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  • Article
    Park MH, Yoon DY, Ban JO, Kim DH, Lee DH, Song S, Kim Y, Han SB, Lee HP, Hong JT.
    Oncotarget. 2015 Nov 17;6(36):38566-77.
    Interleukin (IL)-32, mainly produced by T-lymphocytes, natural killer cells, epithelial cells, and blood monocytes, is dominantly known as a pro-inflammatory cytokine. However, the role of IL-32 on inflammatory disease has been doubtful according to diverse conflicting results. This study was designed to examine the role of IL-32β on the development of collagen antibody (CAIA) and lipopolysaccharide (LPS)-induced inflammatory arthritis. Our data showed that the paw swelling volume and clinical score were significantly reduced in the CAIA and LPS-treated IL-32β transgenic mice compared with non-transgenic mice. The populations of cytotoxic T, NK and dendritic cells was inhibited and NF-κB and STAT3 activities were significantly lowered in the CAIA and LPS-treated IL-32β transgenic mice. The expression of pro-inflammatory proteins was prevented in the paw tissues of CAIA and LPS-treated IL-32β transgenic mice. In addition, IL-32β altered several cytokine levels in the blood, spleen and paw joint. Our data indicates that IL-32β comprehensively inhibits the inflammation responses in the CAIA and LPS-induced inflammatory arthritis model.
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  • Article
    Leventoğlu E, Deniz EB, Kara Ulu N, Polat M, Fidan K.
    Cureus. 2023 May;15(5):e38566.
    Hydatid disease is a parasitic disease caused by Echinococcus granulosus or Echinococcus multilocularis. It is still a serious public health problem in endemic regions such as the Mediterranean basin. Since the complaints caused by the cysts are non-specific and routine laboratory tests do not always yield positive results, diagnosis may be difficult. While liver involvement is present in 70% of cases, larvae escaping from the filtration of the liver cause pulmonary disease in 25% of cases. Although the prevalence of kidney involvement in all hydatid cysts is approximately 2-4%, and isolated kidney involvement is extremely rare at 1.9%. In this case report, we present an extremely rare pediatric case of isolated renal hydatid cyst, the diagnosis of which was somewhat delayed.
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  • Article
    Pellegrino A, Coscione A, Santulli A, Pellegrino G, Paracuollo M.
    Orthop Rev (Pavia). 2022;14(6):38566.
    Periprosthetic fractures around total knee arthroplasty in elderly represent an emerging cause of implant revision and their incidence seems destined to further increase in the upcoming years, considering the ever-increasing number of implanted prostheses. These are complex injuries with very high complication rates. It has been estimated that the incidence of femoral periprosthetic fractures after T.K.A. ranged between 0,3 to 2,5%, but increases up to 38% when considering revision T.K.A. Patient-related risk factors for T.K.A. periprosthetic fracture (T.K.A.P.F.) include osteoporosis, age, female sex, revision arthroplasty and peri-implant osteolysis. The grate debate concerns the choice of the most appropriate fixation device for T.K.A.P.F.: closed or open reduction with internal fixation with either locked plate or intramedullary nail is the most commonly used for treating these fractures. Success of these methods depends on the fracture pattern, the stability of implants, and the patient's bone quality which is often poor in elderly, thus resulting in high complication rates. Conversely, a revision of T.K.A. (R.T.K.A.) should be considered in case of prosthetic component instability, severe comminution or metaphyseal extension of the fracture (that precludes a good fixation), previous treatments failure and severe malalignment of T.K.A. Instead megaprosthesis and allograft-prosthesis composite are necessary in case of sever bone loss. Considering the variability of the clinical scenario of T.K.A.P.F., this complex injury requires and experienced and comprehensive approach based on both facture fixation and/or revision arthroplasty.
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  • Article
    Massaad J, Magremanne M.
    Heliyon. 2024 Oct 30;10(20):e38566.
    MRONJ is a well-known side effect of antiresorptive and antiangiogenic drug treatment. Crohn's disease involves pro-inflammatory interleukins IL-12 and IL-23. Ustekinumab is a targeted therapy antagonist of the p40 subunit of IL-12 and -23 indicated in the treatment of immune-mediated inflammatory diseases. A 72-year-old man with Crohn's disease developed MRONJ after being treated with ustekinumab for four years. The patient presented with bone exposure three months after the extraction of two mandibular teeth. He had no known predisposing factors and never received ARDs. The patient underwent surgical treatment, and ustekinumab treatment was suspended for six months. No recurrence of MRONJ was detected after 12 months. Although the new definition of MRONJ excludes antiangiogenic molecules, tyrosine kinase inhibitors, and mTOR inhibitors alone, some cases have been reported with ustekinumab. This report highlights the possibility of MRONJ occurring when taking ustekinumab for Crohn's disease, even without being treated with antiresorptive drugs.
