Palinkas and Brittany Rhoades Cooper
Dissemination and implementation research in community and public health settings / Cynthia A. Vinson, Katherine A. Stamatakis, and Jon F. Kerner
Dissemination and implementation in social service settings / J. Curtis McMillen and Danielle R. Adams
Implementation science in health care / Alison B. Hamilton and Brian S. Mittman
Health dissemination and implementation within schools / Rebekka M. Lee and Steven L. Gortmaker
Dissemination and implementation research in worksites / Peggy A. Hannon and Jeffrey R. Harris
Policy dissemination research / Jonathan Purtle, Elizabeth A. Dodson, and Ross C. Brownson
Dissemination and implementation research among racial/ethnic minority and other vulnerable populations / Antronette (Toni) Yancey, Beth A. Glenn, Chandra L. Ford, and Lashawnta Bell-Lewis
Dissemination and implementation research in a global context / Rebecca Lobb, Shoba Ramanadhan, and Laura Murray
Future issues in dissemination and implementation research / Ross C. Brownson, Graham A. Colditz, and Enola K. Proctor.Digital Access Oxford 2018 - DigitalMichael C. Klein.Summary: "How often do you hear a doctor saying doctors need to be more accountable, Medicare needs more support and family medicine deserves more respect? Dissident Doctor bristles with refreshingly frank criticisms from inside the health sector, and its author is not just any doctor but a distinguished scientific researcher, veteran medical administrator, Professor Emeritus, recipient of the Order of Canada and lifelong gadfly. In Dissident Doctor, Michael C. Klein intersperses fascinating tales of individual cases with formative elements of his personal life. As the son of American left-wing activists, he grew up singing folk songs about justice and racial equality; as a young doctor his refusal to serve as a military physician during the Vietnam War prompted his immigration to Canada. His early experience working with midwives in Ethiopia-delivering babies using techniques for natural pain relief and without routine episiotomy-were formative, leading him to question many standard but unjustified procedures in Western maternity care. He made many unconventional decisions as a result of his focus on humane medicine, transitioning from a specialization in pediatrics and newborn care to become a family physician, and embracing midwifery before it was approved in Canada. Klein's determination in the face of great opposition, the strength of his convictions, and his humility and sense of humour drive this powerful story of a life and career dedicated to his patients and his principles."-- Provided by publisher.Digital Access ProQuest Ebook Central 2018
- DigitalJeffrey N. Lawton, editor and author.Contents:
1. Teatment of metaphyseal distal radius fractures with a volar locking plate
2. Volar plate/hook pin for volar lunate facet fragment
3. Volar locking plate + dorsal-ulnar plate
4. Volar locking plate and radial styloid plating
5. Volar locking plate for intra-articular distal radius fracture
6. Dorsal plate fixation for distal radius fractures
7. Fragment-specific internal fixation of distal radius fractures
8. Volar ulnar fixation
9. Fractures of the radial column
10. Distal radius fracture: Kapandji (intrafocal) pinning technique
11. Bridge plating for distal radius fractures
12. External fixation and percutaneous pinning for distal radius fractures
13. Ulnar styloid fracture with distal radioulnar joint instability
14. Distal radius fractures with ulnar head and neck fractures
15. DRUJ dislocations/ Galeazzi fracture
16. Distal radius fractures: a clinical casebook
17. Loss of fixation in distal radius fractures
18. Distal radius fracture complicated by carpal tunnel syndrome
19. Complications of distal radus fracture: EPL rupture
Index.Digital Access Springer 2016 - DigitalLeiv M. Hove, Tommy Lindau, Per Hølmer, editors.Summary: Distal radial fractures are still puzzling us 200 years after Colles' classic description. Despite the advent of various new imaging techniques, including 3D CT, the availability of diagnostic adjuncts such as arthroscopy, and treatment options that include more than 30 different volar locking plates, the rate of unsatisfactorytreatment resultsremains very high. Furthermore, while we are aware of more associated injuries, such as carpal ligament tears and injuries to the radioulnar ligament (TFCC), there is still intense debate on the relevance of these injuries. This textbook aims to provide the reader with a complete understanding of distal radius fractures, their inherent problems, and how to manage them successfully. It is written by widely published experts from a part of the globe where distal radius fractures are very common, especially during the winter months. Clear guidance is provided on diagnostic imaging, classification, and assessment of fracture instability. The complete spectrum of operative and nonoperative treatment options are then clearly explained with the aid of step-by-step illustrations. Extensive information is also provided on complications and their treatment. Both students and experienced practitioners will find this book to be an enlightening, practice-oriented reference on the management of these challenging fractures.
Contents:
Distal Radius Fractures: What Is the Problem?
A Historical Review of the Distal Radius Fracture
Anatomy of the Wrist
Biomechanics and Kinematics of the Wrist
Epidemiology
Distal Radius Fractures and Osteoporosis
Outcome Assessment After Distal Radius Fractures
Medicolegal Aspects of Distal Radius Fractures
Imaging
Classification Distal Radius Fractures
How to Assess Fracture Instability
Pharmacologic Treatment of Distal Radial Fractures
Flow Chart for Treatment: A Standardized Treatment Program as an Aid in Primary Treatment of Distal Radius Fractures
The Clinical Dilemma: Nonoperative or Operative Treatment
Clinical Diagnosis, Closed Reduction, and Plaster
Closed Re-reduction: Is It an Alternative
Closed Reduction and External Fixation of Unstable Distal Radius Fractures
Closed Reduction and Percutaneous Pinning
Closed Reduction and Intramedullary Fixation of Distal Radius Fractures
Closed Reduction and External Fixation or Open Reduction and Volar Internal Fixation: The Clinical Dilemma
Combined External Fixation and Internal Fixation
Open Reduction and Volar Plating: Surgical Guide
When Fixed-Angle Volar Plates Are Not Enough: Alternative Fixation Methods in Problem Fractures
Die-Punch Fractures: Open and Arthroscopy-Assisted Fixation
Arthroscopy in Distal Radius Fractures
Associated Injuries in Distal Radius Fractures
Radial Styloid Fractures and Associated Carpal Injuries
Acute Injuries Around the Distal Ulna
Bone Substitutes, Grafts and Cement
The Elderly Osteoporotic Patient
Rehabilitation
Complications: An Overview
Nerve Entrapments and Nerve Injuries in Distal Radius Fractures
Tendon Complications of Distal Radial Fractures
Complex Regional Pain Syndrome
Compartment Syndrome of the Forearm
Extra-articular Malunion of the Radius; Osteotomy of the Radius
Ulnar Shortening Osteotomy After Distal Radius Fracture
Intra-articular Malunion
Distal Radius Fractures and Secondary Carpal Dysfunction
Secondary Osteoarthrosis: Partial or Total Arthrodesis Versus Wrist Arthroplasty
Secondary DRU Joint Problems Instability, Nonunion Styloid, and Ulnocarpal Abutment
Salvage Procedures to the DRU Joint
Wrist Denervation
Associated Fractures of the Distal Ulna
Galeazzi's Fracture and Essex-Lopresti Injuries: Dislocation Fractures of the Forearm
Distal Radius Fractures in Children. - Digitaledited by Jesse Jupiter, Michael Chammas, editor-in-chief: Geert Alexander Buijze.Summary: Edited and authored by leading international experts, Distal Radius Fractures: Evidence-Based Management provides a state-of-the-art overview of diagnosis and management based on today's best practices. Each chapter focuses on one key issue, offering a challenging case and then questioning the reader in an engaging fashion to provide the best available evidence on each topic. Practical and easy to read, this innovative text is a useful resource for all residents, physicians and surgeons who manage fractures. Combines current best practices with the knowledge and experience of a global team of expert contributing authors, with a focus on practical use in applying the evidence. Covers need-to-know topics such as anatomy and biomechanics, diagnostic management, acute fracture management, management of pediatric and elderly fractures, and more. Includes valuable case scenarios, technical tips and tricks, and pearls and pitfalls. Features high-quality illustrations including CT scans, x-rays, and clinical photographs. Consolidates the latest evidence on distal radius fractures into one convenient resource. Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices.
Contents:
Principles of evidence-based management of distal radius fractures
Epidemiology of distal radius fractures
Surgical anatomy of the distal radius
Biomechanics of distal radius fractures
Radiographic parameters of distal radius fractures
Advanced imaging in distal radius fractures
Closed reduction and immobilization of displaced distal radius fractures
Surgical versus conservative interventions for displaced distal radius fractures
Predictors of instability and secondary displacement after conservatively managed distal radius fractures
Minimally invasive plate osteosynthesis of distal radius fractures
Volar, dorsal, and/or radial plating
Comminuted articular distal radius fractures
Extra-articular distal radius fractures with metaphyseal comminution
Bone graft (substitutes) in distal radius fractures
Arthroscopic-assisted treatment of distal radius fractures
Simultaneous fractures of the distal radius and scaphoid
Galeazzi fracture dislocations
Diagnosis and treatment of an Essex-Lopresti injury
Acute distal radioulnar joint instability
Distal ulnar fractures concomitant with distal radius fractures
Persistent ulnar-sided wrist pain after distal radius fracture
Association between radiological and patient-reported outcomes
Rehabilitation protocols after distal radius fracture
Complex regional pain syndrome in distal radius fractures
Pediatric distal radius fractures
Pediatric forearm fractures
Distal radius fracture fixation in the elderly
Prevention of distal radius fractures
Diagnosing the malunited distal radius
Treatment of the extraarticular malunited distal radius
Treatment of the intraarticular malunited distal radius
Three-dimensional planning and surgical guidance of malunion correction
Nonunion of distal radius fractures
Tendon ruptures after distal radius fracture
Chronic DRUJ instability after distal radius fractures
Posttraumatic DRUJ arthritis
Posttraumatic radiocarpal arthritis
Wrist contracture after distal radius fractures.Digital Access - Digitaleditor-in-chief, Francisco del Piñal ; co-editors, Max Haerle, Hermann Krimmer.Summary: "Hand and wrist fractures account for millions of emergency room visits annually. The extraordinary importance of these structures in activities of daily living necessitates great surgical competence in repairing fractures so as to preserve the vast range of motion and utility of this functional anatomic unit. The management theory and techniques for these fractures have seen dramatic changes in the last few decades. This new volume brings together all currently established operative techniques for distal radius fractures, explained in detail and highly illustrated, step by step, with a wealth of brilliant figures and diagrams. Key Features: Comprehensive coverage of all types of injury as well as all the evidence-based therapeutic surgical options. State-of-the-art management of carpal instability, anterior and dorsal rim fractures, radiocarpal dislocation, malunion, and much more. Includes coverage of ligamentous injuries. Contributions by numerous world-renowned surgeons This book is essential for all surgeons in training in orthopaedic surgery and in plastic surgery and highly useful to experienced surgeons"-- Provided by publisher.
Contents:
Anatomy of the Fracture / Simon MacLean, Gregory Bain
Radiology of the Fractured Radius / Mark Ross, Patrick Groarke
Patient-Accident-Fracture Classification of Acute Distal Radius Fractures in Adults / Guillaume Herzberg, Thais Galissard, Marion Burnier
Distal Radius Fracture: The Evidence / Tracy Webber, Tamara D. Rozental
Orthopaedic Treatment: When? / David Warwick, Oliver Townsend
Mini Approaches / Gustavo Mantovani Ruggiero
Spanning Plates / Mitchell G. Eichhorn, Scott G. Edwards
Arthroscopic Management / Yukio Abe
Anterior Rim Fractures / Jorge L. Orbay, Gabriel Pertierra
Dorsal Rim Distal Radius Fractures with Radiocarpal Fracture-Dislocation / Rohit Garg, Jesse Jupiter
Multiplanar Fixation in Severe Articular Fractures / Peter C. Rhee, Alexander Y. Shin
Management of Wrist Open Fractures and Bone Defects / Rames Mattar Junior, Emygdio Jose Leomil de Paula, Luciano Ruiz Torres, Tiago Guedes da Motta Mattar, Gustavo Bersani Silva
Radiocarpal Dislocation / Mark Henry
Common Errors of Volar Plate Fixation / Robert J. Medoff, James M. Saucedo
Distal Ulna Fractures / Christopher Klifto, David Ruch
Distal Radioulnar Joint Instability Associated with Distal Radius Fractures / Shohei Omokawa, Takamasa Shimizu, Kenji Kawamura, Tadanobu Onishi
Distal Radius Fracture in the Elderly / Rohit Arora, Markus Gabl
Extra-articular Malunion / Karl-Josef Prommersberger
Arthroscopic-Guided Osteotomy for Intra-articular Malunion / Francisco del Piñal
Newer Technologies on Managing Distal Radius Fractures / Ladislav Nagy
Distal Radius in Children and Growth Disturbances / Alexandria L. Case, Joshua M. Abzug
Open Surgery for Chronic Scapholunate Injury / Dirck Ananos, Marc Garcia-Elias
Arthroscopic Scapholunate Repair / Max Haerle, Christophe Mathoulin
Treatment of Lunotriquetral Injuries / Benjamin F. Plucknette, Haroon M. Hussain, Lee Osterman
Arthroscopic Management of Perilunate Dislocation and Fracture Dislocation / Jae Woo Shim, Jong-Pil Kim, Min Jong Park
Radiocarpal Pain and Stiffness / Christoph Pezzei, Stefan Quadlbauer
Ulnar Pain and Pronosupination Losses / Riccardo Luchetti, Andrea Atzei
Chronic Distal Radioulnar Joint Instability / Michael C. K. Mak, Pak-Cheong HoDigital Access - DigitalPeter J. Papadakos, Stephen Bertman, editors.Summary: Examining-room computers require doctors to record detailed data about their patients, yet reduce the time clinicians can spend listening attentively to the very people they are trying to help. This book presents original essays by distinguished experts in their fields, addressing such critical problems and making an urgent case for reform, because while electronic technology has revolutionized the practice of medicine, it also poses a unique challenge to health care. Smartphones in the hands of doctors and nurses have become dangerously seductive devices that can endanger their patients. Distracted Doctoring is written for anesthesiologists and surgeons, as well as general practitioners, nurses, and health care administrators and students. Chapters include Electronic Challenges to Patient Safety and Care; Distraction, Disengagement, and the Purpose of Medicine; and Managing Distractions through Advocacy, Education, and Change.
Contents:
Introduction : the problem of distracted doctoring / Peter J. Papadakos and Stephen Bertman
Medicine enters the computer age / Lekshmi Santhosh and Raman Khanna
Electronic challenges to patient safety and care / Stephen Bertman
Addiction to technology and speed / Stephen Bertman
Note to my doctor : lessons from fifty years of distracted driving research / Paul Atchley
Distraction, disengagement, and the purpose of medicine / David Loxterkamp
Taking time to truly listen to our patients / Deepthiman Gowda
When it comes to the physician-patient-computer relationship, the "eyes" have it / Richard Frankel
Impact of EMRs on communication within the doctor-patient relationship / Wei Wei Lee and Maria Lolita Alkureishi
Physician dissatisfaction, stress, and burnout, and their impact on patient care / Alan H. Rosenstein
Distractions in the operating room / Michelle A. Feil
Risk reduction and vigilance in anesthesia / Roy G. Soto, Mallika Thampy, and Sara Neves
Managing distractions through advocacy, education, and change / Donna A. Ford
Electronic devices as potential sources of biological contamination / Roy H. Constantine
Digital distraction and legal risk / James E. Szalados
Electronic etiquette : a curriculum for health professionals / Peter J. Papadakos
Mindful practitioners, mindful teams, and mindful organizations : attending to the core tasks of medicine / Ronald M. Epstein
Afterword : "Physician, Heal Thyself, and Make Haste, Slowly."Digital Access Springer 2017 - DigitalJenara Nerenberg.Summary: "A paradigm-shifting study of neurodivergent women-those with ADHD, autism, and other sensory processing differences-exploring why these traits are overlooked in women and how society benefits from allowing their unique strengths to flourish As a successful, Harvard- and Berkeley-educated writer, entrepreneur, and devoted mother, Jenara Nerenberg was shocked to discover that her "symptoms" that were only ever labeled as anxiety were considered autistic and ADHD. Being a journalist, she dove into the research and uncovered neurodiversity-a framework that moves away from pathologizing "abnormal" versus "normal" brains and instead recognizes the vast diversity of our mental makeups. Divergent Mind is a long-overdue, much-needed answer for women who have a deep sense that they are "different." Sharing real stories from women with ADHD, autism, synesthesia, misophonia, and more, Nerenberg explores how these brain variances present differently in women and dispels widely held misconceptions. She also offers a path forward, describing practical changes in how we can communicate, design our surroundings, and better support divergent minds. When we allow our wide variety of brain makeups to flourish, we create a better tomorrow for us all"-- Provided by publisher.Digital Access 2020Limited to 1 simultaneous userSUNet ID login required
- DigitalDana A. Telem, Colin A. Martin, editors.Summary: This book comprehensively covers diversity, equity and inclusion (DEI) in the context of daily surgical practice. Through real-life illustrative case scenarios and experiences, this book explores DEI and its impact on academic surgery, career development, and clinical practice. Each chapter highlights a commonly encountered scenario and features extensive guidance on how to address each challenge secondary to both implicit explicit biases as well as detailing how to implement best practices. Diversity, Equity and Inclusion provides a detailed guide to the best practices and challenges associated with implementing DEI in day to day surgical practice and is a valuable resource for all surgical practitioners looking for a guide on how to successfully implement DEI strategies into daily clinical practice.
Contents:
Setting the Stage: What is Diversity, Equity and Inclusion?
Best Practices in Recruitment and Retention
Advancement and Leadership Development
Mentorship and Sponsorship
Research track and focus
Selecting one's scope of practice
Selecting one's type of practice
Alternative Paths
Patient Bias and the Surgeon
Gender and Surgery
Race/Ethnicity and Surgery
Sexual Identity and Surgery
Physical or Intellectual Disability and Surgery. . - DigitalMarcus L. Martin, Sheryl L. Heron, Lisa Moreno-Walton, editors ; Anna Walker Jones, managing editor.Contents:
Defining Diversity in Quality Care
Racial/Ethnic Healthcare Disparities and Inequities: Historical Perspectives
Educating Medical Professionals to Deliver Quality Health Care to Diverse Patient Populations
Culturally Competent Faculty
Culturally Sensitive Care: A Review of Models & Educational Methods
Interpreter Services
The Patient-Physician Clinical Encounter
Spiritual Care Services in Emergency Medicine
Lesbian, Gay, or Bisexual (LGB): Caring with Quality and Compassion
Culturally Competent Care of the Transgender Patient
Looking Past Labels: Effective Care of the Psychiatric Patient
Disability and Access
Racial and Ethnic Disparities in the Emergency Department: A Public Health Perspective
Vulnerable Populations: The Homeless and Incarcerated
Vulnerable Populations: The Elderly
Vulnerable Populations: Children
Religio-cultural Consideration When Providing Healthcare to American Muslims
Disparities and Diversity in Biomedical Research
Cultural Competency Case Studies: Transitional Introduction
Case 1: African-American Infant and Family
Case 2: Cambodian Refugee
Case 3: Sickle Cell Crisis
Case 4: Mongolian Spots
Case 5: Death Disclosure
Case 6: Coin Rubbing
Case 7: Toxic Ingestion
Case 8: Adolescent Indian Male Sikh
Case 9: Intimate Partner Violence in the Gay Community
Case 10: West Indian/Caribbean
Case 11: American Indian
Case 12: Spiritualism in the Latino Community
Case 13: Islamic Patient
Case 14: Pediatric Pain. - DigitalSteve H. Koh, Gabriela G. Mejia, Hilary M. Gould, editors.Summary: This book presents an extensive collection of high-yield case vignettes with recommendations for a comprehensive approach to cultural psychiatry. Culture is defined from an anthropological perspective, with an emphasis on aspects of culture beyond race, ethnicity, and other traditional demographic categories. The goal of this book is to offer clinical applications of cultural psychiatry via examination of special populations, systems, and settings. With ever-changing geopolitical environments, institutional structures, and sociodynamics, attention and consideration of context is paramount. Theoretical models and specific frameworks for evaluating cultural influence on the manifestation, development, and treatment response of mental health illnesses are presented. The chapters are organized to showcase different ways in which culture plays into everyday clinical practice. Emphasis is placed on the full sum of the care delivery transaction within a larger context, including public and community systems of care. Real-world case examples are discussed in each chapter to help contextualize the dynamic nature that culture plays in practice across inpatient and outpatient settings. Each case presents with relevant academic and historical background and practical operational advice for psychiatrists providing care within these respective communities. The authors address diverse clinical cases related to refugee and asylum seekers, military service members, survivors of human trafficking, incarcerated populations, and more. Training recommendations and best practices are outlined including psychopharmacology, psychosocial treatments, and cultural adaptations to evidence based treatments. Diversity in Action: Case Studies in Cultural Psychiatry is a useful resource for all psychiatrists, psychologists, general practitioners, social workers, nurses, administrators, public policy officials, and all medical professionals working with a culturally diverse subset of patients seeking mental health.
Contents:
Introduction
Survivors of Torture
Survivors of Human Trafficking
Survivors of Combat Trauma
Co-Occurring Disorders
Telepsychiatry to Rural Populations
Religion, Spirituality, and Mental Health
Biculturalism: the case of two North American neighbors
Correctional Psychiatry
Shifting Gears: Cultural Assimilation into Primary Care
Psychiatric Care in Residential Care Environments. - DigitalPierre-Marie Bosc, Jean-Michel Sourisseau, Philippe Bonnal, Pierre Gasselin, Élodie Valette, Jean-François Bélières, editors.Summary: In contemporary times where farming models are challenged through deep transformations of agricultural organizations and markets, this books proposes a new visit of the diversity of family forms of production to explore their current transformations all over the world. By adopting a comprehensive perspective it allows bringing together several dimensions often studied separately: linkages with markets, territorial development, labour mobility through migrations and livelihood strategies, farms? autonomy, and food security, as well as the many ways of collective action and the role of public policies. The book relies on 18 case studies in the five continents. All were driven with a single and original methodological framework, inspired by the Sustainable Rural Livelihoods. The SRL initial framework was reshaped and adapted to allow each author to fine-tune "what makes family," to understand family labour adaptations to their environment, and to align them with territorial dynamics and public policies in each national situation. Co-written by a network of researchers, this book deepens scientific knowledge on family farming around the world, and at the same time it contributes to test and improve a methodological framework adapted to analyse and of observe rural dynamics. It is dedicated to researchers, teachers and students, agronomists, economists, geographers, sociologists and historians but also experts and practitioners in agricultural and rural development. More widely, NGOs and any citizen willing to understand the family farming's issues in different social contexts, should also find interest in reading it.
Contents:
Foreword
Introduction
Non-Market rationales, an?archaism? worth revisiting
Introduction
Family farming in Polish Podlasie: anachronism or overlooked potential?
Urban and peri-urban agriculture: dairy farms in Cairo, Egypt
Integration into international markets of family cotton farms in Mali
The fragility of the sedentarization of a pastoral Fula population in Benin
Local anchoring and migration as two faces of the same coin
Introduction
Diversified multi-localized family farming in Nicaragua
The iony moment and the Indian farmers of Ecuador
Agriculture in southern Mozambique: an activity based on migrations for work
At the limits of family agriculture: family business forms of production?
Introduction
Between firms and family business farms: small transitory family plantations in Indonesia
Family farming in Brazil, modernized and integrated
Agricultural family enterprises, territories and politics in Argentina
Diversification of activities between strategies of survival and accumulation
Introduction
Family farming confronted by drought and liberalization in Senegal
Long-term accumulation strategies and family farms in Cameroon
The uncertain market integration of family farms in Madagascar
Organization of family in between a collective asset and the limitations of individual strategies
Introduction
From the big to the small family in Burkina Faso: disrupted generations and statuses
A family and its system of pastoral farming without borders, between Niger, Chad and Nigeria
Beyond family farming: determining political and territorial issues
Introduction
Fragmentation of irrigated family farms in southern India
On the roof of the world, the pastoralists of the Tibetan plateau confronted by change
Family agriculture in contemporary Kanak society
Conclusion: Methodological and conceptual contributions
References
List of authors. - DigitalDiane L. Dixon.Summary: "This book is about the lived experiences on the executive path of 12 racially and ethnically diverse hospital and health system CEOs. It is based on interviews. It seeks to learn from the collective wisdom of all the executives to provide a unique glimpse, from their perspectives, into what it takes to navigate the challenges and opportunities of the executive path to the C-suite"-- Provided by publisher.
Contents:
Backgrounds Are the Foundation
Reflections on Race and Ethnicity
Positive Personal Qualities
The Power of Relationships
The Essential Role of Sponsorship
The Executive Path : A Journey, Not a Ladder
Maximizing Career Mobility
When the Going Gets Tough
Leadership Makes the Difference
Discerning What Matters Most
Closing Thoughts for the Journey.Digital Access ProQuest Ebook Central 2020 - Digitaleditors, Michael W. Mulholland, Erika Adams Newman.Summary: "The surgical treatment of human disease is inherently complex. Patients present with symptoms or disabilities that may relate to a variety of underlying causes. In evaluating those symptoms, modern medicine provides multiple diagnostic modalities that may be applied but in proper sequence and economically. Once a diagnosis is secured, treatment recommendations may include both surgical and nonsurgical therapies. In turn, when operative treatment is recommended, a variety of approaches--open, laparoscopic, robotic--are available, each with its particular efficacy, risk, and cost. In addition, surgical patients are inherently variable. Each patient has a unique set of comorbidities and an individual biological milieu. Each requires personalized treatment. These are the complexities that surgeons confront every day, and for which creativity and diversity of thought are essential. Exciting new research demonstrates that problems characterized by complexity and high variability are best solved by teams intentionally constructed to maximize diversity. The premise of The Diversity Promise: Success in Academic Surgery and Medicine Through Diversity, Equity, and Inclusion is that demonstrable advantages come from the intentional mixture of talented people in a stimulating environment. Maximizing performance depends upon teamwork but teams constructed and enabled in a specific way. To be truly impactful, team members must be both talented and diverse. People have differing life experiences based upon age, race, gender, religious belief, and myriad other factors. These experiences, in turn, produce differing perspectives that create a strong competitive advantage for diverse teams."-- From preface.
Contents:
Building an open and inclusive enironment for faculty
Attracting talented medical students
Developing talent in surgery residents.Digital Access - PrintKaren Speerstra, Herbert Anderson ; foreword by Ira Byock, MD.Summary: "The Divine Art of Dying" explores the unique moment when seriously ill people choose to turn toward death. Combining personal stories with solid research on palliative and hospice care, it provides a well-integrated look at the spiritual dimensions of living fully when death is near. Filled with insights from the world's great wisdom traditions along with references from literature, movies, and current culture, it helps identify the life decisions the dying one and his or her loved ones must make, and what their caregivers can expect.
- DigitalOlaf Rusoke-Dierich.Summary: "This book is the very first to cover the decompression theory in detail. It gives many information on all topics of the diving medicine, and is richly and uniquely illustrated. It offers a good guideline of high quality practice in diving medicine. The author provides a very structured and easy to understand book, by covering all aspects of the diving medicine, such as equipment, physiology, and related issues as gas intoxications, venomous animals or damages that can occur in the diving practice. Relevant physiological and anatomical illustrations enlight even complex topics. The Diving medicine book will appeal to health experts like doctors and nurses, but also to diving schools and teachers"-- Provided by publisher.
- Digitalby Elissa P. Benedek, Samantha A. Huettner.Summary: This book explores the impact of divorce on adolescents and young adults, drawing on anecdotes from the authors' own medical and law practices to illustrate how parents' decision-making can powerfully impact their children's well-being before, during, and after a divorce -- even into adulthood.
Contents:
Cover; Half Title; Title Page; Copyright; Contents; Acknowledgments;
Chapter 1 It's A Different World Now;
Chapter 2 The Decision to Divorce: Putting Children First;
Chapter 3 How to Tell Your Children About Your Divorce;
Chapter 4 Minimizing the Effects of the Legal Process on Your Children;
Chapter 5 Impact of Divorce on Children;
Chapter 6 Impact of Divorce on Parenting;
Chapter 7 Parenting Time and Related Issues;
Chapter 8 Special Parenting Issues;
Chapter 9 Parenting Techniques to Build Your Child's Self-Esteem;
Chapter 10 Discipline as Guide and Teacher
Chapter 11 Making Use of Others' Support;
Chapter 12 Danger Signals: When Is Professional Help Needed?;
Chapter 13 Adjusting to Life in a Stepfamily;
Chapter 14 Questions and Answers;
Chapter 15 Additional Resources and Helpful Organizations for Divorced Parents; Index; Back CoverDigital Access ProQuest Ebook Central 2019 - DigitalS. B. Bhattacharyya.Summary: This book is a do-it-yourself guide for clinicians who wish to set up and run a telemedicine facility of their own. The contents are largely based on the understanding and experience gained by the author as a practising physician, management post-graduate (capstone thesis was on telemedicine) and as a business architect for digital health systems over more than thirty years. Full of management techniques, tricks and tips written in an easy-to-follow manner, this book provides sufficient information to clinicians looking to leverage telemedicine to augment their range of service offerings that would lead to increased levels of patient satisfaction. Various aspects related to definitions, technology, infrastructure, methodologies and legal issues for setting up and running telemedicine services have been dealt with to sufficient depths for the readers to help grasp the issues involved. Sections on privacy, confidentiality and data integrity have been provided to help allay the many concerns the readers might have in those regards. Additionally, financial evaluations based on realistic-enough figures have been used to demonstrate that telemedicine is a viable option financially. Although meant primarily for medical doctors, any care provider including institutional will be able to use the contents to plan, design, set up and run telemedicine services that they feel would benefit those who receive their care.
