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  • Book
    Paulo Jorge Bártolo, Bopaya Bidanda, editors.
    Summary: This second edition maintains a focus on integrated biomaterials, computer-aided design, and physical prototyping techniques as examples of the materials and applications that are found in medical environments. All original chapters, written by renowned experts in the field, have been updated along with the addition of four new chapters on: Smart insoles Medical applications of additive manufacturing Additive manufacturing in craniofacial applications Additive manufacturing in hearing aids This wide-ranging treatise on biomaterials and prototyping applications in medicine also focuses on solid freeform fabrication, rapid prototyping, layered manufacturing, and computer-aided design in the development of prosthetic devices. This book is a must-have for bioengineers seeking a comprehensive overview of this important subject and examples of medical applications, as well as researchers and academics in the same field.

    Contents:
    Metallic and Ceramic Biomaterials: Current and Future Developments
    Polymers, Composites and Nano Biomaterials: Current and Future Developments
    Polyurethane Based Materials with Applications in Medical Devices
    Rapid Prototyping of Hydrogels to Guide Tissue Formation
    Engineered Scaffold Architecture Influences Soft Tissue Regeneration
    Customized Implants for Bone Replacement and Growth
    Direct Digital Manufacturing of Complex Dental Prostheses
    Digital Design and Fabrication in Dentistry
    The Development of an Artificial Finger Joint
    Computer-Aided Development of Mega Endo-Prostheses
    Smart Insoles
    Medical Applications of Additive Manufacturing
    Additive Manufacturing in Craniofacial Applications
    Additive Manufacturing in Hearing Aids.
    Digital Access Springer 2021
  • Article
    Koskinen P, Inkovaara J, Ala-Kaila K, Salo M, Nikkari T.
    Ann Clin Res. 1977 Dec;9(6):335-41.
    Since dietary calcium had been reported to reduce plasma lipids, the effects of calcium carbonate (CaCO3, 2 g/day) and the calcium salt of p-chlorphenozyisobutyrate (Ca-CPIB, 2 g/day), both singly and in combination, were studied in outpatients with primary hyperlipidaemia. Three groups of five patients were followed in a double-blind cross-over study, in which placebo and the drugs were given alternately during four-week periods. The main results were: 1) CaCO3 alone did not produce any significant changes in plasma lipids. 2) Ca-CPIB reduced LDL-cholesterol in patients with type IIa and IIb by an average of 29 and 21%, respectively. It also lowered VLDL-triglyceride by 50% in type IIb and by 48% in four out of five patients with type IV. 3) The combination of CaCO3 and Ca-CPIB reduced LDL-cholesterol by 31 and 25% in types IIa and IIb, respectively. It also lowered VLDL-triglyceride by 48-52% in types IIa and by 46% in four out of five patients with type IIb. 4) Three out of five patients with type IV had a rise of LDL-cholesterol while on Ca-CPIB alone; two of the patients had the rise while on the combination. 5) After treatment with Ca-CPIB, either singly or in combination, there was a statistically significant lowering of ESR and of plasma inorganic phosphate and alkaline phosphatase. No clinical side effects were noted.
    Digital Access Access Options
doi:10.1007/978-3-030-35876-1