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  • Article
    Alruwaili TA, Crawford K, Fooladi E.
    Midwifery. 2024 11;138:104147.
    BACKGROUND: Shared decision-making (SDM) in maternity care involves women actively in decisions, thereby reducing decisional conflicts and enhancing satisfaction with care.
    AIM: To investigate SDM and the factors associated with it, and its correlation with respect in maternity care in Saudi Arabia.
    METHODS: A comprehensive, nationwide online questionnaire-based study was conducted between January to May 2023, involving women aged 18 years and above who were either pregnant or had experienced pregnancy/childbirth in the past 12 months. The Mothers' Autonomy in Decision-Making (MADM) scale and the Mothers of Respect Index (MORi) were used. Low to very low SDM was defined as a score of ≤ 24 on the MADM and low to very low respected was defined as a score of ≤ 49 on the MORi.
    RESULTS: A total of 505 women completed the survey. Low to very low SDM was reported by 137 (34.1 %, 95 confidence interval (CI), 29.6 % - 38.9 %) women. Factors significantly associated with low to very low SDM included seeing different obstetricians of different gender at each visit (adjusted odds ratio (AOR) 2.0, 95 % CI, 1.0 - 3.9), not meeting the same obstetrician throughout the pregnancy (AOR 2.6, 95 % CI, 1.2 - 5.6) and having an instrumental vaginal birth (AOR 6.67, 95 % CI, 1.6 - 28.1). There was a positive association between low to very SDM and feeling of low to very low respect ((χ2 = 83.8173, p < 0.001).
    CONCLUSION: More than one-third of women experienced low to very low SDM in maternity care. This should alert healthcare providers to the importance of continuity of care in Saudi Arabia.
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  • Article
    Roque D, Kalyal N, Chowdhury YA, Elhag A, Elliot M, Ashkan K, Vergani F, Bhangoo R, Lavrador JP.
    Brain Spine. 2024;4:104147.
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  • Article
    Li X, Zhu LJ, Chen JP, Shi CY, Niu LT, Zhang X, Yao XS.
    Fitoterapia. 2019 Jul;136:104147.
    One new flavanonol, demethylmatteucinol (1), and nine new flavanone glucoside derivatives, matteflavosides H-J (2-4) and matteuinterates A-F (5-10), were isolated from the rhizomes of Matteuccia intermedia C.Chr., along with 21 known flavanones (11-31). Notably, all of them contain C-methylation in the A-ring. The structures of the compounds were elucidated by spectroscopic methods and chemical derivatization. The α-glycosidase inhibition assay indicated that compounds 12-17 showed potent inhibitory activity with IC50 values of 12.4-69.7 μM, which suggested their hypoglycemic effect.
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  • Article
    Helbing J, Draschkow D, Võ ML.
    Cognition. 2020 03;196:104147.
    We use representations and expectations formed during life-long learning to support attentional allocation and perception. In comparison to traditional laboratory investigations, real-world memory formation is usually achieved without explicit instruction and on-the-fly as a by-product of natural interactions with our environment. Understanding this process and the quality of naturally formed representations is critical to understanding how memory is used to guide attention and perception. Utilizing immersive, navigable, and realistic virtual environments, we investigated incidentally generated memory representations by comparing them to memories for items which were explicitly memorized. Participants either searched for objects embedded in realistic indoor environments or explicitly memorized them for follow-up identity and location memory tests. We show for the first time that memory for the identity of naturalistic objects and their location in 3D space is higher after incidental encoding compared to explicit memorization, even though the subsequent memory tests came as a surprise to participants. Relating gaze behavior to memory performance revealed that encoding time was more predictive of subsequent memory when participants explicitly memorized an item, compared to incidentally encoding it. Our results suggest that the active nature of guiding attentional allocation during proactive behavior allows for behaviorally optimal formation and utilization of representations. This highlights the importance of investigating cognition under ecologically valid conditions and shows that understanding the most natural processes for encoding and maintaining information is critical for understanding adaptive behavior.
