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- Bookeditors, Jame Abraham, James L. Gulley.Summary: "The Bethesda Handbook of Clinical Oncology is a clear, concise, and comprehensive reference book for the busy clinician to use in his or her daily patient encounters. The book has been compiled by clinicians who are working at the National Cancer Institute, National Institutes of Health, Cleveland Clinic, M.D. Anderson, Mayo Clinic as well as scholars from other academic institutions. To limit the size of the book, less space is dedicated to etiology, pathophysiology, and epidemiology and greater emphasis is placed on practical clinical information. For easy accessibility to the pertinent information, long descriptions are avoided, and more tables, pictures, algorithms, and phrases are included."--Provided by publisher.
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Non-small cell lung cancer.Digital Access Ovid 2019 - ArticleBetterle C, Peserico A, Bersani G, Rigon F, Del Prete G.Ric Clin Lab. 1977 Jul-Sep;7(3):242-51.Antibodies to epidermal cytoplasmic antigens were detected by the indirect immunofluorescence (IF) technique in 36% of 100 adult healthy subjects and in 17.6% of 17 normal newborn infants. This type of autoantibody occurred in 33% of 100 cases with vitiligo, in 32.5% of 40 cases with psoriasis, in 55.3% of patients with malignant tumours and in 72.7% of subjects with malignant melanoma. The frequency of the autoimmune reactions was statistically significant only in patients with malignant neoplasms. In the majority of positive cases the IF pattern involved the upper layers of the epidermal cells (U-CYT). The basal layer was generally negative. Only a few cases showed a pattern involving both the upper and the basal layers (G-CYT). However, a wide variation in staining was noted when sera were tested on different skin specimens or different sections of the same skin. To identify the nature of the target antigen(s), absorption experiments of sera were attempted with lyophilized and particulate antigens. Animal and human blood cells and lyophilized homogenates of malignant tumours failed to absorb the autoimmune activity of positive sera. Only a powder preparation of keratin induced a decrease in antibody titres. It is postulated that they are the result of an antigenic stimulation by exogenous substances commonly present in the environment.