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  • Article
    Tang R, Li Y, Xie S, Li N, Chen J, Gao C, Zhu P, Wang X.
    Sci Rep. 2016 12 07;6:38566.
    Raman spectroscopy, synchrotron angle-dispersive X-ray diffraction (ADXRD), first-principles calculations, and electrical resistivity measurements were carried out under high pressure to investigate the structural stability and electrical transport properties of metavanadate MgV2O6. The results have revealed the coordination change of vanadium ions (from 5+1 to 6) at around 4 GPa. In addition, a pressure-induced structure transformation from the C2/m phase to the C2 phase in MgV2O6 was detected above 20 GPa, and both phases coexisted up to the highest pressure. This structural phase transition was induced by the enhanced distortions of MgO6 octahedra and VO6 octahedra under high pressure. Furthermore, the electrical resistivity decreased with pressure but exhibited different slope for these two phases, indicating that the pressure-induced structural phase transitions of MgV2O6 was also accompanied by the obvious changes in its electrical transport behavior.
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  • Article
    Ghamri RA.
    Medicine (Baltimore). 2024 Jun 14;103(24):e38566.
    To assess knowledge about cardiovascular diseases (CVD) among the general population, we emphasized gender-related disparities and other lifestyle and health-related factors. This cross-sectional study was conducted among 395 individuals from the general population of Jeddah, Saudi Arabia. An online questionnaire was administered to assess knowledge of CVD types, symptoms, and risk factors. The majority of participants identified coronary heart disease (73.7%) as having CVD, with no sex effect. Males had higher knowledge regarding cerebrovascular disease (44% vs 31.5%) and congenital heart diseases (60% vs 51.9%) as being part of CVD, while they had lower knowledge of peripheral arterial disease (44% vs 50.7%) than females, respectively (P < .05). Males exhibited better knowledge of heart attack and stroke symptoms than females. Knowledge was optimal for major CVD risk factors, such as smoking (90.6%) and high low-density lipoprotein cholesterol levels (85.1%); however, gaps were observed in recognizing diabetes (56.2%) and stress (69.4%) as factors for CVD. The mean overall knowledge score was 16.33 ± 5.72 25, with no difference between sexes (P = .239). Predictors of good CVD knowledge included university-level education, daily healthy food consumption, and perceived life as highly stressful; nonetheless, sex showed no significant effect. While the general population displayed a suboptimal understanding of CVD, notable sex disparities were observed, highlighting the need for tailored public health interventions. Emphasizing cognitive and behavioral aspects can foster better prevention and management strategies, given the evident gender disparities.
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  • Article
    Tzeng HE, Chang AC, Tsai CH, Wang SW, Tang CH.
    Oncotarget. 2016 Jun 21;7(25):38566-38578.
    A chondrosarcoma is a common, primary malignant bone tumor that can grow to destroy the bone, produce fractures and develop soft tissue masses. Left untreated, chondrosarcomas metastasize through the vascular system to the lungs and ultimately lead to large metastatic deposits of the malignant cartilage taking over lung volume and function. Vascular endothelial growth factor (VEGF)-C has been implicated in tumor-induced lymphangiogenesis and elevated expression of VEGF-C has been found to correlate with cancer metastasis. bFGF (basic fibroblast growth factor), a secreted cytokine, regulates biological activity, including angiogenesis and metastasis. We have previously reported on the important role of bFGF in angiogenesis in chondrosarcomas. However, the effect of bFGF in VEGF-C regulation and lymphangiogenesis in chondrosarcomas is poorly understood. In this investigation, we demonstrate a correlation exists between bFGF and VEGF-C in tissue specimens from patients with chondrosarcomas. To examine the lymphangiogenic effect of bFGF, we used human lymphatic endothelial cells (LECs) to mimic lymphatic vessel formation. We found that bFGF-treated chondrosarcomas promoted LEC tube formation and cell migration. In addition, bFGF knockdown inhibited lymphangiogenesis in vitro and in vivo. We also found that bFGF-induced VEGF-C is mediated by the platelet-derived growth factor receptor (PDGFR) and c-Src signaling pathway. Furthermore, bFGF inhibited microRNA-381 expression via the PDGFR and c-Src cascade. Our study is the first to describe the mechanism of bFGF-promoted lymphangiogenesis by upregulating VEGF-C expression in chondrosarcomas. Thus, bFGF could serve as a therapeutic target in chondrosarcoma metastasis and lymphangiogenesis.