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  • Article
    Horvatits T, Tamminga M, Liu B, Sebode M, Carambia A, Fischer L, Püschel K, Huber S, Fischer EK.
    EBioMedicine. 2022 Aug;82:104147.
    BACKGROUND: The contamination of ecosystem compartments by microplastics (MPs) is an ubiquitous problem. MPs have been observed in mice tissues, and recently in human blood, stool and placenta. However, two aspects remain unclear: whether MPs accumulate in peripheral organs, specifically in the liver, and if liver cirrhosis favours this process. We aimed to examine human liver tissue samples to determine whether MPs accumulate in the liver.
    METHODS: This proof-of-concept case series, conducted in Germany, Europe, analyzed tissue samples of 6 patients with liver cirrhosis and 5 individuals without underlying liver disease. A total of 17 samples (11 liver, 3 kidney and 3 spleen samples) were analyzed according to the final protocol. A reliable method for detection of MP particles from 4 to 30 µm in human tissue was developed. Chemical digestion of tissue samples, staining with Nile red, subsequent fluorescent microscopy and Raman spectroscopy were performed. Morphology, size and composition of MP polymers were assessed.
    FINDINGS: Considering the limit of detection, all liver, kidney and spleen samples from patients without underlying liver disease tested negative for MPs. In contrast, MP concentrations in cirrhotic liver tissues tested positive and showed significantly higher concentrations compared to liver samples of individuals without underlying liver disease. Six different microplastic polymers ranging from 4 to 30 µm in size were detected.
    INTERPRETATION: This proof-of-concept case series assessed the presence of MPs in human liver tissue and found six different MP polymers in the liver of individuals with liver cirrhosis, but not in those without underlying liver disease. Future studies are needed to evaluate whether hepatic MP accumulation represents a potential cause in the pathogenesis of fibrosis, or a consequence of cirrhosis and portal hypertension.
    FUNDING: No funding was received for conducting this investigator driven study.
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  • Article
    Decker KP, Feliciano PG, Kimmel MT, Hogwood AC, Weggen JB, Darling AM, Richardson JW, Garten RS.
    Microvasc Res. 2021 05;135:104147.
    PURPOSE: Lower limb microvascular dysfunction resulting from prolonged sitting (PS) bouts has been revealed to occur independent of sex. Although acute antioxidant supplementation has been reported to blunt conduit artery dysfunction following PS in young males, it is unknown if this protective effect extends to the microvasculature or is relevant in young females, who possess intrinsic vascular protective mechanisms specific to antioxidant defense. Therefore, this study employed an acute antioxidant supplementation to further examine sex differences during PS with a specific focus on microvascular function.
    METHODS: On two separate visits, 14 females (23 ± 3 years) and 12 males (25 ± 4 years) had leg microvascular function (LMVF) assessed (via the passive leg movement technique) before and after 1.5 h of sitting. Prior to each visit, one gram of vitamin C (VC) or placebo (PL) was consumed.
    RESULTS: PS significantly reduced LMVF [PL: (M: -34 ± 20; F: -23 ± 18%; p < 0.01) independent of sex (p = 0.7)], but the VC condition only blunted this reduction in males (VC: -3 ± 20%; p < 0.01), but not females (VC: -18 ± 25%; p = 0.5).
    CONCLUSION: Young males and females reported similar reductions LMVF following PS, but only the young males reported a preservation of LMVF following the VC supplementation. This finding in young females was highlighted by substantial variability in LMVF measures in response to the VC condition that was unrelated to changes in the potential contributors to sitting-induced reductions in LMVF (e.g. lower limb venous pooling, reduced arterial shear rate).
    NEW AND NOTEWORTHY: In this study, we employed an acute Vitamin C (VC) supplementation to examine sex differences in leg microvascular function (LMVF) following a bout of prolonged sitting. This study revealed that prolonged sitting reduced LMVF independent of sex, but only young males reported an attenuation to this lowered LMVF following VC supplementation. The young females revealed substantial variability in sitting-induced changes to LMVF that could not be explained by the potential contributors to sitting-induced reductions in LMVF (e.g. lower limb venous pooling, reduced arterial shear rate).
