Books

"Reduce stress, release pain, and create bodily harmony with this introduction to qigong and the yin/yang balance of tai chi, the ancient Chinese arts of movement meditation. This accessible book features information about these practices as well as insights into their benefits, providing tools for replenishing inner resources and managing energy levels. It also offers advice on making healthier choices in everyday life that will support the body's natural capacity for energy, balance, and well-being"-- Provided by publisher.

Miles, Huberman, and Saldaña's Qualitative Data Analysis: A Methods Sourcebook is the authoritative text for analyzing and displaying qualitative research data. The Fourth Edition maintains the analytic rigor of previous editions while showcasing a variety of new visual display models for qualitative inquiry. Graphics are added to the now-classic matrix and network illustrations of the original co-authors. Five chapters have been substantially revised, and the appendix's annotated bibliography includes new titles in research methods. Graduate students and established scholars from all disciplines will find this resource an innovative compendium of ideas for the representation and presentation of qualitative data. As the authors demonstrate, when researcheres "think display," their analyses of social life capture the complex and vivid processes of the people and institutions studied. -- From back cover.

"Engaging and accessible, this book offers students a complete guide to using NVivo for qualitative data analysis. Drawing on their wealth of expertise, the authors offer detailed, practical advice that relates to students' own experience and research projects. Packed with real-world examples and case studies, the book supports students through every stage of qualitative data analysis."--Provided by publisher

Patton has created the most comprehensive, systematic, and up-to-date review of qualitative methods available. The Third Edition has retained and expanded upon the exhibits, which highlight and summarize major issues, guidelines, the summative sections, tables, and figures as well as the sage advice of the Sufi-Zen master, Halcolm. This revision will help readers integrate and make sense of the great volume of qualitative works published in the past decade.

"Now in its fourth edition, this essential introduction to conducting and interpreting qualitative research is fully revised and updated with new material examining the impact of the web research and social media, data mining and co- designing. This concise, practical and easy-to-use guide continues to show how qualitative research can be employed effectively and appropriately to answer some of the questions confronting health care researchers today"-- Provided by publisher.

Part I: Performance improvement model. Introduction and history of performance improvement -- Defining a performance improvement model -- Identifying improvement opportunities based on performance measurement -- Using teamwork in performance improvement -- Aggregating and analyzing performance improvement data -- Communicating performance improvement activities and recommendations -- Part II: Continuous monitoring and improvement functions. Measuring customer satisfaction -- Refining the continuum of care -- Improving the provision of care, treatment, and services -- Preventing and controlling infectious disease -- Decreasing risk exposure -- Building a safe medication management system -- Managing the environment of care -- Developing staff and human resources -- Part III: Management of performance improvement programs. Organizing and evaluating performance improvement -- Navigating the accreditation, certification, or licensure process -- Implementing effective information management tools for performance improvement -- Managing healthcare performance improvement projects -- Managing the human side of change -- Understanding the legal implications of performance improvement.

"The Third Edition of Quality and Safety Education for Nurses has been thoroughly updated for students in undergraduate Associate, Baccalaureate, Accelerated and BSN completion Nursing programs. There is a chapter focusing on each of the six Quality and Safety Education for Nurses (QSEN) Competency areas, with content on Nursing Leadership and Patient Care Management infused throughout the chapters. The Third Edition also includes new chapters on Systems Thinking, Implementation Science, and Population Health. It includes an Instructor's manual and Powerpoints"-- Provided by publisher.

