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- ArticleMalliarou M, Pappa V, Papathanasiou I, Andreanidis I, Nikolentzos A, Apostolakis I, Sarafis P.Health Psychol Res. 2022;10(3):35640.Introduction: Patients who undergo coronary angiography experience a rather stressful situation. They need information about this invasive procedure which most of the times find either from the internet, their referring physicians, acquaintances or friends with past experience of an invasive procedure.
Aim: The aim of the study was on the one hand to test the potential beneficial effects of an information brochure on undergoing a cardiac catheterization for the first time and on the other hand to highlight the importance of informing patients before coronary angiography and its beneficial effects on both reducing their fear and anxiety.
Methods: Patients were randomly assigned to an experimental group receiving the brochure at least 1 day before the cardiac catheterization (N = 44), or to a control group not receiving the brochure (N = 44). The SFQ, ISQ and STAI tools were distributed to both groups.
Results: All experimental subjects in the intervention group read the brochure. The intervention group had significantly lower scores on both short-term and overall fear compared to the control group. However, the fear of the long-term consequences of cardiac catheterization was similar in both groups. Women had higher fear of the short-term consequences of catheterization than men. The control group experienced a mean satisfaction score of 10.9 points (SD= 2.5 points) while the intervention group had a score of 11.1 points respectively (SD= 2.3 points). In addition, 95, 5% of the control group and 88, 6% of the intervention group patients considered that the provision of information could have been improved. In terms of stress, patients with co-morbidities scored 7.39 points higher, meaning they experienced more symptoms of permanent anxiety, compared to patients who did not have an underlying disease. In addition, the more the patients were satisfied with the information provided, the fewer the symptoms of transient anxiety they experienced.
Conclusions: Providing information in the form of a brochure regarding cardiac catheterization before the procedure, is of great importance and constitutes an efficient intervention. - ArticleHourizadeh J, Joy J, Berger JI, Zainah H.Cureus. 2023 Mar;15(3):e35640.We present a 73-year-old male with a history of end-stage renal disease (ESRD) on dialysis, type 2 diabetes mellitus, coronary artery disease status post stents, prostate carcinoma status post radiation, and prostatectomy, with recurrent bladder neck contracture requiring suprapubic catheter, left urethral stricture with nephrostomy tube placement, penile implant, and recurrent urinary tract infections, who presented to the emergency room complaining of constant bilateral groin pain for one day. Physical exam was significant for suprapubic tenderness and a chronic suprapubic catheter and left-sided nephrostomy tube. An initial examination of the patient's urine revealed turbid, yellow-colored fluid, positive for white blood cells, leukocyte esterase, and bacteria. A urine culture was obtained, which returned positive for E. americana, with >100,000colony-forming units (CFUs)as well as Enterococcus faecalis (E. faecalis) demonstrating low colony counts. The patient was treated with a seven-day course of meropenem 1 gm twice daily, which improved of his symptoms, and then completed a 10-day course of ertapenem 500 mg daily. The patient received a five-day course of vancomycin 1 gm on dialysis days for additional coverage of E. faecalis, despite low colony counts. This is the first documented case of a urinary tract infection caused by E. americana. The organism is primarily found in immunocompromised individuals, and a debate is still ongoing as to whether it is a true pathogen or exists primarily as an opportunistic infection. We suggest further inquiry and study of this resistant organism are paramount in establishing its role in both immunocompromised as well as immunocompetent individuals. E. americana is a multidrug-resistant organism, which to date has sparse documentation regarding its prevalence and potential for morbidity, especially in compromised individuals. In the era of increasing antibiotic resistance, we suggest that more research is needed to understand the pathogenicity of E. americana.