Contents:
Telemedicine
Telemedicine Services
Infrastructural Requirements
Technological Requirements
All Services
Overview & General Principles
Teleconsultation
Telemonitoring
Remote Care
Management Aspects
Legal Aspects.Digital Access Springer 2017 - DigitalA. Tucker Gleason, Bradley W. Kesser.Summary: "Get a quick, expert overview of dizziness and vertigo from childhood through old age with this concise, practical resource. Drs. Bradley W. Kesser and Tucker Gleason have assembled a leading team of experts to address timely clinical topics of interest to otolarynologists and other health care providers who see patients with these common problems. Covers key topics such as the clinical exam and diagnostic techniques, assessment and differential diagnosis in the pediatric population, dizziness and vertigo in the adolescent and the elderly, evaluation of dizziness in the litigating patient, vHIT, positional vertigo in all age groups, vestibular neuritis, migraine-associated vertigo, Meniere's disease, medication-related dizziness in the older adult, and more. Includes information on dizziness demographics and population health, as well as development of the vestibular system and balance function. Consolidates today's available information and experience in this important area into one convenient resource"--Publisher's description.
Contents:
Section 1: Introduction to dizziness. Dizziness demographics and population health
Clinical examination of the dizzy patient in the context of contemporary diagnostic techniques
Section 2: Pediatric. Development of the vestibular system and balance function: differential diagnosis in the pediatric population
Assessment techniques for vestibular evaluation in pediatric patients
The predominant forms of vertigo in children and their associated findings on balance function testing
Section 3: Adolescent and adult. Dizziness and vertigo in the adolescent
Evaluation of dizziness in the litigating patient
vHIT
Positional vertigo: as occurs across all age groups
Vestibular neuritis
Migraine-associated vertigo
Superior canal dehiscence
Meniere's disease: a challenging and relentless disorder
Uncommon causes of disequilibrium in the adult
Section 4: Elderly. Baroreflexes
Vertebrobasilar infarcts and ischemia
Dizziness in the elderly
Medication-related dizziness in the older adult
Vestibular rehabilitation of older adults with dizziness.Digital Access ClinicalKey 2018 - DigitalHiroyoshi Ariga, Sanae M.M. Iguchi-Ariga, editors.Summary: This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson's disease (PD), park7. The DJ-1 gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of DJ-1 in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases. .
Contents:
Introduction/overview
Structural biology of the DJ-1 superfamily
Expression of DJ-1 in patients with neurodegenerative diseases
DJ-1 as an oncogene and its clinical significance
Role of DJ-1 in fertilization
Anti-oxidative stress function of DJ-1
Transcriptional regulation of DJ-1
Regulation of signal transduction by DJ-1
Protein repair by DJ-1 from glycation by glyoxal and methylglyoxal
DJ-1 as a biomarker of Parkinson's disease
Roles of DJ-1 in diabetes mellitus
Therapeutic activities of DJ-1 and its binding compounds against neurodegenerative diseases
DJ-1 as an oncogene and promising target for cancer chemotherapy.Digital Access Springer 2017 - DigitalStefan Jurga, Jan Barciszewski, editors.Summary: This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions. Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylate nucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms. This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.
Contents:
Chapter 1. Establishment, Erasure and Synthetic Reprogramming of DNA Methylation in Mammalian Cells.- Chapter 2. Origin and Mechanisms of DNA Methylation Dynamics in Cancers.- Chapter 3. CpG Islands Methylation Alterations in Cancer: Functionally Intriguing Security Locks, Useful Early Tumor Biomarkers.- Chapter 4. Histone and DNA Methylome in Neurodegenerative, Neuropsychiatric and Neurodevelopmental Disorders.- Chapter 5. DNA Methylation in Neuronal Development and Disease.- Chapter 6. Functional Implications of Dynamic DNA Methylation for the Developing, Aging and Diseased Brain.- Chapter 7. The Methylome of Bipolar Disorder: Evidence from Human and Animal Studies.- Chapter 8. DNA Methylation in Multiple Sclerosis.- Chapter 9. Early Life Stress and DNA Methylation.- Chapter 10. Regulation of 5-hydroxymethylcytosine Distribution by the TET Enzymes.- Chapter 11. Epigenetic Alterations: The Relation Between Occupational Exposure and Biological Effects in Humans.- Chapter 12. DNA Methylation: Biological Implications and Modulation of its Aberrant Dysregulation.- Chapter 13. Functions and Dynamics of Methylation in Eukaryotic mRNA.- Chapter 14. The Role of mRNA m6A in Regulation of Gene Expression.- Chapter 15. G9a and G9a-like Histone Methyltransferases and Their Effect on Cell Phenotype, Embryonic Development, and Human Disease.- Chapter 16. Biomolecular Recognition of Methylated Histones.- Chapter 17. The Role of Protein Lysine Methylation in the Regulation of Protein Function
Looking Beyond the Histone Code.- Chapter 18. Secondary Structures of Histone H3 Proteins with Unmethylated and Methylated Lysine-4 and -9 Resiudes; Characterization Using Circular Dichroism Spectroscopy.- Chapter 19. Asymmetric Dimethylation on Arginine (ADMA) of Histones in Development, Differentiation and Disease.- Chapter 20. A Switch for Transcriptional Activation and Repression: Histone Arginine Methylation.- Chapter 21. Aberrant Epigenomic Regulatory Networks in Multiple Myeloma and Strategies for their Targeted Reversal.- Chapter 22. Metabolic Deregulations Affecting Chromatin Architecture: One-carbon Metabolism and Krebs Cycle Impact Histone Methylation.- Chapter 23. Histone Methylome of the Human Parasite Schistosoma Mansoni. - DigitalAtsushi Kaneda, Yu-ichi Tsukada, editors.Contents:
DNA and histone methylation in epigenetics
Part II: DNA methylation and cancer
Part III: DNA and histone methylation-related events underlying cancer
Part IV: DNA and histone methylation in particular types of cancer
Part V: DNA and histone modifications in diagnosis and therapy of cancer
Part VI: Future directions.Digital Access Springer 2017 - DigitalVadim V. Demidov.Summary: This is the first book portraying to a wide readership many fields of DNA in the world of materials altogether in a single volume. The book provides underlying concepts and state-of-art developments in the emerging fields of DNA electronics, structural DNA nanotechnology, DNA computing and DNA data storage, DNA machines and nanorobots. Future possibilities of innovative DNA-based technologies, such as DNA cryptography, DNA identity tags, DNA nanostructures in biosensing and nanomedicine, as well as DNA-based nanoelectronics are all covered, too. This book is valuable for university students studying engineering and technology; biotech, nanotech, and medical device R & D managers, practitioners and investors; and IP analysts who would like to extend their background in advanced DNA technologies. It is nicely illustrated, which makes it very readable, and it conveys science and principles in a lively language to appeal to a broad audience, from professionals and academics to students and lay readers. Advance Praise for DNA Beyond Genes: "Most students of DNA, and lay readers as well, are interested in the absolutely essential role it plays in biology. However, the properties which make DNA the carrier of genetic information also make it an extraordinary material that can be used as the backbone for a wide variety of nanoengineering applications - these range from information storage and computation to molecular machines and devices to artfully designed logos and symbols. The perfect self-recognition of DNA sequences makes it an ideal building block to synthesize more and more elaborate constructions and imaginative scientists have probably only just scratched the surface of what can eventually be created. Here for the first time in this wonderful book Vadim Demidov explores the full range of the non-biological applications of DNA." Charles R. Cantor Professor Emeritus of Biomedical Engineering, Boston University Member of the USA National Academy of Sciences.
Contents:
Introduction: DNA basics (a primer on DNA)
Hiding and storing messages and data in DNA
DNA as a nanoscale building material
DNA machines and nanobots
DNA-based nanoelectronics
Concluding remarks.Digital Access Springer 2020 - DigitalSeok-Yong Choi, Hyunju Ro, Hankuil Yi.Summary: This book offers step-by-step instruction on DNA cloning, defined as moving genes around plasmids, mutating genes, or mining new genes. The aim is to provide those new to the field with reliable and up-to-date practical guidance while at the same time conveying the scope for creativity. After a brief synopsis of the history of cloning, the fundamentals and prerequisites are explained, covering, for example, software, vectors commonly used in the lab, appropriate choice of restriction endonucleases, the preparation of agarose gels, competent cells, and LB agar plates, and procedures to be followed upon receipt of new plasmids. The remainder of the book is devoted to the clear description of methods and individual steps in cloning. Guidance is provided on the cut and paste method, DNA sequencing, direct sequencing, primer design, PCR-based gene insertion and deletion, epitope tag insertion, the use of RACE technology, BAC recombineering, and much, much more. Sources of error and a variety of techniques that make life considerably easier when cloning are also examined in detail.
Contents:
Part I. What is cloning?
Chapter 1.1 Definition of cloning
Chapter 1.2 Discovering a new gene
Chapter 1.3 Cloning in the past
Chapter 1.4 Cloning in the present
Part II. A prerequisite for cloning
Chapter 2.1 Software useful for cloning design
Chapter 2.2 Vector, plasmid, construct and the Kozak consensus sequence
Chapter 2.3 Multiple cloning sites (MCS)
Chapter 2.4 Restriction endonucleases and star activity
Chapter 2.5 Agarose gel electrophoresis
Chapter 2.6 Pouring LB agar plates
Chapter 2.7 Competent cells
Chapter 2.8 The conversion of DNA mass into molar concentration
Chapter 2.9 Upon receiving new plasmids
Chapter 2.10 cDNA library
Part III. The first step in cloning
Chapter 3.1 Cut & paste
Chapter 3.2 DNA sequencing and direct sequencing
Chapter 3.3 PCR and nested PCR
Chapter 3.4 Fill-in (Full & Partial)
Chapter 3.5 Compatible cohesive ends
Chapter 3.6 Methylation
Chapter 3.7 Three-piece ligation
Chapter 3.8 Site-directed mutagenesis
Chapter 3.9 Structure of plant transformation vectors
Chapter 3.10 Transformation of R. radiobacter
Part IV. The next step of cloning
Chapter 4.1 How to insert a DNA fragment into a gene
Chapter 4.2 How to delete an internal region of a gene
Chapter 4.3 How to insert an epitope tag into a gene
Chapter 4.4 Translational fusion vs. transcriptional fusion
Part V. The last steps of cloning
Chapter 5.1 Method for cloning similar genes in different species
Chapter 5.2 RACE (rapid amplification of cDNA ends)
Chapter 5.3 BAC recombineering
Chapter 5.4 Old trick: partial digestion
Chapter 5.5 Modification of a vector
Chapter 5.6 When you notice a frame shift mutation upon cloning
Chapter 5.7 Reality of cloning: an extremely unlucky case
Part VI. Methods that make your cloning life easier
Chapter 6.1 TA cloning and production of a T-vector
Chapter 6.2 TOPO TA cloning
Chapter 6.3 Gateway cloning
Chapter 6.4 Golden Gate Assembly for a modular cloning
Chapter 6.5 In-Fusion Sequence and Ligation-Independent Cloning (In-Fusion SLIC)
Chapter 6.6 T4 DNA Polymerase Sequence-and Ligation-Independent Cloning (T4 DNA Pol SLIC)
Chapter 6.7 Non-template PCR cloning
Part VII. Advice to cloners
Chapter 7.1 When cloning is not going well
Chapter 7.2 Keep your cloning data organized
Appendix 1. Further readings
Appendix 2. Abbreviations
Appendix 3. Index. - Digitaledited by Svein Valla and Rahmi Lale.Contents:
1. BioBrick assembly standards and techniques and associated software tools / Gunvor Røkke, Eirin Korvald, Jarle Pahr, Ove Øyås and Rahmi Lale
2. Plasmid construction by SLIC or sequence and ligation- independent cloning / Ryan E. Hill and Julian J. Eaton-Rye
3. Quick and clean cloning / Frank Thieme and Sylvestre Marillonnet
4. Hierarchical ligation-independent assembly of PCR fragments / Jonathan L. Schmid-Burgk, Zhen Xie, and Yaakov Benenson
5. USER-derived cloning methods and their primer design / Bo Salomonsen, Uffe H. Mortensen, and Barbara A. Halkier
6. Application of the restriction-free (RF) cloning for multicomponents assembly / Yoav Peleg and Tamar Unger
7. A single-tube assembly of DNA using the transfer-PCR (TPCR) platform / Ariel Erijman, Julia M. Shifman, and Yoav Peleg
8. Circular polymerase extension cloning / Jiayuan Quan and Jingdong Tian
9. Golden gate cloning / Carola Engler and Sylvestre Marillonnet
10. Design and construction of multigenic constructs for plant biotechnology using the goldenbraid cloning strategy / Alejandro Sarrion-Perdigones, Jorge Palaci, Antonio Granell and Diego Orzaez
11. FX cloning : a simple and robust high-throughput cloning method for protein expression / Eric R. Geertsma
12. Minimum GC-rich sequences for overlap extension PCR and primer annealing / Mikiko Nakamura, Ayako Suzuki, Hisashi Hoshida and Rinji Akada
13. Simple cloning and DNA assembly in Escherichia coli by prolonged overlap extension PCR / Chun You and Y.-H. Percival Zhang
14. Combinatorial assembly of clone libraries using site-specific recombination / Vanessa E. Wall, Leslie A. Garvey, Jennifer L. Mehalko, Lauren V. Procter and Dominic Esposito
15. Application of In-Fusion [trademark] cloning for the parallel construction of E. coli expression vectors / Louise E. Bird, Heather Rada, John Flanagan, Jonathan M. Diprose, Robert J.C. Gilbert and Raymond J. Owens
16. Seamless ligation cloning extract (SLiCE) cloning method / Yongwei Zhang, Uwe Werling, and Winfried Edelmann
17. j5 DNA assembly design automation / Nathan J. Hillson
18. FastPCR software for PCR, in silico PCR, and oligonucleotide assembly and analysis / Ruslan Kalendar, David Lee, and Alan H. Schulman.Digital Access Springer 2014 - Digital/Printedited by Jac A. Nickoloff and Merl F. Hoekstra.Contents:
v. 1. DNA repair in prokaryotes and lower eukaryotes
v. 2. DNA repair in higher eukaryotes
v. 3. Advances from phage to humans.Digital AccessPrint Access - DigitalHirak Ranjan Dash, Pankaj Shrivastava, Braja Kishore Mohapatra, Surajit Das, editors.Summary: This book describes the basics and various applications of DNA fingerprinting, including in actual case studies. The book is divided in four modules; Module 1: Basics of DNA Fingerprinting, Module 2: Applications of DNA Fingerprinting, Module 3: DNA Fingerprinting: Case Studies, and Module 4: Future of DNA Fingerprinting. Each module consists of 4 to 5 chapters, written by reputed researchers, academics and forensic scientists from around the globe. The respective chapters cover e.g. related fields, the tools and techniques used, various genotyping kits, real-world case studies, ancient DNA and wild life forensics, molecular diagnosis of human diseases, legal aspects, microbial forensics and the economics of the DNA fingerprinting technique. The book offers a practical guide for professionals, graduate and post-graduate students in the fields of Forensic Science, Medicine, Genetics, Anthropology, Microbiology, and Zoology. It also serves as a useful reference resource, summarizing major technological advances in the field of DNA fingerprinting, the problems faced in this field of science and possible new solutions to these problems. Presently, DNA fingerprinting is utilized in solving the majority of criminal cases; as such, the book is also helpful for investigating agencies, as it includes representative case studies.
Contents:
Module 1_ Basics of DNA Fingerprinting: Chapter 1. DNA Fingerprinting technique: Discovery, Advancements and Milestones
Chapter 2. Genetic Basis of DNA Fingerprinting in Humans
Chapter 3. Comparative Account of the DNA Fingerprinting Techniques: RFLP, STR Typing and NGS
Module 2_ DNA Fingerprinting: Tools and Techniques:
Chapter 4. Techniques involved in DNA Fingerprinting: Isolation, Quantification, PCR, Genotyping and Analysis
Chapter 5. STR Typing and available Kits
Chapter 6. In-silico techniques for analysis of genetic variation among individuals
Chapter 7. Statistical tools and techniques in interpretation of DNA sequencing results
Chapter 8. DNA fingerprinting with homologous multilocus probes and search for DNA markers
Module 3_ Applications of Genetic Fingerprinting:
Chapter 9. Analysis of Ancient DNA
Chapter 10. Wild Life Forensics
Chapter 11. Molecular Diagnosis of Human Genetic Diseases: Application of Genetic Fingerprinting
Chapter 12. Precautions and Recommendations for DNA fingerprinting for forensic applications
Chapter 13. Legal aspects of DNA fingerprinting
Module 4_ DNA Fingerprinting: Case Studies: Chapter 14. Autosomal DNA Typing: Case Studies
Chapter 15. Y-chromosome testing and case studies
Chapter 16. Mitochondrial DNA typing with case studies
Chapter 17. X-chromosome Analysis and Case Studies
Chapter 18 SNP analysis and Case Studies. - Digital/PrintAlbert Jeltsch, Renata Z. Jurkowska, editors.Contents:
Mechanisms and biological roles of DNA methyltransferases and DNA methylation: from past achievements to future challenges / Renata Z. Jurkowska, Albert Jeltsch
DNA and RNA pyrimidine nucleobase alkylation at the carbon-5 position / Yuri Motorin, Salifu Seidu-Larry, Mark Helm
Bacterial DNA methylation and methylomes / Josep Casadesús
Domain structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA methyltransferases / Shoji Tajima, Isao Suetake, Kohei Takeshita, Atsushi Nakagawa, Hironobu Kimura
Enzymology of mammalian DNA methyltransferases / Renata Z. Jurkowska, Albert Jeltsch
Genetic studies on mammalian DNA methyltransferases / Jiameng Dan, Taiping Chen
The role of DNA methylation in cancer / Ranjani Lakshminarasimhan, Gangning Liang
Structure and mechanism of plant DNA methyltransferases / Jiamu Du
DNA methylation and gene regulation in honeybees: from genome-wide analyses to obligatory epialleles / Laura Wedd, Ryszard Maleszka
N6-methyladenine: a conserved and dynamic DNA mark / Zach Klapholz O'Brown, Eric Lieberman Greer
Pathways of DNA demethylation / Wendy Dean
Structure and function of TET enzymes / Xiaotong Yin, Yanhui Xu
Proteins that read DNA methylation / Takashi Shimbo, Paul A. Wade
DNA base flipping: a general mechanism for writing, reading, and erasing DNA modifications / Samuel Hong, Xiaodong Cheng
Current and emerging technologies for the analysis of the genome-wide and locus-specific DNA methylation patterns / J̲örg Tost
DNA methyltransferase inhibitors: development and applications / Marie Lopez, Ludovic Halby, Paola B. Arimondo
Rewriting DNA methylation signatures at will: the curable genome within reach? / Sabine Stolzenburg, Désirée Goubert, Marianne G. Rots
Engineering and directed evolution of DNA methyltransferases / Paola Laurino, Liat Rockah-Shmuel, Dan S. Tawfik
DNA labeling using DNA methyltransferases / MiglėTomkuvienė, Edita Kriukienė, Saulius Klimaašuskas. - Digitaledited by Timothy W. Bredy.Summary: Begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease.
Contents:
Preface
History and modern view on DNA modifications in the brain / B.F. Vanyushin and V.V. Ashapkin
Approaches to detecting DNA base modification in the brain / X. Li and W. Wei
Active DNA demethylation in neurodevelopment / Y. Kang, Z. Wang and P. Jin
TET and 5hmC in neurodevelopment and the adult brain / M. Fasolino, S.A. Welsh and Z. Zhou
Beyond mCG : DNA methylation in noncanonical sequence context / E.A. Mukamel and R. Lister
DNA modifications and memory / J.J. Day
Measuring CpG methylation by SMRT sequencing / Y. Suzuki, J. Korlach and S. Morishita
Epigenetic modifications of DNA and drug addiction / J. Feng and E.J. Nestler
What does the future hold for the study of nucleic acid modifications in the brain? / P.R. Marshall and T.W. Bredy.Digital Access ScienceDirect 2017 - Digitaledited by Benoit P. Leblanc and Sebastien Rodrigue.Contents:
Electrophoretic mobility shift assay using radiolabeled DNA probes
In vitro DNase i footprinting
Determining the architecture of a protein-DNA complex by combining FeBABE cleavage analyses, 3-D printed structures, and the ICM molsoft program
In cellulo DNA analysis: LMPCR footprinting
Southwestern blotting assay
Single-molecule approaches for the characterization of riboswitch folding mechanisms
Probing of nascent riboswitch transcripts
Functional studies of DNA-protein interactions using fret techniques
Precise identification of genome-wide transcription start sites in bacteria by 5'-rapid amplification of cDNA ends (5'-RACE)
Analysis of DNA supercoiling induced by DNA-protein interactions
Precise identification of DNA-binding proteins genomic location by exonuclease coupled chromatin immunoprecipitation (ChIP-exo)
The cruciform DNA mobility shift assay: A tool to study proteins that recognize bent DNA
Individual and sequential chromatin immunoprecipitation protocols
Chromatin endogenous cleavage (ChEC) as a method to quantify protein interaction with genomic DNA in saccharomyces cerevisiae
Selection and validation of spacer sequences for CRISPR-Cas9 genome editing and transcription regulation in bacteria
Detection of short-range DNA interactions in mammalian cells using high-resolution circular chromosome conformation capture coupled to deep sequencing
Global mapping of open chromatin regulatory elements by formaldehyde-assisted isolation of regulatory elements followed by sequencing (FAIRE-seq)
Aggregate and heatmap representations of genome-wide localization data using VAP, a versatile aggregate profiler
Circular dichroism for the analysis of protein-DNA interactions
Quantitative investigation of protein-nucleic acid interactions by biosensor surface plasmon resonance
Identification of nucleic acid high affinity binding sequences of proteins by SELEX.Digital Access Springer 2015 - Printedited by Errol C. Friedberg and Philip C. Hanawalt.
- DigitalChikako Nishigori, Kaoru Sugasawa, editors.Summary: This book focuses on the clinical aspects of DNA repair disorders. Nucleotide excision repair is an important pathway for humans, as it is involved in biologically fundamental functions. This work presents clinical features together with the pathogenesis of DNA repair disorders such as Xertoderma Pigmentosum (XP). Studies on animal models are included as well. Clinical feature characteristics of each clinical subtype of XP are depicted according to the genotype, giving accurate and detailed information about the clinical features in terms of gene alterations, change of protein structure, and dysfunction in some of the repair pathways. This book is unique in that it provides detailed information on clinical features from more than 100 patients with XP-A, which is characterized by very severe manifestation of skin photosensitivity and neurological dysfunction. It will give readers important knowledge for understanding the concept and molecular mechanisms of DNA repair disorders. It also describes how to treat and care for patients with XP based on vast experience in clinical practice. DNA Repair Disorders will be a useful resource not only for physicians and basic scientists who are interested in and/or take care of patients with DNA repair disorders, but also dermatologists, neurologists, and researchers in the field of radiation biology and photobiology.
Contents:
1. Molecular mechanisms of DNA damage recognition for global genomic nucleotide excision repair: a defense system against UV-induced skin cancer
2. Disorders with deficiency in TC-NER: molecular pathogenesis of Cockayne Syndrome and UV-sensitive syndrome
3. Neurological symptoms of xeroderma pigmentosum
4. Hearing impairment in xeroderma pigmentosum: animal models and human studies
5. Epidemiological study of xeroderma pigmentosum in Japan: genotype-phenotype relationship
6. Prenatal diagnosis of xeroderma pigmentosum
7. Neurological disorders and chanllenging intervention in xeroderma pigmentosum and Cockayne syndrome
8. Xeroderma pigmentosum in the UK
9. Cockayne syndrome: clinical aspects
10. Trichothiodystrophy
11. Rothmund-Thomson syndrome
12. Translesion DNA synthesis
13. Ataxia-telangiectasia and Nijmegen breakage syndrome
14. Management of xeroderma pigmentosum.Digital Access Springer 2018 - Digitaledited by Hisao Masai, Marco Foiani.Summary: This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells? strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.
Contents:
Preface
Biography
Chapter1. Historical Perspective of Eukaryotic DNA Replication
Chapter2. Regulation of replication origins
Chapter3. Molecular mechanism for chromatin regulation during MCM loading in mammalian cells
Chapter4. Initiation of DNA replication at the chromosomal origin of E. coli, oriC
Chapter5. Initiation of DNA replication in the archaea
Chapter6. Mechanism of lagging strand DNA replication in eukaryotes
Chapter7. Functions of multiple clamp and clamp-loader complexes in eukaryotic DNA replication
Chapter8. Termination of eukaryotic replication forks
Chapter9. Structure of the MCM2-7 double hexamer and its implications for the mechanistic functions of the Mcm2-7 complex
Chapter10. Architecture of The Saccharomyces cerevisiae Replisome
Chapter11. Replication domains: genome compartmentalization into functional replication units
Chapter12. Rif1-dependent regulation of genome replication in mammals
Chapter13. G-quadruplexes and DNA replication origins
Chapter14. Interaction of Rif1 protein with G-quadruplex in control of chromosome transactions
Chapter15. Chromatin replication and histone dynamics
Chapter16. The temporal regulation of S phase proteins during G1
Chapter17. Roles of SUMO in replication initiation, progression, and termination
Chapter18. The multiple roles of ubiquitylation in regulating challenged DNA replication
Chapter19. Regulation of mammalian DNA replication via the ubiquitin-proteasome system
Chapter20. Coordinating replication with transcription
Chapter21. Fragility extraordinaire: Unsolved mysteries of chromosome fragile sites
Chapter22. Cyclin E deregulation and genomic instability
Chapter23. Replication through repetitive DNA elements and their role in human diseases. - Digitaledited by Brandt F. Eichman.Contents:
Eukaryotic DNA replication with purified budding yeast proteins / Viktor Posse, Erik Johansson, and John F.X. Diffley
Monitoring the replication of structured DNA through heritable epigenetic change / Guillaume Guilbaud and Julian E. Sale
Visualizing replication fork encounters with DNA interstrand crosslinks / Ryan C. James, Marina A. Bellani, Jing Zhang, Jing Huang, Althaf Shaik, Durga Pokharel, Himabindu Gali, Julia Gichimu, Arun K. Thazhathveetil, and Michael M. Seidman
Single-molecule imaging of replication fork conflicts at genomic DNA G4 structures in human cells / Wei Ting C. Lee, Dipika Gupta, and Eli Rothenberg
Studying the DNA damage response in embryonic systems / Elena Lo Furno, Bénédicte Recolin, Siem van der Laan, Antoine Aze, and Domenico Maiorano
Analysis of repair of replication-born double-strand breaks by sister chromatid recombination in yeast / Belén Gómez-González, Pedro Ortega, and Andrés Aguilera
Determining the kinetics of break-induced replication (BIR) by the assay for monitoring BIR elongation rate (AMBER) / Liping Liu, Neal Sugawara, Anna Malkova, and James E. Haber
Genomic mapping of DNA-repair reaction intermediates in living cells with engineered DNA structure-trap proteins / Jingjing Liu, Qian Mei, Sadeieh Nimer, Devon M. Fitzgerald, and Susan M. Rosenberg
A mapping platform for mitotic crossover by single-cell multi-omics / Peter Chovanec and Yi Yin
Characterization of DNA-PK-bound end fragments using GLASS-ChIP / Rajashree A. Deshpande and Tanya T. Paull
Light activation and deactivation of Cas9 for DNA repair studies / Roger S. Zou and Taekjip Ha
A detection method for the capture of genomic signatures : From disease diagnosis to genome editing / Orléna Benamozig, Lou Baudrier, and Pierre Billon
A method to sequence genomic sites of mitotic DNA synthesis in mammalian cells / Jonathan Mailler, Laura Padayachy, and Thanos D. Halazonetis
Loop-seq : A high-throughput technique to measure the mesoscale mechanical properties of DNA / Aakash Basu
Characterization of the telomerase modulating activities of yeast DNA helicases / David G. Nickens and Matthew L. Bochman
Single-molecule studies of yeast Rad51 paralogs / Upasana Roy, Youngho Kwon, Patrick Sung, and Eric C. Greene
Synthesis and polymerase bypass studies of DNA-peptide and DNA-protein conjugates / Suresh S. Pujari and Natalia Tretyakova
An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2 / Davide Moiani, Todd M. Link, Chris A. Brosey, Panagiotis Katsonis, Oliver Lichtarge, Youngchang Kim, Andrzej Joachimiak, Zhijun Ma, In-Kwon Kim, Zamal Ahmed, Darin E. Jones, Susan E. Tsutakawa, and John A. Tainer.Digital Access ScienceDirect 2021 - Digitaledited by Jungsan Sohn.Contents:
Intercellular communication in the innate immune system through the cGAS-STING pathway / Ramya Nandakumar, Samuel Joseph Windross, and Søren R. Paludan
Analysis of human cGAS activity and structure / Wen Zhou, Aaron T. Whiteley, and Philip J. Kranzusch
Chemical synthesis, purification, and characterization of 3′-5′-linked canonical cyclic dinucleotides (CDNs) / Changhao Wang, Min Hao, Qianqian Qi, Yashao Chen, and Jörg S. Hartig
An SPR-based analysis of cGAS substrate KD and steady-state KM values / Erik C. Ralph and Justin Hall
A pyrophosphatase-coupled assay to monitor the NTase activity of cGAS / Richard Hooy and Jungsan Sohn
Tracking the polymerization of DNA sensors and inflammasomes using FRET / Zachary Mazanek and Jungsan Sohn
Monitoring gasdermin pore formation in vitro / Shiyu Xia, Jianbin Ruan, and Hao Wu
Measuring TREX1 and TREX2 exonuclease activities / Wayne O. Hemphill and Fred W. Perrino
Kinetics of DNA-protein association and dissociation by stopped-flow spectroscopy / Johannes Rudolph and Karolin Luger
Characterization of DNA bound cyclic GMP-AMP synthase using atomic force microscopy imaging / Alexander Lushnikov, Richard Hooy, Jungsan Sohn, and Alexey Krasnoslobodtsev
Preparation of filamentous proteins for electron microscopy visualization and reconstruction / Mariusz Matyszewski and Jungsan Sohn
Cryo-EM studies of NAIP-NLRC4 inflammasomes / Nicole Haloupek, Patricia Grob, Jeannette Tenthorey, Russell E. Vance, and Eva Nogales
An integrative protocol for the structure determination of the mouse ASC-PYD filament / Adam Mazur, Petr Broz, and Sebastian Hiller
Protein interactions of the inflammasome adapter ASC by solution NMR / Pedro Diaz-Parga and Eva de Alba
Tracking DNA sensor and inflammasome complexes in cells using confocal microscopy / Brendan Antiochos
Assessment of inflammasome and type I IFN responses to DNA viruses and DNA PAMPS / Guido Massaccesi and Michael A. Chattergoon
Biochemical and microscopic analysis of inflammasome complex formation / Patrycja Swacha, Nelson O. Gekara, and Saskia F. Erttmann
Comet and micronucleus assays for analyzing DNA damage and genome integrity / Hui Jiang, Swarupa Panda, and Nelson O. Gekara
Workflows and considerations for investigating protein interactions of viral DNA sensors / Timothy R. Howard, Bokai Song, and Ileana M. Cristea
TUBE and UbiCRest assays for elucidating polyubiquitin modifications in protein complexes / Swarupa Panda, Hui Jiang, and Nelson O. Gekara.Digital Access ScienceDirect 2019 - DigitalHiromi Nishida, Taku Oshima, editors.Summary: This book comprehensively discusses our current understanding of the role and biological mechanisms of horizontal transfer of genetic elements in the environment, which has been important in the evolution of prokaryotes (archaea and bacteria). Horizontal transfer of genetic elements generates variations of prokaryotes and their genomes. Comparative studies of genomes revealed that it frequently occurred during archaeal and bacterial evolution. The book introduces a variety of studies related to horizontal gene transfer, gene silencing, plasmids, phages, transposons, and the emergence of microbes that degrade man-made xenobiotics and have antimicrobial resistance. Written by leading researchers in DNA traffic, the book is a valuable guide to horizontal transfer for both young scientists and experts in the field. -- Provided by publisher.