Patient safety : a brief history / Robert K. Stoelting -- Cognitive load theory and patient safety / Elizabeth Harry and John Sweller -- Errors and violations / Alan F. Merry -- The human-technology interface / Frank A. Drews and Jonathan R. Zadra -- Deliberate practice and acquisition of expertise / Keith Baker -- Fatigue / Michael Keane -- Situational awareness / Christian Schulz -- Creating a culture of safety / Thomas R. Chidester -- Adverse event prevention and management / Patrick J. Guffey and Martin Culwick -- Complex systems and approaches to quality improvement / Loren Riskin and Alex Macario -- Crisis resource management and patient safety in anesthesia practice / Amanda R. Burden, Jeffrey B. Cooper, and David M. Gaba -- Quality in medical education / Viji Kurup -- Regulating quality / Robert S. Lagasse -- Creating a quality management program / Richard P. Dutton -- Health information technology use for quality assurance and improvement / Christine Doyle -- Safety in remote locations / Samuel Grodofsky, Meghan Lane-Fall, and Mark S. Weiss -- Medication safety / Alan F. Merry -- Operating room fires and electrical safety / Stephan Cohn and P. Alan Klock Jr -- Disruptive behavior : the imperative for awareness and action / Sheri A. Keitz and David J. Birnbach -- Managing adverse events : the aftermath and the second victim effect / Sven Staender.

This book provides a roadmap for optimizing quality and safety within radiology practices, whether academic or private and irrespective of their national setting. All aspects of the radiology workflow are addressed, from imaging appropriateness, examination scheduling, and patient preparation through to imaging protocol optimization (including radiation dose management), modality operations, reporting (including structured reporting), and report communication. The book highlights innovative IT tools, including clinical decision support, that drive compliance with national best practice standards and guidelines. The use of big data tools to manage and enhance clinical delivery is addressed. Finally, metrics designed to measure the value that radiology brings to patient care and patient outcomes are introduced. Readers wishing to deepen their understanding of contemporary best practices regarding quality and safety will find this book to be a rich source of practical information.

1. The many perspectives of quality and safety in neurosurgery -- 2. The history and future of quality and safety in neurosurgery -- 3. Clinical research in quality improvement: complementary approaches to improving neurosurgical practice -- 4. On developing the tools and metrics for a neurosurgical quality program -- 5. The role of clinical registries in health care -- 6. Measuring value of health care: the importance and challenges of measuring true cost -- 7. Teams, competence, and safety in surgery -- 8. Evidence-based practice of neurosurgery: implications for quality and safety -- 9. The physician handoff and its role in quality and safety -- 10. Improving operating room safety -- 11. Using multicenter clinical registries to improve outcomes -- 12. Improving efficiency and mapping surgical procedures using lean methods -- 13. Quality efforts for reducing mortality in neurosurgery -- 14. Reducing readmissions -- 15. Improving outcomes: big data and predictive analytics -- 16. Improving performance by improving education -- 17. Improving outcomes with subspecialization and regionalization -- 18. Quality of care and outcomes in pediatric neurosurgery: incorporating evidence-based practice -- 19. Eliminating unneccessary diagnostic imaging and labs -- 20. Creating national practice standards through collaboration -- 21. Use of risk model for assessment of resident perception of surgical complexity and evaluation of procedural competence -- 22. Use of physical education and nutrition program to improve outcomes.

Drawing on the universal values in health care, the second edition of Quality and Safety in Nursing continues to devote itself to the nursing community and explores their role in improving quality of care and patient safety.

Designed for all providers of women's healthcare - including those undertaking Maintenance of Certification programs, trainees preparing for postgraduate examinations, and those initiating or growing a program of quality improvement and patient safety - this practical manual guides those implementing QI and safety programs with specific emphasis on Obstetrics and Gynecology practice. The content contains a strong case-based element to improve accessibility and understanding. An introductory section covers core attributes needed by all physicians to build a culture of patient safety, including leadership, communication and QI skills. Core clinical skills are then reviewed - in a variety of labor ward, office, operating room, and outpatient settings. Finally systems implications are highlighted, including information transparency and disclosure, training programs, and regulatory and legal implications. The editors are involved with national and international initiatives educating physicians in safety aspects of practice. The book is published in collaboration with the Foundation for EXXcellence.