- ArticleLuo C, Yu LT, Yang MQ, Li X, Zhang ZY, Alfred MO, Liu JL, Wang M.Sci Rep. 2016 10 21;6:35640.Regenerating genes (Reg) have been found during the search for factors involved in pancreatic islet regeneration. Our recent study discovered that pancreatic β-cell-specific overexpression of Reg3β protects against streptozotocin (Stz) -induced diabetes in mice. To investigate its potential roles in the treatment of diabetes, we produced a recombinant Reg3β protein and provided evidence that it is active in promoting islet β-cell survival against Stz- triggered cell death. Though ineffective in alleviating preexisting diabetes, pretreatment of recombinant Reg3β was capable of minimizing the Stz-induced hyperglycemia and weight loss, by preserving serum and pancreatic insulin levels, and islet β-cell mass. No obvious changes were observed in the rate of cell proliferation and hypertrophy in α- or acinar-cells after treatment with recombinant Reg3β. The underlying mechanism of Reg3β-mediated protection seems to involve Akt activation which upregulates Bcl-2 and Bcl-xL levels and consequently promotes cell survival.
- ArticleNajim MA, R Ayoob R, Hameed AA.Heliyon. 2024 Aug 15;10(15):e35640.Carbon nanofibers (CNFs) are prepared from electrospun polyacrylonitrile (PAN) because of their high carbon content. Heat treatment (oxidative stabilization and carbonization) is necessary to convert PAN nanofibers into CNFs. The fixation of fibrous structure of polymer precursor during heat treatment is always considered as a problem. The aim of this work is to study the effects of two different stabilization temperatures and fixation on CNFs prepared from electrospun PAN nanofibers. In this study, we use two different stabilization temperatures (275 and 300 °C) to investigate the effect of temperature on the oxidation, cyclization, crosslinking, aromatization, and dehydrogenation processes that occur during the stabilization heat treatment. Further, we study the effect of electrospun sheet fixation during heat treatment on the fibrous structure of electrospun fibers and methods to prevent shrinkage and folding of the electrospun sheet. Fourier transform infrared spectroscopy revealed the effectiveness of stabilization at 300 °C when transforming PAN elctrospun nanofibers to CNFs. Raman spectroscopy showed that carbonization at 800 °C after stabilization at 300 °C lowers the R-value (ID/IG ratio) comparing with that stabilized at 275 °C which indicates increasing the amount of structurally ordered graphite crystallites relative to the disordered structure. Scanning electron microscopy (SEM) revealed that fixation process maintained a uniform fibrous structure for the stabilized sheets without shrinkage, whereas carbonization at 800 °C without fixation resulted in deformed and folded carbonized PAN with loss in the fibrous structure.
- ArticleChang Y, Hsu HJ, Hsu HH, Wong CE, Chi KY, Lee PH, Huang CC, Lee JS, Chen CM.Medicine (Baltimore). 2023 Oct 20;102(42):e35640.BACKGROUND: The concept of a weekend effect is that patients admitted to hospitals on the weekend tend to have poorer outcomes compared to those admitted on a weekday. Whether there is a weekend effect among patients receiving spine surgery is not well described in the literature. We sought to perform a systematic review with meta-analysis to explore whether a weekend effect exists among patients experiencing spinal surgery.
METHODS: The Cochrane Library, PubMed, Embase, and MEDLINE electronic databases were searched for relevant articles. Meta-analyses were performed using functions available in the metafor package within the R software. We obtained adjusted odds ratios (OR) from included studies and pooled OR through an inverse variance method. A random-effects model was applied for meta-analysis and effect sizes were presented with their corresponding 95% confidence intervals (CI).
RESULTS: Our search strategy identified 316 references from electronic databases and eventually 6 studies were included in the analysis. The pooled result of 5 studies reporting overall complication rate indicated significant increased risk of complications among the weekend admission group (OR, 1.35; 95% CI, 1.01 to 1.80). The pooled results of 3 studies demonstrated no difference in overall mortality rates between these 2 groups of patients (OR, 1.18; 95% CI, 0.67 to 1.97).