Contents:
Functions of Archaeal Nucleoid Proteins: Archaeal Silencers are Still Missing / Maruyama, Hugo (et al.)
Acquired and Innate Immunity in Prokaryotes Define Their Evolutionary Story / Ito, Toshihiro (et al.)
RNA-Mediated Crosstalk Between Bacterial Core Genome and Foreign Genetic Elements / Miyakoshi, Masatoshi
Bacteria-Virus Interactions / Yoshida, Takashi (et al.)
Plasmids and Their Hosts / Shintani, Masaki (et al.)
Overlooked Broad-Host-Range Vector Particles in the Environment / Chiura, Hiroshi X.
Bacterial Transposable Elements and IS-Excision Enhancer (IEE) / Kusumoto, Masahiro (et al.)
Mobile Genetic Elements Involved in the Evolution of Bacteria that Degrade Recalcitrant Xenobiotic Compounds / Nagata, Yuji (et al.)
DNA Traffic in the Environment and Antimicrobial Resistance / Hooton, Steven P. (et al.) - Digitaledited by Monica Rinaldi, Daniela Fioretti, Sandra Iurescia.Contents:
Blueprint for DNA vaccine design / Sandra Iurescia, Daniela Fioretti, and Monica Rinaldi
Enhancement of plasmid-mediated transgene expression / Daniela Fioretti, Sandra Iurescia, and Monica Rinaldi
Strategies for improving DNA vaccine performance/ Sandra Iurescia, Daniela Fioretti, and Monica Rinaldi
Enhancement of DNA vaccine efficacy by intracellular targeting strategies / Elisabete Borges Freitas ... [et al.]
Progresses in DNA-based heterologous prime-boost immunization strategies / Ronald J. Jackson, David B. Boyle, and Charani Ranasinghe
Development of antibiotic-free selection system for safer DNA vaccination / Jeremy M. Luke, Aaron E. Carnes, and James A. Williams
Electroporation-based DNA delivery technology : methods for gene electrotransfer to skin / Anita Gothelf and Julie Gehl
DNA vaccination in skin enhanced by electroporation / Kate E. Broderick, Amir S. Khan, and Niranjan Y. Sardesai
Intradermal vaccination by DNA tattooing / Joost H. van den Berg ... [et al.]
Microneedle applications for DNA vaccine delivery to the skin / Hae-yong Seok ... [et al.]
Multivalent DNA-based vectors for DNA vaccine delivery / Young Hoon Roh ... [et al.]
Superparamagnetic nanoparticle delivery of DNA vaccine / Fatin Nawwab Al-Deen ... [et al.]
Plasmid fermentation process for DNA immunization applications / Aaron E. Carnes and James A. Williams
Pharmaceutical grade large-scale plasmid DNA manufacturing process / Marco Schmeer and Martin Schleef
Protective and therapeutic DNA vaccination against allergic diseases / Almedina Isakovic ... [et al.]
Immunotherapy for Alzheimer's disease : DNA- and protein-based epitope vaccines / Hayk Davtyan, Irina Petrushina, and Anahit Ghochikyan
Tetravalent DNA vaccine product as a vaccine candidate against Dengue / Kevin R. Porter, Nimfa Teneza-Mora, and Kanakatte Raviprakash
DNA vaccination as a treatment for chronic kidney disease / Yuan Min Wang and Stephen I. Alexander.Digital Access Springer 2014 - DigitalKatherine Moran, Rosanne Burson, Dianne Conrad.Summary: "The Doctor of Nursing Practice Project: A Framework for Success, Third Edition provides the foundation for the scholarly process enabling DNP students to work through their project in a more effective, efficient manner. The Third Edition is intended for practical application and remains focused on the scholarly project. In addition, it specifically outlines how the project has been used to prepare clinical scholars for practice, a focus seen nationally. A new chapter on health policy highlights the DNP core competencies that are used to advocate for healthcare policy change. This chapter covers how policy impacts practice, how the DNP nurse is the leader of the profession, their role as it relates to advocacy, the connection of the DNP project and health policy and concludes with an action plan. Coverage of the scholarly project tools and exemplars which highlight the variety of work by DNP nurses are also found throughout the text. Key Features Updated historical perspectives Overview of project variability Coverage of project sustainability and measures of impact New chapter on health policy Navigate 2 Essentials Package which will feature digital versions of the project tools"--Provided by publisher.
Contents:
Machine generated contents note: Section I The Doctor of Nursing Practice Degree Chapter 1 Setting the Stage for the doctor of Nursing Practice Project Chapter 2 Defining the Doctor of Nursing Practice: Current Trends Chapter 3 Scholarship in Practice Chapter 4 Health Care Policy and Advocacy Section II The DNP Project Chapter 5 The Phenomenon of Interest Chapter 6 Developing the DNP Project Chapter 7 Aligning Design, Method, and Evaluation with the Clinical Question Chapter 8 Interprofessional and Intraprofessional Collaboration in the DNP Project Chapter 9 The DNP Project Team Chapter 10 Creating and Developing the Project Plan Chapter 11 Driving the Practicum to Impact the DNP Project Chapter 12 The Proposal Chapter 13 The DNP Project Toolbox Chapter 14 Project Implementation Section III Doctor of Nursing Practice Outcomes Chapter 15 Disseminating the Results Chapter 16 The Rest of the Story
Evaluating the Doctor of Nursing Practice.Digital Access R2Library 2020Limited to 1 simultaneous user - Digital[edited by] Katherine J Moran, Rosanne Burson, Dianne Conrad.Summary: "The Doctor of Nursing Practice Project : A Framework for Success, Fourth Edition guides students and faculty in the DNP project process. With a primary focus on delivering key information on planning, implementing, and evaluating a project, the text also emphasizes the impact that DNP-prepared nurses and well-developed DNP projects have in shaping the future of nursing"-- Provided by publisher.
Contents:
Setting the Stage for the Doctor of Nursing Practice Project
Defining the Doctor of Nursing Practice : Historical and Current Trends
Scholarship in Practice
Population Health and Health Care Policy
The Phenomenon of Interest : Leading to Problem Identification
Validating the Problem and Conceptualizing the Project Plan
Aligning Design, Method, and Evaluation with the Clinical Question
The DNP Project Team : Preparing for Project Implementation
The Proposal
Leading Implementation Through Collaboration
Driving the Practicum to Attain Competency and Leverage Impact through the DNP Project
Evaluating the Doctor of Nursing Practice Project From Data to Knowledge : Disseminating the Results
The Value and Impact of Practice Doctorate Scholarship.Digital Access R2Library 2024Limited to 1 simultaneous user - DigitalJanice P. Nimura.Summary: Elizabeth Blackwell believed from an early age that she was destined for a mission beyond the scope of "ordinary" womanhood. Though the world at first recoiled at the notion of a woman studying medicine, her intelligence and intensity ultimately won her the acceptance of the male medical establishment. In 1849, she became the first woman in America to receive an M.D. She was soon joined in her iconic achievement by her younger sister, Emily, who was actually the more brilliant physician. Exploring the sisters' allies, enemies, and enduring partnership, Janice P. Nimura presents a story of trial and triumph. Together, the Blackwells founded the New York Infirmary for Indigent Women and Children, the first hospital staffed entirely by women. Both sisters were tenacious and visionary, but their convictions did not always align with the emergence of women's rights - or with each other. From Bristol, Paris, and Edinburgh to the rising cities of antebellum America, this richly researched new biography celebrates two complicated pioneers who exploded the limits of possibility for women medicine. As Elizabeth herself predicted, "a hundred years hence, women will not be what they are now"--From dust jacket.
Contents:
Prologue
Bristol
New York
Cincinnati
Betweenity
Admission
Blockley almshouse
Diploma
Paris
Setback
London
Practice
Admission, again
Edinburgh
New faces
Infirmary
Recognition
War
College
Divergence
Coda.Digital Access 2021Limited to 1 simultaneous userSUNet ID login required - PrintGreta Jones.Summary: "This is the first full-length study of doctor migration from Ireland covering roughly a century of the export of Irish medical graduates to other parts of the world. From 1860 around forty percent of Ireland's medical graduates left to pursue careers elsewhere. The book examines the factors which drove emigration, the shifting destinations of the emigrants and the effect of migration both upon them and the Ireland they left behind. This was the migration of a part of the Irish middle class, small in terms of Irish emigration as a whole, but important in the global history of medical migration. At the end of the twentieth century doctor migration as a whole has increased and become a significant part of the medical experience. The book is a contribution to the growing literature on the global history of doctor movements across the world"-- Provided by publisher.
- Printedited by David K.C. Cooper.Summary: The medical profession is rich in those who have made names for themselves outside of medicine. The fields of literature, exploration, business, sport, entertainment, and beyond abound with doctors whose interests lie outside medicine. This book, largely written by members of the medical profession, examines the efforts of doctors in non-medical fields. The doctors discussed here are those who are, or were, well-known to the public for their contributions to their non-medical fields of choice. In many cases, the public may have been unaware that a subject was medically qualified. This book provides wide-ranging and comprehensive biographical sketches of forty-two doctors who are best known to the public for their contributions to fields outside of medicine.--Back cover.
- PrintContents:
v. 1. Chemical substances A-D
v. 2. Chemical substances E-O
v. 3. Chemical substances P-Z
v. 4. Biological exposure indices
v. 5. Physical agents.Print - DigitalChristina Strube, Heinz Mehlhorn, editors.Summary: This book presents the latest information on canine parasites with zoonotic potential, to help avoid human infections. Compiled by international specialists, it covers protozoa, ectoparasites and helminth species of clinical importance in dogs, as well as the state of the art in diagnosis, preventive measures and potentially necessary treatment schemes. Dogs are commonly kept in families around the world and can predispose their human companions to disease. Updating and deepening insights from other specialist literature, the book is intended for practitioners and scientists alike. It also offers practical guidance for veterinary and human physicians and highlights unexplored research areas, making it a valuable resource for students and educated non-experts with an interest in parasitology, infectiology and zoonotic pet diseases.
Contents:
Chapter 1: Introduction
Chapter 2: The zoonotic dog roundworm Toxocaracanis, a worldwide burden of public health
Chapter 3: Canine leishmaniasis
Chapter 4: The Challenges with Canine Giardia
Chapter 5: Dogs and their role in the eco-epidemiology of Chagas disease
Chapter 6: Echinococcus species - tiny tapeworms
Chapter 7: An update on the status of hydatidosis/echinococcosis in domestic animals, wildlife and humans in Australia
Chapter 8: Dipylidiumcaninum
Chapter 9: Ancylostoma caninum and other canine hookworms
Chapter 10: Strongyloidiasis
really a zoonosis?
Chapter 11: Dirofilaria spp. Do they get under your skin (or into your heart)?
Chapter 12: Guinea worm infection in dogs: a case of reverse zoonosis that impedes Dracunculusmedinensiseradication
Chapter 13: Ticks, dogs and humans - an endangered community
Chapter 14: Trematodes attacking dogs and humans. - PrintMathias Harrer [and three others].Summary: "This book serves as an accessible introduction into how meta-analyses can be conducted in R. Essential steps for meta-analysis are covered, including pooling of outcome measures, forest plots, heterogeneity diagnostics, subgroup analyses, meta-regression, methods to control for publication bias, risk of bias assessments and plotting tools. Advanced, but highly relevant topics such as network meta-analysis, multi-/three-level meta-analyses, Bayesian meta-analysis approaches, SEM meta-analysis are also covered. A companion R package, dmetar, is introduced in the beginning of the guide. It contains data sets and several helper functions for the meta and metafor package used in the guide"-- Provided by publisher.
Contents: <br/
>1. Introduction.
2. Discovering R.
3. Effect Sizes.
4. Pooling Effect Sizes.
5. Between-Study Heterogeneity.
6. Forest Plots.
7. Subgroup Analyses.
8. Meta-Regression.
9. Publication Bias.
10. "Multilevel" Meta-Analysis.
11. Structural Equation Modeling Meta-Analysis.
12. Network Meta-Analysis.
13. Bayesian Meta-Analysis.
14. Power Analysis.
15. Risk of Bias Plots.
16. Reporting & Reproducibility.
17. Effect Size Calculation & Conversion. - PrintPhilip C. Hébert.Summary: "The third edition of Doing Right: A Practical Guide to Ethics for Medical Trainees and Physicians is a practical guide to analyzing and resolving the ethical dilemmas medical practitioners face on a day-to-day basis. Drawing extensively on real-life scenarios, this book takes a case-based approach to provide students and practitioners with the advice and skills they need to help their patients and overcome ethical challenges in the field. Fully revised to include up-to-date coverage of such important topics as patient-practitioner relationships in the digital age and advances in reproductive medicine and reproductive technologies, this third edition of Doing Right will provide readers with the most up-to-date guidebook to medical ethics available."--Publisher's website.
Contents:
Ethics matters : doing ethically sound medicine
The almost revolution : autonomy and patient-based care
No man an island : confidentiality and trust
The power to heal : truth and deception in clinical practice
The power to choose : due care and informed consent
The waning and waxing self : capacity and incapacity in medical care
Helping and not harming : beneficence and non-maleficence
Conduct becoming : medical professionalism and managing error
Beyond the patient : doing justice to justice
Labour pains : ethics and new life
A dark wood : end-of-life decisions
Questions of culture, genetics, and science. - DigitalMeerambika Mahapatro.Summary: This book discusses health care issues related to domestic violence, using extensive case studies from India. By discussing the global literature, legal systems, methodological challenges of gathering information on domestic violence, and health systems issues, along with learnings from case studies, it fills a significant gap in the literature between health care policy and practice vis-à-vis victims of domestic violence. It therefore enables a systemic and systematic response to incidents of domestic violence. Policy instructions, court verdicts, government interventions, community-based direct interventions and related case discussions in the book help in the understanding and management of cases. Though the book uses case studies from India, it addresses globally relevant issues for health care professionals. In view of the paucity of application of systematic evidence-based knowledge, the holistic perspective presented in the book is important to prevent domestic violence, protect women's rights, and promote healthcare and wellbeing of women and children facing domestic violence. Medical professionals are expected to intervene in instances of injuries related to domestic violence--a responsibility that they are currently unable to fulfill due to lack of training in recognizing abuse and lack of tools for intervention. This book improves hands-on-knowledge by providing information on where to refer victims for assistance and timely intervention. Comprehensive yet lucid, this book is useful for academics, policy makers, non-government organizations and women's rights groups in helping victims during and after a violent episode and also in improving reporting and referral services.Digital Access Springer 2018
- PrintParveen Ali, Julie McGarry, editors.Summary: This book is taking a broad health focused approach towards Domestic Violence and Abuse (DVA). It is now well established that DVA exerts a significant and detrimental impact on the health and wellbeing of those who experience abuse. Universally healthcare professionals encounter individuals and families where DVA is or has taken place. This book is beneficial to a range of health care professionals through an exploration of theories and classifications of DVA, consideration of DVA in different contexts and consideration of the core issues surrounding working with individuals and families where DVAhas been identified. It provides a much needed evidence based addition to the existing texts in this field in terms of the inclusion of real life scenarios, reflective exercises and pointers for further practice development. This book is a key point of reference for professionals working within a broad range of health care environments.
Contents:
Foreword
About the authors
Acknowledgments
1. DVA/IPV understanding and setting the context for the book (set out the DVA occurs everywhere in healthcare settings)
2. Why is DVA/IPV a health issue? ? global and UK policy context
3. The impact of DVA/IPV on health ? explore long/short term physical and mental health. The concept of health as multi-faceted
4. Clinical settings where DVA/IPV may be encountered
5. The response of healthcare professionals to DVA/IPV ? barriers and opportunities to effective identification and management (perhaps include the screening debate)
6. DVA and hard to reach groups
7. DVA and children
8. DVA and older populations
9. Working with other agencies
10. Reflection and future learning . - Printedited by Kristopher P. Croome, Paolo Muiesan, C. Burcin Taner.Summary: This book presents the first comprehensive review of all facets of liver transplantation using DCD donors. Each of the 19 chapters are written by leading experts in the field, representing some of the most experienced DCD liver transplant programs in the world. Several topics have overlapping coverage in different chapters, providing the reader with the perspective of multiple experts on crucial topics. Chapters also highlight the steps towards building a DCD liver transplant program, the importance of donor and recipient selection, as well as state-of-the-art developments and future directions in the utilization of these organs. Donation after Circulatory Death (DCD) Liver Transplantation serves as a valuable resource for all those involved in liver transplantation using DCD donors.
Contents:
The History of DCD Liver Transplant
Ethics and Law of DCD Transplant
Donor Procurement Operation in Donation after Circulatory Death Donors
Predicting the likelihood a DCD donor will expire
Warm Ischemia time
Ischemia Reperfusion Injury and therapeutic strategy in Donation after Circulatory Death (DCD) liver transplantation
Donor Selection in DCD liver transplantation
Thrombolytic Therapy in Liver Transplantation Using Grafts from Donation After Circulatory Death Donors
Recipient Selection in DCD-Liver Transplantation
Outcomes in DCD liver transplantation
Non-biliary Complications Associated with liver grafts from Donation After circulatory Death donors
Ischemic Cholangiopathy
Hypothermic machine perfusion in liver transplantation using grafts from donation after circulatory death donors
Normothermic Regional Perfusion
Ex Vivo Normothermic Machine Perfusion
Liver Transplantation From Uncontrolled DCD Donors
Developing a DCD Liver Transplant Program
Anesthesia for DCD Liver Transplantation
DCD Liver Transplant: The OPO Perspective.Digital Access Springer 2020 - Digitaledited by Marco Diana, Gaetano Di Chiara and Pier Franco Spano.Summary: Progress in Brain Research is a well-established international series examining major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume, concentrates on state-of-the-art of dopamine research: from basic science to clinical applications. It covers topics including thalamostriatal synapses as a substrate for dopamine action; the multilingual nature of dopamine neurons; ethanol-mechanisms along the mesolimbic dopamine system, and much more. Progress in Brain Research is the most acclaimed and accomplished series in neuroscience, firmly established as an extensive documentation of the advances in contemporary brain research. The volumes, some of which are derived from important international symposia, contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry, and the behavioral sciences.The most acclaimed and accomplished series in neuroscienceThis volume looks at dopamine researchin the light of the newest scholarly discoveries and insights.Digital Access ScienceDirect 2014
- DigitalJin-Xia Zhu, editor.Summary: Dopamine is widely present in the central and peripheral nervous systems, as well as in non-nervous systems. Parkinson's disease is well recognized as a dopaminergic neurodegenerative disorder, and affected patients often show early signs of gastrointestinal disorders at initial stages of the disease. Apart from the changes that occur in emotion, movement behaviors, learning and memory, metabolism etc., dopamine has also been demonstrated to play very crucial roles in the functional regulation of peripheral organs such as the heart, blood vessels, kidneys, and gut. Most recently, dopamine function in the gut has received enormous attention. Not only does dopamine regulate gut motility, ion transport, and mucosal barrier, but it is becoming more pertinent that more than 60% of dopamine in the body stems from the gut, which has not yet been properly addressed and substantially explored. Therefore, this book will discuss the brain-gut axis by providing novel and significant insight into the essence of gut-derived dopamine in mammals. It aims to inspire further research on dopaminergic regulation of gut function and disease genesis.
Contents:
1 Introduction
2 Synthesis and Metabolism of Gut Dopamine
3 Dopamine Receptors in the Gastrointestinal Tract
4 Dopamine and Gastrointestinal Mucosa Function
5 Dopamine and Gastrointestinal Mobility
6 Dopamine in the Pancreas. - PrintAnna Lembke, M.D.Summary: We are living in a time of unprecedented access to high-reward, high-dopamine stimuli: drugs, food, news, gambling, shopping, gaming, texting, sexting. The smartphone is the modern-day hypodermic needle, delivering digital dopamine 24/7 for a wired generation. Lembke explores new scientific discoveries that explain why the relentless pursuit of pleasure leads to pain-- and what to do about it. She illustrates how finding contentment and connectedness means keeping dopamine in check. The secret to finding balance is combining the science of desire with the wisdom of recovery. -- adapted from jacket
Contents:
Introduction: The problem
The pursuit of pleasure. Our masturbation machines ; Running from pain ; The pleasure-pain balance
Self-binding. Dopamine fasting ; Science, time, and meaning ; A broken balance?
The pursuit of pain. Pressing on the pain side ; Radical honesty ; Prosocial shame
Conclusion: Lessons of the balance. - Digitaledited by Mario Tiberi.Contents:
Genetic and epigenetic methods for analysis of the dopamine D2 receptor gene / Laura M. Fiori , Mireille Daigle , and Paul R. Albert
Characterization of D1 dopamine receptor posttranscriptional regulation / Eldo V. Kuzhikandathil
Computational approaches in the structure-function studies of dopamine receptors / Mayako Michino and Lei Shi
Cell-free protein synthesis and purification of the dopamine D2 receptor / Dipannita Basu ... [et al.]
Wnt ligand binding to and regulation of dopamine D2 receptors / Sehyoun Yoon , Mi-Hyun Choi , and Ja-Hyun Baik
Regulation of pre- and postsynaptic protein phosphorylation by dopamine D2 receptors / Alessandra Bonito-Oliva, Giada Spigolon, and Gilberto Fisone
Study of dopamine D1 receptor regulation by G protein-coupled receptor kinases using whole-cell phosphorylation and cross-linking methods / Keyvan Sedaghat ... [et al.]
Ubiquitination of dopamine receptor studied by sequential double immunoprecipitation / Kamila Skieterska, Pieter Rondou, and Kathleen Van Craenenbroeck
Dopamine receptors in the subthalamic nucleus : identification and localization of D5 receptors / Lionel Froux ... [et al.]
MALDI mass spectrometry imaging of dopamine and PET D1 and D2 receptor ligands in rodent brain tissues / Richard J. A. Goodwin, Mohammadreza Shariatgorji, and Per E. Andren
Positron emission tomography imaging of dopaminergic receptors in rats / Boguslaw Szczupak and Abraham Martín
Transactivation of receptor tyrosine kinases by dopamine receptors / Jeff S. Kruk ... [et al.]
Dopamine receptors in human embryonic stem cell differentiation / Glenn S. Belinsky ... [et al.]
Calcium and phospholipase Cβ signaling through dopamine receptors / Lani S. Chun, R. Benjamin Free, and David R. Sibley
Intracellular trafficking assays for dopamine D2-like receptors / Chengchun Min, Mei Zheng, and Kyeong-Man Kim
Study of crosstalk between dopamine receptors and ion channels / Ping Su, Albert H. C. Wong, and Fang Liu
Study of dopamine receptor and dopamine transporter networks in mice / Victor Gorgievski, Eleni T. Tzavara, and Bruno Giros
Optogenetic regulation of dopamine receptor-expressing neurons / T. Chase Francis and Mary Kay Lobo
Characterization of D3 dopamine receptor agonist-dependent tolerance property / Samantha R. Cote and Eldo V. Kuzhikandathil
Dopamine D1 and D2 receptors in chronic mild stress : analysis of dynamic receptor changes in an animal model of depression using in situ hybridization and autoradiography / Dariusz Zurawek ... [et al.].Digital Access Springer 2015 - DigitalMichael Hofbeck, Karl-Heinz Deeg, Thomas Rupprecht.Contents:
1. The normal examination
2. Atrial septal defects
3. Ventricular septal defect
4. Atrioventricular septal defect
5. Patent ductus arteriosus
6. Aortopulmonary window
7. Pulmonary stenosis
8. Pulmonary atresia with intact ventricular septum (PAiVS)
9. Tricuspid atresia
10. Ebsteins anomaly
11. Tetralogy of Fallot
12. Pulmonary atresia and ventricular septal defect
13. Truncus arteriosus
14. Double outlet right ventricle
15. Transposition of the great arteries
16. Functionally univentricular heart
17. Anomalous pulmonary venous connections
18. Anomalies of left ventricular inflow and mitral valve
19. Aortic stenosis, regurgitation and anomalies of the left ventricular outflow tract
20. Hypoplastic left heart syndrome
21. Coarctation of the aorta
22. Interruption of the aortic arch
23. Vascular rings and anomalies of the aortic arch vessels
24. Echocardiographic differential diagnosis of cyanotic infants
25. Echocardiography for the neonatologist.Digital Access Springer 2017 - DigitalKarl-Heinz Deeg, Thomas Rupprecht, Michael Hofbeck ; with contributions by Doris Franke, Michael Riccabona, Heiko Dudwiesus.Summary: This book covers the full range of current applications of Doppler sonography in infancy and childhood, describing the variety of potential findings with the aid of a wealth of images. After an introductory chapter on the physical and technical basis of Doppler sonography, applications of cerebral Doppler sonography in infancy and of transcranial Doppler sonography in childhood are addressed, with numerous examples of imaging appearances. The major part of the book is devoted to Doppler sonography of the brain, face and neck and of the abdomen, covering normal abdominal vessels, liver, spleen, pancreas, and mesenteric and renal circulation. Imaging of the ovaries and testes is also presented, encompassing the differential diagnosis of acute scrotum and other space-occupying lesions of the testis. The book closes by considering Doppler sonography of soft tissue and vascular malformations, and the influence of congenital heart malformations on flow parameters in peripheral arteries. Doppler Sonography in Infancy and Childhood will be an invaluable reference for pediatricians, neonatologists, pediatric sonographers, and pediatric and general radiologists.
Contents:
Physical and technicalbasics of Doppler sonography
Cerebral Doppler sonography in infancy
Transcranial cerebral Doppler sonography in childhood
Dopplersonography of the thyroid and of the soft tissue of face and neck
Doppler sonography of normal abdominal vessels
Doppler sonography of the liver
Doppler sonography of the spleen
Doppler sonography of the pancreas
Doppler sonography of the mesenteric circulation and bowel
Renal Doppler sonography
Dopplersonography of the adrenal gland
Doppler sonography of the testes
Doppler sonography of the ovaries
Doppler sonography of soft tissue and vascular malformations
Influence of congenital heart malformations on flow parameters in peripheral arteries. - DigitalBogdan Czerniak.Contents:
General considerations
Clinical considerations and imaging of bone tumors / Colleen M. Costelloe and John E. Madewell
Molecular biology of bone tumors
Benign osteoblastic tumors
Osteosarcoma
Benign cartilage lesions
Malignant cartilage tumors
Fibroosseous lesions
Fibrous and fibrohistiocytic lesions
Giant-cell lesions
Ewing's sarcoma and related entities
Hematopoietic tumors / April Ewton
Vascular lesions
Neurogenous tumors and neurofibromatosis affecting bone / Gregory N. Fuller
Cystic lesions
Miscellaneous mesenchymal tumors
Adamantinoma of long bone
Chordoma and related lesions
Metastic tumors in bone / John D. Reith
Synovial lesions
Sclerosing bone lesions
Tumor-induced osteomalacia and rickets
Reactive and metabolic conditions simulating neoplasms of bone
Precancerous conditions.Digital Access ClinicalKey 2016 - DigitalJablonski, Stanley.Digital Access
- PrintDorland, W. A. Newman.Print Access
- DigitalVictor R. Alekseev, Bernadette Pinel-Alloul, editors.Summary: This is the second volume on dormancy in aquatic organisms. The book is divided into three parts whereby the first part is devoted to several groups of aquatic organisms which are under-studied in terms of the dormancys role in the life cycle. The second part looks at the use of dormancy phenomena in science and potential human applications. Furthermore, part 3 comprises of examples of using modeling in relation to dormancy phenomenon and it opens with a theoretical analysis of studies of biological information, including seasonal information. This work can be used as a text book for students as well as a manual for science and practice purposes in ecology, aquaculture, nature protection and space researches with regards to creating ecological life supporting systems and discovering extraterrestrial life on other planets with harsh environmental conditions.