This book is a comprehensive and timely compilation of strategy, methods, and implementation of a proof of concept modified quality module of Good Laboratory Practices (GLP). This text provides a historical overview of GLP and related standards of quality assurance practices in clinical testing laboratories as well as basic research settings. It specifically discusses the need and challenges in audit, documentation, and strategies for its implications in system-dependent productivity striving research laboratories. It also describes the importance of periodic training of study directors as well as the scholars for standardization in research processes. This book describes different documents required at various time points of a successful Ph.D and post-doc tenure along with faculty training besides entire lab establishments. Various other areas including academic social responsibility and quality assurance in the developing world, lab orientations, and communication, digitization in data accuracy, auditability and back traceability have also been discussed. This book will be a preferred source for principal investigators, research scholars, and industrial research centers globally.

Development of superior crops that have consistent performance in quality and in quantity has not received the same emphasis in the field of genetics and breeding as merited. Specialty trait requires special focus to propagate. Yet basic germplasm and breeding methodologies optimized to improve crops are often applied in the development of improved specialty types. However, because of the standards required for specialty traits, methods of development and improvement are usually more complex than those for common commodity crops. The same standards of performance are desired, but the genetics of the specialty traits often impose breeding criteria distinct from those of non-specialty possessing crops. Specifically, quality improvement programs have unique characteristics that require careful handling and monitoring during their development for specific needs. Adding value either via alternative products from the large volumes of grain produced or development of specialty types is of interest to producers and processors. This work assimilates the most topical results about quality improvement with contemporary plant breeding approaches. The objective of this book is to provide a summary of the germplasm, methods of development, and specific problems involved for quality breeding. In total, fourteen chapters, written by leading scientists involved in crop improvement research, provide comprehensive coverage of the major factors impacting specialty crop improvement.

1 Challenges and Opportunities for Biotech Quality by Design -- 2 Lessons Learned From Monoclonal Antibody Applications to the Office of Biotechnology Products Quality by Design Pilot Program -- 3 Definitions and Scope of Key Elements of QbD -- 4 An Overview of Quality by Design for Drug Product -- 5 Development of Drug Product Formulations: Molecular Design and Early Candidates Screening -- 6 Approaches for Early Developability Assessment of Proteins to Guide Quality by Design of Liquid Formulations -- 7 Application of QbD Principles to Late-stage Formulation Development for Biological Liquid Products -- 8 Application of QbD Principles for Lyophilized Formulation Development -- 9 Drug Substance Frozen Storage and Thawing -- 10 Quality by Design as Applied to Drug Substance Formulation using Ultrafiltration and Diafiltration -- 11 A QbD Approach in the Development and Scale-up of Mixing Processes -- 12 Application of QbD Elements in the Development and Scale-up of a Commercial Filtration Process -- 13 Application of QbD Elements in the Development and Scale-up of Commercial Filling Process -- 14 Lyophilization Process Design and Development Using QbD Principles -- 15 Visible and Subvisible Protein Particle Inspection Within a QbD-based Strategy -- 16 Quality by Design for Distribution of Environmentally Sensitive Pharmaceutical Products -- 17 Quality by Design for Primary Container Components -- 18 Devices and Combination Products for Biopharmaceuticals -- 19 Applicability of QbD for Vaccine Drug Product Development -- 20 Automation and High Throughput Technologies in Biopharmaceutical Drug Product Development with QbD Approaches -- 21 Critical Quality Attributes, Specifications, and Control Strategy -- 22 Multivariate Analysis for Process Understanding, Monitoring, Control and Optimization in Lyophilization Processes -- 23 Using Mathematical Modeling and Prior Knowledge for QbD in Freeze-drying Processes -- 24 Application of Multivariate Statistical Process Monitoring to Lyophilization Process -- 25 Application of PAT in Real-time Monitoring and Controlling of Lyophilization Process -- 26 Product Homogeneity Assessment during Validation of Biopharmaceutical Drug Product Manufacturing Processes -- 27 Application of Quality by Design Principles to the Drug Product Technology Transfer Process -- 28 Regulatory Considerations For Implementation of the QbD Paradigm for Biologics: Laying the Foundation for Product and Process Lifecycle Management.

