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  Zitelli and Davis' Atlas of Pediatric Physical Diagnosis. Eighth edition

  [edited by] Basil J. Zitelli, Sara C. McIntire, Andrew J. Nowalk, Jessica Garrison

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• Article

  A pepsin-revealed material possibly related to chromosomal banding.

  Byarugaba W.

  Chromosoma. 1978 Jul 31;67(3):275-83.

  The enzymes pepsin, alpha-chymotrypsin, trypsin, RNase and DNase were applied to preparations of human metaphase chromosomes before staining to study whether dissociable materials related to the formation of G-, Q- and C-bands would be seen. Treatment with active pepsin but not the other enzymes revealed material with ribonucleo-protein properties which dissociated from the chromosomes and formed a halo.--Lateral extensions from the chromatids stretched to the rim of the halo and appeared at positions corresponding to G-bands. A G-band may be defined as a ring of stable chromatid-matrix binding at positions where the chromatids coil to form lateral extensions.

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  PubMed