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  • Article
    He J, Ren X, Zhang Q, Wang S, Li Z, Cai K, Li M, Hu Y, Ran Q, Luo Z.
    Biomaterials. 2025 Apr;315:122924.
    The insufficient activation and impaired effector functions of T cells in the immunosuppressive tumor microenvironment (TME) substantially reduces the immunostimulatory effects of radiotherapy. Herein, a multifunctional nanoradiosensitizer is established by integrating molecularly engineered aptamer precursors into cisplatin-loaded liposomes for enhancing radio-immunotherapy of solid tumors. Exposure to ionizing radiation (IR) following the nanoradiosensitizer treatment would induce pronounced immunogenic death (ICD) of tumor cells through cisplatin-mediated radiosensitization while also trigger the detachment of the aptamer precursors, which further self-assemble into PD-L1/PD-1-bispecific aptamer-based T cell engagers (CA) through the bridging effect of tumor-derived ATP to direct T cell binding onto tumor cells in the post-IR TME in a spatial-temporally programmable manner. The CA-mediated post-IR tumor-T cell engagement could override the immunosuppressive barriers in TME and enhance T cell-mediated recognition and elimination of tumor cells while minimizing systemic toxicities. Overall, this work offers an innovative approach to enhance the radio-immunotherapeutic efficacy in the clinics.
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  • Article
    Rahmati Z, Roushani M, Hosseini H.
    Talanta. 2022 Jan 15;237:122924.
    During recent decades, we have witnessed a great improvement in the performance of aptamer-based sensors, specifically when aptamers are combined with new nanomaterials; as a platform for biosensors. The design of hollow carbon-based materials has also received a lot of attention due to its excellent properties in various applications. Herein, we aim at designing hierarchical porous Ni(OH)2 nanosheets on hollow N-doped carbon nanoboxes Ni(OH)2@N-C n-box). In this sense, we obtained the hollow N-C n-box skeletons from the Fe2O3 nanocubes template. The development of label-free electrochemical aptasensor was carried out using the covalently immobilizing NH2-functionalized aptamer on Ni(OH)2@N-C n-box as an efficient substrate. The Ni(OH)2@N-C n-box was characterized using scanning fourier transform infrared spectroscopy (FTIR), X-ray Diffraction (XRD), Brunauer, Emmett and Teller (BET), transmission electron microscopes (TEM) and electron microscopy (FESEM). The electrochemical evaluations clarified the fact that a linear relationship exists between the alpha-fetoprotein (AFP) contents and the charge transfer resistance (Rct) (from 1 fg mL-1 to 100 ng mL-1) with a low detection limit of 0.3 fg mL-1. Moreover, regarding the aptasensor, the superior detection recoveries were experienced in real biological samples, illustrating its great detection performance and practical feasibility. Considering the aptasensor application, these studies showed that Ni(OH)2@N-C n-box possesses different enhanced electrochemical features, making it appropriate as an electrode material for aptasensor application.
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  • Article
    Dain L, Zhu G.
    Int J Pharm. 2023 May 10;638:122924.
    Glioblastoma multiforme (GBM) is a deadly and difficult to treat primary brain tumor for which satisfactory therapeutics have yet to be discovered. While cancer immunotherapeutics, such as immune checkpoint inhibitors, have successfully improved the treatment of some other types of cancer, the poorly immunogenic GBM tumor cells and the immunosuppressive GBM tumor microenvironment have made it difficult to develop GBM immunotherapeutics. Nucleic acids therapeutics and vaccines, particularly those of mRNA, have become a popular field of research in recent years. This review presents the progress of nucleic acid therapeutics and vaccines for GBM and briefly covers some representative delivery methods of nucleic acids to the central nervous system (CNS) for GBM therapy.
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  • Article
    Ali S, Sethy BK, Mina BL, Meena HR, Kala S, Kumar A, Rashmi I, Meena GL, Sharma GK.
    J Environ Manage. 2024 Nov;370:122924.