This book follows the continuum of cancer care model as its outline vide infra. As cancer is now a very multidisciplinary disease, it encourages dedicated professionals from various specialties as well as active patient cooperation in order to improve successful treatment and survival. This text will serve as a detailed reference source for healthcare providers intending to improve the quality of survivorship of cancer patients, as well as help create affordable care plans. Initially it discusses the current cancer care crisis on a global and then national platform. Chapters include discussions about disability adjusted life years lost, lost productivity, loss of life and its impact upon the nation and communities. In order to deescalate the financial impact of cancer on society and government, this text incorporates smarter and efficient treatment alternatives that will also improve the survivorship of patients, families and caregivers. It also illustrates how prevention and screening programs can be incorporated to improve cancer care. Quality Cancer Care: Survivorship Before, During and After Treatment will become an invaluable resource for healthcare professionals and clinical staff involved in the delivery of cancer care.

This practical, unique textbook provides a foundation for the essential elements of patient safety and quality improvement (QI) for orthopaedic trainees, though the content covered will be of interest to veteran clinicians as well. Currently, there are few existing resources and didactics focused on this crucial yet often overlooked area of medical practice, which makes this the first true textbook on the subject within the field of orthopaedic surgery. Utilizing a user-friendly approach including generous figures, tables, and bulleted key points, the text presents comprehensive background information on QI principles, models, and patient safety. More specifically, it focuses on orthopaedic concerns, such as biologics and implants, registries, checklists, surgical site infection risk reduction, use of evidence-based medicine and care maps, simulation to improve care, and shifting from volume to value, among others. Related topics such as diversity and inclusion, provider wellness strategies, leadership strategies to develop an efficient and safe work culture, and innovation are also presented. Throughout, the aim is to demonstrate that QI is a multidisciplinary goal that can only flourish in an environment of supportive accountability. With contributions by leaders in the field, Quality Improvement and Patient Safety in Orthopaedic Surgery provides trainees and surgeons in the field a valuable and pragmatic toolkit for successful and sustainable clinical practice.

This comprehensive textbook provides a state of the art overview of the means by which quality in patient care is ensured within the field of nuclear medicine. Acknowledged experts in the field cover both management aspects, such as laws, standards, guidelines, patient safety, management instruments, and organisations, and specific issues, including radiation safety and equipment. Quality in Nuclear Medicine not only presents detailed information on the topics discussed but should also stimulate further discussion and offer an important tool to all professionals in the field of nuclear medicine and their stakeholders. Readers will find that the book provides a wealth of excellent guidance and reflects the pioneering role of nuclear medicine in advancing different aspects of quality within medicine.

This book reviews quality definition, measurement, improvement, value, and accountability for obesity management. The interplay between quality, cost, access and satisfaction is fully depicted with a goal toward not only fulfilling current standards but also anticipating future needs. A thorough inventory of current best practices in all aspects of obesity care is cataloged with a gap analysis also employed for potential areas of improvement to be road mapped. All chapters are written by experts in their fields and include the most up-to-date scientific and clinical information, take home messages, and questions towards following the requirements of quality certification in obesity management. Quality in Obesity Treatment provides a comprehensive, contemporary review of this field and serves as a valuable resource for Bariatric Surgeons, Primary Care Physicians, Policy Makers, Insurance Administrators, Bariatricians, and any medical specialty interested in obesity quality management with likely candidates coming from GI, endocrinology, cardiology, sleep medicine and orthopedics.