Contents:
PART I: Strategies and mechanisms of diapause in aquatic invertebrates
1. Professor Oscar Ravera: long life in science
2. Introduction to dormancy in aquatic invertebrates: mechanism of induction and termination, hormonal and molecular-genetic basis
3. Dormancy in freshwater tardigrades
4. Fish: diapause, dormancy, aestivation, and delay in gonad development
5. Cysts and resting eggs from marine zooplankton. Dimension of the phenomenon, physiology of rest, ecological and biogeographic implications
PART II: The role of diapause in science and human uses
6. Studying on dormancy in space conditions
7. Resistance of dormant eggs of cladocera to anthropogenic pollutants
8. Mechanisms facilitating dispersal of dormant eggs in a planktonic crustacean
9. Seasonal diphenism in daphnia from temperate environments: Organismal traits and molecular regulation
10. The role of chemical interactions in embryonic diapause induction in zooplankton
11. Aquatic invertebrate dormancy and medicine
PART III: Dormancy, biological information and modelling
12. Biological information and dormancy in aquatic population modeling
13. Biological information, dormancy and individual based modeling of daphnia population dynamics
14. The role of biotic and abiotic interactions in summer diapause in cyclopoids: Conceptual model and field validation in southern Quebec boreal lakes
15. The model of dynamics of population number of the plankton
16. Use of simulation to analyze parasite impacts on Volga delta Brachionus calyciflorus pallas rotifer dynamics: Abundance, reproduction and transition to diapause. - DigitalJohn Scott Baird.Summary: This book chronicles the life and accomplishments of Dorothy Hansine Andersen, a pioneering American pathologist and pediatrician who was the first person to define, diagnose, and treat cystic fibrosis. Divided into three parts, the book begins by detailing Anderson's early life, including being orphaned as an adolescent, her college career, and her laborious start in the medical field. Part II then examines Andersen's role in defining the new disease cystic fibrosis of the pancreas and her career of active engagement in various clinical pursuits and research, both in pathology and pediatrics. Chapters in this section also discuss the numerous attempts made by others to minimize Andersen's work through gender bias and the Matilda Effect. The book concludes by reviewing the foundations laid for CF, Andersen's legacy, and her terminal illness. Featuring an engaging narrative style, Dorothy Hansine Andersen is a historically relevant, invaluable text for anyone interested in the life of Dorothy Anderson and the nascence of cystic fibrosis diagnoses.
Contents:
Part I: Life before Babies Hospital
Chapter 1: A beginning
Chapter 2: Orphaned
Chapter 3: College and medical school
Chapter 4: False start
Chapter 5: A reboot
Part II: Babies Hospital during the McIntosh Era
Chapter 6: Historical perspectives
Chapter 7: Synergy
Chapter 8: Andy's abandoned farm
Chapter 9: Scoring the first goal
Chapter 10: CF firsts
Chapter 11: To Dr. Andersen who has pulled me through many a tough year
Chapter 12: McIntosh, pediatric pathology, and Columbia University.-Chapter 13: CF sweat and the Matilda Effect
Chapter 14: Glycogen storage diseases
Chapter 15: Celiac disease
Chapter 16: Randomized, controlled trials
Chapter 17: Babies Hospital siblings
Chapter 18: A last decade of CF research
Chapter 19: Pediatric heart diseases
Part III: Beyond Babies Hospital and the McIntosh Era
Chapter 20: Time to enjoy the view
Chapter 21: A foundation and a club for CF
Chapter 22: The end of an era
Chapter 23: Cancer. - Digitalclinical editor, Margaret Harvey, PhD, MSN, MAT, CNE, Chamberlain College of Nursing, Indianapolis Campus President.Summary: Calculate correct dosages with safety and confidence, with the easy-to-follow nursing expertise of Dosage Calculations Made Incredibly Easy! 5th edition. This fully illustrated guide offers the complete how-to on calculating dosages for all drug forms and administration routes, with numerous practice exercises and seasoned guidance on interpreting drug orders accurately. Understand class materials more fully, get ready for the NCLEX or certification exam, or refresh your calculation skills with this enjoyable text.
Contents:
Fractions / Carol Lee Cherry
Decimals and percentages / MaryAnn Edelman
Ratios, fractions, proportions, and solving for X / Carol Lee Cherry
Dimensional analysis / MaryAnn Edelman
Metric system / Lisa Benson
Alternative measurement systems / Lisa Benson
Drug orders / Donna Blair
Administration records / Donna Blair
Preventing drug errors / Nancy J. Cichra
Calculating oral drug dosages / Nancy J. Cichra
Calculating topical and rectal drug dosages / Jacqueline Sue Inman
Calculating parenteral injections / Jacqueline Sue Inman
Calculating IV infusions / DeLaina A. McCane
Calculating pediatric dosages / Sarah Wallace
Calculating obstetric drug dosages / Cheryl L. DeGraw
Calculating critical care dosages / DeLaina A. McCane.Digital Access Ovid 2016 - Digitaledited by Rakesh K. Tekade.Summary: Dosage Form Design Parameters, Volume II, examines the history and current state of the field within the pharmaceutical sciences, presenting key developments. Content includes drug development issues, the scale up of formulations, regulatory issues, intellectual property, solid state properties and polymorphism. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of dosage form design parameters. Chapters delve into a particular aspect of this fundamental field, covering principles, methodologies and the technologies employed by pharmaceutical scientists. In addition, the book contains a comprehensive examination suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnology and related industries.
Contents:
Front-matter
Copyright
Dedication
List of Contributors
About the Editor
Levels of Solid State Properties: Role of Different Levels During Pharmaceutical Product Development
Basics of Crystallization Process Applied in Drug Exploration
Role of Amorphous State in Drug Delivery
Particulate Level Properties and its Implications on Product Performance and Processing
Bulk Level Properties and its Role in Formulation Development and Processing
Concepts of Hypothesis Testing and Types of Errors
Experimental Design and Analysis of Variance
Basic Concept and Application of Sampling Procedures
Statistical Techniques in Pharmaceutical Product Development
Drug–Excipient Interaction and Incompatibilities
Documentation Protocol in Product Development Including Clinical Records
Correlation Between In Vitro and In Vivo Screens: Special Emphasis on High Throughput Screening and High Throughput Pharmacokinetic Analysis
Sterilization of Pharmaceuticals: Technology, Equipment, and Validation
Package Development of Pharmaceutical Products: Aspects of Packaging Materials Used for Pharmaceutical Products
Package Types for Different Dosage Forms
Food and Drug Laws Affecting Pharmaceutical Product Design, Development, and Commercial Manufacturing
Guiding Principles for Human and Animal Research During Pharmaceutical Product Development
Applications of Computers in Pharmaceutical Product Formulation
Patents and Other Intellectual Property Rights in Drug Delivery
Computer-Aided Prediction of Pharmacokinetic (ADMET) Properties
Ethics and Legal Protection of Uses of Computer Applications in Pharmaceutical Research
IndexDigital Access ScienceDirect 2018 - DigitalA-Yong Yu, editor.Summary: This book introduces the principle, main parameters, acquisition mode and operation procedure of Optical Quality Analysis System II (OQAS II) based on double-pass technology. OQAS II is increasingly used in the diagnosis and assessment of ocular diseases, especially for cataract. In this book, the clinical practice of OQAS II in the field of refractive cataract surgery is emphasized, including the preoperative/postoperative evaluation of visual quality, the timing of cataract surgery, the prediction of the visual quality after cataract surgery and doctor-patient communication. We hope the book provides a reference for the clinical application of the OQAS II in the field of cataract and helps to form the worldwide standard specification to a certain extent.
Contents:
Visual quality in the age of refractive cataract surgery
Analysis of objective visual quality based on Double-pass technology
Clinical significance of the main parameters of Double-pass Optical Quality Analysis System
Acquisition mode and operation procedure of Double-pass Optical Quality Analysis System
Clinical application of objective evaluation of tear film optical quality
Objective classification of cataract
Timing of cataract surgery
Prediction of the visual quality after cataract surgery
Doctor-patient Communication
Comparison of cataract treatment methods
Optimal treatment timing for posterior capsule opacification. . - DigitalHildegard Wittlinger, Dieter Wittlinger, Andreas Wittlinger, Maria Wittlinger.Contents:
Anatomy and physiology of the circulation of the blood
Anatomy of lymph vessels and lymph nodes
Physiology of the lymphatic system, lymph, and interstitium
Lymphedema
Equilibrium and balance as the aim of the massage
Indications and contraindications for manual lymph drainage
Effect of manual lymph drainage on the smooth muscles of blood vessels and lymphangions
Diagnostic examination and edema measurement
Massage techniques
Treatments of the individual parts of the body
Special techniques
Treatment model for secondary lymphedema
Complementary treatments
Historical background.Digital Access Thieme MedOne Education 2019 - PrintJohn F. Strauss.Summary: "This compelling biography traces the life and times of pediatrician Wilhelm Strauss from his childhood in Prague and his late Hapsburg monarchy medical education in Vienna, to his practice of social medicine in Wiener Neustadt during the Julius Tandler era. It continues with the painful disruptions of the 'Anschluss' and his forced exile in Baghdad, and concludes unexpectedly in New York State, USA. Reproduced in the book are valuable documents in Strauss' own words describing the state of pediatric medicine at the beginning of the First Austrian Republic"-- back cover.
- DigitalFiona Subotsky.Summary: Exploring how medicine and psychiatry are portrayed in gothic literature, this engaging book illustrates how Stoker's famous work was influenced by nineteenth-century attitudes to disease and medicine and reveals many previously unknown links. Extracts from many sensational stories of the time are presented, and the role of doctors and their appearance and contribution to gothic fiction is investigated. The book covers topics such as asylums, their purpose, practice and patients, deadly diseases echoing the symptoms of vampirism, and the otherworldly allure of the undead. Dracula for Doctors is an entertaining and informative examination of how Victorian medical knowledge and culture informed Stoker's gothic masterpiece. This book suggests that Stoker, who had many medical connections, was able to link lurid stories of operations and asylums with fictional horror and suspense. Fans of gothic literature, as well as those of medical history and the supernatural, will find this an enjoyable read.
Contents:
Body and mind
Medico-gothic
Stoker medical circles
Asylum doctors
The gothic asylum
Renfield, the pet lunatic
The other patients
Diagnosing Dracula
Dread, disease and the asylum
Occult blood
Holes in the skull
Dead, alive or undead
Therapeutic armamentarium
Compelling eyes
Beastliness
Vivisection or animal torture?
Demons and doctors
Scientists and the supernatural
And Dracula for dentists
Sex and death.Digital Access Cambridge 2019 - DigitalKenneth J. Tennessen.Summary: "This monograph is the first of its kind devoted entirely to the dragonfly nymphs of North America north of Mexico, the focus being accurate identification of the 330 species of Anisoptera that occur in the region. Nymphal external morphology is described and illustrated in detail, and all terms needed to navigate the dichotomous keys are defined. Species are tabulated with references that provide the most detailed, accurate descriptions for each; species that are inadequately described are so indicated. The key separating the seven families in the region contains several new characters. The families are then covered separately: Aeshnidae (13 genera), Gomphidae (17 genera), Petaluridae (2 genera), Cordulegastridae (2 genera), Macromiidae (2 genera), Corduliidae (7 genera), and Libellulidae (29 genera). Each family is further characterized, followed by a generic key. A drawing of the habitus and diagnostic details for each genus are provided, along with additional diagnostic remarks and notes on habitat and life cycle; for each genus, a map shows its geographic distribution in North America. Full-grown nymphs of all known species of each genus are keyed and diagnosed; characters that apply to earlier instars are noted. Morphological variation in character states was analyzed in order to assess the reliability of previously utilized characters and to discover new characters. Most of the characters used to distinguish all levels of taxa are illustrated; a total of 702 figures, comprising 1,800 original drawings, along with selected photographs where necessary for clarity, accompany the keys. Measurements of total length, head width, and other variables for each species are provided in tables. Difficulties with past keys and descriptions, including errors, omissions and other shortcomings, are addressed. The importance of nymph characters in helping solve generic and specific distinctions and their role in phylogenetic studies is emphasized. Methods for collecting, rearing, and preserving dragonfly nymphs and exuviae are presented. The final chapter discusses research opportunities on North American Anisoptera nymphs, including taxonomic needs, studies on structure and function, life history and microhabitat, water quality indices and conservation efforts. The habitus drawings of all genera are arranged according to family in five plates (Appendix I); although the book is intended as a lab manual, these plates conveniently allow for comparison based on nymph shape making field identification to genus possible in many cases. Appendix II contains a brief history of dragonfly nymph studies in North America. A glossary and an index to scientific names are included."
Contents:
Intro; Dedication; Preface; References; Contents; Part I: Preliminary Material;
1: Introduction; References;
2: Nymph Anatomy and Instar Determination; 2.1 The Head; 2.2 The Thorax; 2.3 The Abdomen; 2.4 External Morphological Outgrowths; 2.4.1 Determining Gender; 2.5 Growth; 2.5.1 Determining Instar; References;
3: Using the Keys; 3.1 Specimen Preparation; References;
4: List of Species Treated; 4.1 Odonata Diversity in the Americas; 4.2 The Anisoptera Fauna of North America; 4.3 State and Province Abbreviations; 4.4 Species List with Nymph References; References 12.3 Cannaphila Kirby, 188912.4 Celithemis Hagen, 1861; 12.5 Crocothemis Brauer, 1868; 12.6 Dythemis Hagen, 1861; 12.7 Erythemis Hagen, 1861; 12.8 Erythrodiplax Brauer, 1868; 12.9 Idiataphe Cowley, 1934; 12.10 Ladona Needham, 1897; 12.11 Leucorrhinia Brittinger, 1850; 12.12 Libellula Linnaeus, 1758; 12.13 Macrodiplax Brauer, 1868; 12.14 Macrothemis Hagen, 1868; 12.15 Miathyria Kirby, 1889; 12.16 Micrathyria Kirby, 1889; 12.17 Nannothemis Brauer, 1868; 12.18 Orthemis Hagen, 1861; 12.19 Pachydiplax Brauer, 1868; 12.20 Paltothemis Karsch, 1890; 12.21 Pantala Hagen, 1861
7: Gomphidae7.1 Aphylla Selys, 1854; 7.2 Arigomphus Needham, 1897; 7.3 Dromogomphus Selys, 1854; 7.4 Erpetogomphus Selys, 1858; 7.5 Gomphurus Needham, 1901; 7.6 Hagenius Selys, 1854; 7.7 Hylogomphus Needham, Westfall and May, 2000; 7.8 Lanthus Needham, 1897; 7.9 Octogomphus Selys, 1873; 7.10 Ophiogomphus Selys, 1854; 7.11 Phanogomphus Carle, 1986; 7.12 Phyllocycla Calvert, 1948; 7.13 Phyllogomphoides Belle, 1970; 7.14 Progomphus Selys, 1854; 7.15 Stenogomphurus Carle, 1996; 7.16 Stylogomphus Fraser, 1897; 7.17 Stylurus Needham, 1897; References;
8: Petaluridae 8.1 Tachopteryx Uhler in Selys, 18598.2 Tanypteryx Kennedy, 1917; References;
9: Cordulegastridae; 9.1 Cordulegaster Leach, 1815; 9.2 Zoraena Kirby, 1890; References;
10: Macromiidae; 10.1 Didymops Rambur, 1842; 10.2 Macromia Rambur, 1842; References;
11: Corduliidae; 11.1 Cordulia Leach, 1815; 11.2 Dorocordulia Needham, 1901; 11.3 Epitheca Charpentier, 1840; 11.4 Helocordulia Needham, 1901; 11.5 Neurocordulia Selys, 1871; 11.6 Somatochlora Selys, 1871; 11.7 Williamsonia Davis, 1913; References;
12: Libellulidae; 12.1 Brachymesia Kirby, 1889; 12.2 Brechmorhoga Kirby, 1894 Part II: Systematic
s5: Key to the Families; 5.1 Key to Anisoptera Families of North America, F-0 to F-5; 5.1.1 Family Diagnoses; References;
6: Aeshnidae; 6.1 Aeshna Fabricius, 1775; 6.2 Anax Leach, 1815; 6.3 Hemianax Selys, 1883; 6.4 Basiaeschna Selys, 1883; 6.5 Boyeria McLachlan, 1896; 6.6 Coryphaeschna Williamson, 1903; 6.7 Epiaeschna Hagen, 1877; 6.8 Gomphaeschna Selys, 1871; 6.9 Gynacantha Rambur, 1842; 6.10 Nasiaeschna Selys, 1900; 6.11 Oplonaeschna Selys, 1883; 6.12 Remartinia Navás, 1911; 6.13 Rhionaeschna Förster, 1909; 6.14 Triacanthagyna Selys, 1883; ReferencesDigital Access Springer 2019 - Digital[edited by] Jan Odom-Forren.Contents:
Sect. I: The postanesthesia care unit
Sect. II: Physiologic considerations in the PACU
Sect. III: Concepts in anesthetic agents
Sect. IV: Nursing care in the PACU
Sect. V: Special considerations.Digital Access R2Library 2018Limited to 2 simultaneous users - Digital[edited by] Jan Odom-Forren.Summary: "Drain's PeriAnesthesia Nursing: A Critical Care Approach, 8th Edition provides comprehensive clinical content tailored specifically for perianesthesia nurses. An easy-to-use format with five distinct sections -- covering the PACU, anatomy and physiology, pharmacology, nursing care, and special considerations -- means you get the equivalent of five books in one. Nursing and pharmacologic interventions are integrated with in-depth coverage of pathophysiology, and updated content includes the latest standards and current issues affecting perianesthesia nursing practice. Focusing on research, documentation, and psychosocial considerations, this is the one book that can take you all the way from being a novice nurse in the PACU to preparing for CPAN®or CAPA® certification! Five separate sections provide comprehensive coverage, including the PACU, anatomy and physiology, pharmacology, nursing care, and special considerations. Coverage of current policies and issues affecting perianesthesia nursing practice includes patient safety, infection control, managed care implications, pain management, and bioterrorism. Comprehensive information on the various types of anesthetic agents familiarizes you with what will be used in the PACU. Special Considerations section details the care of patients with conditions such as malignant hyperthermia, substance abuse, sickle cell anemia, and cardiac arrest"-- Publisher's description.
Contents:
Section I: The postanesthesia care unit. Space planning and basic equipment systems
Perianesthesia nursing as a specialty
Management and policies
Crisis resource management in the PACU
Infection prevention and control in the PACU
The changing health care system and its implications for the PACU
Patient safety and legal issues in the PACU
Ethics in perianesthesia nursing
Evidence-based practice and research
Section II: Physiologic considerations in the PACU. The nervous system
The cardiovascular system
The respiratory system
The renal system
Fluids and electrolytes
The endocrine system
The hepatobiliary and gastrointestinal system
The integumentary system
The immune system
Section III: Concepts in anesthetic agents. Basic principles of pharmacology
Inhalation anesthesia
Nonopioid intravenous anesthetics
Opioid intravenous anesthetics
Neuromuscular blocking agents
Local anesthetics
Regional anesthesia
Section IV: Nursing care in the PACU. Transition from the operating room to the PACU
Assessment and monitoring of the perianesthesia patient
Patient education and care of the perianesthesia patient
Postanesthesia care complications
Assessment and management of the airway
Pain management
Care of the ear, nose, throat, neck, and maxillofacial surgical patient
Care of the ophthalmic surgical patient
Care of the thoracic surgical patient
Care of the cardiac surgical patient
Care of the vascular surgical patient
Care of the orthopedic surgical patient
Care of the neurosurgical and neurointerventional patient
Care of the thyroid and parathyroid surgical patient
Care of the gastrointestinal, abdominal, and anorectal surgical patient
Care of the genitourinary surgical patient
Care of the obstetric and gynecologic surgical patient
Care of the breast surgical patient
Care of the plastic and reconstructive surgical patient
Care of the patient undergoing bariatric surgery
Care of the ambulatory surgical patient
Care of the laser/laparoscopic surgical patient
Section V: Special considerations. Care of the patient with chronic disorders
Care of the pediatric patient
Care of the older patient
Care of the pregnant patient
Care of the patient with substance use disorder
Care of the patient with thermal imbalance
Care of the shock trauma patient
Care of the intensive care unit patient in the PACU
Bioterrorism and its impact on the PACU
Cardiopulmonary resuscitation in the PACU
International perspectives on perienesthesia nursing and competence.Digital Access ClinicalKey Nursing 2024 - DigitalBenjamin Ehrlich.Summary: This work contains the first English translation of the lost dream diary of Santiago Ramón y Cajal (1852-1934), the Nobel Prize-winning "father of modern neuroscience."
Contents:
Part 1. The founder of modern neuroscience. Cajal's legacy ; Cajal and psychology ; Cajal and dream research ; Cajal and Freudianism in Spain ; Comparing the lives of Cajal and Freud ; The effects of hypnosis and suggestion ; On the divergence of psychology and neuroanatomy ; Cajal's psyche and his readings of Freud
"The Father of Modern Neuroscience" and his father
The dream diary's strange fate
Part 2. The dream diary of Santiago Ramón y Cajal. The dreams of Cajal.Digital Access Oxford 2016 - DigitalTomoaki Shirao, Yuko Sekino, editors.Summary: This book is the first comprehensive review of drebrin, which plays pivotal roles in various cellular events, via forming unique actin cytoskeletons, including synapse formation and in synaptic function. Particularly the loss of drebrin from dendritic spines is used as a marker of dementia in neurological disorders such as Alzheimer's disease. Since drebrin was first identified by our group in 1985, many studies of drebrin have been done in various fields, including not only molecular biology, biophysics, cell biology, neuroscience, clinical studies, spermatogenesis, immunology, and cancer metastasis, but others as well. The structure of this book facilitates the understanding of the whole picture of studies on drebrin. The volume begins with a general introduction to drebrin, and then the chapters in the second part provide the basic knowledge for further understanding. The third part examines its function in the nervous system, and the fourth part discusses its function in the non-nervous system. This work will appeal to researchers who are interested in cytoskeletal dynamics at membrane-cytoskeletal interface as well as the number of them who use drebrin as a tool, such as a marker of synaptic function or a disease marker. This volume is kept as concise as possible in order to be understood by readers in diverse scientific disciplines"--Publisher's description.
Contents:
History of drebrin discovery as an general introduction. General introduction to drebrin / Tomoaki Shirao, Yuko Sekino
Basic information about drebrin. Molecular cloning of drebrin: progress and perspectives / Nobuhiko Kojima
Biochemistry of drebrin and its binding to actin filaments / Ryoki Ishikawa
Phosphorylation of drebrin and its role in neuritogenesis / Phillip R. Gordon-Weeks
Remodeling of actin filaments by drebrin a and its implications / Elena E. Grintsevich
Cell shape change by drebrin / Kensuke Hayashi
Drebrin in nervous system. Localization of drebrin: light microscopy study / Tomoaki Shirao, Noriko Koganezawa, Hiroyuki Yamazaki, Kenji Hanamura, Kazuyuki Imamura
Making of a synapse: recurrent roles of drebrin a at excitatory synapses throughout life / Chiye Aoki, Ang D. Sherpa
Drebrin in neuronal migration and axonal growth / Kenji Hanamura
Drebrin and spine formation / Hideto Takahashi, Yusuke Naito
Role of drebrin in synaptic plasticity / Yuko Sekino, Noriko Koganezawa, Toshiyuki Mizui, Tomoaki Shirao
Drebrin in Alzheimer's disease / Yuta Ishizuka, Kenji Hanamura
Drebrins and connexins: a biomedical perspective / Irina V. Majoul, Justus S. Ernesti, Eugenia V. Butkevich, Rainer Duden
Homer, spikar, and other drebrin-binding proteins in the brain / Hiroyuki Yamazaki, Tomoaki
Role of drebrin at the immunological synapse / Vera Rocha-Perugini, Mónica Gordon-Alonso, Francisco Sánchez-Madrid
Drebrin regulation of calcium signaling in immune cells / Jonathan Pabon, Man Kit Law, Avery August
Drebrin and spermatogenesis / Haiqi Chen, Michelle W.M. Li, C. Yan Cheng
Drebrin at junctional plaques / Wiebke K. Ludwig-Peitsch
Juxtanuclear drebrin-enriched zone / Wiebke K. Ludwig-Peitsch
Drebrin in renal glomeruli / Wiebke K. Ludwig-Peitsch. - DigitalPink, Daniel H.Summary: In today's fast-paced world, it's tough to find the time to read. But with Joosr guides, you can get the key insights from bestselling non-fiction titles in less than 20 minutes. Whether you want to gain knowledge on the go or find the books you'll love, Joosr's brief and accessible eBook summaries fit into your life. Find out more at joosr.com. Rewarding good performance and punishing the not so good is so ingrained in our approach to management that it's hard to conceive of an alternative. But there is a better way to motivate-one that taps into our human nature and lets us thrive. For.Digital Access eBook Comp Acad 2015
- DigitalGuenter B. Risse.Contents:
1. Domain of contagion and confinement
2. Framing "loathsome" diseases
3. Tides of inertia and neglect
4. Location: Not in my backyard
5. Banished: sojourns of the damned
6. Belle of California's Molokai
7. Wary minders: custodians and caregivers
8. Hope for cures: nature or science
9. Modern isolation: humanizing castaways.Digital Access ProQuest Ebook Central 2016 - DigitalGuy Echalier, Norbert Perrimon, Stephanie E. Mohr.Contents:
1. Composition of the body fluid of Drosophilia and the design of culture media for drosophilia cells
2. Primary cell cultures of Drosophilia embryonic cells
3. Continuous Drosophilia cell lines established in vitro
4. Cells or tissues in course of differentiation
5. Hormonal control of development of insects: implications in organ or cell cultures of Drosophilia
6. Directed genetic methods for establishing continuous cell lines
7. Organ culture methods for the Drosophilia wing imaginal disc
8. Functional genomics screens in Drosophilia cells
9. CRISPR-based perturbation of gene function in Drosophilia cells
10. Compendium of Drosophilia cell line resources and plasmid vectors at the Drosopilia Genome Resource Center
Index.Digital Access ScienceDirect 2018 - DigitalWu-Min Deng, editor.Summary: This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics. Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression. Readers will discover the beauty of the fly models genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use. This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems. This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease.Digital Access Springer 2019
- DigitalMasamitsu Yamaguchi, editor.Contents:
1. Drosophila as a model organism
2. Adult intestine aging model
3. Alzheimer's Disease model system using Drosophilia
4. Parkinson's Disease Model
5. Repeat Expansion Disease Models
6. Amyotrophic lateral sclerosis model
7. Drosophila charcot-marie-tooth disease models
8. Drosophila as a model to gain insight into the role of IncRNAs in neurological disorders
9. Muscular dystrophy model
10. Drosophila as a cancer model
11. From Drosophila blood cells to human leukemia
12. Diseases associated with mutation of replication and repair proteins
13. Drosophila models to investigate insulin action and mechanisms underlying human diabetes mellitus
14. Metabolomics: state-of-the -art technologies and applications on Drosophila melanogaster
15. Humanized flies and resources for cross-species study
16. Design for flies + of mice and men: design approaches to Drosophila melanogaster.Digital Access Springer 2018 - Digitaledited by Diana P. Bratu, Gerard P. McNeil.Contents:
Drosophila melanogaster oogenesis : an overview / John M. McLaughlin and Diana P. Bratu
Basic techniques in Drosophila ovary preparation / Letitia Thompson, Kristen Randolph, and Amanda Norvell
Mosaic analysis in the Drosophila melanogaster ovary / Thomas Rubin and Jean-René Huynh
Genetic mosaic analysis of stem cell lineages in the Drosophila ovary / Kaitlin M. Laws and Daniela Drummond-Barbosa
Culturing Drosophila egg chambers and investigating developmental processes through live imaging / Lathiena Manning and Michelle Starz-Gaiano
Border cell migration : a model system for live imaging and genetic analysis of collective cell movement / Mohit Prasad [and four others]
Visualizing microtubule networks during Drosophila oogenesis using fixed and live Imaging / Kevin Legent, Nicolas Tissot, and Antoine Guichet
Visualization of actin cytoskeletal dynamics in fixed and live Drosophila egg chambers / Christopher M. Groen and Tina L. Tootle
Single-molecule RNA in situ hybridization (smFISH) and immunofluorescence (IF) in the Drosophila egg chamber / Livia V. Bayer [and three others]
Fluorescent in situ hybridization of nuclear bodies in Drosophila melanogaster ovaries / Zehra F. Nizami, Ji-Long Liu, and Joseph G. Gall
Ultrastructural analysis of Drosophila ovaries by electron microscopy / Thomas R. Hurd [and seven others]
Immuno-electron microscopy and electron microscopic in situ hybridization for visualizing piRNA biogenesis bodies in Drosophila ovaries / Shinsuke Shibata [and six others]
Visualizing cytoophidia expression in Drosophila follicle cells via immunohistochemistry / Ömür Y. Tastan and Ji-Long Liu
Detection of cell death and phagocytosis in the Drosophila ovary / Tracy L. Meehan [and three others]
Analysis of cell cycle switches in Drosophila oogenesis / Dongyu Jia , Yi-Chun Huang , and Wu-Min Deng
Global run-on sequencing (GRO-seq) library preparation from Drosophila ovaries / Nikolay V. Rozhkov
Bioinformatics analysis to identify RNA-protein interactions in oogenesis / Ravinder Singh.Digital Access Springer 2015 - Digitaledited by Joost J.L.M. Bierens.Summary: Since the first edition of the Handbook on Drowning in 2005, many epidemiological data have confirmed the burden of drowning in several parts of the world. Studies have increased the understanding of effective drowning prevention strategies, rescue techniques, and treatment options. Much has been learned about submersion and immersion hypothermia, SCUBA-diving injuries, the life-saving preparations of water-related disasters and how to deal with forensic investigations. In this updated second edition, experts from around the world provide a complete overview of current research data, consensus statements and expert opinions. The book Drowning provides evidence-based practical information and has a unique informative value for various groups with tasks, duties and responsibilities in this domain. In addition, the book may be an inspiration for future networks and research initiatives.
