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  • Article
    Bogard JR, Farook S, Marks GC, Waid J, Belton B, Ali M, Toufique K, Mamun A, Thilsted SH.
    PLoS One. 2017;12(4):e0175098.
    Malnutrition is one of the biggest challenges of the 21st century, with one in three people in the world malnourished, combined with poor diets being the leading cause of the global burden of disease. Fish is an under-recognised and undervalued source of micronutrients, which could play a more significant role in addressing this global challenge. With rising pressures on capture fisheries, demand is increasingly being met from aquaculture. However, aquaculture systems are designed to maximise productivity, with little consideration for nutritional quality of fish produced. A global shift away from diverse capture species towards consumption of few farmed species, has implications for diet quality that are yet to be fully explored. Bangladesh provides a useful case study of this transition, as fish is the most important animal-source food in diets, and is increasingly supplied from aquaculture. We conducted a temporal analysis of fish consumption and nutrient intakes from fish in Bangladesh, using nationally representative household expenditure surveys from 1991, 2000 and 2010 (n = 25,425 households), combined with detailed species-level nutrient composition data. Fish consumption increased by 30% from 1991-2010. Consumption of non-farmed species declined by 33% over this period, compensated (in terms of quantity) by large increases in consumption of farmed species. Despite increased total fish consumption, there were significant decreases in iron and calcium intakes from fish (P<0.01); and no significant change in intakes of zinc, vitamin A and vitamin B12 from fish, reflecting lower overall nutritional quality of fish available for consumption over time. Our results challenge the conventional narrative that increases in food supply lead to improvements in diet and nutrition. As aquaculture becomes an increasingly important food source, it must embrace a nutrition-sensitive approach, moving beyond maximising productivity to also consider nutritional quality. Doing so will optimise the complementary role that aquaculture and capture fisheries play in improving nutrition and health.
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  • Article
    Jia Q, Yi Q, Xu Z, Liu X, Zhou Z, Zhang J.
    Sci Total Environ. 2024 Nov 01;949:175098.
    In this research, an innovative approach to quantify the impact of damming on phosphorus (P) reallocation between suspended sediments (SS) and water was proposed. P allocation can be described by the surface complexation model, with the impact of damming quantified by four variables: P load, suspended sediment concentration (SSC), particle size, and pH. Iron/aluminium (Fe/Al) oxide-adsorbed P (Fe/Alo-P) was identified as the exchangeable P during adsorption/desorption equilibrium with a series of heterogeneous sediment samples from two large Asian rivers, the Mekong River and the Yellow River. In both rivers, the Fe/Alo-P concentration increased from the tail towards the dam of the reservoirs, primarily attributed to the decrease in particle size from the tail towards the dam of the reservoirs. The Fe/Alo-P concentration in the Lancang River was higher than that in the Yellow River, ranging from 14.5 to 119.9 mg kg-1 and from 14.5 to 22.1 mg kg-1, respectively. The soluble reactive P (SRP) concentration decreased with decreasing SSC, while finer suspended sediment particles containing more Fe/Alo-P greatly offset the reduction in SRP concentration. When the maximum Fe/Alo-P concentration in the finest particles of SS was assumed to be 100 mg kg-1, the P equilibrium concentration (ce) decreased from 0.028 mg L-1 to 0.008 mg L-1 when the SSC decreased from 64 g L-1 to 1 g L-1 for SS with a median grain size (D50) of 32 μm and an Fe/Alo-P concentration of 11 mg kg-1. However, ce increased from 0.008 mg L-1 to 0.021 mg L-1 when the D50 of SS decreased from 32 μm to 4 μm with an SSC of 1 g L-1 and an Fe/Alo-P concentration of 76 mg kg-1 for 4-μm SS. The SRP concentration is sensitive to the Fe/Alo-P concentration in SS, and the P allocation ratio between sediments and water is comparable.
    Digital Access Access Options
  • Article
    De Sarro C, Tallarico M, Pisano M, Gallelli L, Citraro R, De Sarro G, Leo A.
    Eur J Pharmacol. 2022 Aug 05;928:175098.
    Glucagon-like peptide-1 (GLP-1) is a hormone that can regulate several neuronal functions. The modulation of GLP-1 receptors emerged as a potential target to treat several neurological diseases, such as epilepsy. Here, we studied the effects of acute and chronic treatment with liraglutide (LIRA), in genetically epilepsy prone rats (GEPR-9s). We have also investigated the possible development of tolerance to antiseizure effects of diazepam, and how LIRA could affect this phenomenon over the same period of treatment. The present data indicate that an acute treatment with LIRA did not diminish the severity score of audiogenic seizures (AGS) in GEPR-9s. By contrast, a chronic treatment with LIRA has shown only a modest antiseizure effect that was maintained until the end of treatment, in GEPR-9s. Not surprisingly, acute administration of diazepam reduced, in a dose dependent manner, the severity of the AGS in GEPR-9s. However, when diazepam was chronically administered, an evident development of tolerance to its antiseizure effects was detected. Interestingly, following an add-on treatment with LIRA, a reduced development of tolerance and an enhanced diazepam antiseizure effect was observed in GEPR-9s. Overall, an add-on therapy with LIRA demonstrate benefits superior to single antiseizure medications and could be utilized to treat epilepsy as well as associated issues. Therefore, the potential use of GLP1 analogs for the treatment of epilepsy in combination with existing antiseizure medications could thus add a new and long-awaited dimension to its management.
    Digital Access Access Options
  • Book
    Heather Thompson-Brenner [and 7 others].
    Summary: "The Renfrew Unified Treatment for Eating Disorders and Co-occurring Emotional Disorders is an integrative, transdiagnostic, principle-based approach to address patterns of emotional avoidance, emotion sensitivity, and negative affect that produce and maintain the symptoms of eating disorders and co-occurring emotional disorders. The Renfrew Unified Treatment Model (UT) was developed through an extensive process of adapting the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) for use with patients with severe and diverse eating disorders. The modules of the UT are distinct from other approaches due to their cohesive (internal and collective) focus on how each module addresses these shared maintaining mechanisms. There is extensive evidence that eating disorders typically co-occur with other emotional disorders. There is also extensive evidence that eating disorders and other emotional disorders share common maintaining mechanisms, reflecting aspects of emotional functioning"-- Provided by publisher.

    Contents:
    PREPARING FOR TREATMENT
    MODULE 1 MOTIVATION AND GOALS
    MODULE 2 UNDERSTANDING EMOTION
    MODULE 3 MINDFUL EMOTION AWARENESS
    MODULE 4 COGNITIVE FLEXIBILITY
    MODULE 5 BEHAVIORAL FLEXIBILITY
    MODULE 6 CONFRONTING PHYSICAL SENSATIONS
    MODULE 7 EMOTION EXPOSURES
    RELAPSE PREVENTION
    Appendix A
    Appendix B.
    Digital Access Oxford [2021]