This open access book provides a concise yet comprehensive overview on how to build a quality management program for hematopoietic stem cell transplantation (HSCT) and cellular therapy. The text reviews all the essential steps and elements necessary for establishing a quality management program and achieving accreditation in HSCT and cellular therapy. Specific areas of focus include document development and implementation, audits and validation, performance measurement, writing a quality management plan, the accreditation process, data management, and maintaining a quality management program. Written by experts in the field, Quality Management and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy: A Practical Guide is a valuable resource for physicians, healthcare professionals, and laboratory staff involved in the creation and maintenance of a state-of-the-art HSCT and cellular therapy program.

In the last decades, major advances have been made in assisted reproductive technologies (ART) and the public demand for these procedures has increased globally. All ART clinics, from those just starting out to the well established, must employ the latest equipment and implement the best practices, while ensuring that their resources are effectively engaged to optimize patient outcomes. This is a tenet of the fiduciary role of physicians and it is increasingly recognized as a quantifiable goal regulated by formal certifications and accreditations. Quality management protocols such as those proposed by the International Organization for Standardization (ISO) are being rapidly adopted as standards of measure. Quality Management in ART Clinics: A Practical Guide provides easily adoptable ways to implement and improve formalized quality management systems. Essential to any clinic to achieve best practices and maintenance of formal regulatory certifications, this book brings together the know-how of experienced opinion leaders operating in key areas worldwide. The book offers an overview of primary regulations in the ART field, with attention to quality management demands, and links specific requirements to practical steps for implementation. Filled with process and procedure examples, flow diagrams and administrative form templates, this book is the first of its kind, gathering the necessary elements for optimizing practice, management, and quality assurance.

In recent years, the attention of the scientific and social community has not solely been on producing new findings, but increasingly also on the related issues of the reliability, safety, and efficacy of the discoveries made, as well as the efficient and effective use of resources. The adoption of management models and tools can help scientists to improve their research, ensuring valuable, robust and dependable outcomes. Quality disciplines have been widely used for decades in industrial and business fields, building a knowledge base that can be translated and exploited, much to the advantage of scientific research. However, quality references in scientific research are still extremely rare and largely limited to an international guideline and a few sector-specific standards. Despite WHO and EU Commission campaigns, there are still precious few practical texts that offer researchers guidance on quality principles and provide simple tools and methodologies for their daily work. The book, starting from the problem of the reproducibility of scientific results and the substantial contribution that the Quality approach can make to research (Chapter 1), introduces the reader to key principles and basic concepts of Quality and illustrates both general and research-specific quality standards, paving the way for further discussion (Chapter 2). In turn, Chapter 3 presents detailed applications of Quality principles in various aspects of research, from study and ethics to materials and equipment management. Chapters 4 and 5, respectively, are devoted to Quality tools and Quality methodologies, as well as soft skills, all of which are valuable to scientific experimentation and study management. The concepts and practical tools discussed are extensively illustrated with examples from actual applications in scientific research.

While the healthcare system continues to shift towards more emphasis on quality metrics, there remains a substantial gap between the expectations of healthcare policies and standards of hospital administrations vs. the realistic care provided by the average healthcare provider. This book offers the perspective of the healthcare provider and aims to fulfill the unmet need to educate other healthcare providers on recognizing quality measures and understanding how to achieve them to meet standards of quality care. This book covers the historical perspective of quality measures, the context of their existence, their utility, and the contemporary issues related to their use. Simultaneously, it critically addresses the quality of these quality metrics and presents the evidence available to date on the efficacy and the limitations of these quality measures. This text is all-inclusive and is organized into chapters that include the evolution of quality metrics in healthcare, the practical role of hospitals, as well as the practical role of individual healthcare providers in addressing quality metrics. The chapters also include assessment of quality metrics that uniquely pertain to medical and surgical practices, as well as non-clinical quality metrics that specifically target undergraduate and graduate medical training. Finally, the book reflects on the use of contemporary quality metrics and their impact on outcomes, patient care, and public health and policy making. In these chapters, tables and illustrations, including algorithms, will be used to provide systematic approaches to common issues related to quality metrics. In addition, historical anecdotes and case presentations will be used to address pearls in contemporary practice of quality metrics. Quality Measures is the definitive reference on quality metrics in healthcare and is a valuable resource for healthcare providers, trainees, administrators and public health agencies.