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  • Article
    Tang ED, Inohara N, Wang CY, Nuñez G, Guan KL.
    J Biol Chem. 2003 Oct 03;278(40):38566-70.
    The nuclear factor kappaB (NF-kappaB)/Rel family of transcription factors participates in a wide range of biological activities including inflammation, immunity, and apoptosis. NF-kappaB is kept inactive in the cytoplasm in unstimulated cells by virtue of the masking of its nuclear localization sequence by bound IkappaB protein. Cellular stimuli trigger the destruction of IkappaB proteins and the liberation of NF-kappaB to enter the nucleus and activate gene expression. A multisubunit IkappaB kinase complex (IKK) phosphorylates IkappaB proteins and mediates the activation of NF-kappaB by proinflammatory stimuli such as tumor necrosis factor alpha. Phosphorylation of IkappaB proteins triggers their polyubiquitination and their subsequent recognition and degradation by the proteasome. The IKK complex contains two catalytic subunits, IKKalpha and IKKbeta, and a noncatalytic subunit, NF-kappaB essential modifier/IKKgamma. IKK activation depends upon the phosphorylation of residues in the activation loop of IKKbeta and the subsequent activation of IKKbeta kinase activity. However, the events contributing to IKKbeta phosphorylation are not well understood. Here, we present evidence that the activation of IKKbeta depends on its ability to form homotypic interactions and to transautophosphorylate. We find that an intact leucine zipper in IKKbeta is necessary for homotypic interactions, kinase activation, and phosphorylation on its activation loop. Enforced oligomerization of an IKKbeta mutant defective in forming homotypic interactions restores kinase activation. Homotypic interactions allow IKKbeta molecules to transautophosphorylate one another on their activation loops. Finally, the oligomerization of IKKbeta is stimulated by tumor necrosis factor alpha in cultured cells. Our findings support a model whereby ligand-induced homotypic interactions between IKKbeta molecules result in IKKbeta phosphorylation and consequently IKK activation.
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  • Article
    Xiong H, Ma X, Zhang H.
    Opt Express. 2021 Nov 08;29(23):38557-38566.
    Heat-sensitive materials have great applications in sensor, detector, and tunable photoelectric devices. However, the wave-thermal effect of the heat-sensitive material is rarely been investigated in the THz range. Here, we propose the incorporation of heat-sensitive material (strontium titanate (STO)) within a THz absorber. The simulated results show that the absorptance and frequency can be dynamically controlled by the temperature of STO. Because the absorbed THz waves are finally converted into heat, then we research the theoretical mechanism of heat generation. Theoretical analysis shows that there are two reasons for the temperature rise: surface plasmon polariton (SPP) and ohmic loss of gold patch; Electromagnetic energy consumption inside the loss materials. To verify the theory, finally, we use COMSOL Multiphysics to research the nanosecond wave-thermal effect. The transient temperature of the wave-thermal effect is calculated quantitatively. The quantitative prediction of temperature variation can provide good guidance for thermal regulation and wave-thermally tunable THz devices.
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  • Article
    Ikuta T, Inagaki T, Inaba K, Honjo T, Kazama T, Enbutsu K, Kashiwazaki T, Kasahara R, Umeki T, Takesue H.
    Opt Express. 2020 Dec 21;28(26):38553-38566.
    The minimum requirements for an optical reservoir computer, a recent paradigm for computation using simple algorithms, are nonlinearity and internal interactions. A promising optical system satisfying these requirements is a platform based on coupled degenerate optical parametric oscillators (DOPOs) in a fiber ring cavity. We can expect advantages using DOPOs for reservoir computing with respect to scalability and reduction of excess noise; however, the continuous stabilization required for reservoir computing has not yet been demonstrated. Here, we report the continuous and long-term stabilization of an optical system by introducing periodical phase modulation patterns for DOPOs and a local oscillator. We observed that the Allan variance of the optical phase up to 100 ms was suppressed and that the homodyne measurement signal had a relative standard deviation of 1.4% over 62,500 round trips. The proposed methods represent important technical bases for realizing stable computation on large-scale optical hybrid computers.
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  • Article
    Zhou H, Shen Y, Chen M, Fei C, He J.