    United Nation Sustainable Development Goal 15.3 make a note of growing significance of management and restoration strategies for degraded land, and advocating globally for collaborative frameworks of innovative applied research and policy. Present study, quantified the impacts of the staggered contour trenching (SCT) technology in conjunction with silvi-pasture production system on regulating and provisioning ecosystem services of degraded mini-watersheds. Impacts of the SCT on hydrologic regulating ecosystem services were quantified by employing the paired watershed approach. Concept of watersheds with and without treatments was employed for computing non-hydrologic regulating and provisioning ecosystem services of the SCT in conjunction with silvi-pasture system. Results of analyses revealed that the SCT density of 505 trenches ha-1 had the highest reduction in the hydrologic regulating services namely, mean annual runoff event, runoff amount and soil loss, which were 35.5, 63.3, and 3.73%, respectively followed by 378, and 186 trenches ha-1. The highest improvement in the effective rainfall (9.9%) and effective rainfall efficiency (15.0%) was also with 505 trenches ha-1. The SCT density of 505 trenches ha-1 had retained silt 23.1 and 1.2 times higher than that of 378 and 186 trenches ha-1. The values of the post-treatment non-hydrologic regulating services of 505 trenches ha-1 were many folds higher compare to other trenching densities. Improvement in the non-hydrologic regulating services of the available -nitrogen, -potash and -potassium, and soil organic carbon values of the post-treatment of 505 trenches ha-1 were 36.7, 44.2, 25.8, and 25.0% than their pre-treatment values, respectively. Provisioning ecosystem services in term of the yields of the wood biomass of the Acacia nilotica and the Cenchrus ciliaris were the highest with 505 trenches ha-1 than the control (no trench) by 166.2 and 21.5%, respectively. Study indicated that 505 trenches ha-1 SCT density in the silvi-pasture production system was the best practices in conserving and maintaining the degraded land ecosystem services. These findings would be very supportive to the policy makers and degraded land managers for reclaiming and improving the sustainability and ecosystem functioning of the degraded land ecosystem for achieving the SDG 5.3 and maintaining the land degradation neutrality.
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  • Article
    Li Z, Sun X.
    Life Sci. 2024 Sep 15;353:122924.
    The liver is considered unique in its enormous capacity for regeneration and self-repair. In contrast to other regenerative organs (i.e., skin, skeletal muscle, and intestine), whether the adult liver contains a defined department of stem cells is still controversial. In order to compensate for the massive loss of hepatocytes following liver injury, the liver processes a precisely controlled transcriptional reprogram that can trigger cell proliferation and cell-fate switch. Epigenetic events are thought to regulate the organization of chromatin architecture and gene transcription during the liver regenerative process. In this review, we will summarize how changes to the chromatin by epigenetic modifiers are translated into cell fate transitions to restore liver homeostasis during liver regeneration.
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  • Article
    Cabral G, Ren B, Bisio H, Otey D, Soldati-Favre D, Brown KM.
    Microbiol Spectr. 2024 Oct 03;12(10):e0122924.
    Apicomplexan parasites mobilize ionic calcium (Ca2+) from intracellular stores to promote microneme secretion and facilitate motile processes including gliding motility, invasion, and egress. Recently, a multipass transmembrane protein, ICM1, was found to be important for calcium mobilization in Plasmodium falciparum and P. berghei. Comparative genomics and phylogenetics have revealed putative ICM orthologs in Toxoplasma gondii and other apicomplexans. T. gondii possesses two ICM-like proteins, which we have named TgICM1-L (TGGT1_305470) and TgICM2-L (TGGT1_309910). TgICM1-L and TgICM2-L localized to undefined puncta within the parasite cytosol. TgICM1-L and TgICM2-L are individually dispensable in tachyzoites, suggesting a potential compensatory relationship between the two proteins may exist. Surprisingly, mutants lacking both TgICM1-L and TgICM2-L are fully viable, exhibiting no obvious defects in growth, microneme secretion, invasion, or egress. Furthermore, loss of TgICM1-L, TgICM2-L, or both does not impair the parasite's ability to mobilize Ca2+. These findings suggest that additional proteins may participate in Ca2+ mobilization or import in Apicomplexa, reducing the dependence on ICM-like proteins in T. gondii. Collectively, these results highlight similar yet distinct mechanisms of Ca2+ mobilization between T. gondii and Plasmodium.IMPORTANCECa2+ signaling plays a crucial role in governing apicomplexan motility; yet, the mechanisms underlying Ca2+ mobilization from intracellular stores in these parasites remain unclear. In Plasmodium, the necessity of ICM1 for Ca2+ mobilization raises the question of whether this mechanism is conserved in other apicomplexans. Investigation into the orthologs of Plasmodium ICM1 in T. gondii revealed a differing requirement for ICM proteins between the two parasites. This study suggests that T. gondii employs ICM-independent mechanisms to regulate Ca2+ homeostasis and mobilization. Proteins involved in Ca2+ signaling in apicomplexans represent promising targets for therapeutic development.