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  • Article
    Yu M, Zhang YL, Liu JL, Wang SJ, Zhang GJ.
    Bioorg Chem. 2020 10;103:104147.
    Two pairs of new sesquineolignan enantiomers (1a/1b and 1c/1d), two pair of new 4',7-epoxy-8,3'-neolignan enantiomers (2a/2b and 3a/3b), and a pair of new 3',7-epoxy-8,4'-oxyneolignan enantiomers (4a/4b), along with two pairs of known 4',7-epoxy-8,3'-neolignan enantiomers (5a/5b and 6a/6b), were obtained from the stems and leaves of Triadica sebifera. The structures of the enantiomers were elucidated by spectroscopic analyses, and their absolute configurations were assigned by the experimental ECD spectra. Among them, compounds 5b, 6a and 6b showed inhibitory activities against NO production in activated microglial BV-2 cells, with IC50 values of 14.3, 23.2 and 33.3 μM, respectively.
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  • Article
    Mellett M.
    Cell Immunol. 2020 08;354:104147.
    CARD14 is a scaffold molecule predominantly expressed in keratinocytes and genetic variants in the CARD14 gene confer an increased risk of inflammatory skin disease. Due to its association with common skin diseases psoriasis and atopic dermatitis, the biological function of CARD14 is of relevant interest to human health. CARD14 recruits BCL10 and MALT1 to form the CARD-BCL10-MALT1 complex, which modulates NF-κB and MAPK signalling pathways, yet little is known about how CARD14 is regulated or activated in the context of the innate immune response and in chronic inflammation. This review summarises the current understanding of the molecular function and regulatory mechanisms of CARD14 and highlights recent findings in human disease and murine mouse models.
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  • Article
    Varga S, Pfister R, Neszmélyi B, Kunde W, Horváth J.
    Acta Psychol (Amst). 2024 Mar;243:104147.
    Features of actions are bound to coincidentally occurring stimuli so that re-encountering a stimulus retrieves a previous action episode. One hallmark of the purported mechanism in binding/retrieval tasks is a reliable reaction time advantage for repeating a previous response if tone stimuli repeat rather than alternate across trials. Other measures than reaction times yielded surprisingly mixed results, however. This is particularly true for continuous response features like force or response duration. We therefore conducted two experiments to resolve this disconnect between different measures. Experiment 1 tested for a potentially inflated effect in reaction time data, whereas Experiment 2 took the converse approach of studying conditions that would elicit similarly strong effects on alternative measures. Our results show that confounds in terms of auditory change detection do not inflate reaction time differences, reinforcing an interpretation of these effects as reflecting binding and retrieval. Moreover, strong effects on alternative measures appeared if these features were rendered task-relevant and came with sufficient variability. These observations provide critical evidence for binding and retrieval accounts, especially by showing that these accounts extend from binary decisions to continuous features of an actual motor response.
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  • Article
    Goldsworthy J, Watling CN, Rose C, Larue G.
    Appl Ergon. 2024 Jan;114:104147.
    Distracted driving remains a significant cause of traffic accidents globally, including in Australia. However, many younger drivers still admit to using a phone while driving. A simulated driving study investigated the neurophysiological effects of visual, auditory, and higher-order cognitive (i.e., requiring the use of executive functions) distraction on young drivers. In total, 24 young adults aged 18-25 years completed four 8 min simulated driving sessions while concurrently engaging in various distractor tasks. Neurophysiological arousal was measured via EEG. Additionally, subjective workload and objective driving performance were assessed. Frontal beta and gamma power exhibited their highest levels during tasks involving higher-order cognitive and visual demands. The higher-order cognitive condition was rated as the most mentally demanding. In comparison, the visual condition had the most significant impact on both the standard deviation of speed and standard deviation of lateral positioning. This study has significant implications for all road users, particularly those aged 18-25 years, and it reinforces the importance of not using a phone while driving.
