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    Retired Reference Periodicals (Downstairs)
    v. 1, 3-27, 1989-96.
    SHELVED UNDER: National Medical Expenditure Survey (U.S.). Research findings.
    1
  • Article
    Kimura M, Waki I, Kokubo M.
    Jpn J Pharmacol. 1978 Oct;28(5):693-7.
    Oosponol (4-hydroxymethylketone-8-hydroxyisocoumarin) is a metabolic product isolated from Oospora astringens which originated from house dust in a room of an asthmatic patient. The compound and the structurally related isocoumarins were studied to determine the inhibition of histamine release induced by compound 48/80 from isolated rat peritoneal mast cells. The released histamine was assayed by fluorometry. The compounds tested were not observed to release histamine. Some of 4-acyl-isocoumarins inhibited the histamine release at doses less than 10 micrometers, whereas the 3-acyl- and the 4-alkyl-compounds were not effective at doses over 100 microns. The pretreatment of mast cell with the compound for 15 min before the application of compound 48/80 was more effective than the simultaneous administration. The mode of inhibitory action of KIT-302, 4-(4'-carboxy-benzoyl)-isocoumarin, was non-competitive antagonism to compound 48/80 on the mast cells.
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doi:10.1254/jjp.28.693