Contents:
Introduction
History
The Epidemiology of Drowning
The Prevention of Drowning
Rescue Organisational Aspects: Planning, Training and Preparation.- Rescue Techniques
Resuscitation
Hospital Treatment
Brain Resuscitation in the Drowning Victim
Immersion Hypothermia
Water-related Disasters
Breath-hold, SCUBA and Hose Diving
Investigation of Drowning Accidents
Important Websites. - Printedited by Jasbir M. Singh, Lyle Miller, Harbans Lal.Contents:
v. 1. Experimental pharmacology
v. 2. Clinical and socio-legal aspects
v. 3. Neurobiology and influences on behaviour
v. 4. New aspects of analytical and clinical toxicology. - DigitalMichel Burnier, editor.Summary: "This book provides a critical and comprehensive review of the methodologies available for measuring drug adherence in clinical practice, including those relying on emerging technologies. The authors discuss the risk factors of non-adherence and shed light on how to identify patients at risk of poor adherence. Drug therapies in chronic diseases rely heavily on the patient's adherence, since drugs that are not taken are ineffective and leave the patient at high risk of developing clinical complications. Given the absence of new drugs for the treatment of hypertension, drug adherence is particularly important in these patients to improve blood pressure control. The book further investigates a new aspect, namely the importance of drug adherence in clinical trials and studies and draws attention to the limits of developing drugs without significant information on drug adherence. Several chapters are dedicated to the importance of adherence in specific forms of hypertension, such as resistant hypertension, dyslipidemia and hypertension associated with cardiovascular risk. As experts confronted with drug adherence in their daily practice, the authors analyse the real effectiveness of several interventions aimed at improving drug adherence and put particular emphasis on the importance of an interdisciplinary approach involving nurses and pharmacists. The volume also includes a careful analysis of the health and economic impact of poor adherence. The book is aimed at physicians, pharmacists, students and all health professionals dealing not only with hypertension or dyslipidemia, but also with chronic asymptomatic diseases such as diabetes, HIV or chronic respiratory diseases."-- Provided by publisher.
- Digitalby Brian A. Baldo, Nghia H. Pham.Summary: The second edition of this book spans the broad range of modern therapeutic drugs, from small molecules to biologic recombinant proteins. It offers a comprehensive review of the classification and description of different drug-induced systemic and cutaneous hypersensitivities; an up-to-date coverage of individual culprit drugs in each group of therapeutics; the diagnosis and mechanisms of reactions; and important structure-activity relationships. New content expands to two areas of drug allergy that have recently experienced explosive growth: biological therapies and new targeted chemotherapies. Other new and expanded chapters address antimicrobials; drugs used in anesthesia and surgery; opioids; non-targeted anti-cancer drugs; vaccines; and newly understood reaction mechanisms. This new edition includes photographs of a wide variety of cutaneous manifestations that will be of use to other clinicians as well as allergists and dermatologists. In addition to its wide clinical emphasis, the book's mechanistic and structure-activity detail will provide valuable background for researchers and investigators in universities, medical research institutes, drug companies, and regulatory agencies. The second edition of Drug Allergy is an essential reference for practitioners across the medical disciplines from specialist clinicians, surgeons, GPs, residents, and medical students to nurses, pharmacists, dentists, and those taking undergraduate and graduate courses in the biomedical sciences.
Contents:
Ch. 1. Adverse reactions to drugs and drug allergy
Ch. 2. Classification and descriptions of allergic reactions to drugs
Ch. 3. Mechanisms of hypersensitivity
Ch. 4. Diagnosis of allergic reactions to drugs
Ch. 5. Beta-Lactam antibiotics
Ch. 6. Other antimicrobial drugs
Ch. 7. Drugs and other agents used in anesthesia and surgery
Ch. 8. Opioid analgesic drugs
Ch. 9. Nonsteroidal anti-inflammatory drugs
Ch. 10. Contrast media
Ch. 11. Corticosteroids
Ch. 12. Proton pump inhibitors
Ch. 13. Targeted drugs for cancer therapy. Approved monoclonal antibodies
Ch. 14. Non-targeted drugs for cancer therapy
Ch. 15. Other approved therapeutic monoclonal antibodies
Ch. 16. Other biologics
Ch. 17. Vaccines. - DigitalDavid A. Khan, Aleena Banerji.Contents:
Chapter 1. Epidemiology of drug allergy
Chapter 2. Economic impact of drug allergy
Chapter 3. Drug allergy: definitions and phenotypes
Chapter 4. Immune mechanisms of drug allergy
Chapter 5. Pharmacogenomics of drug allergy
Chapter 6. Cutaneous reactions to drugs
Chapter 7. Basics of skin testing and drug challenges
Chapter 8. In vitro and in vivo tests for drug hypersensitivity reactions
Chapter 9. Drug desensitization
Chapter 10. Penicillins
Chapter 11. Cephalsporin allergy
Chapter 12. Macrolide allergy
Chapter 13. Quinolone allergy
Chapter 14. Sulfonamide drug allergy
Chapter 15. Other antibiotic allergy
Chapter 16. Multiple drug intolerance syndrome
Chapter 17. Aspirin-exacerbated respiratory disease
Chapter 18. Other NSAIDs reactions
Chapter 19. Chemotherapy allergy
Chapter 20. Hypersensitivity reactions to monoclonal antibodies
Chapter 21. Perioperative allergy
Chapter 22. Adverse reactions to contrast media
Chapter 23. Corticosteroids
Index.Digital Access ScienceDirect 2018 - Digital[edited by] Adriana Tiziani.Summary: This text can be used in conjunction with Havard's Nursing Guide to Drugs 9th edition as part of the suite of resources for undergraduate and Diploma of nursing students. Each case starts with an introduction, where the presenting condition and symptoms are outlined and as the case progresses, more details of the patient's condition, tests, medications and other considerations are provided. All cases come together with a conclusion where the patient outcomes are highlighted, followed by a discussion of the key considerations for the case. Multiple Choice Questions are integrated throughout and rationales are provided for all answers. This is perfect for use during exam preparation or as a study tool, providing an engaging approach to learning and revision.
Contents:
Case studies
General adult. Diabetes ; Epilepsy ; Gastrointestinal bleed ; Anticoagulation
General paediatric. Managing acute asthma ; Management of a child with gastroenteritis ; Management of a neonate with bacterial meningitis ; Management of a child with a urinary tract infection (UTI)
Aged care. Medication administration for the older person within a residential aged care facility ; Medication administration for the older person in the community ; Medication and the older person with dementia ; Medication administration for the older person admitted to the acute care environment
Palliative care. Managing complex pain using opioids and adjuvant medications ; Managing breathlessness and associated anxiety ; Polypharmacy and end of life issues ; Symptom management at end of life
Midwifery. Induction of labour and group B streptococcus (GBS) ; Elective lower segment caesarean section (LSCS) ; Threatened preterm labour and urinary tract infections (UTIs) ; Iron deficiency anaemia.Digital Access ClinicalKey Nursing 2016 - DigitalBernardo Cortese, editor.Summary: This book provides a comprehensive, up-to-date summary of drug-coated balloon (DCB) technology and the role of DCBs in the treatment of coronary and peripheral arterial disease. In addition to clear explanation of how DCBs work, readers will find an enlightening analysis of the mistakes and successes of the past decade and the emergence of the latest delivery systems, which combine a more deliverable device with much improved drug delivery to the vessel wall. The full range of current applications of DCBs are reviewed in detail, drawing on the latest scientific evidence. Due attention is paid to newer devices, with provision of technical insights and documentation of the available clinical data. Ongoing research projects, remaining technical challenges, likely future directions, and reimbursement issues are also carefully considered. This book will be a useful tool for any interventional cardiologist, interventional radiologist, or vascular surgeon who wishes to acquire a deep knowledge of this technology and its application in both coronary and peripheral interventions.
Contents:
1 The history of drug-coated balloons
2 Previous mistakes and how to prevent them in the future
3 Local drug delivery to prevent restenosis of coronary and peripheral arteries
4 Technical insights on drug-coated balloons
5 Potential clinical advantages of DCB in specific clinical settings
6 The role of drug-coated balloons for the treatment of coronary in-stent restenosis
7 The role of drug-coated balloons for the treatment of native coronary vessels
8 The role of drug-coated balloons for the treatment of coronary bifurcations.-9 Dissection management with drug-coated balloons
10 The role of drug-coated balloons on late lumen enlargement
11 The role of drug-coated balloons for the treatment of peripheral in-stent restenosis
12 The role of drug-coated balloons for the treatment of native SFA
13 The role of drug-coated balloons for the treatment of native below-the-knee arteries
14 The role of drug-coated balloons for the treatment of other peripheral vessels
15 Drug-coated balloons: lessons from the real world
16 Stent use after drug-coated balloons
17 Drug coated balloons and antithrombotic treatment
18 Cost/effectiveness and reimbursement policies with drug-coated balloons
19 Newer devices-technical insights & preliminary scientific data
20 Current technical challenges and the future of drug-coated balloons. - PrintAnna Lembke, MD.Contents:
1. What is addiction, who's at risk, and how do people recover?
2. Prescription drugs as the new gateway to addiction
3. Pain is dangerous, difference is psychopathology : the role of illness narratives
4. Big Pharma joins Big Medicine : co-opting medical science to promote pill-taking
5. The drug-seeking patient : malingering versus the hijacked brain
6. The professional patient : illness as identity and a right to be compensated
7. The compassionate doctor, the narcissistic injury, and the primitive defense
8. Pill mills and the Toyota-ization of medicine
9. Addiction, the disease insurance companies still won't pay doctors to treat
10. Stopping the cycle of compulsive prescribing. - Digitaledited by Binghe Wang, Longqin Hu, Teruna J. Siahaan.Contents:
1. Factors that impact the developability of drug candidates
2. Physiological, biochemical, and chemical barriers to oral drug delivery
3. Physicochemical properties, formulation, and drug delivery
4. Targeted bioavailability: a fresh look at pharmacokinetic and pharmacodynamic issues in drug discovery and development
5. The role of transporters in drug delivery and excretion
6. Intracellular delivery and disposition of small-molecular-weight drugs
7. Cell culture models for drug transport studies
8. Intellectural property and regulatory issues in drug delivery research
9. Presystemic and first-pass metabolism
10. Pulmonary drug delivery: pharmaceutical chemistry and aerosol technology
11. Transdermal delivery of drugs using patches and patchless delivery systems
12. Prodrug approaches to drug delivery
13. Liposomes as drug delivery vehicles
14. Nanoparticles as drug delivery vehicles
15. Evoluation of controlled drug delivery systems
16. Pathways for drug delivery to the central nervous system
17. Metabolic activation and drug targeting
18. Targeted delivery of drugs to the colon
19. Receptor-mediated drug delivery
20. Protein and peptide conjugates for targeting therapeutics and diagnostics to specific cells
21. Drug delivery to the lymphatic system
22. The development of cancer theranostics: a new emerging tool toward personalized medicine
23. Intracellular delivery of proteins and peptides
24. Vaccine delivery: current routes of administration and novel approaches
25. Delivery of genes and oligonucleotides
Index.Digital Access Wiley 2016 - Digitaledited by Chun Li, Mei Tian.Contents:
Introduction to molecular imaging / Vikas Kundra
PET/SPECT : instrumentation and imaging techniques / Yuan-Chuan Tai
Photoacoustic tomography and its application in drug delivery and photothermal therapy / Liang Song Lihong Wang
Raman microspectral imaging for label-free detection of nanoparticle-mediated cellular and sub-cellular drug delivery / Tatyana Chernenko ... [et al.]
Anatomical and functional MRIi / Edward F. Jackson
Quantitative imaging in drug delivery / Kooresh Shoghi
PET imaging of small-molecular-weight drug pharmacokinetics / Stephen M. Moerlein and Zhude Tu
Imaging peptides, proteins, and antibody delivery / F. L. Giesel and C. Kratochwil
In vivo imaging and delivery of siRNA / Zdravka Medarova and Anna Moore
Imaging cell therapy / Yijie Linag and Jeff W.M. Bulte
Radiolabeled liposomes as drug delivery nano-theranostics / William T. Phillips ... [et al.]
Polymeric micelles as imaging agents and drug delivery systems / Jun Zhao and Chun Li
Perfluorocarbon nanoparticles: translating bench opportunities to the clinic / G.M. Lanza ... [et al.]
Cancer theranostics with hollow gold nanospheres / Wei Lu and Chun Li
Imaging pulmonary drug delivery / Stephen Newman
In-vivo imaging for validation of oral dose performance / Fiona McInnes and Howard Stevens
Role of large animal models in translational studies of imaging and targeted drug delivery / Rajesh K. Uthamanthil and Mei Tian
Imaging transcatheter delivery to liver tumors / Adil AL-Nahhas, Meeran Naji, Imene Zerizer
Direct visualization of therapeutic radionuclides distribution using nuclear medicine imaging: i-131 in metastatic thyroid carcinoma / Ho Young Lee ... [et al.]
Imaging drug delivery to the cns using translational positron emission tomography studies / Chi-Ming Lee, Katarina Varns.Digital Access Wiley 2014 - DigitalJayvadan K. Patel, Vijaykumar Sutariya, Jagat Rakesh Kanwar, Yashwant V. Pathak, editors.Summary: This book addresses the issues relating to a wide variety of ocular diseases from which millions of people suffer. Long-term challenges include visual impairment and ocular blindness. Certain ocular diseases are quite rare, whereas others, such as cataracts, age-related macular degeneration (AMD), and glaucoma, are very common, especially in the aging population. A rapid expansion of new technologies in ocular drug delivery and new drug candidates, including biologics, to treat these challenging diseases in the retina and posterior segments of the eye have recently emerged. These approaches are necessary because the eye has many unique barriers to drug delivery. Thus, this timely reference Drug Delivery for the Retina and Posterior Segment Disease compiles and analyzes recent advances in the research and development of drug delivery systems for retina and posterior segment diseases of the eye, with an emphasis on the use of implantable devices, iontophoresis as well as micro- and nanoparticles.
Contents:
Intro; Foreword; Preface; Contents; Contributors; Part I: Introduction and Basic Concept of Drug Delivery for Retina and Posterior Segment Disease;
Chapter 1: Anatomy and Physiology of Retina and Posterior Segment of the Eye; Introduction; Sensory Retina; Foveal Cytoarchitecture; Synaptic Connectivity; Uveal Arterial Circulation; Development and Anatomy of the Central Retinal Artery; Barrier System of the Retina; Optic Disc and Cup; Laminar Organization of the Optic Disc; Prelaminar Part; Laminar Region; Postlaminar Region; Myelination of the Ganglionic Axons
Chapter 3: Drug Delivery to Posterior Segment of the Eye: Conventional Delivery Strategies, Their Barriers, and RestrictionsIntroduction; Posterior Segment of the Eye; Drug Delivery Strategies for Posterior Eye, Their Barriers, and Restrictions; Topical Drug Application; Systemic Drug Delivery; Intravitreal Route; Periocular Route or Transscleral Diffusion; Transscleral Iontophoresis; Ocular Implants; References;
Chapter 4: Penetration Routes to Retina and Posterior Segment; Introduction; Systemic Route; Topical Route; Periocular and Suprachoroidal Routes; Intraocular Routes; Conclusion Metabolic Activity of the RPE and the PhotoreceptorsModulatory and Protective Role of the RPE; Optic and Non-optic Retina; Physiologic Properties of the Photoreceptors; Retinal Pathways and Synaptic Integration; Pupillary Light Reflex and Circadian Rhythm; Conclusions; References;
Chapter 2: Pharmacotherapy of Diabetic Macular Edema and Retinopathy; Introduction; Diabetic Retinopathy; Characteristics of Diagnosis; Treatments and Therapy; Diabetic Macular Edema; Characteristics of Diagnosis; Treatments and Therapy; Conclusion; Future Trends; References Specific Anti-VEGF DrugsOther Methods of Treatment; Routes of Drug Delivery; Conclusion; References; Part II: Nanotechnology Based Formulations for Retina and Posterior Segment Disease;
Chapter 6: Liposomes for Retina and Posterior Segment Disease; Introduction; Liposomes; Drug Loading; Drug Delivery; Targeted Drug Delivery; Application in Ocular Drug Delivery; Role of Surface Charge and Vesicle Type in Liposome-Corneal Interaction; Passive Targeting Drug-Encapsulated Liposomes; Low Molecular Weight Chitosan-Coated Liposomes - DigitalCélia Luiza Petersen Vitello Kalil, Valéria Campos, editors.Summary: Skin accounts for approximately 15% of an adult's total body weight, with a surface of about 2m². It provides an entry and exit barrier to various substances, offers effective protection against harmful substances, microorganisms and ultraviolet radiation, and is also paramount in immunology and body homeostasis, preventing dehydration and loss of essential minerals. The topical route has a number of advantages over oral and parenteral routes: no first-pass metabolism, greater convenience resulting in better treatment compliance, lower side-effect frequency, and prompt dosing cessation if required. However, the stratum corneum allows penetration of only 1 to 5% of substances applied topically, making this application route much less efficient. Lipophilic and small molecules (up to 500 Da) can cross the stratum corneum, since keratinocytes are covered by a lipid matrix, while it is virtually impossible for hydrophilic and large drugs to cross intact, normal skin, which means that passive topical delivery is restricted. To address this, techniques have been developed aimed at optimizing drug skin penetration by means of chemical, mechanical and physical methods, such as adding permeating active agents and using occlusion, iontophoresis, microneedling, lasers and intense pulsed light, and it is now possible to deliver medication to different skin layers or transdermally to the systemic circulation. Drug delivery is a hot topic in dermatology, with a Pubmed search generating 203431 articles. Offering a detailed review of this emerging therapeutic option, including the various methods available, this unique book guides physicians and doctors in selecting the correct technologies, technique and products for each patient. .
Contents:
Chapter 1. Understanding Skin and Drug Delivery
Chapter 2. How to Optimize Drug Delivery in Dermatology?
Chapter 3. Dermatological Applications of Drug Delivery Systems
Chapter 4. Drug Delivery-Associated Dermatological Technologies and Techniques
Chapter 5. Microneedling and Drug Delivery
Chapter 6. Intense Pulsed Light and Drug Delivery
Chapter 7. Fractional Non-Ablative Laser and Drug Delivery
Chapter 8. Ablative Fractional Lasers & Drug Delivery
Chapter 9. Switched and Drug Delivery
Chapter 10. Radiofrequency, Infra-red and Others Technologies for Drug Delivery
Chapter 11. Drug Delivery in the Treatment of Alopecia
Chapter 12. Digital Microneedling and Drug Delivery
Chapter 13. Active Agents in Injectable Drug Delivery
Chapter 14. Microinfusion of Drugs into the Skin (MMP®) & Drug Delivery
Chapter 15. Protocols for Drug Delivery. - Digitaleditor, Alejandro D. Ricart.Contents:
Drug-delivery systems in cancer therapy / Alejandro D. Ricart
Drug-delivery considerations in oncology / Alejandro D. Ricart
Antibody-drug conjugates / Alejandro D. Ricart
Fusion proteins / Samir Dalia & Salvador Bruno
Polymer-drug conjugates / Núria Mulet-Margalef, Josep Maria Miquel & Jordi Rodon
Drug protein-bound particles and polysaccharide-drug conjugates / Karina A. Peters, Matías Chacón & Alejandro D. Ricart
Liposomal drug carriers / Daniel S. Lewi, Karina A. Peters & Pedro M. Polit. - Digitaledited by Kewal K. Jain, Jan PharmaBiotech, Basel, Switzerland.Contents:
Current Status and Future Prospects of Drug Delivery Systems
A Method for Screening Mitochondrial Fusogenic Envelopes for use in Mitochondrial Drug Delivery
Ultrasound-directed, Site-specific Gene Delivery
Synthesis of Thermoresponsive Polymers for Drug Delivery
Recombinant Stem Cells as Carriers for Cancer Gene Therapy
Microfluidic-based Manufacture of siRNA-lipid Nanoparticles for Therapeutic Applications
Microneedle-iontophoresis Combinations for Enhanced Transdermal Drug Delivery
Polymer Nanoparticle-based Controlled Pulmonary Drug Delivery
Antibody Labeling with Radioiodine and Radiometals
Self Assembling Peptide -based Delivery of Therapeutics for Myocardial Infarction
Applications of Chitosan Nanoparticles in Drug Delivery
A Method for Evaluating Nanoparticle Transport through the Blood Brain Barrier in vitro
Bacterial Systems for Gene Delivery to Systemic Tumours
Synthesis of a Smart Nanovehicle for Targeting Liver
Intranasal Delivery of Chitosan-siRNA Nanoparticle Formulation to the Brain
Intrathecal Delivery of Analgesics.Digital Access Springer 2014 - Digitaleditor, Anthony J Hickey, RTI International, Research Triangle Park, NC, USA ; consulting editors, Amit Misra, CSIR Central Drug Research Institute, Lucknow, India, P. Bernard Fourie, University of Pretoria, Pretoria, South Africa.Digital Access Wiley 2016
- DigitalMargareta Hammarlund-Udenaes, Elizabeth C.M. de Lange, Robert G. Thorne, editors.Summary: This book describes the different approaches for drug delivery to the brain with an emphasis on the physiology of the blood-brain barrier (BBB) and the governing principles and concepts for drug delivery across the BBB. It contains cutting-edge methods for studying drug delivery and administering drugs into the brain. The book also explores different approaches for predicting human brain concentrations as well as the influence of disease and drug industry perspectives. In addition to wide-ranging coverage of physiological concepts relevant to central nervous system (CNS) drug delivery, a detailed review of brain structure, function, blood supply and fluids is also provided. In each chapter, descriptions of future challenges and unresolved questions are combined with points for discussion. This unique combination of material makes this book a valuable resource for students and for established academic and industry scientists looking to learn about state-of-the-art drug delivery research. It is also a source for stimulating new ideas among experts already performing CNS drug delivery research or working in related areas. Margareta Hammarlund-Udenaes (Ph.D.) is a Professor in Pharmacokinetics and Pharmacodynamics (PK/PD) at Uppsala University and the Head of the Translational PK/PD Group. Her research is focused on studying pharmacokinetic aspects of BBB transport of drugs in relation to CNS effects, and it has led to the development of new concepts and methods within the BBB transport area, focusing on unbound drug relationships. Elizabeth C.M. de Lange (Ph.D.) is Head of the Target Site Equilibration Group at the Division of Pharmacology of the Leiden Academic Center for Drug Research (LACDR). Her research program focuses on the development of generally applicable predictive PK/PD models on CNS drugs using advanced in vivo animal models and mathematical modeling techniques, with a number of recent successes. Robert G. Thorne (Ph.D.) is an Assistant Professor in Pharmaceutical Sciences at the University of Wisconsin-Madison School of Pharmacy. He was previously a research scientist and faculty member in the Department of Physiology & Neuroscience at the New York University School of Medicine. His research focuses on diffusive and convective transport within the CNS and the development, refinement and optimization of strategies for delivering biologics into the brain.
Contents:
Part I. Physiology and basic principles for drug handling by the brain
Part II. Pharmacokinetic concepts in brain drug delivery
Part III. Industrial approaches for investigation of potential central nervous system drugs
Part IV. Strategies for improved central nervous system drug delivery
Part V. Brain drug delivery in disease conditions.Digital Access Springer 2014 - Digitaledited by Atta-ur-Rahman, FRS, Honorary Life Fellow, Kings College, University of Cambridge, UK and Muhammad Iqbal Choudhary, H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan.Digital Access ScienceDirect 2014
- DigitalMadhu Dikshit, editor.Springer Nature eBook.Summary: Over the years, India has attained a prominent global position in the manufacture of Generic Drugs. This success can be attributed to its synthetic organic chemistry and chemical engineering strengths, nurtured by the timely policies of the Government of India. However, breakthrough successes in New Drug Discovery have remained elusive, despite the brilliant and sustained efforts of many Indian researchers and Pharma establishments. The Indian National Science Academy thought it appropriate to document Indias New Drug Discovery Research (NDDR) journey to date. Gathering contributions from prominent researchers in the Indian Pharma Industry and Academia, this book highlights their efforts, achievements, and the status quo of Indian NDDR. .
Contents:
Chapter 1. Traditional Medical System (TMS) for Sustainable Healthcare in India
Chapter 2. Modern Drug Discovery and Development for TB- The India Narrative
Chapter 3. Indian Discovery Effort in the Quest of Novel Antibiotics
Chapter 4. New Drug Discovery and Development in India to Counter Malaria
Chapter 5. Modern Drug Discovery and Development in the area of Leishmaniasis
Chapter 6. Modern Drug Discovery and Development: Diabetes and lifestyle disorders Part I Introduction to Diabetes and Prevalence in India
Chapter 7. Modern Drug Discovery and Development: Diabetes and lifestyle disorder Part II Type 2 Diabetes Mellitus: Marketed drugs and mechanisms
Chapter 8. Modern Drug Discovery and Development: Diabetes and lifestyle disorders Part III Anti-diabetes research in India: Contributions from industrial organizations
Chapter 9. Modern Drug Discovery and Development: Diabetes and lifestyle disorders Part IV Indian Academia Tryst with Cardio-metabolic Drug Discovery and Development
Chapter 10. Modern drug discovery and development in the area of Cancer: Indian context
Chapter 11. Biopharmaceutical development in India: recommendations on collaboration and innovation to enable affordable healthcare
Chapter 12. Regulatory requirements and Quality Standards in Indias Clinical Trials Journey
Chapter 13. Indian Pharma Perspective: New Drug Discovery and Development- Indian Pharmaceutical Industry. - Digital/PrintSubash Chandra Gupta, Sahdeo Prasad, Bharat B. Aggarwal, editors.Summary: "Second comprehensive volume focuses on anti-inflammatory nutraceuticals and their role in prevention and therapy of various chronic diseases. Food and drug administration (FDA) approved drugs such as steroids, non-steroidal anti-inflammatory drugs (NSAIDS), statins and metformin have been shown to modulate inflammatory pathways, but their long-term intake has been associated with numerous side effects. Thus dietary agents which can modulate inflammatory pathways in humans, are likely to exhibit enormous potential. Leading experts describe the latest results of anti-inflammatory nutraceuticals and their role in prevention and therapy of various chronic diseases"--Publisher's description.
Contents:
Cinnamon and chronic diseases / Mitra Hariri, Reza Ghiasvand
Silymarin and its role in chronic diseases / Neha, Amteshwar S. Jaggi, Nirmal Singh
Eugenol and its role in chronic diseases / S. Fujisawa, Y. Murakami
Catechins and its role in chronic diseases / Yohei Shirakami, Hiroyasu Sakai, Takahiro Kochi, Mitsuru Seishima, Masahito Shimizu
Capsaicin and its role in chronic diseases / E. S. Fernandes, A. R. A. Cerqueira, A. G. Soares, Soraia K. P. Costa
Diallyl sulfide and its role in chronic diseases prevention / Shankar Suman, Yogeshwer Shukla
Lupeol and its role in chronic diseases / Fan-Shiu Tsai, Li-Wei Lin, Chi-Rei Wu
Gingerol and its role in chronic diseases / Yasmin Anum Mohd Yusof
Potential use of flavopiridol in treatment of chronic diseases / Thejal Srikumar, Jaya Padmanabhan
Plumbagin and its role in chronic diseases / Pharkphoom Panichayupakaranant, Md Iftekhar Ahmad
Anethole and its role in chronic diseases / Ana Clara Aprotosoaie, Irina-Iuliana Costache, Anca Miron
The role of indirubins in inflammation and associated tumorigenesis / Xinlai Cheng, Karl-Heinz Merz
CDDO and its role in chronic diseases / Bryan J. Mathis, Taixing Cui
Evodiamine and its role in chronic diseases / Qunyou Tan, Jingqing Zhang
Guggulsterone and its role in chronic diseases / Takanori Yamada, Ken Sugimoto
Deguelin and its role in chronic diseases / Jonathan Boyd, Alice Han
Quercetin and its role in chronic diseases / Ganiyu Oboh, Ayokunle O. Ademosun, Opeyemi B. Ogunsuyi
Eucalyptol and its role in chronic diseases / Geun Hee Seol, Ka Young Kim
Auraptene and its role in chronic diseases / Giuseppe Derosa, Pamela Maffioli, Amirhossein Sahebkar. - Digitaledited by Yvonne Will, J. Eric McDuffie, Andrew J. Olaharski, Brandon D. Jeffy.Summary: As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. - Guides researchers as to what drug safety experiments are both practical and useful- Covers a variety of key topics - safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and -omics tools- Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods- Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practicesDigital Access Wiley 2016
- DigitalSyed Tabish R. Zaidi and Jason A. Roberts, edtiors.Contents:
Betalactams: Penicillins
Betalactams: Cephalosporins
Aminoglycosides
Quinolones
Carbapenems
Glycopeptides and antibiotics for Gram-Positive Bacterial Infections
Azole antifungals
Echinocandins antifungals
Polyene antifungals
Miscellaneous antimicrobials. .Digital Access Springer 2016 - DigitalHaur Yueh Lee, Daniel Creamer, editors.Summary: Cutaneous adverse drug reactions are common and range from the benign to those which are life-threatening. The clinical presentation of these dermatoses is varied and many may mimic common skin conditions. Consequently, diagnosis in drug-induced skin disease is challenging and the treatment considerations are complex. This book aims to bridge the divide between dermatology and allergy by providing a comprehensive review on the pathomechanisms and clinical features of cutaneous adverse drug reactions. Broken up into three distinct sections: General Considerations, Reaction Patterns, and Special Drug Categories, these chapters cover the common and rare adverse skin reactions and provide information on recent advances - particularly immunopathology and pharmacogenetics - as well as highlighting new adverse drug signals and novel therapies. Drug Eruptions is a must-have resource for dermatologists, allergists, internal physicians and general practitioners.