    Opt Express. 2019 Dec 23;27(26):38553-38566.
    In this paper, we propose a cost-efficient, polarization-insensitive and widely-tunable wavelength conversion scheme for orthogonal frequency division multiplexing (OFDM) signal based on four-wave mixing (FWM) in semiconductor optical amplifier (SOA). In this scheme, electrical OFDM signal directly drives directly modulated laser (DML) to achieve intensity modulation, then the modulated signal lightwave and pump are coupled and injected into a polarization-diversity structure for performing FWM in SOA. The analytical results show that the proposed scheme is polarization-insensitive and has a wider conversion range compared with the parallel pump scheme and orthogonal pump scheme. We have also numerically demonstrated wavelength conversion of 16QAM-OFDM signal by employing the proposed scheme. The results can be agreed with the theoretical analyses. In addition, the impact of input optical power, line-width of external cavity laser (ECL) and injection current of SOA on the system performance are also studied.
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  • Article
    Ortalli AL, Fiore L, Di Napoli J, Rapacioli M, Salierno M, Etchenique R, Flores V, Sanchez V, Carri NG, Scicolone G.
    PLoS One. 2012;7(6):e38566.
    BACKGROUND: Retinotopic projection onto the tectum/colliculus constitutes the most studied model of topographic mapping and Eph receptors and their ligands, the ephrins, are the best characterized molecular system involved in this process. Ephrin-As, expressed in an increasing rostro-caudal gradient in the tectum/colliculus, repel temporal retinal ganglion cell (RGC) axons from the caudal tectum and inhibit their branching posterior to their termination zones. However, there are conflicting data regarding the nature of the second force that guides nasal axons to invade and branch only in the caudal tectum/colliculus. The predominant model postulates that this second force is produced by a decreasing rostro-caudal gradient of EphA7 which repels nasal optic fibers and prevents their branching in the rostral tectum/colliculus. However, as optic fibers invade the tectum/colliculus growing throughout this gradient, this model cannot explain how the axons grow throughout this repellent molecule.
    METHODOLOGY/PRINCIPAL FINDINGS: By using chicken retinal cultures we showed that EphA3 ectodomain stimulates nasal RGC axon growth in a concentration dependent way. Moreover, we showed that nasal axons choose growing on EphA3-expressing cells and that EphA3 diminishes the density of interstitial filopodia in nasal RGC axons. Accordingly, in vivo EphA3 ectodomain misexpression directs nasal optic fibers toward the caudal tectum preventing their branching in the rostral tectum.
    CONCLUSIONS: We demonstrated in vitro and in vivo that EphA3 ectodomain (which is expressed in a decreasing rostro-caudal gradient in the tectum) is necessary for topographic mapping by stimulating the nasal axon growth toward the caudal tectum and inhibiting their branching in the rostral tectum. Furthermore, the ability of EphA3 of stimulating axon growth allows understanding how optic fibers invade the tectum growing throughout this molecular gradient. Therefore, opposing tectal gradients of repellent ephrin-As and of axon growth stimulating EphA3 complement each other to map optic fibers along the rostro-caudal tectal axis.
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  • Article
    Kurnik-Łucka M, Latacz G, Bucki A, Rivera-Meza M, Khan N, Konwar J, Skowron K, Kołaczkowski M, Gil K.
    ACS Omega. 2023 Oct 17;8(41):38566-38576.
    Salsolinol (1-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol) is a close structural analogue of dopamine with an asymmetric center at the C1 position, and its presence in vivo, both in humans and rodents, has already been proven. Yet, given the fact that salsolinol colocalizes with dopamine-rich regions and was first detected in the urine of Parkinson's disease patients, its direct role in the process of neurodegeneration has been proposed. Here, we report that R and S enantiomers of salsolinol, which we purified from commercially available racemic mixture by means of high-performance liquid chromatography, exhibited neuroprotective properties (at the concentration of 50 μM) toward the human dopaminergic SH-SY5Y neuroblastoma cell line. Furthermore, within the study, we observed no toxic effect of N-methyl-(R)-salsolinol on SH-SY5Y neuroblastoma cells up to the concentration of 750 μM, either. Additionally, our molecular docking analysis showed that enantiomers of salsolinol should exhibit a distinct ability to interact with dopamine D2 receptors. Thus, we postulate that our results highlight the need to acknowledge salsolinol as an active dopamine metabolite and to further explore the neuroregulatory role of enantiomers of salsolinol.
