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• Journal

  Maternal and Child Health Data Base. Descriptive Narrative

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  Retired Reference (Downstairs)

  1978/81-1984/88

  RG530 .M425

  8
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• Article

  Suppression of murine leukaemia virus production by ouabain and interferon in mouse cells.

  Tomita Y, Kuwata T.

  J Gen Virol. 1978 Feb;38(2):223-30.

  Ouabain markedly inhibited the growth of the mouse cell lines K3b and JLS-V9 and the production of murine leukaemia virus (MuLV) in them. The inhibition of MuLV production was abolished by exposing the cells to normal medium or by adding a high concentration (43 mM) of K+ ions to the ouabain-containing medium. MuLV production was reduced by ouabain more rapidly than host cell directed protein synthesis. After treatment of cells with ouabain (0.5 mM) for 7 h, extracellular reverse transcriptase reverse transcriptase activities were reduced by 87 to 92%. However, the intracellular level of polymerase activities remained almost unchanged (77 to 98% relative to the control). Mouse interferon inhibited the production of MuLV in K3b cells and this antiviral action was not blocked by 0.5 mM-ouabain.

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