Contents:
Section I: General Considerations
Chapter 1: Pharmacogenetics of Cutaneous Adverse Drug Reactions
Chapter 2: Mechanisms of Drug Hypersensitivity
Chapter 3: Histopathology of Cutaneous Adverse Drug Reactions
Chapter 4: Skin Tests in Evaluating Drug Eruptions
Chapter 5: In vitro Drug Allergy Testing
Section II: Reaction Patterns
Chapter 6: Drug-induced urticaria
Chapter 7: Exanthematous Drug Eruptions
Chapter 8: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
Chapter 9: Acute Generalized Exanthematous Pustulosis
Chapter 10: Drug Reaction Eosinophilia and Systemic Symptoms (DRESS)
Chapter 11: Fixed Drug Eruptions and Generalized Bullous Fixed Drug Eruptions
Chapter 12: Lichenoid Drug Eruptions
Chapter 13: Drug-induced Connective Tissue Disorders
Chapter 14: Drug-induced Vasculitis
Chapter 15: Drug-induced Autoimmune Bullous Diseases
Chapter 16: Other Drug-induced Inflammatory Skin Reactions
Chapter 14: Drug-induced Vasculitis
Chapter 15: Drug-induced Autoimmune Bullous Diseases
Chapter 16: Other Drug-induced Inflammatory Skin Reactions
Chapter 17: Drug-induced Photosensitivity
Chapter 18: Drug-induced Pruritus Without Primary Rash
Chapter 19: Drug-induced Nail Changes
Chapter 20: Drug-induced Hair Changes
Chapter 21: Drug-induced Pigmentary Disorders
Section III: Special Drug Categories
Chapter 22: Immediate and Delayed Reactions to Beta-lactams
Chapter 23: Hypersensitivity Reactions to Iodinated Radiocontrast Media
Chapter 24: Cutaneous Adverse Reactions to Biologic Agents
Chapter 25: Cutaneous Reactions to Oncologic Targeted Therapy
Chapter 26 :Cutaneous Reactions to Oncologic Immunotherapy. . - DigitalKewal K. Jain.Summary: This book is a first-of-its kind reference that systematically organizes and describes the adverse effects of drugs on the nervous system. Drug safety is recognized as an important aspect of pharmaceutical companies as well as practice of medicine. Chapters include case reports of adverse effects of drugs that are published as well as reported to drug manufacturers. The book scope is broad as it covers lack of efficacy, drug resistance, drug-disease and drug-drug interactions. This information is used to improve the use of drugs as well as to design better and safer drugs for the future, and is relevant to personalized medicine in trying to match the right drugs to the patients. Drug-induced Neurological Disorders offers a unique approach to this important topic by integrating clinical neurology with pharmacology with a focus on effects of drugs on the nervous system including those used for the treatment of neurological disorders as well systemic diseases. Many adverse effects involve multiple systems of the body and the syndromes with predominant effect on the nervous system are included in this book.
Contents:
1. Introduction, history and epidemiology of drug-induced neurological disorders
2. Neurologic symptoms as adverse drug reactions
3. Role of the blood-brain barrier in effects of drugs on the brain
4. Pathomechanisms of drug-induced neurological disorders
5. Adverse effects of drugs on the fetal nervous system
6. Principles of management of drug-induced neurological disorders
7. Methods of drug delivery to the nervous system and DIND
8. Neurological complications of anesthesia
9. Neurological complications of cancer therapies
10. Adverse effects of biological therapies on the nervous system
11.Drug-induced aseptic meningitis
12. Drug-induced intracranial hypertension
13. Drug-induced encephalopathies
14. Drug-induced disorders of memory and dementia
15. Drug-induced disturbances of consciousness
16. Drug-induced neuro-psychiatric disorders
17. Neurological effects of drug abuse
18. Drug-induced sleep disorders
19. Drug-induced seizures
20. Drug-induced movement disorders
21. Tardive dyskinesia
22. Drug-induced headaches
23. Drug-induced cerebrovascular disorders
24. Drug-induced disorders of cranial nerves
25. Drug-induced neurootological disorders
26. Drug-induced neuro-ophthalmological disorders
27. Drug-induced disorders of smell and taste
28. Drug-induced peripheral neuropathies
29. Drug-induced disorders of the autonomic nervous system
30. Drug-induced neuromuscular disorders
31. Drug-induced myopathies
32. Drug-induced spinal disorders
33. Drug-induced cerebellar disorders
34. Eosinophilia-myalgia syndrome
35. Drug-induced pituitary disorders
36. Serotonin syndrome
37. Drug-induced Guillain-Barré syndrome
38. Neuroleptic malignant syndrome. - Digital/PrintFrederick "Fritz" T. Fraunfelder, Frederick "Rick" W. Fraunfelder, Wiley A. Chambers ; associate editor, Bree Jensvold-Vetsch.Digital Access ScienceDirect 2015Print
- DigitalFrederick "Fritz" T. Fraunfelder and Frederick "Rick" W. Frauenfelder.Contents:
National Registry of Drug-Induced Ocular Side Effects
Ocular drug delivery and toxicology
Methods for evaluating drug-induced visual side effects
Anti-infectives
Drugs affecting the central nervous system
Drugs affecting the autonomic nervous system
Analgesics, narcotic antagonists, and drugs used to treat arthritis
Drugs used in anesthesia
Gastrointestinal drugs
Cardiac, vascular, and renal drugs
Hormones and drugs affecting hormonal mechanisms
Drugs affecting blood formation and coagulability
Homeostatic and nutrient drugs
Drugs used to treat allergic and neuromuscular disorders
Oncolytic drugs
Heavy metal antagonists and miscellaneous drugs
Drugs used in the management of human immunodeficiency virus/acquired immunodeficiency syndrome
Drugs used in ophthalmology
Herbal medicine– and dietary supplement–induced ocular side effects.Digital Access ClinicalKey 2021 - DigitalSarah Cousty and Sara Laurencin-Dalicieux, editors.Contents:
Adverse Drug Reactions in the Orofacial Region: How Does it Work?
Drug-Induced Gingival Overgrowth
Drug-Induced Oral Mucosa Pigmentation
Oral Manifestations of Drug Allergy
Drug-Induced Oral Ulcerations
Drug-Induced Oral Lichenoid Reactions / White Lesions
Drug-Induced Osseous Complications
Drug-Induced Oral Bleeding
Drug-Induced Taste Disturbances
Drug-Induced Salivary Gland Disturbances : Xerostomia, Pain, Swelling, Hypersalivation, Discoloration of Saliva
Drug-Induced Oral Infections
Drug-Induced Peri-Oral and Facial Complications.Digital Access Springer 2021 - Digital[edited by] Nico de Vries, Ottavio Piccin, Olivier M. Vanderveken, Claudio Vicini.Summary: "Obstructive sleep apnea is the most prevalent sleep-related breathing disorder, impacting an estimated 1.36 billion people worldwide. In the past, OSA was almost exclusively treated with Continuous Positive Airway Pressure (CPAP), however, dynamic assessment of upper airway obstruction with Drug-Induced Sleep Endoscopy (DISE) has been instrumental in developing efficacious alternatives. Drug-Induced Sleep Endoscopy: Diagnostic and Therapeutic Applications by Nico de Vries, Ottavio Piccin, Olivier Vanderveken, and Claudio Vicini is the first textbook on DISE written by world-renowned sleep medicine pioneers"-- Provided by publisher.Digital Access
- Digitaleditors, Patrick M. Malone, Meghan J. Malone, and Sharon K. Park.Contents:
Introduction to the concept of drug information
Formulating an effective response: a structured approach
Drug information resources
Drug literature evaluation I: controlled clinical trial evaluation
Literature evaluation II: beyond the basics
The application of statistical analysis in the biomedical sciences
Pharmacoeconomics
Evidence-based clinical practice guidelines
Journal clubs
Legal aspects of drug information practice
Ethical aspects of drug information practice
Professional communication of drug information
Pharmacy and therapeutics committee
Drug evaluation monographs
Drug shortages and counterfeit drugs
Quality improvement and the medication use system
Medication misadventures I: adverse drug reactions
Medication misadventures II: medication and patient safety
Policy, procedure, and guideline development
Project management
Investigational drugs
Pharmaceutical industry and regulatory affairs
Assessing drug promotions
Drug information in ambulatory care
Drug information and contemporary community pharmacy practice
Pharmacy informatics: enabling safe and efficacious medication use
Drug information education and training
Appendices
Glossary
Answers for case studies
Answers for self-assessment questionsDigital Access AccessPharmacy 2018 - Printthe Mediphor Editorial Group, Division of Clinical Pharmacology, Stanford University School of Medicine ; editor, Richard J. Mangini ; editorial board, Terrence F. Blaschke, Stanley N. Cohen, David S. Tatro.
- PrintVasta, Bruno M.Contents:
v. 1. 1967-1970
v. 2. 1970-1971. - DigitalManjunath P. Pai, Jennifer J. Kiser, Paul O. Gubbins, Keith A. Rodvold, editors.Summary: The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes – “Mechanisms and Models of Drug Interactions” and “Antimicrobial Drug Interactions”. This volume, “Antimicrobial Drug Interactions,” delivers a quick clinical resource that distills relevant drug interactions by antimicrobial drug class. The book provides informative tables on specific drug-drug interactions that include the degree and severity of the expected interaction. A mechanistic basis for drug-drug interactions is also provided to link observed interactions to pharmacologic characteristics of key drug classes. This complete resource is organized by major antibacterial, antimycobacterial, antiviral, antifungal, antimalarial, and antiprotozoal class. In line with current innovations in antimicrobial drug development, a distinct chapter on the pharmacologic management of drug interactions in hepatitis B virus (HBV) and hepatitis C virus (HCV)-related infections is included. Two new chapters are dedicated to the management of human immunodeficiency virus (HIV) drug-drug interactions given the breadth of antiretroviral class-specific effects. This comprehensive review of known drug interactions and strategies to manage them is an invaluable resource to all health care practitioners.
Contents:
Beta-Lactam Antibiotics
Macrolides, Azalides, and Ketolides
Quinolones
Glycopeptides, Lipopeptides, and Lipoglycopeptides
Miscellaneous Antibiotics
Drugs for Tuberculosis
Drug Interactions in HIV: Protease and Integrase Inhibitors
Drug Interactions in HIV: Nucleoside, Nucleotide, and Nonnucleoside Reverse Transcriptase Inhibitors and Entry Inhibitors
Hepatitis B and Hepatitis C Antiviral Agents
Drug Interactions of Non-HIV Antiviral Agents
Antifungal Agents
Antimalarial Agents
Antiprotozoal and Anthelminthic Agents.Digital Access Springer 2018 - Digitaledited by Manjunath P. Pai, Jennifer J. Kiser, Paul O. Gubbins, Keith A. Rodvold.Summary: The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes - "Mechanisms and Models of Drug Interactions" and "Antimicrobial Drug Interactions". This volume, "Mechanisms and Models of Drug Interactions," delivers a text that enhances clinical knowledge of the complex mechanisms, risks, and consequences of drug interactions associated with antimicrobials, infection, and inflammation. The book provides a comprehensive review of basic clinical pharmacology with a focus on metabolism and transporter-mediated drug interactions. The chapters address materials that cannot be retrieved easily in the medical literature, including materials focused on the complex interrelationship of acute infection, inflammation, and the risk of drug interactions in the Drug-Cytokine chapter. The Food-Drug and Herb-Drug interactions chapters remain definitive resources. A new chapter on in vitro modeling of drug interactions is included along with updates on design and data analysis of clinical drug interaction studies. Authoritative discussion of models for regulatory decision-making on drug-drug interactions provides the necessary framework to aid antimicrobial drug development. This concise review of the mechanisms and models of drug interactions provides important insights to health care practitioners as well as scientists in drug development.
Contents:
Introduction to Drug-Drug Interactions
Mechanisms of Drug Interactions I: Absorption, Metabolism, and Excretion
Mechanisms of Drug Interactions II: Transport Proteins
Drug-Food Interactions
Drug-Cytokine Interactions
Interactions between Herbs and Antiinfective Medications
In vitro Modeling of Drug-Drug Interactions
Probe Cocktail Studies
Design and Data Analysis in Drug Interaction Studies. - Digitaledited by Kenneth K.W. To and William C.S. Cho.Summary: "Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy"--Publisher's description.
Contents:
Drug repurposing for cancer therapy--an introduction
A ligand-centric approach to identify potential drugs for repurposing: case study with aurora kinase inhibitors
Machine learning strategies for identifying repurposed drugs for cancer therapy
Unveiling potential anticancer drugs through in silico drug repurposing approaches
Increasing opportunities of drug repurposing for treating breast cancer by the integration of molecular, histological, and systemic approaches
The success story of drug repurposing in breast cancer
A personalized medicine approach to drug repurposing for the treatment of breast cancer molecular subtypes
Successful stories of drug repurposing for cancer therapy in hepatocellular carcinoma
Stories of drug repurposing for pancreatic cancer treatment--Past, present, and future
Animal models and in vivo investigations for drug repurposing in lung cancer
Identification of chemosensitizers by drug repurposing to enhance the efficacy of cancer therapy
Drugs repurposed to potentiate immunotherapy for cancer treatment
Nanoparticle-based formulation for drug repurposing in cancer treatment
Nanotechnological approaches in cancer: the role of celecoxib and disulfiram
Clinical trials on combination of repurposed drugs and anticancer therapies.Digital Access ClinicalKey 2020 - DigitalAlicia Ponte-Sucre, Maritza Padrón-Nieves, editors.Summary: Providing a comprehensive review of the epidemiology and pathology of Leishmania and Leishmaniasis, this book offers a close examination of this parasitic disease and its resistance to drugs, including its molecular basis, consequences and possible treatments.
Contents:
Leishmaniasis : the biology of a parasite
Determinant features in leishmaniasis
Molecular evolution and phylogeny of leishmania
The role of reservoirs : cananie leishmaniasis
Epidemiology of leishmaniasis in the time of drug resistance (the miltefosine era)
The role of the immune system in resistance to infection
Challenges in the diagnosis, treatment and control of leishmaniasis in times of drug resistance
Co-infection with HIV
Visceral leishmaniasis
American tegumentary leishmaniasis
The challenges of effective leishmaniasis treatment
Molecular features of drug resistant leishmania
The role of proteomics in the study of drug resistance
The role of ABC transporters in drug-resistant leishmania
Functional analysis of leishmania membrane (non-ABC) transporters involved in drug resistance
Tools and strategies to circumvent drug resistance in leishmania
Bioinformatics in leishmania drug design
P-glycoprotein-like transportyers in leishmania : a search for reversal agents
The concept of fitness in leishmania. - Digitaledited by Norbert Handler and Helmut Buschmann.Contents:
Introduction. Polypharmacology in Drug Discovery / Oscar Méndez-Lucio, J Jesús Naveja, Hugo Vite-Caritino, Fernando D Prieto-Martínez, José L Medina-Franco
Selectivity of Marketed Drugs. Kinase Inhibitors / Peng Wu, Michael Givskov, Thomas E Nielsen
Repositioning of Drug - New Indications for Marketed Drugs / Ren Kong, Stephen T Wong
Discovery Technologies for Drug Repurposing / Naiem T Issa, Stephen W Byers, Sivanesan Dakshanamurthy
Unselective Drugs in Drug Discovery. Personalized Medicine / Christian Noe, Volker Baumann
Drug Discovery Strategies for the Generation of Multitarget Ligands against Neglected Tropical Diseases / Annachiara Gandini, Federica Prati, Elisa Uliassi, Maria L Bolognesi
Designing Approaches to Multitarget Drugs / Luca Costantino, Daniela Barlocco
The Linker Approach / Daniel Merk, Manfred Schubert-Zsilavecz
Merged Multiple Ligands / Hongming Chen, Udo Bauer, Ola Engkvist
Pharmacophore Generation for Multiple Ligands / Norbert Handler
Cellular Assays / Ye Fang
Therapeutic Areas for Designed Multiple Ligands. Developing Serotonergic Antidepressants Acting on More Than the Serotonin Transporter / Gerard J Marek
Multiple Ligands Targeting the Angiotensin System for Hypertension / Agustin Casimiro-Garcia
Multiple Peroxisome Proliferator-Activated Receptor-Based Ligands / Dmytro Kukhtar, Miquel Mulero, Raul Beltrán-Debón, Cristina Valls, Gerard Pujadas, Santiago Garcia-Vallve
Antibiotics / Jean-Philippe Surivet, Philippe Panchaud
Multiple Ligands in Neurodegenerative Diseases / Julien Lalut, Christophe Rochais, Patrick Dallemagne.Digital Access Wiley 2017 - DigitalSummary: "ASHP's Drug Shortages is the most widely recognized leading source of evidence-based drug shortage information for clinicians, consumers, and health policy leaders."Digital Access STAT!Ref Current yearLimited to 2 simultaneous users
- Digitaledited by Alexandru Mihai Grumezescu.Contents:
1. Treatment strategies in cancer from past to present
2. Nanotechnology-based drug delivery systems: challenges and opportunities
3. Nanotechnology applications in drug controlled release
4. Target-specific delivery: an insight
5. Stimuli-responsive nanosystems for drug-targeted delivery
6. Stimuli sensitive ocular drug delivery systems
7. Stimuli-sensitive nanomaterials for antimicrobial drug delivery
8. Stimuli-responsive micelles: a nanoplatform for therpeutic and diagnostic applications
9. Design of targeting pepetides for nanodrugs for treatment of infectious diseases and cancer
10. Targeting drugs to cell and organ using nanoparticles
11. Extracellular vesicles as a recipe for design smart drug delivery systems for cancer therapy
12. Advancements in exogeneous techniques for stimuli-sensitive delivery systems
13. Ligand-directed tumor targeting with hybrid viral phage nanoparticles
14. Delivering miRNA modulators for cancer treatment
15. Oral controlled and sustained drug delivery systems: concepts, advances, preclinical and clinical status
16. Hydrogels: from simple networks to smart materials- advances and applications
17. Recent advances in understanding of blood-brain tumor barrier (BTB) permeability mechanisms that enable better detectino and treatment of brain tumors
18. Polymeric nanocarriers for site-specific gene therapy
19. Cyclodextrin-based polymeric nanosystems
20. Lipid nanoparticles: in vitro and in vivo approaches in drug delivery and targeting
Index.Digital Access ScienceDirect 2018 - DigitalCarolina Witchmichen Penteado Schmidt, Fabiana Gatti Menezes.Contents:
1. Introduction
2. The main diseases in pediatric oncohematology
3. The main protocols in pediatric oncohematology
4. Background on drug interactions
5. Food
drug interactions
6. Body surface
7. Carboplatin dosage calculation
8. Creatinine clearance estimate.Digital Access Springer 2017 - Print
- DigitalXiaodong Liu, Guoyu Pan, editors.Contents:
Intro; Preface; Contents; Contributors;
Chapter 1: Overview: Role of Drug Transporters in Drug Disposition and Its Clinical Significance; 1.1 General Consideration; 1.2 Physiological Roles of Drug Transporters; 1.3 Roles of Drug Transporters in Inter-organ Communication; References;
Chapter 2: ABC Family Transporters; 2.1 Introduction; 2.1.1 General Properties of ABC Transporters; 2.1.2 Overview of Human ABC Gene Subfamilies; 2.1.2.1 ABCA Family; 2.1.2.2 ABCB Family; 2.1.2.3 ABCC Family; 2.1.2.4 ABCD Family; 2.1.2.5 ABCG Family; 2.2 P-Glycoprotein (P-GP/ABCB1) 2.2.1 General Properties and Distribution of P-GP2.2.2 Substrates and Inhibitors of P-GP; 2.2.3 Physiological and Pharmacological Functions of P-GP; 2.2.3.1 Function of P-GP at Blood-Brain Barrier; 2.2.3.2 Function of P-GP at Fetal-Maternal Barrier Function; 2.2.3.3 Function of P-GP at Hepatobiliary Excretion; 2.2.3.4 Function of P-GP in Restricting Oral Bioavailability of Drugs; 2.2.3.5 P-GP Function in the Kidney; 2.2.3.6 P-GP Function in Immune System; 2.2.4 Pharmacological Significance of P-GP Inhibition; 2.2.5 ABCB1 Polymorphisms and P-GP Expression/Function 2.3 Multidrug Resistance-Associated Proteins (MRPs/ABCCs)2.3.1 Multidrug Resistance-Associated Protein 1 (MRP1/ABCC1); 2.3.1.1 General Properties and Distribution of MRP1; 2.3.1.2 Substrates and Inhibitors of MRP1; 2.3.1.3 Pharmacological Functions of MRP1; 2.3.2 Multidrug Resistance Protein 2 (MRP2/ABCC2); 2.3.2.1 General Properties and Distribution of MRP2; 2.3.2.2 Substrates and Inhibitors of MRP2; 2.3.2.3 Pharmacological and Toxicological Functions of MRP2; 2.3.3 Multidrug Resistance Protein 3 (MRP3/ABCC3); 2.3.3.1 General Properties of MRP3 2.3.3.2 Pharmacological and Physiological Functions of MRP32.3.4 Multidrug Resistance Protein 4 (MRP4/ABCC4); 2.3.4.1 General Properties of MRP4; 2.3.4.2 Pharmacological and Physiological Function of MRP4; 2.3.5 Other Multidrug Resistance Proteins; 2.3.5.1 Multidrug Resistance Protein 5 (MRP5); 2.3.5.2 Multidrug Resistance Protein 6 (MRP6/ABCC6); 2.3.5.3 Multidrug Resistance Protein 7 (MRP7/ABCC10); 2.3.5.4 Multidrug Resistance Protein 8 (MRP8/ABCC11); 2.4 Breast Cancer Resistance Protein (BCRP/ABCG2); 2.4.1 General Properties and Distribution of BCRP; 2.4.2 Substrates and Inhibitors of BCRP 2.4.3 Pharmacological and Physiological Functions of BCRP2.4.3.1 Roles of BCRP in Disposition and Toxicity/Efficacy of Drugs; 2.4.3.2 BCRP and Side Population; 2.4.3.3 BCRP and Alzheimerś Disease; 2.4.3.4 BCRP and Hyperuricemia; 2.4.3.5 BCRP and Cancer; 2.5 ABC Genes and Human Genetic Disease; 2.5.1 Cystic Fibrosis and CFTR; 2.5.2 Adrenoleukodystrophy; 2.5.3 Sulfonylurea Receptor; 2.5.4 Bile Salt Transport Disorders; 2.5.5 Retinal Degeneration and ABCA4; 2.5.6 Mitochondrial Iron Homeostasis; 2.5.7 Sterol Transport Deficiencies; References;
Chapter 3: SLC Family Transporters 3.1 General IntroductionDigital Access Springer 2019 - Digitaleditors, Monique Elseviers, Björn Wettermark, Anna Birna Almarsdóttir, Morten Andersen, Ria Benko, Marion Bennie, Irene Eriksson, Brian Godman, Janet Krska, Elisabetta Poluzzi, Katja Taxis, Vera Vlahović-Palčevski, Robert Vander Stichele.Digital Access Wiley 2016
- DigitalYasuyuki Kihara, editor.Summary: This edited work presents a series of reviews focusing on Druggable Lipid Signaling Pathways. It enables researchers in both academic institutions and industry as well as physicians to understand historical aspects of lipid signaling and future directions of drug discovery targeting lipid signaling pathways. This book provides 9 pathways including acyltransferases, prostanoids, leukotrienes, epoxy fatty acids, sphingolipids, lysophospholipids, endocannabinoids, phosphoinositides, and lipid GPCRs. Readers will discover the importance of each lipid signaling pathway that contributes to broad range of diseases including neurological and neuropsychiatric diseases, pain, metabolic syndromes, cardiovascular diseases, cancer, dermatological diseases, fibrosis, inflammation, etc. Also, readers will recognize that many drugs targeting lipid signaling have been clinically used. Drugs currently under development are also discussed in each chapter, which includes some information about clinical trials and strategic drug designs.
Contents:
Preface
Introduction of Druggable Lipid Signaling Pathway
Biosynthetic Enzymes of Membrane Glycerophospholipid Diversity as Therapeutic Targets for Drug Development
Druggable Prostanoid Pathway
Targeting Leukotrienes as a Therapeutic Strategy to Prevent Comorbidities Associated with Metabolic Stress
Epoxy Fatty Acids are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation
Druggable Sphingolipid Pathway
Druggable Lysophospholipid Pathway
Druggable targets in endocannabinoid signaling
Drugging the phosphoinositide 3-kinase (PI3K) and phosphatidylinositol 4-kinase (PI4K) family of enzymes for treatment of cancer, immune disorders, and viral/parasitic infections
Druggable Lipid GPCRs: Past, Present, and Prospects. - Digital/PrintPrepared for the National Advisory Heart Council by May Sherman.Contents: <br/
>1. Anticholesteremic, anticoagulant, cholesteremic, fibrinolytic, hemoplastic, and vasoactive agents.-
-2. Cause and cure of hypertension; drugs and the kidney.-
-3. Cause and cure of heart failure and shock.Digital Access - DigitalMuyassar Turaeva.Summary: The book outlines post-Soviet style of health management in Central Asia. Regional studies on Central Asia to date have focused on states, politics, religion and inter-ethnic relations but not on the health system within the region. Soviet-style policies have also covered only other aspects relevant for the region. This book highlights the public health situation of the region with a focus on drug abuse, HIV/AIDS in the context of increased mobility, and drug trafficking routes which became even more porous after the break-up of the Soviet Union. Based on a qualitative study, the empirical data in the book was collected during long-term fieldwork conducted in Uzbekistan and Turkmenistan in 2010-2011 as well as shorter stays in Uzbekistan between 2012-2016. The analysis of the empirical material largely draws on the works of Foucault, particularly his concept of biopolitics when analyzing Soviet-style health management that is still practiced in the region. Applying the Foucauldian genealogical method, this study has been structured to trace the genealogy of epidemics to understand the historical path of drug abuse in the region as well as the discursive genealogy of drug politics and drug abuse. Applying the same genealogical method of Foucault, the formative and discursive trajectory of the institution of Uchyot was traced to contextualize the health governance methods that have historical legacy of Soviet-style governance and control of the total population. Drugs and Public Health in Post-Soviet Central Asia: Soviet-Style Health Management is a unique resource for academic specialists, practitioners/professionals, and advanced undergraduate and graduate students in public health, as well as a range of scholars and professionals in sociology, political science, anthropology, and anyone with an interest in the Central Asia region, drug addiction, or HIV. The book also could appeal to international donors in the field of HIV/drug addiction who are working in the region.
Contents:
Chapter 1. Introduction
Chapter 2. Genealogy of Drug Abuse and HIV Infection in Central Asia
Chapter 3. Biopolitics of Foucault in Post-Soviet Central Asia
Chapter 4. Individual Concerns of Drug Users and Drug Consumption Patterns Among the Research Participants
Chapter 5. Socially and Culturally Embedded Drug Abuse
Chapter 6. HIV-positive Drug Users: Concerns and Problems
Chapter 7. Lessons Learned and Recommendations
Index. - DigitalTelmo Mota Ronzani, editor.Summary: This book goes beyond the traditional approaches to drug use and discusses the issue from a societal perspective, integrating contributions from different disciplines such as psychology, public health, anthropology, law, public policies and sociology to address specifically the social aspects of the phenomenon. Given its complexity, drug use demands a multidisciplinary approach from many different perspectives, but despite the vast literature about the topic, the majority of the books are restricted either to a purely medical perspective (focused mainly on treatment techniques) or to a criminological perspective (focused mainly on drug trafficking and organized crime). The social approach adopted in this volume challenges this dichotomy and analyzes both the social contexts to which drug use is related and the social and political consequences of the attitudes and policies adopted by governments and other social groups towards drug users, addressing topics such as: Drugs and poverty Drugs and gender Drugs and race Drugs and territory Stigmatization of drug use Prohibitionism Given its broad and innovative approach, Drugs and Social Context - Social Perspectives on the Use of Alcohol and Other Drugs will be of interest for researchers, clinicians and other health professionals, since the study of the social aspects of drug use is central to everyone who deals with the issue.
Contents:
Section 1. Drugs and Society
Chapter 1.The context of drug use in the consumer society
Chapter 2. The stigmatization of drug use as mechanism of legitimation of exclusion
Chapter 3. Social Effects of Prohibitionism in the Americas and New Drug Policies
Section 2. Social Issues
Chapter 4.Drugs and Poverty: interfaces of oppression in the capitalist world
Chapter 5.Drugs and Gender
Chapter 6. Drugs and Race
Chapter 7. (Des)Occupation of urban and rural spaces, gentrification and drug use. - DigitalBengt Källén.Contents:
Introduction
The alert clinician
Animal experiments and adverse drug reaction reports
Some epidemiological principles
Pregnancy outcomes with the exception of congenital malformations
Congenital malformations
Identification of maternal use of drugs
The problem of confounding
Statistics
Lumping or splitting? Paternal use of drugs
Timing of drug use and effects on the embryo or fetus
Repeated studies and meta-analysis
Pharmacovigilance
Information on the risk with drug use during pregnancy
Concluding remarks.Digital Access Springer 2016 - Digitaledited by Christof Schaefer, Paul Peters, and Richard K. Miller.Digital Access ClinicalKey 2015
- DigitalCarl P. Weiner, Clifford Mason.Summary: "Comprehensive and easy to use, Drugs for Pregnant and Lactating Women, 3rd Edition, remains your #1 resource for reliable information on virtually all of today's drugs and herbal supplements and how they interact with pregnancy and lactation. This logically organized reference has been frequently emulated, but not duplicated. The 3rd Edition has been thoroughly updated to keep you current with new drugs, changes in FDA labeling, and more in-depth information on interactions. Designed for ease of use in the clinical setting, it provides the key drug information needed by physicians, nurses, physician assistants, and others involved in the care of pregnant and lactating women"--Publisher's description.Digital Access ClinicalKey 2019
- DigitalGerald G. Briggs, Roger K. Freeman, Craig V. Towers.Summary: Put essential information at your fingertips -- before you prescribe. The updated 11th edition of Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk lists more than 1,200 commonly prescribed drugs taken during pregnancy and lactation, with detailed monographs that provide the information you need on known or possible effects on the mother, embryo, fetus, and nursing infant. For the 11th edition, this bestselling reference has two new authors, both highly knowledgeable on the effects of drugs on the embryo-fetus and nursing infant: Craig V. Towers, a maternal-fetal medicine specialist, and Alicia B. Forinash, a clinical pharmacologist specialist in obstetrics. -- Provided by publisher.Digital Access
- DigitalXavier Bosch, Manuel Ramos-Casals, Munther A. Khamashta, editors.Digital Access Springer 2014
- DigitalColin Chan, editor.Summary: This handbook is a concise, easy-to-read, practical guide that conveys the core knowledge necessary to diagnose, classify, grade, and manage dry eye disease effectively and efficiently. A series of succinct, informative chapters cover the following key topics: definition and classification, epidemiology, office-based screening and diagnostics, artificial tears, medical management, surgical management, and future directions. Current guidelines, published studies, and the personal experience of internationally recognized dry eye experts are distilled into practical tips that will be of value during daily clinical routine. Highlighted boxes are included to emphasize the most important points or clinical pearls, and tables and flow charts will further assist the eye care practitioner in using the book as a quick reference. The closing chapter presents case examples that build upon the instruction provided earlier in the book by illustrating the optimal approach to diverse scenarios that may be encountered in the clinic.