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  • Article
    Starke R, Siles JA, Fernandes MLP, Schallert K, Benndorf D, Plaza C, Jehmlich N, Delgado-Baquerizo M, Bastida F.
    J Proteomics. 2021 04 15;237:104147.
    We lack a predictive understanding of the environmental drivers determining the structure and function of archaeal communities as well as the proteome associated with these important soil organisms. Here, we characterized the structure (by 16S rRNA gene sequencing) and function (by metaproteomics) of archaea from 32 soil samples across terrestrial ecosystems with contrasting climate and vegetation types. Our multi-"omics" approach unveiled that genes from Nitrosophaerales and Thermoplasmata dominated soils collected from four continents, and that archaea comprise 2.3 ± 0.3% of microbial proteins in these soils. Aridity positively correlated with the proportion of Nitrosophaerales genes and the number of archaeal proteins. The interaction of climate x vegetation shaped the functional profile of the archaeal community. Our study provides novel insights into the structure and function of soil archaea across climates, and highlights that these communities may be influenced by increasing global aridity.
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  • Article
    Ng KH, Srinivas V, Srinivasan R, Balasubramanian M.
    Archaea. 2013;2013:104147.
    Euryarchaeota and Crenarchaeota are two major phyla of archaea which use distinct molecular apparatuses for cell division. Euryarchaea make use of the tubulin-related protein FtsZ, while Crenarchaea, which appear to lack functional FtsZ, employ the Cdv (cell division) components to divide. Ammonia oxidizing archaeon (AOA) Nitrosopumilus maritimus belongs to another archaeal phylum, the Thaumarchaeota, which has both FtsZ and Cdv genes in the genome. Here, we used a heterologous expression system to characterize FtsZ and Cdv proteins from N. maritimus by investigating the ability of these proteins to form polymers. We show that one of the Cdv proteins in N. maritimus, the CdvB (Nmar_0816), is capable of forming stable polymers when expressed in fission yeast. The N. maritimus CdvB is also capable of assembling into filaments in mammalian cells. However, N. maritimus FtsZ does not assemble into polymers in our system. The ability of CdvB, but not FtsZ, to polymerize is consistent with a recent finding showing that several Cdv proteins, but not FtsZ, localize to the mid-cell site in the dividing N. maritimus. Thus, we propose that it is Cdv proteins, rather than FtsZ, that function as the cell division apparatus in N. maritimus.
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  • Article
    Dorn-In S, Führer L, Gareis M, Schwaiger K.
    Food Microbiol. 2023 Feb;109:104147.
    Vacuum packaging and storage conditions at chilled temperatures are commonly used in order to prolong the shelf life of meat. Under these conditions and time-temperature abuse, cold-tolerant (facultatively) anaerobic spoilage microorganisms can continue growing. This study investigated growth of six relevant spoilage microorganisms in vacuum-packed beef (n = 12, 72 subsamples, stored at 10 °C for 28 days) using culture and qPCR methods. Correspondingly, six qPCRs were newly developed/modified (for total bacteria, lactic acid bacteria (LAB), Enterobacterales, total fungi, Kazachstania psychrophila, and cold-tolerant Clostridium spp.). Besides microbial quantification, four spoilage appearances of meat (gas production, spoilage odor, % drip loss, and meat color) were observed. Results obtained from culture and qPCR show that total bacteria, LAB, and Enterobacterales reached their stationary phase at day 7 when spoilage parameters such as gas production were statistically increased and a deviation of odor was detected. Fastidious cold-tolerant Clostridium spp. and K. psychrophila could be detected from day 7. Based on microbiological and sensory analysis results, the maximum shelf life of vacuum-packed beef stored at 10 °C is 7 days. The developed qPCR has the potential to be used as an alternative method to culturing for determination of microbial growth.
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  • Article
    Planas-Sitjà I.
