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- ArticleVan Dugteren GR, Wiggelinkhuizen J.Arch Dis Child. 1979 Oct;54(10):795-8.Bilateral staghorn renal calculi in a 7-year-old girl with cystinuria were dissolved over a period of 6 months, using a high fluid intake, urinary alkalinisation, and D-penicillamine. Even in children with extensive cystine urolithiasis, medical management may avert the need for surgery.