CONCLUSIONS: In spinal surgical patients, the weekend effect significantly contributes to a higher complication rate. Knowledge of potential adverse events in patients admitted on weekends is necessary for spinal surgeons and caregivers to improve patient outcomes with spinal surgery. - ArticleKefala AM, Fortescue R, Alimani GS, Kanavidis P, McDonnell MJ, Magiorkinis E, Megremis S, Paraskevis D, Voyiatzaki C, Mathioudakis GA, Papageorgiou E, Papadopoulos NG, Vestbo J, Beloukas A, Mathioudakis AG.BMJ Open. 2020 04 07;10(4):e035640.INTRODUCTION: Both stable chronic obstructive pulmonary disease (COPD) and acute exacerbations represent leading causes of death, disability and healthcare expenditure. They are complex, heterogeneous and their mechanisms are poorly understood. The role of respiratory viruses has been studied extensively but is still not adequately addressed clinically. Through a rigorous evidence update, we aim to define the prevalence and clinical burden of the different respiratory viruses in stable COPD and exacerbations, and to investigate whether viral load of usual respiratory viruses could be used for diagnosis of exacerbations triggered by viruses, which are currently not diagnosed or treated aetiologically.
METHODS AND ANALYSIS: Based on a prospectively registered protocol, we will systematically review the literature using standard methods recommended by the Cochrane Collaboration and the Grading of Recommendations Assessment, Development and Evaluation working group. We will search Medline/PubMed, Excerpta Medica dataBASE (EMBASE), the Cochrane Library, the WHO's Clinical Trials Registry and the proceedings of relevant international conferences on 2 March 2020. We will evaluate: (A) the prevalence of respiratory viruses in stable COPD and exacerbations, (B) differences in the viral loads of respiratory viruses in stable COPD vs exacerbations, to explore whether the viral load of prevalent respiratory viruses could be used as a diagnostic biomarker for exacerbations triggered by viruses and (C) the association between the presence of respiratory viruses and clinical outcomes in stable COPD and in exacerbations.
ETHICS AND DISSEMINATION: Ethics approval is not required since no primary data will be collected. Our findings will be presented in national and international scientific conferences and will be published in peer reviewed journals. Respiratory viruses currently represent a lost opportunity to improve the outcomes of both stable COPD and exacerbations. Our work aspires to 'demystify' the prevalence and clinical burden of viruses in stable COPD and exacerbations and to promote clinical and translational research.
PROSPERO REGISTRATION NUMBER: CRD42019147658. - ArticleCho J, Kang S, Lee B, Moon J, Lim YS, Jang M, Choi W.Opt Express. 2021 Oct 25;29(22):35640-35650.Ballistic waves directly carry image information in imaging through a scattering medium, but they are often obscured by much intense multiple-scattered waves. Detecting early arriving photons has been an effective method to extract ballistic waves in the transmission-mode imaging. However, it has been difficult to identify the temporal distribution of ballistic waves relative to the multiple scattering waves in the quasi-diffusive regime. Here, we present a method to separately quantify ballistic and multiple-scattered waves at their corresponding flight times even when multiple scattering is much stronger than the ballistic waves. This is realized by measuring the transmission matrix of an object embedded within scattering medium and comparing the coherent accumulation of ballistic waves with their incoherent addition. To further elucidate the temporal behavior of ballistic waves in quasi-diffusive regime, we analyze the flight time difference between ballistic and multiple-scattered waves and the effect of coherence gating on their relative intensities for the scattering medium of different thicknesses. The presented method to distinctively detect the temporal behavior of ballistic and multiple-scattered waves will lay a foundation to exploit multiple-scattered waves for deep-tissue imaging.
- ArticleNawaz HM, Kylsten P, Hamada N, Yamamoto D, Smith CI, Lindvall JM.PLoS One. 2012;7(5):e35640.BACKGROUND: A central question within biology is how intracellular signaling pathways are maintained throughout evolution. Btk29A is considered to be the fly-homolog of the mammalian Bruton's tyrosine kinase (Btk), which is a non-receptor tyrosine-kinase of the Tec-family. In mammalian cells, there is a single transcript splice-form and the corresponding Btk-protein plays an important role for B-lymphocyte development with alterations within the human BTK gene causing the immunodeficiency disease X-linked agammaglobulinemia in man and a related disorder in mice. In contrast, the Drosophila Btk29A locus encodes two splice-variants, where the type 2-form is the more related to the mammalian Btk gene product displaying more than 80% homology. In Drosophila, Btk29A displays a dynamic pattern of expression through the embryonic to adult stages. Complete loss-of-function of both splice-forms is lethal, whereas selective absence of the type 2-form reduces the adult lifespan of the fly and causes developmental abnormalities in male genitalia.
