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- ArticleRegar RK, Kamthan M, Gaur VK, Singh SP, Mishra S, Dwivedi S, Mishra A, Manickam N, Nautiyal CS.Chemosphere. 2024 Nov;368:143672.Rivers are critical ecosystems that support biodiversity and local livelihoods. This study aimed to evaluate the effects of metal contamination and anthropogenic activities on microbial and phage community dynamics within major Indian river ecosystems, focusing on the Ganga, Narmada, Cauvery, and Gomti rivers -using metagenomic techniques, Biolog, and ICP-MS analysis. Significant variations in microbial communities were observed both within each river and across the four systems, influenced by ecological factors like geography and hydrology, as well as anthropogenic pressures. Downstream sites consistently exhibited higher microbial diversity, with prevalence of Acidobacteria, Actinobacteria, Verrucomicrobia, Firmicutes, and Nitrospirae dominating, while Proteobacteria and Bacteroides declined. The Ganga River showed a higher abundance of bacteriophages compared to other rivers, which gradually reduced with the increment of anthropogenic impact. Functional gene analysis revealed correlations between carbon utilization and metal resistance in contaminated sites. ICP-MS analysis indicates elevated chromium and lead levels in downstream sites of all rivers compared to upstream sites. Interestingly, pristine upstream sites in the Ganga had higher trace element levels than those in Narmada and Cauvery, likely due to its Himalayan origin. Both the Ganga and Cauvery rivers contained numerous metal resistance genes. The Alaknanda was identified as the primary source of microbial communities, bacteriophages, trace elements, and heavy metals in the Ganga. These findings offer new insights into anthropogenic influences on river microbial dynamics and highlight the need for targeted monitoring and management strategies to preserve river health.
- ArticlePLOS ONE Staff.PLoS One. 2015;10(11):e0143672.
- ArticleBinda G, Di Iorio A, Monticelli D.Sci Total Environ. 2021 Mar 01;758:143672.The chemical analysis of tree rings has attracted the interest of researchers in the past five decades in view of the possibility of exploiting this biological indicator as a widely available, high-resolution environmental archive. Information regarding the surrounding environment can be derived either by directly measuring environmental variables (nutrient availability, presence of pollutants, etc.) or by exploiting proxies (e.g. paleoclimatic and paleoenvironmental reconstructions). This review systematically covers the topic and provides a critical view on the reliability of dendrochemical information. First, we introduce the determinable chemical species, such as major elements, trace metals, isotopic ratios, and organic compounds, together with a brief description of their uptake mechanisms and functions in trees. Subsequently, we present the possibilities offered by analytical techniques in the field of tree ring analysis, focusing on direct methods and recent developments. The latter strongly improved the details of the accessible information, enabling the investigation of complex phenomena associated with plant life and encouraging the direct analysis of new analytes, particularly minor organic compounds. With regard to their applications, dendrochemical proxies have been used to trace several processes, such as environmental contamination, paleoclimate reconstruction, global environmental changes, tree physiology, extreme events, ecological trends, and dendroprovenance. Several case studies are discussed for each proposed application, with special emphasis on the reliability of tracing each process. Starting from the reviewed literature data, the second part of the paper is devoted to the critical assessment of the reliability of tree ring proxies. We provide an overview of the current knowledge, discuss the limitations of the inferences that may be drawn from the dendrochemical data, and provide recommendations for the best practices to be used for their validation. Finally, we present the future perspectives related to the advancements in analytical instrumentation and further extension of application fields.
- Bookedited by John Schneekloth and Martin Pettersson.Summary: Existing paradigms for drug discovery have focused largely on enzymes and other proteins as drug targets. In recent years, however, different varieties of ribonucleic acids have emerged as a viable focus for target-based drug discovery, with the potential to revolutionize the strategy and approach for this essential step in the drug development process. RNA as a Drug Target: The Next Frontier for Medicinal Chemistry offers a practice-oriented introduction to developing drug-like small molecules that selectively modulate both coding and non-coding RNAs. Beginning with a description and characterization of existing druggable RNAs, the book discusses how to approach different RNA targets for drug discovery. The result is a crucial resource for targeting RNAs and creating the next generation of life-saving pharmaceuticals. RNA as a Drug Target provides an expert introduction to a new frontier in pharmaceutical research for medicinal chemists, biochemists, molecular biologists, and members of the pharmaceutical industry. -- Provided by publisher.Digital Access Wiley [2024]