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  • Article
    Xiang C, Zhong G, Wang H.
    mBio. 2024 Jul 17;15(7):e0122924.
    A recent study published in mBio by Cao et al. demonstrated that the helminth Trichinella sprialis (Ts) alleviates COVID-19-related cytokine storms in an IL-9-dependent way (Z. Cao, J. Wang, X. Liu, Y. Liu, et al., mBio 15:e00905-24, 2024, https://doi.org/10.1128/mbio.00905-24). A cytokine storm is a severe immune response characterized by the overproduction of proinflammatory cytokines, such as TNF-α and IFN-γ, leading to tissue damage and mortality in COVID-19 patients. This study indicated that IL-9 is crucial in protecting against cytokine storm syndromes associated with SARS-CoV-2 infection and proposed that anti-inflammatory molecules from Ts excretory/secretory (TsES) products could be a novel source for treating such illnesses.
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  • Article
    Bai X, Zhang X, Li Y, Lu L, Li B, He X.
    PLoS One. 2015;10(3):e0122924.
    Unilateral ligation of the tendon of anterior superficial part of rat masseter muscle (TASM) leads to long-lasting allodynia. Sex differences in peripheral mu-opioid receptor (MOR)-mediated analgesia under persistent myogenic pain are not well understood. In this study, we examined (1) whether locally applied MOR agonists attenuate persistent pain following TASM ligation in a sex dependent manner, (2) whether there are sex differences of MOR expression changes in rat trigeminal ganglia (TG). The effects of MOR agonist, D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt (DAMGO), were assessed 14 days after TASM ligation in male, female and orchidectomized (GDX) male rats. MOR mRNA and protein levels in TG 14 days following tendon ligation were also determined. The mechanical thresholds of the injured side were significantly decreased in both male and female rats, from 3 days to 28 days after TASM ligation. A10 μg DAMGO significantly attenuated allodynia in male rats. A 10-fold higher dose of DAMGO was required in female and GDX male rats to produce the level of anti- allodynia achieved in male rats. The level of MOR mRNA in TG from male rats was significantly greater 14 days after TASM ligation compared with the sham-operated male rats, but not from female and GDX male rats. After TASM ligation, males had significantly more MOR immunoreactivity in TG compared to sham-operated males. The MOR levels increased to 181.8% of the sham level in male rats receiving tendon injury. But there was no significant change in female rats receiving tendon injury compared to the sham female rats. Taken together, our data suggest that there were sex differences in the effects of peripheral MOR agonists between male and female rats under TASM ligation developing long-lasting pain condition, which is partly mediated by sex differences in the changes of MOR expressions and testosterone is an important factor in the regulation of MOR.
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  • Article
    Hongprasit A, Okamoto Y, Toida T, Ogra Y.
    J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Sep 01;1181:122924.