    Behav Processes. 2020 Aug;177:104147.
    Many animals live in groups and engage in collective actions which can enhance their fitness. One common example is collective decision-making, which mainly arises from social interactions that modify the individual behaviour. Despite the widespread interest in animal personalities on the one hand and in social effects (such as social organisation, social learning or anti-predator behaviour) on the other, the question of how the amount of among-individual differences, coupled with social interactions, influence group cohesion has rarely been addressed. For this purpose, I used a modelling approach based on aggregation behaviour of cockroaches to explore the mechanisms underlying such context-dependent behaviour. The results of simulations considering different degrees (none, medium, high) of personality variation in a non-social and social context were compared to experimental patterns of aggregation dynamics in cockroaches. The comparison between the simulated and experimental data show that only a model that considers differences in individuals was able to reproduce the experimental patterns of individuals and groups. In addition, the comparison between models suggest that some individuals may play a keystone role during aggregation dynamics, influencing the behaviour of others and facilitating the collective decision. Finally, I show that personality variation amplifies the effects of social inter-attractions, thus increasing the speed of aggregation, shedding light on the mechanisms underpinning social modification of individual behaviour.
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  • Article
    Zhou D, Gan Z, Shi X, Patwari A, Rush E, Bonzel CL, Panickan VA, Hong C, Ho YL, Cai T, Costa L, Li X, Castro VM, Murphy SN, Brat G, Weber G, Avillach P, Gaziano JM, Cho K, Liao KP, Lu J, Cai T.
    J Biomed Inform. 2022 09;133:104147.
    OBJECTIVE: The growing availability of electronic health records (EHR) data opens opportunities for integrative analysis of multi-institutional EHR to produce generalizable knowledge. A key barrier to such integrative analyses is the lack of semantic interoperability across different institutions due to coding differences. We propose a Multiview Incomplete Knowledge Graph Integration (MIKGI) algorithm to integrate information from multiple sources with partially overlapping EHR concept codes to enable translations between healthcare systems.
    METHODS: The MIKGI algorithm combines knowledge graph information from (i) embeddings trained from the co-occurrence patterns of medical codes within each EHR system and (ii) semantic embeddings of the textual strings of all medical codes obtained from the Self-Aligning Pretrained BERT (SAPBERT) algorithm. Due to the heterogeneity in the coding across healthcare systems, each EHR source provides partial coverage of the available codes. MIKGI synthesizes the incomplete knowledge graphs derived from these multi-source embeddings by minimizing a spherical loss function that combines the pairwise directional similarities of embeddings computed from all available sources. MIKGI outputs harmonized semantic embedding vectors for all EHR codes, which improves the quality of the embeddings and enables direct assessment of both similarity and relatedness between any pair of codes from multiple healthcare systems.
    RESULTS: With EHR co-occurrence data from Veteran Affairs (VA) healthcare and Mass General Brigham (MGB), MIKGI algorithm produces high quality embeddings for a variety of downstream tasks including detecting known similar or related entity pairs and mapping VA local codes to the relevant EHR codes used at MGB. Based on the cosine similarity of the MIKGI trained embeddings, the AUC was 0.918 for detecting similar entity pairs and 0.809 for detecting related pairs. For cross-institutional medical code mapping, the top 1 and top 5 accuracy were 91.0% and 97.5% when mapping medication codes at VA to RxNorm medication codes at MGB; 59.1% and 75.8% when mapping VA local laboratory codes to LOINC hierarchy. When trained with 500 labels, the lab code mapping attained top 1 and 5 accuracy at 77.7% and 87.9%. MIKGI also attained best performance in selecting VA local lab codes for desired laboratory tests and COVID-19 related features for COVID EHR studies. Compared to existing methods, MIKGI attained the most robust performance with accuracy the highest or near the highest across all tasks.
    CONCLUSIONS: The proposed MIKGI algorithm can effectively integrate incomplete summary data from biomedical text and EHR data to generate harmonized embeddings for EHR codes for knowledge graph modeling and cross-institutional translation of EHR codes.