METHODOLOGY/PRINCIPAL FINDINGS: Out of 7004-7979 transcripts expressed in the four sample groups, 5587 (70-79%) were found in all four tissues and strains. Here, we investigated the role of Btk29A type 2 on a transcriptomic level in larval CNS and adult heads. We used samples either selectively defective in Btk29A type 2 (Btk29A(ficP)) or revertant flies with restored Btk29A type 2-function (Btk29A(fic Exc1-16)). The whole transcriptomic profile for the different sample groups revealed Gene Ontology patterns reflecting lifespan abnormalities in adult head neuronal tissue, but not in larvae.
CONCLUSIONS: In the Btk29A type 2-deficient strains there was no significant overlap between transcriptomic alterations in adult heads and larvae neuronal tissue, respectively. Moreover, there was no significant overlap of the transcriptomic changes between flies and mammals, suggesting that the evolutionary conservation is confined to components of the proximal signaling, whereas the corresponding, downstream transcriptional regulation has been differentially wired. - ArticleIslas SR, Cuéllar-Cruz M.ACS Omega. 2021 Dec 28;6(51):35629-35640.The Precambrian era is called the first stage of the Earth history and is considered the longest stage in the geological time scale. Despite its duration, several of its environmental and chemical characteristics are still being studied. It is an era of special relevance not only for its duration but also because it is when a set of conditions gave rise to the first organism. This pioneer organism has been proposed to have been formed by a mineral and an organic part. A chemical element suggested to have been part of the structure of this cell is iron. However, what special characteristic does iron have with respect to other chemical elements to be proposed as part of this first cell? To answer this and other questions, it is indispensable to have a model that will allow extrapolating the first chemical structures of the pioneer organism formed in the Precambrian. In this context, for several decades, in vitro structures chemically formed by silica-carbonates have been synthetized, called biomorphs, because they could emulate living organisms and might resemble primitive organisms. It has been inferred that because biomorphs form structures with characteristic morphologies, they could resemble the microfossils found in the cherts of the Precambrian. Aiming at providing some insight on how iron contributed to the formation of the chemical structures of the primitive organism, we evaluated how iron contributes to the morphology and chemical-crystalline structure during the synthesis of these compounds under different conditions found in the primitive atmosphere. Experimentally, synthesis of biomorphs was performed at four different atmospheric conditions including UV light, nonionizing microwave radiation (NIR-mw), water steam (WS), and CO2 in the presence of Fe2+, Fe3+, and Fe2+/Fe3+, obtaining 48 different conditions. The produced biomorphs were observed under scanning electron microscopy (SEM). Afterward, their chemical composition and crystalline structure were analyzed through Raman and IR spectroscopy.
- ArticleKim M, Serra F.RSC Adv. 2018 Oct 15;8(62):35640-35645.Arrays of topological defects in liquid crystals are fascinating systems, as isotropic and anisotropic phases of the same material can co-exist and be arranged in regular periodic structures. The arrays thus form spatially-varying optical pathways, in patterns that can be used for optics, as novel photonic structures, optical gratings, lenses or metamaterials, and for molecular and colloidal self-assembly. However, for practical applications, it is necessary that the arrays are tunable without direct intervention of the experimenters. Here, we demonstrate single-domain, tunable arrays of topological defects in nematic liquid crystals, using a method inspired by the recent work by Orihara and colleagues. The regularity and domain size of the defect arrays are obtained by using periodic lateral modulation of electric fields generated by incompletely etched electrodes with periodic conductivity. The period of the arrays, i.e. the characteristic spacing between defects, is controllable not only through the applied electric field strength and frequency but also by varying the size of the patterned electrodes. We believe these results open a new way to design and fabricate large-scale, single-domain, tunable and scalable device architectures that are optically functional.
- ArticleMullins MA, Wang T, Shahan K, Zaha VG, Goswami R, Sulistio M, Gerber DE, Pruitt SL.Cancer. 2025 Jan 01;131(1):e35640.INTRODUCTION: The shared risk profiles for cancer and heart disease suggest many individuals with cancer may have an implantable cardioverter defibrillator (ICD). ICDs can have dramatic cancer end-of-life care implications including painful and distressing shocks. ICD prevalence and association with aggressive end-of-life care among individuals with breast, colorectal, and pancreatic cancer was evaluated using the Surveillance, Epidemiology, and End Results-Medicare dataset.
