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- ArticleOwen CA, Bowie EJ, Fass DN, Perez RA, Cole TL, Stewart M.Mayo Clin Proc. 1979 Jun;54(6):375-80.Two Puerto Rican families were studied. One family included a number of members with dysfibrinogenemia occasionally associated with hypofibrinogenemia. The second family had members with von Willebrand's disease. The two diseases merged in the proband's immediate family; the affected members of this family exhibited a mild bleeding disorder. Others in the two families had no obvious bleeding tendency.