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  • Article
    Renkema A, Zipp JS, Tahan HM, Warren JI, MacDonald R.
    Nurse Educ Pract. 2024 Oct;80:104147.
    AIM: To inform the development of statewide core competencies for new graduate nurses at the beginning of their professional career and after completing a 12-month nurse residency program.
    BACKGROUND: Although studies have attempted to clarify the expected core competencies of new graduate nurses at the beginning of their professional career, results are mixed. Additionally, nurse residency program competency expectations vary.
    DESIGN: A retrospective cross-sectional study using a purposive sample of a national nurse residency program database.
    METHODS: Wilcoxon Signed Rank tests compared retrospective self-report data between January 1st 2017 and December 31st 2019, from 2916 acute care hospital new graduate nurses working in the state of Maryland, USA, to examine their perceptions of competency at hire and after completing a nationally standardized 12-month nurse residency program. The study used six domains from the Casey Fink Graduate Nurse Experience Survey© 2006 and the Vizient/AACN Nurse Residency Program™ Progression survey.
    RESULTS: New graduate nurses' self-report of competency increased from a mean score of 4.81 at the beginning of a nurse residency program to 6.67 after completion of 12-month nurse residency program (scale of 0-10). At the beginning of a nurse residendy program, new graduate nursesreported a low level of comfort in three of the six survey domains: communication and leadership, high-intensity skills and patient safety. At 12 months, new graduate nurses reported higher levels of comfort in all six survey domains, with statistically significant increases (Wilcoxon Signed Rank test, α =0.05).
    CONCLUSIONS: Four domains for ongoing competency development were identified for the nurse residency program curriculum-communication and leadership, patient safety, complex patient assignments and end-of-life care-with the expectation that new graduate nurses achieve competency at program completion. New graduate nurses' perceptions corroborated findings from a statewide study of academicians and practice leaders, thus helping to develop realistic core competencies for new graduate nurses entering the workforce and after completing a 12-month nurse residency program.
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  • Article
    Nazari AR.
    Med Eng Phys. 2024 04;126:104147.
    BACKGROUND: Two main problems examining the mechanism of cancer progression in the tissues using the computational models are lack of enough knowledge on the effective factors for such events in vivo environments and lack of specific parameters in the available computational models to simulate such complicated reactions.
    METHODS: In this study, it was tried to simulate the progression of cancerous lesions in the bone tissues by an independent parameter from the anatomical and physiological characteristics of the tissues, so to degrade the orthotropic mechanical properties of the bone tissues, a virtual temperature was determined to be used by a well-known framework for simulation of damages in the composite materials. First, the reliability of the FE model to simulate hyperelastic response in the intervertebral discs (IVDs) and progressive failure in the bony components were verified by simulation of some In-Vitro tests, available in the literature. Then, the progression of the osteolytic damage was simulated in a clinical case with multiple myeloma in the lumbar vertebrae.
    RESULTS: The FE model could simulate stress-shielding and diffusion of lesion in the posterior elements of the damaged vertebra which led to spinal stenosis. The load carrying shares associated with the anterior half and the posterior half of the examined vertebral body and the posterior elements were estimated equal to 41 %, 47 % and 12 %, respectively for the intact condition, that changed to 14 %, 16 % and 70 %, when lesion occupied one third of the vertebral body.
    CONCLUSION: Correlation of the FE results with the deformation shapes, observed in the MRIs for the clinical case study, indicated appropriateness of the procedure, proposed for simulation of the progressive osteolytic damage in the vertebral segments. The future studies may follow simulation of tumor growth for various metastatic tissues using the method, established here.
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  • Article
    Eras JC, Santos VS, Gutierrez AS, Vandecasteele C.
    Data Brief. 2019 Aug;25:104147.
