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  • Article
    Qiu S, Xiao C, Robertson RM.
    PLoS One. 2016;11(9):e0163976.
    There is considerable interest in the therapeutic benefits of long-term sensory stimulation for improving cognitive abilities and motor performance of stroke patients. The rationale is that such stimulation would activate mechanisms of neural plasticity to promote enhanced coordination and associated circuit functions. Experimental approaches to characterize such mechanisms are needed. Drosophila melanogaster is one of the most attractive model organisms to investigate neural mechanisms responsible for stimulation-induced behaviors with its powerful accessibility to genetic analysis. In this study, the effect of chronic sensory stimulation (pulsed light stimulation) on motor activity in w1118 flies was investigated. Flies were exposed to a chronic pulsed light stimulation protocol prior to testing their performance in a standard locomotion assay. Flies responded to pulsed light stimulation with increased boundary preference and travel distance in a circular arena. In addition, pulsed light stimulation increased the power of extracellular electrical activity, leading to the enhancement of periodic electrical activity which was associated with a centrally-generated motor pattern (struggling behavior). In contrast, such periodic events were largely missing in w1118 flies without pulsed light treatment. These data suggest that the sensory stimulation induced a response in motor activity associated with the modifications of electrical activity in the central nervous system (CNS). Finally, without pulsed light treatment, the wild-type genetic background was associated with the occurrence of the periodic activity in wild-type Canton S (CS) flies, and w+ modulated the consistency of periodicity. We conclude that pulsed light stimulation modifies behavioral and electrophysiological activities in w1118 flies. These data provide a foundation for future research on the genetic mechanisms of neural plasticity underlying such behavioral modification.
    Digital Access Access Options
  • Article
    Laursen SN, Fruergaard M, Dodhia MS, Posth NR, Rasmussen MB, Larsen MN, Shilla D, Shilla D, Kilawe JJ, Kizenga HJ, Andersen TJ.
    Sci Total Environ. 2023 Aug 15;886:163976.
    Rivers and estuaries are regarded as major pathways of microplastic (MP) transport from terrestrial areas to marine ecosystems. Despite this knowledge on the transport dynamics and fate of MP in freshwater riverine and brackish estuarine waters is limited. Via ex situ settling experiments emulating the Msimbazi River and Estuary in Dar es-Salaam, Tanzania, we demonstrate that flocculation and subsequent settling of positively buoyant MP and fine-grained suspended sediment in riverine and estuarine waters are important for the environmental fate of the plastic particles. Our results show that settling velocities of MP and fine-grained sediment in estuarine water were between five and 21 times larger than in freshwater, explained by the increase in ionic strength that occurs when particles enter saline water. This confirms the concept of increased flocculation and settling of fine-grained particles as they are transported from freshwater to estuarine and marine waters. The implication is that land-based sources of small positively buoyant high-density polyethylene (HDPE) MP transported by rivers will tend to settle and accumulate in estuarine environments and thereby lead to a decrease in the overall load of MPs delivered to the wider marine environment. Thereby our results support the notion of estuaries as MP traps and that flocculation explains the trapping of large quantities of MP debris. Based on these findings we recommend that the interaction of MP with fine-grained sediment should be taken into account when transport models of this pollutant are established.
    Digital Access Access Options
  • Book
    Donald W. Buck II.
    Summary: Minimally invasive, office-based aesthetic surgeries are performed millions of times per year all across the globe. In this highly visual, practical reference, Dr. Donald W. Buck II and a team of expert contributing authors bring you fully up to date with today's most sought-after procedures. Minimally Invasive Aesthetic Surgery is a must-have reference for plastic and aesthetic surgeons, both in practice and in training, who currently have or want to establish a minimally invasive aesthetic procedure practice. Offers authoritative guidance on the minimally invasive procedures you are most likely to perform, including chemodenervation, vaginal rejuvenation, soft tissue filler and Botox, non-invasive liposculpting, laser hair removal and vein ablation, hair transplantation, and more. Includes practical chapters on how to establish a minimally-invasive aesthetic procedure practice and the basics of skincare. Provides fundamental information such as product descriptions and background, the science behind the technology, indications for procedures, and contraindications. Contains technical, "how-to? pearls from key aesthetic opinion leaders worldwide, including tips on post-procedural care, outcomes, and managing complications. Features procedural videos of chemical peels, laser hair removal and laser vein ablation, redraping and setting sutures, treatment of suprapatellar wrinkled skin under local infiltration anesthesia, and more. An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

    Contents:
    Basics of Skin Care
    Chemical Peels
    Chemodenervation
    Soft Tissue Fillers
    Laser Resurfacing
    Laser Hair Removal and Vein Ablation
    Suture Lifts
    Noninvasive Liposculpting
    Hair Transplantation
    Vaginal Rejuvenation: Nonsurgical Options.
    Digital Access ClinicalKey [2023]
doi:10.1371/journal.pone.0163976 doi:10.1016/j.scitotenv.2023.163976