Contents:
Introduction
Definition and classification of dry eye
Epidemiology of dry eye
How to choose the right artificial tear
Practical office based screening and diagnostics
Medical management of dry eye
Procedural / surgical management of dry eye
Case studies
Future directions and research. - DigitalPaolo D'Odorico, Amilcare Porporato, Christiane Wilkinson Runyan, editors.Summary: By combining the analysis of biotic and abiotic components of terrestrial ecosystems, this book synthesizes material on arid and semiarid landscapes, which was previously scattered among various books and journal articles. It focuses on water-limited ecosystems, which are highly sensitive to fluctuations in hydrologic conditions and, in turn, play an important role in affecting the regional water cycle. Intended as a tool for scientists working in the area of the earth and environmental sciences, this book presents the basic principles of eco-hydrology as well as a broad spectrum of topics and advances in this research field. Written by authors with diverse areas of expertise who work in arid areas around the world, the contributions describe the various interactions between the biological and physical dynamics in dryland ecosystems, ranging from basic processes in the soil-vegetation-climate system, to landscape-scale hydrologic and geomorphic processes, ecohydrologic controls on soil nutrient dynamics, and multiscale analyses of disturbances and patterns.
Contents:
Chapter 1. Introduction
SECTION 1: FUNDAMENTAL PROCESSES AND INTERACTIONS IN THE SOIL-CLIMATE-VEGETATION SYSTEM
Chapter 2. Soil Moisture Dynamics in Water-Limited Ecosystems
Chapter3. Soil physical properties and associated soil-root interactions
Chapter 4. Ecophysiology of plants in dry environments
Chapter 5. Ecohydrology of Photosynthesis
Chapter 6. Ecohydrological controls on the deposition of non-rainfall water, N and P to dryland ecosystems
Interactions and feedbacks between climate and dryland vegetations
SECTION 2: HYDROGEOMORPHOLOGY AND LANDFORMS OF ARID AND SEMIARID LANDSCAPES
Chapter 8. The history and evolution of desert hydrology and landforms: The role of climate change
Chapter 9. Ecohydrological implications of aeolian processes in drylands
Chapter 10. Hydrological and geomorphological significance of riparian vegetation in drylands
SECTION 3: ECOHYDROLOGIC CONTROLS on NUTRIENT CYCLING and DISTURBANCES
Chapter 11. Ecohydrological and stoichiometric controls on soil carbon and nitrogen dynamics in drylands
Chapter 12. Modeling of Phosphorus Dynamics in Dryland Ecosystems
Chapter 13. Microbial nitric oxide, nitrous oxide and nitrous acid emissions from drylands
Chapter 14. Fire regimes in dryland landscapes
Chapter 15. Termites as mediators of the water economy of arid savanna ecosystems
SECTION 4: ECOHYDROLOGY OF A VARIETY OF DRYLAND ECOSYSTEMS
Chapter 16. Interactions of water and nitrogen on primary productivity across spatial and temporal scales in grassland and shrubland ecosystems
Chapter 17. Deforestation, water availability, and nutrient cycling in dry forests
Chapter 18. Vegetation pattern formation in drylands
Chapter 19. Ecohydrology of agroecosystems
Interactions between local and global processes
Chapter 20. Ecohydrology of urban ecosystems
Chapter 21. Desertification and land degradation. - Digitaledited by Roberto Lewis-Fernández, Neil Krishan Aggarwal, Ladson Hinton, Devon E. Hinton, Laurence J. Kirmayer.Contents:
Machine generated contents note: 1. Cultural Formulation Before DSM-5 / Laurence J. Kirmayer
2. The Core and Informant Cultural Formulation Interviews in DSM-5 / Roberto Lewis-Fernandez
3. Supplementary Modules
Overview / Ladson Hinton
Supplementary Module 1 Explanatory Model / Mitchell G. Weiss
Supplementary Module 2 Level of Functioning / Sofie Baarnhielm
Supplementary Module 3 Social Network / Ladson Hinton
Supplementary Module 4 Psychosocial Stressors / Ladson Hinton
Supplementary Module 5 Spirituality, Religion, and Moral Traditions / Francis G. Lu
Supplementary Module 6 Cultural Identity / Neil Krishan Aggarwal
Aspects of Cultural Identity Related to National, Ethnic, and Racial Background; Language; and Migration / Sushrut Jadhav
Aspects of Cultural Identity Related to Spirituality, Religion, and Moral Traditions / Francis G. Lu
Aspects of Cultural Identity Related to Gender Identity and Sexual Orientation Identity / Mark L. Hatzenbuehler
Supplementary Module 7 Coping and Help Seeking / Devon E. Hinton
Supplementary Module 8 Patient-Clinician Relationship / Sofie Baarnhielm
Supplementary Module 9 School-Age Children and Adolescents / Jaswant Guzder
Supplementary Module 10 Older Adults / Ladson Hinton
Supplementary Module 11 Immigrants and Refugees / Monica Scalco
Supplementary Module 12 Caregivers / Iqbal Ahmed
4. Clinical Implementation of the Cultural Formulation Interview
Planning and Assessment / Neil Krishan Aggarwal
Use of the Cultural Formulation Interview in Different Clinical Settings / Lizardo Cruzado
Administrative Perspectives on the Implementation and Use of the Cultural Formulation Interview / Angela Tang Soriano
Application of the Cultural Formulation Interview in International Settings / Smita Neelkanth Deshpande
5. Cultural Competence in Psychiatric Education Using the Cultural Formulation Interview / Hendry Ton
6. Conclusion: The Future of Cultural Formulation / Laurence J. Kirmayer.Digital Access PsychiatryOnline 2016 - DigitalSophia Wang, M.D., Abraham M. Nussbaum, M.D., FAPA.Contents:
Addressing behavioral and mental problems in community settings
The diagnostic DS : the building blocks to diagnosing mental health disorders in older adults
Beyond the diagnostic DS : other common clinical challenges
The 15-minute older adult diagnostic interview
The 30-minute older adult diagnostic interview
The DSM-5 older adult diagnostic interview
A brief version of DSM-5
A stepwise approach to differential diagnosis
The mental status examination : a psychiatric glossary
Selected DSM-5 assessment measures
Rating scales and alternative diagnostic systems
Psychoeducational interventions
Psychosocial interventions
Psychotherapeutic interventions
Psychopharmacological interventions
Brain stimulation interventions
Mental health treatment planning
Concluding counsel.Digital Access PsychiatryOnline 2017 - Digital/Printedited by John W. Barnhill.Contents:
Neurodevelopmental disorders
Schizophrenia spectrum and other psychotic disorders
Bipolar and related disorders
Depressive disorders
Anxiety disorders
Obsessive-compulsive and related disorders
Trauma- and stressor-related disorders
Dissociative disorders
Somatic symptom and related disorders
Feeding and eating disorders
Elimination disorders
Sleep-wake disorders
Sexual dysfunctions
Gender dysphoria
Disruptive, impulse-control, and conduct disorders
Substance-related and addictive disorders
Neurocognitive disorders
Personality disorders
Paraphilic disorders.Digital Access PsychiatryOnline 2014 - Digital/PrintMichael B. First.Contents:
Part I. Differential diagnosis step by step
Part II. Differential diagnosis by the trees
Part III. Differential diagnosis by the tables
Neurodevelopmental disorders
Schizophrenia spectrum and other psychotic disorders
Bipolar and related disorders
Depressive disorders
Anxiety disorders
Obsessive-compulsive and related disorders
Trauma- and Stressor-related disorders
Dissociative disorders
Somatic symptom and related disorders
Feeding and eating disorders
Sleep-wake disorders
Sexual dysfunctions
Gender dysphoria
Disruptive, impulse-control, and conduct disorders
Substance-related and addictive disorders
Neurocognitive disorders
Personality disorders
Paraphilic disorders.Digital Access PsychiatryOnline 2014Print - Digitalby Robert J. Hilt, Abraham M. Nussbaum.Contents:
Addressing behavioral and mental problems in community settings
Common clinical concerns
The 15-minute pediatric diagnostic interview
The 30-minute pediatric diagnostic interview
DSM-5 pediatric interview
A brief version of DSM-5
A stepwise approach to differential diagnosis
The mental state examination : a psychiatric glossary
Selected DSM-5 assessment measures
Rating scales and alternative diagnostic systems
Developmental milestones
Mental health treatment planning
Psychosocial interventions
Psychotherapeutic interventions
Psychopharmacology
Ideas for practice, education, and research.Digital Access PsychiatryOnline 2016 - Digitaledited by John W. Barnhill.Summary: "DSM-5-TR Clinical Cases clarifies and discusses psychiatric diagnosis with a particular focus on how diagnoses have evolved from DSM-5. Designed for teachers, students, and clinicians, this book presents a broad range of patient vignettes that cover the diagnostic waterfront. Each of the 104 cases is followed by a discussion by an expert clinician, who describes an approach to diagnosis through an exploration of psychiatric and personal history, symptom clusters, laboratory tests, and clinical ambiguities. The discussants also address the important ways in which diagnosis might be affected by such demographic issues as ethnicity, sexual orientation, and gender identity. Anyone interested in understanding the interface between disorder classification and patient diagnosis will find DSM-5-TR Clinical Cases compelling, captivating, and enlightening"-- Provided by publisher.
Contents:
Neurodevelopmental Disorders
Schizophrenia Spectrum and Other Psychotic Disorders
Bipolar and Related Disorders
Depressive Disorders
Anxiety Disorders
Obsessive-Compulsive and Related Disorders
Trauma- and Stressor-Related Disorders
Dissociative Disorders
Somatic Symptom and Related Disorders
Feeding and Eating Disorders
Elimination Disorders
Sleep-Wake Disorders
Sexual Dysfunctions
Gender Dysphoria
Disruptive, Impulse-Control, and Conduct Disorders
Substance-Related and Addictive Disorders
Neurocognitive Disorders
Personality Disorders
Paraphilic Disorders.Digital Access PsychiatryOnline 2023 - Printedited by Thomas A. Widiger ... [et al.].
- DigitalPatricia M. Carrascosa, Ricardo C. Cury, Mario J. García, Jonathon A. Leipsic, editors.Summary: This book focuses on the rapidly developing and promising novel applications of Dual Energy CT (DECT) in cardiovascular medicine. Although developed many years ago, DECT represents the newest significant advancement in the field of computed tomography, the clinical utility of which has recently expanded as many new applications have been developed. In the field of cardiovascular medicine, DECT has been applied for purposes such as the evaluation of myocardial ischemia, myocardial viability and atherosclerotic plaque characterization. As the first book of its kind, Dual-Energy CT in Cardiovascular Imaging contains practical and clinically relevant information on the protocols used that provide precise quantification of coronary artery stenosis using either different monochromatic levels or material decomposition, reduction of beam hardening artifacts in perfusion studies and optimizing endovenous contrast, among others. It is therefore a valuable read for residents, fellows and practicing clinicians in cardiac imaging and cardiology.
Contents:
Introduction to DECT
Technical aspects of DECT with dual source
Technical aspects of DECT with dual layer
Gemstone Imaging
Neurovascular Imaging
Neck imaging
Thoracic imaging
Abdominal imaging
Upper and lower limbs imaging
Technical Advancements for Cardiac Imaging
Plaque characterization
Accuracy of DECT in coronary arteries
Beam Hardening Reduction and Image Quality Improvements with DECT
Myocardial CT perfusion
Myocardial viability
Pitfalls
Limitations
Management of radiation
Future. - DigitalCarlo N. De Cecco, Andrea Laghi, U. Joseph Schoepf, Felix G. Meinel, editors.Summary: The aim of this book is fourfold: to describe the basic principles of Dual Energy CT (DECT) imaging, to explain how post-processing is utilized, to critically appraise the strengths and weaknesses of the technique in oncologic imaging, and above all, to demonstrate the contribution of DECT in the management of oncologic patients. Information is provided on the practice and interpretation of DECT and its impact on clinical decision making in a variety of oncological settings, including tumors of the head and neck, lung, liver, pancreas, gastrointestinal system, kidney, and musculoskeletal system. DECT is an innovative imaging technique in which the application of two distinct energy settings provides a transition from density-based image to spectral imaging. As detailed in this book, DECT acquisition allows the simultaneous generation of multiple datasets which enable the radiologist to address varied diagnostic problems in oncologic imaging using a multiparametric approach, having clear advantages in tumor detection, lesion characterization and evaluation of treatment response.
Contents:
Dual Energy CT: Basic Principles
Dual Energy CT: Post-Processing and Image Analysis Strategies in Oncologic Imaging
Dual Energy CT of Head and Neck Tumors
Dual Energy CT of Lung Tumors
Dual Energy CT of Liver Tumors
Dual Energy CT of Pancreatic Tumors
Dual Energy CT of Gastrointestinal Tumors
Dual Energy CT of Genitourinary Tumors
Dual Energy CT of Musculoskeletal Tumors.Digital Access Springer 2015 - Digitaleditors, Daniel J. Wallace, Bevra Hannahs Hahn ; associate editors, Mary K. Crow [and five others].Summary: "For more than 50 years, Dubois’ Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It’s an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes"--Publisher's description.
Contents:
History of lupus
Definition and classification of lupus and lupus-related disorders
The epidemiology of lupus
Overview of lupus pathogenesis
Genetics of human SLE
Epigenetics of lupus
The environment and the host
The innate immune system in SLE
B cells and generation of antibodies
T cells
Adaptive and innate immunoregulatory cells
Cytokines in lupus
Immunometabolism
Animal models in lupus
Abnormalities in immune complex clearance and apoptotic cell clearance
The role of complement in SLE
Apoptosis and inflammatory forms of cell death
Tissue damage in lupus : free radicals and fibrosis
Pathogenesis of fibrosis—the lung as a model
Pathogenesis of lupus nephritis
Pathogenesis of accelerated atherosclerosis and vascular injury in systemic lupus erythematosus
Pathogenesis of cutaneous lupus
Pathogenesis of neuropsychiatric lupus
Pathogenesis of antiphospholipid antibody syndrome
Pathogenesis of Sjögren's
Structure and derivation of autoantibodies
Antinuclear antibodies, antibodies to DNA, histones, and nucleosomes
Antibodies against ENA (SM, RNP, SSA, SSB)
Antibodies against C1q
Antilipoprotein and antiendothelial cell antibodies
Drug-induced lupus erythematosus
Overview and clinical presentation
Skin disease in cutaneous lupus erythematosus
The musculoskeletal system and bone metabolism
Lupus and the cardiopulmonary system
Lupus and the nervous system : clinical aspects, psychopathology, and imaging
Gastrointestinal and hepatic systems
Hematologic and lymphoid abnormalities in SLE
Neonatal lupus : pathogenesis and clinical approaches
Pregnancy and autoimmune disease, reproductive and hormonal issues
Systemic lupus erythematosus in childhood and adolescence
Clinical aspects of antiphospholipid syndrome
Lupus and infections
Ocular, aural, and oral manifestations of lupus
Clinical aspects of Sjögren's
Clinical application of serologic tests, serum protein abnormalities, and other clinical laboratory tests in systemic lupus erythematosus
Differential diagnosis and disease associations
Incomplete lupus, undifferentiated connective tissue disease, and mixed connective tissue disease
Clinical markers, metrics, indices, and clinical trials
Lupus biomarkers
Principles of therapy, local measures, and NSAIDs
Antimalarial medications
Systemic glucocorticoid therapy for SLE
Immunosuppressive drug therapy
Complementary and alternative medications, specialized and niche therapies
Adjunctive treatments and preventive measures
Targeted therapies in SLE
Management of cutaneous lupus erythematosus
Epidemiology and management of lupus nephritis
Management of Sjögren's
Socioeconomic and disability aspects
Prognosis and mortality of SLE.Digital Access ClinicalKey 2019 - DigitalXuan Hieu Cao, Paul Fourounjian, Wenqin Wang, editors.Summary: This book tells the story behind the first Spirodela genome sequencing project. Further, it describes the current genomics applications of these findings, and efforts to sequence new genomes within the family. The closing chapters address the sequencing of the over 1 Gigabase Wolffia genomes, which could have major impacts on genome evolution and agricultural research. The duckweed or Lemnaceae family is a collection of 5 genera and 37 species of the smallest, fastest-growing flowering plants. Many of these aquatic monocotyledonous plants can grow all over the world, in a variety of climates. Given their simplified and neotenous morphology, duckweeds have been researched for several decades as a model species for plant physiology and ecotoxicological research, contributing to our understanding e.g. of flowering response, plant circadian systems, sulfur assimilation pathways and auxin biosynthesis. In addition, duckweed-based treatment has been a favorite and feasible means, especially in developing countries, of removing phosphorus and pharmaceutical chemicals from sewage and wastewater. With a dry annual mass yield per hectare of up to 80 tonnes (equivalent to 10 tonnes of protein), duckweed is also a promising aquatic crop in new modern and sustainable agriculture. Besides being an excellent primary or supplemental feedstock for the production of livestock and fish, duckweed biomass can be utilized as a potential resource for human nutrition, biofuel, or bioplastics, depending on water quality as well as protein or starch accumulating procedures. These academic and commercial interests have led to international efforts to sequence the Spirodela polyrhiza genome, the smallest and most ancient genome in the family.
Contents:
Importance of duckweeds in basic research and its industrial applications
Background history of the international Spirodela genome sequencing initiatives
Cytogenetics and karyotype evolution of duckweeds
Duckweed organelle genomes
Repetitive sequences: Impacts and uses in the Spirodela genome
Genotyping by sequencing of duckweeds
Genome and transcriptome of Landoltia punctata
Transcriptome responses of Spirodela polyrhiza
Strategies & tools for sequencing duckweeds
Transformation development in duckweeds.Digital Access Springer 2020 - DigitalLisa A. Newman, Jessica M. Bensenhaver, editors.Summary: This volume reviews the evolution of information regarding the epidemiology of DCIS and its modes of detection, as well as treatment options as a function of both clinical trial data and ongoing investigational therapeutic prospects. Several of the challenging and clinically-relevant scenarios of DCIS that appear in daily practice is discussed, including the difficulties of distinguishing "true" DCIS from borderline patterns of other breast diseases and the therapeutic implications of differentiating these various diagnoses. Particular attention is paid to pathologic evaluation of DCIS, including histologic patterns and the importance of margin evaluation/margin control. The text also explores the data regarding DCIS in medical research in hereditary susceptibility for breast cancer and race/ethnicity-associated disparities in breast cancer. Written by experts in the field, Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer is a comprehensive, state-of-the art review of the field, and serves as a valuable resource for clinicians, surgeons and researchers with an interest in breast cancer.
Contents:
Epidemiology of Ductal Carcinoma In Situ
Role of Screening Mammography in Early Detection/Outcome from Breast Cancer
Imaging DCIS: Digital/Film Screening Mammography, Tomosynthesis, MRI, Ultrasonography
Pathology of Ductal Carcinoma In Situ: Features and Diagnostic Challenges
Molecular Markers in DCIS
History of Ductal Carcinoma In Situ Management Based Upon Data from Prospective, Randomized Clinical Trials
Extent and Role of Margin Control for DCIS Managed by Breast-Conserving Surgery
Ductal Carcinoma In Situ Treated With Breast Conserving Surgery Alone
DCIS Managed with BCS: Whole-Breast XRT vs. Partial Breast XRT
Anti-HER2/neu Therapy in DCIS
Role of Genetic Profiling and Recurrence Scores in Treatment Planning for DCIS
DCIS and Sentinel Lymph Node Biopsy
Role of Postmastectomy Radiation for DCIS
Monitoring and Surveillance Following DCIS Treatment
DCIS and Hereditary Susceptibility for Breast Cancer
Introduction, Evolution and Application of the Van Nuys Prognostic Index in DCIS
Disparities in DCIS Detection and Outcomes Related to Race/Ethnicity.Digital Access Springer 2015 - DigitalJeffrey R. Marcus, Anna R. Carlson.Summary: Contains 27 videos and 36 illustrations with extensive accompanying text.Digital Access Thieme MedOne Plastic Surgery 2022
- Digital[edited by] Preeya K. Gupta, Nandini Venkateswaran.Summary: "Concise, authoritative, and easy to navigate, The Duke Manual of Corneal and Cataract Surgery offers a step-by-step, highly illustrated approach to the most commonly performed procedures in corneal and cataract surgery. Ideal for cornea and cataract specialists, ophthalmic surgeons, residents, and fellows, it contains practical guidance from Drs. Nandini Venkateswaran and Preeya K. Gupta, as well as other experts at Duke University, making it an unparalleled "how-to" manual for the wide variety of cases and operative scenarios you may encounter. Offers a step-by-step outline for each surgical procedure, from preoperative considerations through postoperative care, including numerous surgical pearls. Contains dozen of full-color photographs and illustrations that clearly depict techniques and other essential aspects of corneal and cataract surgery. Covers surgery basics, gas and liquid surgical aides, pediatrics, and management of challenging surgical scenarios"-- Provided by publisher.Digital Access LWW Health Library 2022
- Digital[edited by] Divakar Gupta, Leon W. Herndon, Jr., Kelly W. Muir.Summary: "Concise, authoritative, and easy to navigate, The Duke Manual of Glaucoma Surgery offers a step-by-step, highly illustrated approach to the most commonly performed glaucoma surgeries and procedures. Ideal for glaucoma specialists, ophthalmic surgeons, residents, and fellows, it contains practical guidance from Drs. Divakar Gupta, Leon Herndon, Kelly Muir, as well as other experts at Duke University, making it an unparalleled "how-to" manual for the wide variety of cases and operative scenarios you may encounter. Offers a step-by-step outline for each surgical procedure, from preoperative considerations through postoperative care, including numerous surgical pearls. Contains 200 full-color photographs and illustrations that clearly depict techniques and other essential aspects of glaucoma surgery. Covers surgery basics, pediatrics, and management of challenging surgical scenarios. Provides access, via the eBook, to surgical videos from the Duke archive"--Publisher's description.
Contents:
Section 1: Just the basics. Preoperative discussion
Setting up for surgery
Section 2: Trabeculectomy. Preoperative considerations for trabeculectomy
Different ways to administer antimetabolites
Limbal versus fornix conjunctival flap
Steps of a trabeculectomy
Scleral flap and sclerostomy construction
Ex-press shunt implantation with mitomycin C
Releasable sutures
Conjunctival closures
Postoperative medications and manipulations for trabeculectomy
Section 3: Tube shunts. Preoperative planning and considerations for tube shunts
Types of shunts, tube ligation, patch materials
Ahmed valved tube shunt
Nonvalved tube shunt
Tube placement locations
Special cases: neovascular and uveitic glaucoma
Special cases: prior scleral buckle
Postoperative medications and manipulations for tube shunts
Section 4: Angle-based surgery. Preoperative considerations for angle-based surgery
Intraoperative gonioscopy
Trabecular meshwork stents
Ab interno trabeculotomy: trabectome
Goniotomy with the Kahook dual blade
Ab interno trabeculotomy and viscocanaloplasty
Goniosynechialysis
Postoperative medications and considerations for angle-based surgery
Section 5: Subconjunctival bypass. Preoperative considerations for xen implantation
Xen ab interno implantation
Xen ab externo implantation
Postoperative considerations for xen implantation
Section 6: Cycloblative laser. Preoperative planning and considerations for cyclophotocoagulation
Endocyclophotocoagulation
Transscleral diode cyclophotocoagulation
Micropulse cyclophotocoagulation
Section 7: Cataract and lens surgery in the glaucoma patient. Preoperative planning for cataract and lens surgery in the glaucoma patient
Considerations for combined cataract and glaucoma surgery
Special cases: angle closure
Special cases: nanophthalmos
Special cases: exfoliation syndrome
Clinical evaluation and surgical management of subluxed and dislocated intraocular lens implant
Secondary Iol placement: sulcus, sutured, aciol
Section 8: Trabeculectomy revisions. Preoperative considerations for trabeculectomy revisions
Excision and pull down
Conjunctival autograft
Transconjunctival suturing
Bleb compression sutures
Revisions for bleb dysesthesia
Section 9: Tube shunt revisions. Preoperative planning and considerations for tube shunt revisions
Tube shunt revision for exposure
Tube shunt repositioning
Tube extender
Tube shunt revision for hypotony
Section 10: Challenging surgical cases. Management of intraoperative malignant glaucoma
Management of hemorrhagic choroidals
Scleral windows in nanophthalmos
Drainage of serous choroidals
Cyclodialysis cleft repair
Section 11: Clinic lasers. Selective laser trabeculoplasty
Peripheral iridotomy
Iridoplasty.Digital Access LWW Health Library 2022 - DigitalLaura B. Enyedi, MD, Nandini Gandhi, MD, Tammy L. Yanovitch, MD, MHSc.Digital Access LWW Health Library 2021
- Digital[edited by] Sharon Fekrat ; associate editors Avni Patel Finn, Akshay S. Thomas ; illustrations by Xi Chen.Summary: "Concise, authoritative, and easy to navigate, The Duke Manual of Vitreoretinal Surgery offers a step-by-step, highly illustrated approach to the most commonly performed vitreoretinal operating room procedures. Ideal for vitreoretinal surgeons, ophthalmology residents, retina fellows, and OR nurses and scrub techs, it contains practical guidance from the highly esteemed vitreoretinal surgery fellowship program at Duke University making it an unparalleled “how-to” manual for the wide variety of cases and operative scenarios you may encounter"-- Provided by publisher.
Contents:
Section I. Just the basics
section II. Pars plana vitrectomy
section III. Vitreoretinal surgical adjuncts
section IV. Exchanges
section V. Rhegmatogenous retinal detachment
section VI. Macular surgery
section VII. Lensectomy and secondary iol placement
section VIII. Diabetic vitrectomy
section IX. Pediatric vitreoretinal surgery
section X. Vitreoretinal surgery for tumors and uveitis
section XI. Challenging vitreoretinal surgical scenarios.Digital Access - Digitaledited by Mina K. Dulcan.Summary: "Dulcan's Textbook of Child and Adolescent Psychiatry provides in-depth, DSM-5-aligned evidence-based clinical guidance in such areas as neurodevelopmental and other psychiatric disorders; psychosocial treatments; pediatric psychopharmacology; and special topics, including cultural considerations, youth suicide, legal and ethical issues, and gender and sexual diversity. This third edition includes expanded information on telehealth, e-mental health, and pediatric consultation-liaison psychiatry"-- Provided by publisher.Digital Access PsychiatryOnline 2022
- DigitalErika Mendoza, Christopher R. Lattimer, Nick Morrison, editors.Summary: This book describes in detail the use of duplex ultrasound for exploration of the superficial veins and their pathology. It has a practical orientation, presenting numerous clinical situations and explaining how to identify the different sources of reflux, specially in the groin. The investigation of pathology of the saphenous trunks, perforators, and side branches is described in detail. As duplex ultrasound plays an important role during various venous surgical procedures, its application pre-, intra-, and postoperatively is presented. Furthermore, the sonographic appearances of thrombotic pathology of superficial and deep veins, edema, and other conditions that may be observed while exploring the veins are fully described. The book is based on the authors{u2019} extensive clinical experience and is intended to assist fellow practitioners who want to learn more about the technique. It includes a wealth of informative images with the aim of covering every potential situation.
Contents:
The Ultrasound Scanner
Anatomy of the Superficial Veins
Pathophysiology of the Superficial Venous System
Ultrasound-Based Classifications of Varicose Veins
Duplex Ultrasound Examination of Superficial Leg Veins
Flow Provocation Manoeuvres for the Diagnosis of Venous Disease Using Duplex Ultrasound
Examination of the Great Saphenous Vein
Examination of the Small Saphenous Vein
Perforating Veins
Tributaries
Superficial Vein Thrombosis
Ultrasound in Varicose Vein Treatment
Ultrasound After Venous Intervention
Deep Leg Veins
Examination of Superficial Veins in the Presence of Deep Venous Disease
Differential Diagnosis of Leg Oedemas of Venous and Lymphatic Origin
Incidental Findings During a Venous Examination of the Leg. - DigitalPaul M. N. Werker, Joseph Dias, Charles Eaton, Bert Reichert, Wolfgang Wach, editors.Contents:
Epidemiology and Patients Views
Cellular and Extra-cellular Events
Genetics and Associations
Collagenase Injection
Percutaneous Needle Fasciotomy (PNF)
Assessment
Comparative Studies
Surgical Techniques and Recurrence
Related Diseases and Other Treatments
Future Paths of Research.Digital Access Springer 2017 - DigitalMarco Rizzo, editor.Contents:
1. Nonoperative management of finger flexion contracture in Dupuytren's disease: orthotic intervention and tissue mobilization techniques
2. Needle aponeurotomy in the management of Dupuytren's contracture
3. Ultrasound assisted needle aponeurotomy in the management of Dupuytren's contracture
4. Corticosteroid injections and needle aponeurotomy in the management of Dupuytren's contracture
5. Clostridial collagenase injections in the treatment of Dupuytren's contracture
6. Minimally invasive partial fasciectomy
7. Surgical fasciotomy for Dupuytren's contracture
8. Surgical fasciectomy for Dupuytren's contracture
9. Wide awake Dupuytren's fasciectomy: a pathoanatomical approach
10. .Surgical open palm (McCash) technique
11. Treatment of Dupuytren's contracture with dermofasciectomy
12. Surgical fasciectomy for recurrent disease
13. Use of dynamic external fixator (digit widget) in Dupuytren's contracture
14. The distal interphalangeal joint in Dupuytren's disease
15. Knuckle pads (Garrod's nodules) of the fingers: painful dorsal nodules on the PIP joints of the fingers and concomitant recurrent Dupuytren's contracture
16. Arthrodesis in treatment of Dupuytren contracture
17. Amputation in management of severe Dupuytren's contracture
18. Treatment of Dupuytren's contracture in the young
19. Recurrent Dupuytren contracture treated with fasciectomy and skin grafting
Index.Digital Access Springer 2016 - DigitalStuart Silverman, Bo Abrahamsen, editors.Contents:
Foreword
Preface
Osteoporosis: Pathophysiology & Epidemiology
Antiresorptives
Anabolics
Tools for Assessing Fracture Risk and for Treatment Monitoring
Treatment Failure
Epidemiology of Atypical Subtrochanteric and Femoral Shaft Fractures
Bisphosphonate-Related Atypical Femoral Fractures and Their Radiographic Features
Factors Contributing to Atypical Femoral Fractures
Clinical Presentation of Atypical Femur Fractures
Effects of Antiresorptive Therapy on Bone Microarchitecture
Management of Atypical Femoral Fractures
Osteonecrosis of the Jaw: Clinico-Pathologic and Radiologic Features
Epidemiology of Osteonecrosis of the Jaws from Antiresorptive Treatment
Management of Osteonecrosis of the Jaw in Patients Receiving Antiresorptive Treatment
Long-Term Efficacy and Safety of Treatments for Osteoporosis
Management of Drug Holidays
Patients Who Do Not Take Their Osteoporosis Medications: Can We Help Them Become Compliant?