    Improving and managing the electricity efficiency in hotel facilities is essential to reduce the hotel operation costs and its environmental impacts. The data presented shows the evolution of the electricity consumption and management between 2013 and 2015 in two hotel facilities in Cuba (one beach hotel and one city hotel). The data additionally includes the daily measures used to develop control tools for an energy management system. The data presented in the article relates to the research study: Tools to improve forecasting and control of the electricity consumption in hotels Cabello et al., 2016, and it corresponds to the energy audits developed in one beach hotel (Hotel A) and one city hotel (Hotel B) in Cuba.
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  • Article
    Teixeira-Soares CM, Viana AGA, Ribeiro IM, Silva KDP, Sancler-Silva YFR, Machado-Neves M.
    J Equine Vet Sci. 2022 12;119:104147.
    Endometritis is a relevant cause of subfertility in mares. However, the accurate diagnosis, essential for effective treatment, can be difficult due to the variability of results and interpretations resulting from different examination methods and sample collection techniques. The present work compared gynecological evaluation methods and sample collection techniques to diagnose endometritis in subfertile mares. Forty animals with a history of subfertility were selected for gynecological evaluation using clinical methodologies, such as perineal conformation, transrectal palpation and ultrasonography, vaginoscopy, and digital examination of the cervix. In addition, we performed laboratory analyses, including uterine microbiological culture and endometrial cytology and histology, of which the latter is the gold standard for the diagnosis of endometritis. Samples were collected for microbiological culture and endometrial cytological evaluations using three different techniques: a commercial cytobrush/swab collector, low-volume uterine flush, and a new tested technique, by flush the fragment resulting from the endometrial biopsy. Transrectal palpation and ultrasound showed the best results among clinical examinations. However, they were less efficient in laboratory tests of endometrial cytology and uterine microbiological culture, in which the latter showed the highest sensitivity and specificity for endometritis compared with endometrial histology. The use of multiple results from different methods has also proved to be an effective alternative for diagnosis. Among the techniques used to collect endometrial material for cytology and microbiological culture, the most effective and practical in this study was the commercial cytobrush/swab collector.
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  • Article
    Kajal P, Bhutani N, Saini K, Kadian P.
    Ann Med Surg (Lond). 2022 Aug;80:104147.
    Introduction: Ovarian teratomas are most common germ cell neoplasms. Immature ovarian teratoma comprises less than 1% of all ovarian teratomas. It usually occurs in first two decades of life.
    Case presentation: We report a case of 4 years old female child presenting with pain and huge lump in lower abdomen. On abdominal ultrasonography, it revealed a solid-cystic pelvic lesion arising from left ovary. Magnetic resonance imaging (MRI) corroborated the ultrasonographic findings. She underwent laparotomy with right oophorectomy with excision of the mass. The histopathological examination of the excised mass confirmed it to be immature ovarian teratoma with yolk sac tumor. The patient had an uneventful recovery with no sign of tumor recurrence at a one and a half year follow-up.
    Conclusion: In spite of immature ovarian teratomas having aggressive behaviour and lethal outcome, a high degree of suspicion and timely management can translate into a very good eventual prognosis.
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doi:10.1016/j.midw.2024.104147 doi:10.1016/j.bas.2024.104147 doi:10.1016/j.fitote.2019.04.002 doi:10.1016/j.cognition.2019.104147 doi:10.1016/j.ebiom.2022.104147 doi:10.1016/j.mvr.2021.104147 doi:10.1016/j.bioorg.2020.104147 doi:10.1016/j.cellimm.2020.104147 doi:10.1016/j.actpsy.2024.104147 doi:10.1016/j.apergo.2023.104147 doi:10.1016/j.jprot.2021.104147 doi:10.1155/2013/104147 doi:10.1016/j.fm.2022.104147 doi:10.1016/j.beproc.2020.104147 doi:10.1016/j.jbi.2022.104147 doi:10.1016/j.nepr.2024.104147 doi:10.1016/j.medengphy.2024.104147 doi:10.1016/j.dib.2019.104147 doi:10.1016/j.jevs.2022.104147 doi:10.1016/j.amsu.2022.104147