METHODS: A total of 37,306 Medicare beneficiaries aged ≥66 years with stage 3 or 4 cancer who died between 2005 and 2016 were identified. ICD prevalence, ICD-related care utilization that might present opportunities to discuss end-of-life implications and association with aggressive end-of-life care (>1 emergency department visit, intensive care unit admission, >1 hospitalization, terminal hospitalization, chemotherapy, and invasive or life-extending procedures) in the last month of life was assessed using multivariable logistic regression.
RESULTS: Among cancer decedents, 6% had an ICD. More individuals with an ICD (31%) died in the hospital than individuals without an ICD (25%; p < .001). Half (46%) of individuals with an ICD had device programming or interrogation visits that could be an opportunity for device discussion. In adjusted models, ICD presence was associated with higher odds of every indicator of aggressive end-of-life care other than chemotherapy.
CONCLUSION: Many older cancer decedents in the United States had an ICD, and those with ICDs received more aggressive care at the end of life. Results suggest there are opportunities to discuss ICD and goals of care, raise awareness and encourage shared decision-making for this population to ensure goal-concordant care, and improve end-of-life care quality. - ArticleYilmaz B, Aktas B, Altinbas A, Ginis Z, Ozturk G, Ekiz F, Kilincalp S, Deveci M, Simsek Z, Coban S, Basar O, Yuksel O.Hepat Mon. 2016 Sep;16(9):e35640.BACKGROUND: Liver biopsy is an invasive procedure that is currently still necessary for predicting underlying hepatic injury related to chronic viral hepatitis B (CVHB). To date, none of the studied non-invasive methods have been able to replace liver biopsy. An apoptotic serum marker, M30, which has been reported to indicate ongoing liver fibrosis, has been popular in recent years.
OBJECTIVES: We aimed to investigate the possible role of M30 in predicting CVHB-associated hepatic injury and its severity.
METHODS: Forty-eight patients undergoing liver biopsy for evaluation of the severity of CVHB-related liver injury and 40 healthy controls were included in this cross-sectional study. M30 levels were determined for all CVHB patients and controls, and other laboratory parameters and demographic features were obtained from our hospital's database.
RESULTS: The mean ages of patients and controls were 39.7 and 45.7 years, respectively, and 35% of the controls and 52% of the patients were male. In contrast to lower platelet counts, transaminase and M30 levels were both higher in the patient group than in the controls. Among the investigated parameters, only transaminase increased as the fibrosis stage changed from mild to moderate; however, none of the laboratory parameters, including M30, differed as the histological activity index (HAI) score increased.
CONCLUSIONS: M30 levels were higher in CVHB patients compared to healthy controls. However, M30 levels were similar in the mild and moderate stages of fibrosis, so they did not indicate the severity of underlying fibrotic or inflammatory processes in CVHB patients. - ArticleVeronesi G, Moros M, Castillo-Michel H, Mattera L, Onorato G, Wegner KD, Ling WL, Reiss P, Tortiglione C.ACS Appl Mater Interfaces. 2019 Oct 02;11(39):35630-35640.Many attempts have been made to synthesize cadmium-free quantum dots (QDs), using nontoxic materials, while preserving their unique optical properties. Despite impressive advances, gaps in knowledge of their intracellular fate, persistence, and excretion from the targeted cell or organism still exist, precluding clinical applications. In this study, we used a simple model organism (Hydra vulgaris) presenting a tissue grade of organization to determine the biodistribution of indium phosphide (InP)-based QDs by X-ray fluorescence imaging. By complementing elemental imaging with In L-edge X-ray absorption near edge structure, unique information on in situ chemical speciation was obtained. Unexpectedly, spectral profiles indicated the appearance of In-O species within the first hour post-treatment, suggesting a fast degradation of the InP QD core in vivo, induced mainly by carboxylate groups. Moreover, no significant difference in the behavior of bare core QDs and QDs capped with an inorganic Zn(Se,S) gradient shell was observed. The results paralleled those achieved by treating animals with an equivalent dose of indium salts, confirming the preferred bonding type of In3+ ions in Hydra tissues. In conclusion, by focusing on the chemical identity of indium along a 48 h long journey of QDs in Hydra, we describe a fast degradation process, in the absence of evident toxicity. These data pave the way to new paradigms to be considered in the biocompatibility assessment of QD-based biomedical applications, with greater emphasis on the dynamics of in vivo biotransformations, and suggest strategies to drive the design of future applied materials for nanotechnology-based diagnosis and therapeutics.