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  • Article
    Pisk J, Đilović I, Hrenar T, Cvijanović D, Pavlović G, Vrdoljak V.
    RSC Adv. 2020 Oct 15;10(63):38566-38577.
    Synthesis of hydrazones (1a-4a and 1b-4b), quinazolines (3c·MeOH and 3d·MeOH), and hydrazone-Schiff bases (4c and 4d) is achieved by combining suitable aldehydes (2,3- or 2,4-dihydroxybenzaldehyde) with four hydrazides (isonicotinic, nicotinic, and 2- or 4-aminobenzoic acid hydrazide). A suite of approaches for their preparation is described: solution-based synthesis, mechanosynthesis, and solid-state melt reactions. The mechanochemical approach is generally a better choice for the quinazolines, while the solid-state melt reaction is more efficient for derivatives of (iso)nicotinic based hydrazones. Crystalline amine-functionalised hydrazones 4a and 4b undergo post-synthetic modifications in reactions with 3- or 4-pyridinecarbaldehyde vapours to form hydrazone-Schiff bases 4a-3py, 4b-3py, 4a-4py, and 4b-4py. Mechanochemical and vapour-mediated reactions are followed by ex situ powder X-ray diffraction and IR-ATR methods, respectively. The chemometric analysis of these data using principal component analysis provided an insight into the reaction profiles and reaction times. Azines (5a and 5b), achieved from aldehydes and hydrazine, reversibly change colour in response to temperature changes. The structures of all products are ascertained by a combined use of spectroscopic and X-ray diffraction methods. The cytotoxic and antimicrobial activities of all compounds against selected human cancer cell lines and bacterial strains are evaluated.
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  • Article
    Gao Y, Zhang Y.
    RSC Adv. 2018 Nov 14;8(67):38566-38573.
    In recent years, brown carbon aerosols, as important contributors to light absorption and climate forcing by aerosols, have been forefront in the field of atmospheric research. Aqueous brown carbon can be formed through the aqueous reaction of glyoxal (GX) with glycine (Gly). GX-Gly mixtures exhibit changes in their optical properties in the ultraviolet and near visible regions, which can be monitored with ultraviolet/visible and fluorescence spectroscopy. In this study, we quantified the absorption and excitation-emission matrix spectra during the formation of aqueous brown carbon, which was generated from GX-Gly mixtures. The formation of brown carbon was further evidenced using several optical parameters, including absorption coefficient, absorption Angstrom exponents, mass absorption coefficient, effective quantum yields and fluorescence lifetime values. The results of hydrogen peroxide oxidation photolysis revealed the probable removal processes of the atmospheric aqueous brown carbon. The fluorescence lifetime values of the brown carbon samples were less than 10 ns. Liquid chromatography combined with mass spectrometry analysis was used to investigate the probable chemical composition of the brown carbon samples from GX-Gly mixtures.
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  • Article
    Škrbić BD, Buljovčić M, Antić I.
    Environ Sci Pollut Res Int. 2022 May;29(25):38551-38566.
    This study aimed to determine seasonal (summer vs. winter) and spatial distribution of the selected heavy elements (HEs) (As, Cd, Co, Cr, Cu, Ni, and Pb) in soil samples collected from a typical Central European town, Novi Sad, Serbia. The highest Pb concentrations were observed in summer because of intensive ground-flushing, whereas Cu had its highest concentration in winter, which may be attributed to traffic emissions. Source characterization and spatial distribution were carried out using cluster analysis (CA), principal component analysis (PCA), variogram calculation and theoretical model fitting, GIS-based geostatistical methods, and positive matrix factorization (PMF) data processing tools. Environmental impact of HEs found in different functional areas demonstrated that the quantified concentrations of Pb, As, Co, and Cu ranked soil as unpolluted to moderately polluted, while the presence of Co, Ni, and Cr classified urban soil as moderately polluted. Pollution load index (PLI) suggested a significant HEs enrichment while the new modified approach to Nemerow integrated risk index (NIRI) indicated high risk, being extreme for some selected locations. Machine learning classifiers were used for the first time to identify the differences between urban soil and dust samples in situations when simultaneous analysis of both matrices was carried out, as well as for temporal distribution (summer versus winter), based on the obtained concentration of HEs. Variogram calculation suggested that the pattern in spatial variability within the system emerged from the combined action of key structural factors (e.g., the parent soil material, landforms and topography, and climate) and random factors related to human activities. The estimated human health risk for two segments of the population revealed that ingestion is the primary route of exposure to HEs for children and adults.