Principles of measurement scales -- Developing a questionnaire -- Scores and measurement : validity, reliability, sensibility -- Multi-item scales -- Factor analysis and structural equation modelling -- Item response theory and differential item functioning -- Item banks, item linking, and computer-adaptive tests -- Choosing and scoring questionnaires -- Clinical trials -- Samples sizes -- Cross-sectional analysis -- Exploring longitudinal data -- Modelling longitudinal data -- Missing data -- Practical and reporting issues -- Death and quality-adjusted survival -- Clinical interpretation -- Biased reporting and response shift -- Meta-analysis.

This book explores the meaning of quality of life in care for older persons and introduces the reader to their main concerns when receiving care. Based on qualitative research, it pays particular attention to the needs and requirements of older people, considering their individual family situations, social circumstances, values and lifestyles. Person-centred care is a way of providing nursing care that puts older people and their families at the core of all decisions, seeing each person as an individual, and working together to develop appropriate solutions. Following an introduction to the concept of quality of life in old age, the book reviews essential findings from worldwide research into the experiences of older people with regard to nursing care and the impact of these experiences on their quality of life. It investigates health promotion, care provided in nursing homes and assisted living facilities, and palliative care. Each chapter includes a brief introduction to the respective field of nursing care and the problems it has to deal with, concluding with a discussion of their implications for nursing practice in the respective field of care. In closing, the evidence from qualitative research is discussed in relation to current gerontological theories.

This book introduces a multidimensional system that evaluates quality of life in China by pursuing a quantitative and analytical approach. A host of factors, including economic conditions and individual wellbeing, can affect peoples satisfaction with their lives. In addition to GDP-associated indicators, sociological and environmental factors are also relevant when it comes to evaluating quality of life. Providing a general framework, while also considering gender, education and geographical differences in assessing quality of life, the book offers policy suggestions for improving both individual quality of life and the health of society as a whole.

Part I. Historical Aspects -- 1. Historical Aspects of Quality in Healthcare -- 2. Quality and Standardization of Medical Education -- 3. The History of Quality Assessment in Spine Care -- Part II. Methodology in Quality Assessment -- 4. Choice of Quality Metrics for Assessment of the Spine Patient -- 5. Patient-Reported Outcomes -- 6. Registries in Spine Care in the United States -- 7. Registries in Spine Care: UK and Europe -- 8. Concepts of Risk Stratification in Measurement and Delivery of Quality -- 9. Risk Adjustment Methodologies -- Part III. Healthcare Systems -- 10. Healthcare Systems in the United States -- 11. The National Health Service (NHS) in England: Trying to Achieve Value-Based Healthcare -- 12. Quality Spine Care in Australasia -- 13. Healthcare Systems: India -- 14. Healthcare Systems and Quality Assessment of Spine Care in Japan -- 15. Overview of Healthcare System in China -- Part IV. Implementation of Quality Reporting -- 16. Conditions of Care and Episode Groups -- 17. Aligning Healthcare Systems -- 18. Building Quality Metrics into a Practice -- 19. Impact of Quality Assessment on Clinical Practice, Intermountain Healthcare -- 20. Impact of Quality Assessment on Clinical Practice, Kaiser Permanente -- 21. How Quality is Assessed in Insurance Markets -- 22. Centers of Excellence and Payer-Defined Quality Assessment -- 23. Reporting Quality Results -- 24. Achieving Success in Quality Reporting.