- ArticleHuang GG, Lee CJ, Yang J, Chang CH, Sathiyendiran M, Lu ZZ, Lu KL.ACS Appl Mater Interfaces. 2016 Dec 28;8(51):35634-35640.An evanescent wave infrared chemical sensor was developed to selectively detect volatile amines with heterocyclic or phenyl ring. To achieve this goal, a rhenium-based metallacycle with a "molecular-trap" structure was designed and synthesized as host molecules to selectively trap amines with heterocyclic or phenyl ring through Re-amine and π-π interactions. To explore the trapping properties of the material, a synthesized Re-based molecular trap was treated on an IR sensing element, and wide varieties of volatile organic compounds (VOCs) were examined to establish the selectivity for detection of amines. Based on the observed IR intensities, the Re-based molecular trap favors interaction with amines as evidenced by the variation of absorption bands of the Re molecular trap. With extra π-π interaction force, molecules, such as pyridine and benzylamine, could be detected. After optimization of the parameters for IR sensing, a rapid response in the detection of pyridine was observed, and the linear ranges were generally up to 10 mg/L with a detection limit around 5.7 μg/L. In the presence of other VOCs, the recoveries in detection of pyridine were all close to 100%.
- BookKelly Vess, MA.Summary: "Children with speech sound disorders are at higher risk of academic failure, behavioral difficulties, motor impairments, language delays, and literacy deficits. Speech Sound Disorders: Comprehensive Evaluation and Treatment by Kelly Vess provides the necessary tools to use research-based practices when diagnosing and treating preschoolers. Sophisticated yet readerfriendly, this interactive book is certain to revolutionize the methodology therapists use to treat children with these disorders and globally improve outcomes. Through a step-by-step process, readers will learn to critically review and evaluate research in practice. Guidance is provided on how to create educationally rich activities to comprehensively treat children with speech sound disorders. Readers will not only learn how to integrate research into practice, but also how to research their own practices to continually grow as professionals and advance the field. In addition, invaluable insights are provided on how to make efficient use of limited therapy time by targeting executive function, social communication, motor skills, language skills, and literacy skills while treating children with speech sound disorders"-- Provided by publisher.Digital Access Thieme MedOne ComSci [2021]
- ArticleHeidemann AC, Schipke CG, Kettenmann H.J Biol Chem. 2005 Oct 21;280(42):35630-40.Nicotinic acid adenine dinucleotide phosphate (NAADP+) has been identified as a novel second messenger triggering Ca2+ release from intracellular stores. Here we report that murine cortical astrocytes in culture and in acute slices respond with transient intracellular Ca2+ increases to extracellularly applied NAADP+ and express the NAADP+-producing enzyme CD38. The Ca2+ transients triggered by NAADP+ occurred with an average delay of 35 s as compared with ATP-triggered Ca2+ signaling, suggesting that NAADP+ may have to enter the cell to act. Blockage of connexin hemichannels (a possible entry route for NAADP+ into the cell) reduced the number of astrocytes responding to NAADP+. Disruption of lysosomes as the suggested site of NAADP+ receptors reduced the number of astrocytes responding to NAADP+ strongly. The NAADP+-triggered Ca2+ signal also depended on intact endoplasmic reticulum Ca2+ stores linked to activation of inositol 1,4,5-trisphosphate receptors and on the activity of voltage-gated Ca2+ channels. Adenosine receptor-mediated signaling contributes to the NAADP+-evoked signal, since it is strongly reduced by the adenosine receptor blocker CGS-15943. Moreover, NAADP+ triggered responses in all other cell types (cultured cerebellar neurons, microglia, and oligodendrocytes) of the central nervous system.