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  • Article
    Durkalec MM, Nawrocka A, Kitowski I, Filipek A, Sell B, Kmiecik M, Jedziniak P.
    Environ Sci Pollut Res Int. 2023 Mar;30(13):38566-38581.
    The golden eagle (Aquila chrysaetos) and the white-tailed eagle (Haliaeetus albicilla), being apex predators and facultative scavengers, can bioaccumulate different environmental contaminants, including toxic elements that may adversely affect their health. We analyzed the levels of cadmium (Cd), lead (Pb), and other metals and metalloids, including arsenic (As), barium (Ba), beryllium (Be), cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), magnesium (Mg), manganese (Mn), molybdenum (Mo), selenium (Se), thorium (Th), thallium (Tl), uranium (U), vanadium (V), and zinc (Zn) in liver samples taken from three golden eagles and 36 white-tailed eagles that were found dead across Poland to verify their exposure. We also used a systematic review to summarize the available literature data on Cd, Pb, and other studied elements in the liver of both eagle species. Analyses of trace elements in the liver samples of the Polish eagles revealed interspecific differences in Cd, Cu, and Mn and differences in Co, Mn, Tl, and Zn among study regions. All elements tested except Pb were below the suggested thresholds linked with adverse health effects in birds. The hepatic Pb found in almost half of all the tested individuals suggests environmental exposure to this toxic element. One of the tested white-tailed eagles had hepatic Pb above the threshold of sublethal poisoning. Although our results seem optimistic, as previous Polish studies showed a higher prevalence of birds with hepatic Pb exceeding the toxicity threshold, they indicate that exposure to this toxic metal could still pose an additional threat to the health of Polish eagles.
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  • Article
    Sun X, Lu X, Huang S, Xi L, Liu L, Liu B, Weng Q, Zhang L, Schmidt OG.
    ACS Appl Mater Interfaces. 2017 Nov 08;9(44):38556-38566.
    Germanium is a promising anode material for lithium ion batteries because of its high theoretical specific capacity and low operation voltage. However, a significant challenge in using Ge-based anodes is the large volume variation during cycling that causes pulverization and capacity fade. Despite intense studies in the past decade, unsatisfactory cycling stability of the Ge-based electrodes still impedes their widespread applications. In this study, we demonstrate a high-performance electrode through the synergistic combination of a high-capacity Ge film grown on a three-dimensional current collector and an in situ formed poly(vinylidene fluoride)-hexafluoropropene/SiO2 protective layer. Specifically, the polymer matrix is in continuous contact with the surface of the Ge shell, which provides improved mechanical and ionic transport properties. As a highlight, we present impressive cycling stability over 3000 cycles at 1 C rate with a capacity retention as high as 95.7%. Furthermore, the LiCoO2-Ge full battery operates at an average voltage of 3.3 V at 0.5 C and maintains good electrochemical performance, suggesting great potential for applications in energy storage and conversion devices.
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  • Book
    Uri Alon.
    Summary: "Systems Medicine: Physiological Circuits and the Dynamics of Disease introduces the topic of physiological circuits, in which cells and organs communicate with each other. Rather than circuits inside a cell, it discusses circuits between cells. This is the level relevant to the most common and deadly diseases that currently plague humanity. The goal is to start from basic principles or 'laws' and derive why physiology is built the way it is, and why certain diseases happen while others don't. By the end of the book, you will be able to use simple but powerful mathematical models to describe physiological circuits. The models are powerful because they turn details into useful understanding and new ways to think about treating diseases. We will understand the fundamental causes of some of the most mysterious diseases: diabetes, autoimmune diseases, and age-related diseases such as lung fibrosis and cancer. The trajectory begins with basic principles. From these are derived circuits and their fragility to disease. The book explores (i) hormone circuits, (ii) immune circuits, and (iii) aging and age-related disease, and culminates in a periodic table of diseases. It is written in a very accessible style, suitable for anyone with a background in biology, engineering, physics, math, engineering, computer science, chemistry, or other subjects"-- Provided by publisher.

    Contents:
    The insulin-glucose circuit
    Dynamical compensation, mutant resistance, and type-2 diabetes
    The stress hormone axis as a two-gland oscillator
    Autoimmune diseases as a fragility of mutant surveillance
    Inflammation and fibrosis as a bistable system
    Basic facts of aging
    Aging and saturated repair
    Age-related diseases
    Periodic table of diseases
    Epilogue: Simplicity in systems medicine.
    Digital Access T&Fonline 2023
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