    The simultaneous detection of cyanide (CN), thiocyanate (SCN), and selenocyanate (SeCN) by a HPLC-fluorescence detector (FLD) with the post-column König reaction was recently reported. SCN and SeCN are also detectable by HPLC-inductively coupled plasma mass spectrometry (HPLC-ICP-MS) because sulfur and selenium can be detected, respectively, without any pre- or post-treatment. ICP-MS has high sensitivity for selenium and sulfur detection and is robust to sample matrices. In this study, we compared HPLC-FLD with the post-column König reaction and HPLC-ICP-MS in terms of SCN and SeCN detection sensitivity and linearity. The limit of detection (LOD) for SCN indicated that HPLC-FLD with the post-column König reaction was 354 times more sensitive than HPLC-ICP-MS. Likewise, the LOD for SeCN indicated that HPLC-FLD was 51 times more sensitive than HPLC-ICP-MS. These results demonstrated that HPLC-FLD was a more suitable technique for SeCN and SCN detection than HPLC-ICP-MS. We previously reported that SeCN was generated in selenite-exposed mammalian cells to detoxify excess selenite. HPLC-FLD with the post-column König reaction enabled good separation and detection for quantifying SCN and SeCN in mammalian cell lines exposed to selenite. The intracellular SCN and SeCN concentrations determined by this technique suggested differences in the metabolic capacity for selenite to form SeCN among the cell lines. In addition, since the amount of intracellular SCN and SeCN were significantly decreased by pretreatment of myeloperoxidase (MPO) inhibitors, SCN and SeCN were resulted from the interaction of sulfur and selenium with endogenous CN, respectively, generated with MPO.
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  • Book
    editors, Marcela Albuquerque Cavalcanti de Albuquerque, Alejandra de Moreno de LeBlanc, Jean Guy LeBlanc, and Raquel Bedani.
    Summary: "The book deals with advances made in the functionalities of lactic acid bacteria (LAB) such as, their effect on vitamin D receptor expression, impact on neurodegeneratives pathologies, production of B-vitamins for food bio-enrichment, production of bacteriocins to improve gut microbiota dysbiosis, production of metabolites from polyphenols and their effects on human health, effect on reducing the immunoreaction of food allergens, as biological system using time-temperature to improve food safety, and the use of probiotic in animal feed. The book also reviews the use of LAB and probiotics technologies to develop new functional foods and functional pharmaceutical"-- Provided by publisher.

    Contents:
    Cell-cell communication in lactic acid bacteria : potential mechanisms / Lima, EMF, Quecán, BXV, Cunha, LR, Franco, BDGMF, and Pinto, UM
    Probiotic dose-response and strain number / Ouwehand, A
    Impact of lactic acid bacteriaon bioavailability and digestibility / Hess, J
    Lactic acid bacteria application to decrease food allergies / Bíscola, V, Albuquerque, MAC, Nunes, TP, Vieira, ADS, and Franco, BDGM
    Lactic acid bacteria bacteriocins and their impact on human health / Todorov, S and Chikindas, ML
    Probiotics, vitamin D, and vitamin D receptor in health and disease / Battistini, C, Nassani, N, Saad, SMI, and Sun, J
    B-group vitamin producing lactic acid bacteria : a tool to bio-enrich foods and delivery natural vitamin to the host / Albuquerque, MAC, Terán, MM, Garutti, LHG, Cucik, ACC, Saad, SMI, and LeBlanc, JG
    Effect of short-chain fatty acids produced by probiotics : functional role toward the improvement of human health / da Silva, MF, de Lima, MSF, and Converti, A
    Impact of probiotics on human gut microbiota and the relationship with obesity / Bianchi, F and Sivieri, K
    Probiotics in the management of inflammatory bowel disease and irritable bowel syndrome / Celiberto, LS, Vallance, BA, and Cavallini, DCU
    The potential use of lactic acid bacteria in neurodegenerative pathologies / Perez-Visñuk, D, Terán, MM, de Giori, GS, LeBlanc, JG and de Moreno de LeBlanc, A
    The role of the microbiota and the application of probiotics in reducing the risk of cardiovascular diseases / Bedani, R and Saad, SMI
    Metabolites of polyphenols produced by probiotic microorganisms and their beneficial effects on human health and intestinal microbiota / Beres, C, Cabezudo, I, and Maidin, NM
    . Application of lactic acid bacteria in time-temperature integrators : a tool to monitor the quality and safety of perishable foods / Girardeau, A, Bíscola, V, Keravec, S, Corrieu, G and Fonseca, F
    Impact of probiotics on animal health / Sabo, SS, Villalobos, EF, Piazentin, ACM, Lopes, AM, and Oliveira, RPS.
    Digital Access TandFonline [2020]