This book provides a comprehensive survey of the pharmacokinetic models used for the quantitative interpretation of contrast-enhanced imaging. It discusses all the available imaging technologies and the problems related to the calibration of the imaging system and accuracy of the estimated physiological parameters. Enhancing imaging modalities using contrast agents has opened up new opportunities for going beyond morphological information and enabling minimally invasive assessment of tissue and organ functionality down to the molecular level. In combination with mathematical modeling of the contrast agent kinetics, contrast- enhanced imaging has the potential to provide clinically valuable additional information by estimating quantitative physiological parameters. The book presents the broad spectrum of diagnostic possibilities provided by quantitative contrast-enhanced imaging, with a particular focus on cardiology and oncology, as well as novel developments in the area of quantitative molecular imaging along with their potential clinical applications. Given the variety of available techniques, the choice of the appropriate imaging modality and the most suitable pharmacokinetic model is often challenging. As such, the book provides a valuable technical guide for researchers, clinical scientists, and experts in the field who wish to better understand and properly apply tracer-kinetic modeling for quantitative contrast-enhanced imaging.

This open access book presents the rise of technology-enabled methods and tools for objective, quantitative assessment of Quality of Life (QoL), while following the WHOQOL model. It is an in-depth resource describing and examining state-of-the-art, minimally obtrusive, ubiquitous technologies. Highlighting the required factors for adoption and scaling of technology-enabled methods and tools for QoL assessment, it also describes how these technologies can be leveraged for behavior change, disease prevention, health management and long-term QoL enhancement in populations at large. Quantifying Quality of Life: Incorporating Daily Life into Medicine fills a gap in the field of QoL by providing assessment methods, techniques and tools. These assessments differ from the current methods that are now mostly infrequent, subjective, qualitative, memory-based, context-poor and sparse. Therefore, it is an ideal resource for physicians, physicians in training, software and hardware developers, computer scientists, data scientists, behavioural scientists, entrepreneurs, healthcare leaders and administrators who are seeking an up-to-date resource on this subject.

Faithful propagation of the genome during division is a process fundamental to all cells. Eukaryotic cells segregate their chromosomes by attaching them via the kinetochore, a large multi-protein complex, to a microtubule spindle that physically moves the chromosomes to the daughter cells. The kinetochore is assembled at the site of the centromere, a specialized chromatin domain and set of associated proteins. In most organisms, the identity of the centromere is not determined by an underlying DNA sequence but by the incorporation of a centromere-specific histone H3 variant called CENP-A. How the cell recognizes these centromere-specific histones as the site for kinetochore assembly and the site at which to replenish CENP-A during cell division remains a major unanswered question. Many experimental techniques have been used to probe the function of the centromere, but quantitative fluorescence imaging has proved especially useful because of its molecular specificity, high sensitivity, and ability to examine single cells and single centromeres. Accurate quantitative analysis of images is critical to being able to apply fluorescence imaging to centromeres, where often meaningful intensity differences between treatments can be a factor of two or smaller, and meaningful spatial distances are far smaller than the diffraction limit of light. Empirical determination of the accuracy of an image analysis method is necessary to have confidence in these subtle measurements. We first present a series of quantitative image metaanalysis tools whose aim is to provide a quantitative metric to compare different analysis methods, and we develop an accurate and linear automated method for quantifying the intensities of centromeres in fluorescence images. Next, we describe a new superresolution microscopy methodology that can be used to measure and correct the optical aberrations introduced by cells, a critical step for measuring spatial distances at centromeres. Finally, we combine fluorescence imaging with a system for biochemical reconstitution of centromeric chromatin to examine the question of how CENP-A is recognized as the site at which the cell will incorporate additional CENP-A during cell division. We find that the six amino acids at the CENP-A C-terminus are both necessary and sufficient for this recognition.

