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  International Forum of Allergy & Rhinology

  Digital Access Wiley v. 1-, 2011-
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• Article

  Relationships between antibodies to native DNA and glomerulonephritis in systemic lupus erythematosus.

  Tron F, Bach JF.

  Clin Exp Immunol. 1977 Jun;28(3):426-32.

  Anti-native DNA antibodies have been evaluated in forty-six lupus patients' sera for antigen-binding capacity, affinity and precipitating activity. Diffuse proliferative glomerulonephritis was significantly correlated with the presence of high serum level of free anti-native DNA antibodies. Weak affinities were more often found in patients with than without glomerular changes but several patients had high-affinity anti-DNA antibodies and severe glomerulonephritis. No correlation was found between anti-DNA antibody-precipitating activity and renal lesions.

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  PubMed