Search

Search Results

• Journal

  Indiana Medicine

  Print Access Request

  Location

  Version

  Call Number

  Items

  Stored offsite. Please request print.

  v. 77-83, 1984-90.

  13
  Get Shareable Link

  View Details
• Article

  Application of the Free-Wilson technique to structurally related series of homologues. Quantitative structure-activity relationship studies of narcotic analgetics.

  Katz R, Osborne SF, Ionescu F.

  J Med Chem. 1977 Nov;20(11):1413-9.

  A series of benzomorphans with ED50 values determined in vivo by the hot-plate method in mice is analyzed by the modified Free-Wilson method. The QSAR yields 36 substituent constants (ai) with contributions to the overall activity in agreement with experimental data. Substituent constant values obtained for benzomorphans are used in calculating log (1/C) values for six morphinans. An excellent correlation is obtained (r = 0.95) between the six calculated and observed activities. The possibility of extending the Free-Wilson approach from one series of homologues to another is demonstrated.

  Digital Access Access Options
  Get Shareable Link

  PubMed