Fractures and Healing on Antiresorptive Therapy
Antiresorptive Therapy and Mortality and Cancer Incidence
Other Safety Concerns
The Impact of Regulatory and Scientific Organizations Recommendations on Clinical Decision Making
Integrated Clinical View on Long-Term Management of Patients with Osteoporosis
Conclusions. - DigitalMark Dutton.Summary: This book introduces a conceptual framework about the art of physical therapy to give the entry-level physical therapy student a broad foundation from which to support their journey through the typical physical therapy curriculum. The purpose of this text is to cover the fundamental skills that most physical therapists will use for the rest of their careers.
Contents:
Chapter 1: The Profession
Chapter 2: Healthcare Regulations
Chapter 3: Evidence-Informed Practice
Chapter 4: Foundations of Movement
Chapter 5: Patient/Client Management
Chapter 6: Movement Dysfunction
Chapter 7: Correcting Movement Dysfunction
Chapter 8: Preparation for Patient Care
Chapter 9: Monitoring Vital Signs
Chapter 10: Bed Mobility, Patient Positioning, and Draping
Chapter 11: Mobility
Chapter 12: Manual Muscle Testing
Chapter 13: Patient Transfers and Mobility
Chapter 14: Gait Training
Appendix A: Standards of Practice for Physical Therapy
Appendix B: Criteria for Standards of Practice for Physical Therapy
Appendix C: Code of Ethics
Appendix D: Standards of Ethical Conduct for the Physical Therapist Assistant
Appendix E: American Physical Therapy Association (APTA).Digital Access AccessPhysiotherapy 2021 - DigitalMark Dutton, PT.Summary: "This book introduces a conceptual framework about the art of physical therapy to give the entry-level physical therapist assistant (PTA) student a broad foundation from which to support their journey through a typical curriculum. The purpose of this text is to cover the fundamental skills that most PTAs will use for the rest of their careers. This text provides a historical perspective on the physical therapy profession, an introduction to healthcare policy, and a definition of evidence-informed practice, and various chapters describing specific areas of clinical expertise, including how to enhance a patient's function in such tasks as bed mobility, transfers, and gait training. Chapter 1 provides a historical perspective on the physical therapy profession. Chapter 2 introduces the reader to essential healthcare policies. Chapter 3 describes the importance of evidence-informed practice and clinical decision-making. Chapter 4 outlines clinical documentation. With every patient interaction, the clinician should always ensure patient and clinician safety. Throughout the remaining chapters, the emphasis is placed on patient and clinician safety through correct body mechanics, the application of assistive and safety devices, and the effective use of infection control procedures. Chapter 5 helps prepare the clinician for patient care. Chapter 6 describes the various methods by which a clinician can take a patient's vital signs and the significance of each of these vital signs. Chapter 7 covers the various methods to perform bed mobility skills, correctly drape and position a patient. Chapter 8 teaches the reader how to perform range of motion assessments and apply range of motion techniques as a treatment method. Chapter 9 describes the various methods to accurately test the strength of each of the patient's muscles. Chapter 10 describes wheelchair mobility skills and the various methods by which the clinician or clinical team can transfer a patient from and to various surfaces. Chapter 11 details the various components and parameters of gait and how to train a patient to ambulate with or without an assistive device. Finally, chapter 12 attempts to put all of the information together by providing a patient example"-- Provided by publisher.
Contents:
The physical therapy profession
Healthcare regulations
Evidence informed practice and clinical decision-making
Clinical documentation
Preparation for patient care
Taking vital signs
Bed mobility, patient positioning, and draping
Mobility and range of motion
Manual muscle testing
Patient transfers and wheelchair mobility
Gait training
Putting it all together.Digital Access AccessPhysiotherapy 2022 - DigitalMark Dutton, PT, Allegheny General Hospital, West Penn Allegheny Health System (WPAHS), Adjunct Clinical Instructor, Duquesne University, School of Health Sciences, Pittsburgh, Pennsylvania.Summary: Dutton's Orthopaedic Examination, Evaluation and Intervention provides readers with a systematic logical approach to the evaluation and intervention of the orthopedic patient. In this comprehensive and up-to-date fourth edition, Dutton strikes the perfect balance in its coverage of examination and treatment. The textbook emphasizes the appropriate use of manual techniques and therapeutic exercise while outlining the correct applications of electrotherapeutic and thermal modalities as adjuncts to the rehabilitative process.
Contents:
Anatomy
Examination and evaluation
Intervention
The extremities
The spine and TMJ
Special considerations.Digital Access AccessPhysiotherapy 2017 - DigitalMark Dutton.Summary: "This book aims to provide the reader with a systematic and evidence-based approach to the examination and intervention of the orthopaedic patient from the viewpoint of an expert on the movement system"-- Provided by publisher.
Contents:
The Musculoskeletal system
Tissue behavior, injury, healing, and treatment
The nervous system
Patient/client management
Differential diagnosis
Gait and posture analysis
Imaging studies in orthopaedics
The intervention
Pharmacology for the orthopaedic physical therapist
Manual techniques
Neurodynamic mobility and mobilizations
Improving muscle performance
Improving mobility
Improving neuromuscular control
Improving cardiovascular endurance
The Shoulder
Elbow
The forearm, wrist, and hand
Hip
The knee
Lower leg, ankle, and foot
Vertebral column
The craniovertebral region
Vertebral artery
The cervical spine
The temporomandibular joint
The thoracic spine
Lumbar Spine
The sacroiliac joint
Special populations.Digital Access AccessPhysiotherapy 2020 - PrintMark Dutton.Summary: "This book aims to provide the reader with a systematic and evidence-based approach to the examination and intervention of the orthopaedic patient as an expert on the movement system"-- Provided by publisher.Digital Access AccessPhysiotherapy 2023
- DigitalMathias Baehr, Michael Frotscher.Summary: "The sixth edition of Duus' classic Topical Diagnosis in Neurology builds on the clear, integrated presentation of anatomy, function, and disorders of the central nervous system that made it a success for almost over five decades, serving as a quick reference for practitioners and trainees alike. It elucidates the neuroanatomical pathways that lead to specific clinical syndromes, and demonstrates how comprehensive anatomical knowledge combined with a thorough neurological examination can help localize and categorize a lesion and arrive at a differential diagnosis. The time-tested logical, thematic structure with useful summaries, at the beginning of each chapter, and color-coded section headings enable readers to distinguish neuroanatomical from clinical material at a glance and enable efficient and time saving study. Features of the sixth edition: - New tables and clinical case examples - Improved descriptions of neuroanatomical/neurophysiological basics in the context of clinical symptoms - Twenty-three new illustrations, to a total of more than 400 illustrations - A wide range of study aids and clinical correlations that support the emphasis on integrative medicine in the current medical school curricula Topical Diagnosis in Neurology is an ideal reference for neurologists and neuroscientists who correlate neurological diseases with anatomical location to arrive at a diagnosis or understand a clinical syndrome. It is also an essential tool for trainees and advanced students who need a solid grounding in key neurofunctional relationships"--Provided by publisher.Digital Access Thieme MedOne Education 2019
- DigitalAngelo A. Licata, Susan E. Williams.Summary: Dual-energy X-ray absorptiometry (DXA) is the principal x-ray technology used to diagnose osteoporosis in its early, asymptomatic stages, to assess treatment efficacy, and to guide treatment decisions. It remains the gold standard today. A DXA Primer for the Practicing Clinician: A Case-Based Manual for Understanding and Interpreting Bone Densitometry is based on actual clinical encounters and treatment dilemmas encountered by the authors. The content is derived from years of clinical practice and presentations given by the authors at regional and national conferences. It exemplifies not only the complete body of knowledge provided through these lectures but also the full range of previously undiscussed nuances of DXA interpretation. This practical, easy-to-read text captures many of the common challenges of DXA interpretation that clinicians often encounter. The central focus of the book is the presentation of what is normal and what is problematic when using DXA. It presents real-life case histories, their corresponding DXA images, the problems encountered and their solutions. Unique in approach and presentation, this one-of-a-kind case-based manual will be of immense value to all clinicians and students motivated to optimize their diagnostic skills and assessment of patients with abnormal bone densities
Contents:
Introduction - How does one go from bone mineral density measurements to a diagnosis of osteoporosis
What Is Osteoporosis?
What Happens After I Order a DXA?
What Is FRAX®?-- The DXA Report: What Every Referring Clinician Needs to Know
Technological Errors in DXA Scanning: Common Errors in Diagnosing and Monitoring
Monitoring Treatment Efficacy: DXA Pearls and Pitfalls
Special Considerations in Common GI Diseases, Obesity, and Following Bariatric Surgery
UFOs: Unexpected Foreign Objects
Challenging Cases. - DigitalKathleen D. Sanford, DBA, RN, CENP, FACHE, Senior Vice President and Chief Nursing Officer, Catholic Health Initiatives, Englewood, Colorado, Stephen L. Moore, MD, Senior Vice President and Chief Medical Officer, Catholic Health Initiatives, Englewood, Colorado.Summary: "Healthcare leaders are facing major change in how healthcare is delivered as we move from fee-for-service payment models to pay for value. Physicians and hospitals are evolving from separate financial entities (with relationships varying from customers/workshops to competitors) to unified systems. Government policy maker, payers, and hordes of consultants advise hospitals to increase physician leadership in all parts of the system. However, few have proposed how this can be done when the gaps between hospitals and physicians are so wide. Physicians do not trust healthcare leaders, lack leadership and teamwork skills, and have little knowledge of how systems work. Some hospital leaders are working to overcome these gaps by setting up dyad leadership teams, consisting of a physician and an experienced manager/leader. The physician member of the team helps with the first gap; the nurse or other dyad partner is important to manage the other gaps. Until now, with the publication of Dyad Clinical Leadership, there has not been a source to help clinical dyad partners learn and understand how to work together in this emerging management model. Kathleen D. Sanford, DBA, RN, CENP, FACHE, Senior Vice President and Chief Nursing Officer at Catholic Health Initiatives (CHI), builds on CHI's success with this unique playbook for the model"--Provided by publisher.
Contents:
Chapter 1. An introduction to a new leadership model
Chapter 2. How did we get here and what do we need to get out of here?
Chapter 3. Developing a dyad
Chapter 4. Power, persuasion, politics, and perceptions
Chapter 5. Culture shock: dyads as both harbingers and architects of cultural change
Chapter 6. Dyads as catalysts for renewing the strength of the leadership team
Chapter 7. Learning dyad skills
Chapter 8. What do you believe?
Chapter 9. Forming dyad-led teams and multiple partnerships
Chapter 10. What we say today may not be true tomorrow.Digital Access Ovid 2015 - DigitalLawrence Berk, editor.Contents:
Art of dying / Lawrence Berk
Dying: what happens in the cells and tissues / Lawrence Berk
Dying: what happens to the body after death / Vernard Adams
Quality of life at the end of life / Lodovico Balducci and Miriam Innocenti
Legal aspects of oncology care for dying patients / Marshall B. Knapp
Spiritual care: an essential aspect of cancer care / Kenneth J. Doka
Religious views of the afterlife / Christopher M. Moreman
A historical perspective of death in the western world / David San Filippo
Economic aspects of death and dying in oncology / Vlad Dolgopolov
Oncologists and death / Lawrence Berk
Pediatric cancer and end-of-life / Kathleen G. Davis
Symptom management of the dying oncology patient / Lawrence Berk.Digital Access Springer 2017 - PrintJeffrey Pfeffer.Summary: "In this timely, provocative book, Jeffrey Pfeffer contends that many modern management commonalities such as long hours, work-family conflict, and economic insecurity are toxic to employees--hurting engagement, increasing turnover, and destroying people's physical and emotional health--while also being inimical to company performance. He argues that human sustainability should be as important as environmental stewardship. You don't have to do a physically dangerous job to confront a health-destroying, possibly life-threatening workplace ... In "Dying for a Paycheck", Jeffrey Pfeffer marshals a vast trove of evidence and numerous examples from all over the world to expose the infuriating truth about modern work life: even as organizations allow management practices that actually sicken and kill their employees, those policies do not enhance productivity or the bottom line, thereby creating a lose-lose situation. Exploring a range of important topics, including layoffs, health insurance, work-family conflict, work hours, job autonomy, and why people remain in toxic environments, Pfeffer offers guidance and practical solutions that all of us--employees, employers, and the government--can use to enhance workplace well-being. We must wake up to the dangers and enormous costs to today's workplace, Pfeffer argues. "Dying for a Paycheck" is a clarion call for a social movement focused on human sustainability. Pfeffer makes clear that the environment we work in is just as important as the one we live in, and with this urgent book he opens our eyes and shows how we can make our workplaces healthier and better."--Jacket flaps.
Contents:
Introduction
Management decisions and human sustainability
The enormous toll of toxic workplaces
Layoffs and economic insecurity : a lose-lose proposition
No health insurance, no health
Health effects of long work hours and work-family conflict
Two critical elements of a healthy workplace
Why people stay in toxic workplaces
What might--and should--be different. - Digital/PrintJonathan M. Metzl.Summary: A physician reveals how right-wing backlash policies have mortal consequences-even for the white voters they promise to help Named one of the most anticipated books of 2019 by Esquire and the Boston Globe In the era of Donald Trump, many lower- and middle-class white Americans are drawn to politicians who pledge to make their lives great again. But as Dying of Whiteness shows, the policies that result actually place white Americans at ever-greater risk of sickness and death. Physician Jonathan M. Metzl's quest to understand the health implications of "backlash governance" leads him across America's heartland. Interviewing a range of everyday Americans, he examines how racial resentment has fueled progun laws in Missouri, resistance to the Affordable Care Act in Tennessee, and cuts to schools and social services in Kansas. And he shows these policies' costs: increasing deaths by gun suicide, falling life expectancies, and rising dropout rates. White Americans, Metzl argues, must reject the racial hierarchies that promise to aid them but in fact lead our nation to demise.
Contents:
Introduction: dying of whiteness
Part I: Missouri: The cape
Risk
Interview: I can't just make it go away
The man card
Interview: we gotta take up arms
Preventative medicine
Interview: the biggest heart
What was the risk?
Interview: the whys and what-ifs
Trigger warnings
Part 2: Tennessee: Unaffordable
Cost
In the name of affordable care
Focus
Socialism
Everybody
De-progressive
The numbers tell the story
Part 3: Kansas: Beneath the surface
There's no place like home
The Kansas experiment
Interview: a downward cycle
Austerity
Interview: a bad rap
The schools
Interview: the race card
Congestive heart failure
Interview: no matter what he does
Millions of millions
Conclusion: the castle doctrine
Notes
Index.Digital Access EBSCO 2019Limited to 1 simultaneous user - Printedited by Avivah Zuckerman and David W. Weiss.
- DigitalJeffrey N. Weiss.Summary: Blindness or serious vision impairment is one of the most feared disabilities known to humankind. A 2016 report compiled by the National Eye Institute (NEI) of the National Institutes of Health (NIH) and Prevent Blindness America states that although half of all blindness can be prevented, the number of people who suffer vision loss continues to increase. The technique of dynamic light scattering (DLS) was developed by physicists in the late 1960s to early 1970s. DLS is now emerging as a potential ophthalmic tool, making possible studies of virtually every tissue and fluid comprising the eye, thus pushing the envelope for broader applications in ophthalmology. This book presents a comprehensive review of the application of light scattering in clinical use. It is the first of its kind, offering insight to how DLS can be applied to the human eye as well as animals. Chapters discuss DLS in neurological diseases, including protocols, informed consent, and patents. Dynamic Light Scattering Spectroscopy of the Human Eye is a must-have resource for physicians, engineers, and physicists interested in the clinical application of DLS to diagnose and potentially treat medical conditions in a non-invasive, quantitative and novel way. .
Contents:
Chapter 1. Anatomy of the eye
Chapter 2. Light Scattering
Chapter 3. Dynamic Light Scattering (DLS)
Chapter 4. DLS Animal Experiments
Chapter 5. DLS Human Experiments
Chapter 6. DLS in Neurologic diseases - Protocol
Chapter 7. DLS in Neurologic diseases Informed Consent
Chapter 8. Patents. . - Digital[edited by] Daniel H. Kim, MD, FAANS, FACS, Professor, Director of Spinal Surgery, Reconstructive Peripheral Nerve Surgery, Department of Neurosurgery, Memorial Hermann, the University of Texas Health Science Center at Houston, Houston, Texas, Dilip K. Sengupta, MD, DrMed, Director, Clinical Research, Attending Spine Surgeon, Texas Back Institute, Plano, Texas, Frank P. Cammisa Jr., MD, FACS, Chief, Spinal Surgical Service, Attending Surgeon, Spine Care Institute, Hospital for Special Surgery, Professor of Orthopedic Surgery, Weill Medical College of Cornell University, New York, New York, Do Heum Yoon, MD, PhD, Professor, Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of Korea, Richard G. Fessler, MD, PhD, Professor, Department of Neurological Surgery, Rush University College of Medicine, Chicago, Illinois.Summary: "Dynamic Reconstruction of the Spine, Second Edition, is an up-to-date, comprehensive resource on the instrumentation, technologies, and fundamental science integral to achieving spine motion preservation and stabilization. This revised text covers not only the latest technologies and surgical approaches, including MIS techniques, but also significantly more detail on the clinical biomechanics of the spine than the previous edition. Readers will appreciate the guidance this book provides on how to: successfully adopt new technology, find appropriate indications, address common safety and efficacy issues, and answer health economics questions for ethics committees and payers. Key Features: A substantial revision, with entirely new chapters in three quarters of the book, including a large section on basic as well as more advanced biomechanics topics. Highly visual - contains 20% more figures than the previous edition. Discusses and explains current advances in genetic and molecular technologies used to repair the spinal disc Includes an unbiased critique of the pro cons, clinical outcomes, and comparative outcomes of different devices. This new edition is an indispensable reference for orthopedic surgeons, neurosurgeons, and radiologists, as well as residents and fellows seeking the latest information on the technologies used in spine motion preservation and stabilization"-- Provided by publisher.Digital Access Thieme MedOne Neurosurgery 2015
- DigitalPallaval Veera Bramhachari, editor.Summary: This book discusses various components of the innate and adaptive immune response in combating viral infections, presenting the recent advances in our understanding of innate immunity recognition of viruses and highlighting the important role of inflammation, cytokines such as interferon, toll-like receptors and leukocytes in the initial detection of invading viruses and subsequent activation of adaptive immunity. It also summarizes the role of the adaptive immunity against viral infections through clearance of virus and establishment of memory response that protects against the recurrent infections. In addition, the book examines the role of DNA and RNA sensors in viral recognition and in controlling viral infection. Lastly, it reviews the latest developments in the development of the rational viral vaccines. As such it is a useful resource book for postgraduate and early researchers wanting to gain insights into the immune response to viral infections.
Contents:
Chapter 1. Significance and dynamics of immune responses during viral pathogenesis
Chapter 2. Antibody-dependent enhancement of viral infections
Chapter 3. Inflammation during virus infection: swings and roundabouts
Chapter 4. Interferons and their role in Viral infection
Chapter 5. Role of Cytokines in combating viral infections: Siginificance and relevance
Chapter 6. B cells and their role in combating viral diseases
Chapter 7. Significant role of Cellular activation in viral infections Bojjibabu Chidipi1 Samuel Ignatious Bolleddu, Ganugula Mohana Sheela and Alavala Mattareddy
Chapter 8. Macrophages/Micro vesicles and their task in viral diseases Macrophages/Microvesicles and their task in viral diseases
Chapter 9. T cells in viral infections: The myriad flavours of antiviral immunity
Chapter 10. Potentiality of Toll Like Receptors (TLRs) in viral infections
Chapter 11. Activation and immune evasion of viruses from Complement system
Chapter 12. microRNAs and their role in viral infection
Chapter 13. Evolution, Distribution and Diversity of Immunodeficiency Viruses
Chapter 14. Role of immune cells in Hepatitis B infection
Chapter 15. Role of RNA Sensors in Immunity against Viral Diseases
Chapter 16. Role of DNA Sensors in Immunity against Viral Diseases
Chapter 17. Advanced immunotechnological methods for detection and diagnosis of viral infections: Current applications and future challenges
Chapter 18. Current advances in viral vaccines development and Research.Digital Access Springer 2020 - Digital[edited by] Merle Myerson.Summary: "Dyslipidemia: A Clinical Approach is intended as a low-cost, quick-reference, easy-to-navigate guide for a broad range of healthcare professionals that will provide high-yield decision-making tools to ensure confidence in patient treatment and management of those who are suffering from a lipids disorder or related disease. Content will include detailed drug tables, information on important drug interactions, and also non-statin alternatives for those patients who cannot tolerate statins. In addition, decision-making algorithms and careful patient management plans will be included to ensure quicker and more effective treatment and management of patients"--Provided by publisher.
Contents:
1. A historical perspectives on lipids and cardiovascular disease
2. Basic lipid and lipoprotein biochemistry for clinical lipidologists
3. Guidelines and risk scores
4. Lipid measurement
5. Step-by-step diagnosis and management plan
6. Lifestyle modification in the management of dyslipidemia
7. Lipid medications overview: prescription and nonprescription preparations
8. Statins
9. Nonstain medications: omega-3 fatty acids, fibrates, bile acid sequestrants, niacin, and cholesterol absorption inhibitors
10. Hypertriglyceridemia
11. Safety and tolerability of lipid-lowering medications
12. Familial hypercholesterolemia: family disease
13. Complex dyslipidemias
14. Children and adolescents step-by-step evaluation and management plan
15. Lipid management in special populations.Digital Access Ovid 2019 - DigitalAbhimanyu Garg.Summary: Dyslipidemias: Pathophysiology, Evaluation and Management provides a wealth of general and detailed guidelines for the clinical evaluation and management of lipid disorders in adults and children. Covering the full range of common through rare lipid disorders, this timely resource offers targeted, practical information for all clinicians who care for patients with dyslipidemias, including general internists, pediatric and adult endocrinologists, pediatricians, lipidologists, cardiologists, internists, and geneticists. For the last twenty years, there has been a growing recognition worldwide of the importance of managing dyslipidemia for the primary and secondary prevention of atherosclerotic vascular disease, especially coronary heart disease. This has been mainly due to the publication of the guidelines of National Cholesterol Education Programs Adult Treatment Panel and Pediatric Panel from the United States. These guidelines have stimulated generation of similar recommendations from all over the world, particularly Europe, Canada, Australia and Asia. Developed by a renowned group of leading international experts, the book offers state-of-the-art chapters that are peer-reviewed and represent a comprehensive assessment of the field. A major addition to the literature, Dyslipidemias: Pathophysiology, Evaluation and Management is a gold-standard level reference for all clinicians who are challenged to provide the best care and new opportunities for patients with dyslipidemias.
Contents:
Lipoprotein Physiology
Epidemiology of Blood Lipids and Lipoproteins
Lipoprotein(a)
Lipoproteins and Cardiovascular Disease Risk
Detection and Treatment of Children and Adolescents with Dyslipidemia
Type 2 Diabetes Mellitus and Dyslipidemia
Type 1 Diabetes Mellitus and Dyslipidemia
Dyslipidemia in Chronic Kidney Disease and Nephrotic Syndrome
Dyslipidemia in HIV-infected Patients
Monogenic Hypercholesterolemia
Primary Hypertriglyceridemia
Genetic Disorders of HDL Metabolism
Sitosterolemia and Other Rare Sterol Disorders
Genetic Abetalipoproteinemia & Hypobetalipoproteinemia
Drug-induced Dyslipidemia
Lipodystrophies and Dyslipidemias
Novel Genes for Dyslipidemias: Genome-Wide Association Studies
Perspectives on Cholesterol Guidelines
Nutrition and Coronary Heart Disease Prevention
Phytosterol Therapy
N-3 Fatty Acids: Role in Treating Dyslipidemias and Preventing Cardiovascular Disease
Polyphenols for Cholesterol Management
Dietary Supplements for Cholesterol Management
Statins: Risk-Benefits and Role in Treating Dyslipidemias
Fibrates: Risk-Benefits and Role in Treating Dyslipidemias
Niacin: Risk-Benefits and Role in Treating Dyslipidemias
Bile Acid Sequestrants: Risk-Benefits and Role in Treating Dyslipidemias
Cholesterol Absorption Inhibitor-Ezetimibe: Risk-Benefits and Role in Treating Dyslipidemias
Low Density Lipoprotein (LDL) Apheresis
Novel Lipid Lowering Agents.Digital Access Springer 2015 - DigitalRoger P. Smith.Summary: Dysmenorrhea is estimated to effect upwards of 70% of women during their lifetime and heavy menstrual periodsis one of the most frequently given reasons for hysterectomy in the United States. Despite the dramatic growth of dysmenorrhea treatment with non-steroidal anti-inflammatory agents (NSADs) in the 1980s, young women continue to go undiagnosed and under treated. The diagnosis and management of heavy menstrual bleeding has even poorer general understanding because of its more complicated etiologies. With a working knowledge of the underlying pathophysiology, all clinicians should be able to establish both the diagnosis and a credible treatment plan that will result in a significant chance of clinical improvement for most patients. This book addresses the pathophysiologic underpinnings of both dysmenorrhea and menorrhagia and provides clinicians with practical approaches to establishing the diagnosis, proven tactics for successful therapeutic interventions and dealing with the challenging atypical case, and effective patient counseling. It teaches principles, including the role prostaglandins play in both conditions, as well as procedures, like surgical options and TENS, providing a balance of the practical and the esoteric. The inclusion of patient education and counseling materials additionally increases its usefulness for the busy clinician. This is an ideal guide for ob/gyn clinicians, residents, and trainees caring for patients with these common, but often misunderstood diseases.
- DigitalKrishnakumar Thankappan, Subramania Iyer, Jayakumar R Menon, editors.Digital Access Springer 2018
- Digitaleditors, Alfonso Fasano, Francesca Morgante.Contents:
Dystonia : a clinician's guide to diagnosis, pathophysiology and treatment / Alfonso Fasano & Francesca Morgante
Symptoms of dystonia / Alfonso Fasano, Sophie Lehnerer & Antonio Emanuele Elia
Pathophysiology of dystonia / Francesca Morgante
Classification of dystonia / Nardo Nardocci & Giovanna Zorzi
Genetics of dystonia / Toshitaka Kawarai & Ryuji Kaji
Medication for dystonia / Christoph Kamm
Surgical treatment of dystonia / Wolfgang Fogel & Wolfgang Jost
Physical management of dystonia / Roongroj Bhidayasiri. - DigitalPetr Kanovsky, Kailash P. Bhatia, Raymond L. Rosales, editors.Contents:
Part I. Pathophysiology and nosology of dystonia
Dystonia: History of the term and syndrome
Physiology of dystonia
Genetics of dystonia
Nosology and classification of dystonia
Secondary dystonias
Dystonia
parkinsonism syndromes
Dystonia in multiple system atrophy and progressive supranuclear palsy
Psychogenic dystonia
Part II. Treatment of dystonia
Pharmacological treatment of dystonia
Botulinum toxin treatment of dystonia
Long-term BoNT treatment of dystonia
Brain plasticity in dystonia
Surgical treatment of dystonia
Indications of deep brain stimulation in dystonia
Pitfalls of deep brain stimulation in dystonia
Neurorehabilitation in dystonia
Dystonia in Art: The Impact of Psychiatric and Neurological Disease on the Work of the Sculptor F.X. Messerschmidt.Digital Access Springer 2015
- Dacie and Lewis Practical haematology. Twelfth edition. [12th ed.] — Designing urban food policies : concepts and approaches (190)
- Designing your life : how to build a well-lived, joyful life. First edition. — Diagnostic ultrasound. 5th edition. (190)
- Diagnostic ultrasound : physics and equipment. Third edition. — Disruptive behavior : development, psychopathology, crime, and treatment (190)
- Disruptive cooperation in digital health — Dystonia and dystonic syndromes (188)
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Features systematic reviews that summarize the effects of interventions and makes a determination whether the intervention is efficacious or not.
Cochrane reviews are created through a strict process of compiling and analyzing data from multiple randomized control trials to ensure comprehensiveness and reliability.
Provides systematic coverage of the psychological literature from the 1800s to the present through articles, book chapters and dissertations. PIER (Physicians' Information and Education Resource) is a Web-based decision-support tool designed for rapid point-of-care delivery of up-to-date, evidence-based guidance for primary care physicians. Cochrane Central Register of Controlled Trials (CENTRAL) provides access to 300,000 controlled trials that have been identified the Cochrane Collaboration. Provides drug information targeted for patients. A continually updating drug monograph. ECRI Guidelines Trust: A comprehensive database of evidence-based clinical practice guidelines and related documents. MedlinePlus: A repository of health information from the National Library of Medicine. Links are from trusted sites. No advertising, no endorsement of commercial companies or products LPCH CareNotes via MicroMedex: Patient education handouts customized by LPCH clinical staff Micromedex Lab Advisor: Evidence based laboratory test information Provides patient handouts from the American Academy of Family Physician.Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities.
In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.
A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.A web-based, decision support system for infectious diseases, epidemiology, microbiology and antimicrobial chemotherapy. The database, updated weekly, currently includes 337 diseases, 224 countries, 1,147 microbial taxa and 306 antibacterial (-fungal, -parasitic, -viral) agents and vaccines.
Over 10,000 notes outline the status of specific infections within each country.
Provides online, full-text access to Springer's journal titles as well as journals from other publishers.
Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.
Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present. A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.