Cancer genome sequencing has been instrumental in identifying the genomic alterations that occur in human tumors. The functional importance of the vast majority of these alterations, both alone and in combination, remains unknown and largely uninvestigated due to lack of tools enabling high-throughput interrogation of coincident genetic alterations in vivo. This thesis describes a method that integrates tumor barcoding with CRISPR/Cas9-mediated genome editing and ultra-deep barcode sequencing (Tuba-seq) to interrogate multiple tumor genotypes simultaneously in autochthonous mouse models of human cancer. I demonstrate the quantification of the effects of eleven of the most frequently inactivated genes in human lung adenocarcinoma and uncover the methyltransferase Setd2 and the splicing factor Rbm10 as novel suppressors of lung cancer growth. By quantifying the in vivo fitness advantage conferred by inactivation of each of these eleven genes in combination with inactivation of p53 or Lkb1, we identify unexpected context-dependent tumor suppression. I further demonstrate the ability of tumor barcoding to investigate clonal relationships between tumors and metastases, as well as uncover potential drugs to inhibit metastatic progression. These approaches will redefine our ability to understand how tumor suppressor inactivation impacts tumor initiation, growth, malignant transformation, and ultimately lead to the identification of therapy responses. Specifically, we can begin to investigate genotype specific drug responses and hope to inform a more precise and personalized era of patient care.

The community of commensal bacteria, viruses and eukaryotic microorganisms within our gastrointestinal tract, the gut microbiota, is a fundamental part of our biology. Foundational work has demonstrated that these organisms are required for proper development of the immune, circulatory and central nervous systems; and changes in the membership of this community are associated with pathologies such as obesity, colorectal cancer, type 2 diabetes and inflammatory bowel diseases. Though much research has focused on community composition assessed by pyrosequencing, emerging evidence suggests that many of these disease states are also associated with changes in bacterial localization within the intestines. However, standardized imaging and quantitation methods have not been established yet in the field. The work in this dissertation develops and validates such methods, and applies them to determine the effects of a low fiber diet on spatial organization of the gut microbiota. Chapter 1 contains a literature review of existing tools to study the microbiota, with a focus on the advantages and limitations of different imaging strategies. Chapter 2 includes the histological, imaging, and computational methods developed to develop a high-resolution imaging and quantification pipeline, using gnotobiotic and humanized mice on a polysaccharide-deficient diet as a test case. Chapter 3 further develops the work from Chapter 2, with a focus on host response to a low fiber diet. Chapter 4 contains perspectives and future directions for the applications of imaging to the gut microbiota field.

A crucial challenge for radiology is maintaining high interpretation accuracy in the face of increasing imaging workload and limited time to review and interpret the images for each patient. Variation in interpretation accuracy among radiologists is a recognized challenge. Two techniques that could help radiologists improve their interpretation are Content-based Image Retrieval (CBIR) for diagnostic support, and lesion size tracking for evaluating response to treatment. CBIR provides assists radiologists to find images from a database that are similar in terms of shared imaging features to the images they are interpreting. The performance of CBIR hinges critically on features that characterize lesions. In the first half of the talk, I will focus on the development of a novel quantitative imaging feature that describes the margin characteristics of lesions. This new margin sharpness feature is robust to variation in lesion segmentation, and achieves excellent CBIR performance in clinical datasets. Tracking lesion size in response to treatment is a crucial component for patient management as well as towards finding the best cancer therapy through clinical trials. Traditionally, tracking lesion size using serial Computed Tomography (CT) scans is largely a manual and tedious process. In the second half of the talk, I will present a novel method to automatically track and segment lymph nodes in serial CT scans. My method has achieved excellent overall segmentation performance compared to manual segmentation provided by radiologists. Ultimately, I envision that the translation of both of the above methods to the clinic will improve diagnostic accuracy, precision, and efficiency.

Philosophy of science and introduction to epidemiology -- Routine data sources and descriptive epidemiology -- Standardisation -- Surveys -- Cohort studies -- Case-control studies -- Intervention studies -- Life tables, survival analysis and cox regression -- Systematic reviews and meta-analysis -- Prevention strategies and evaluation of screening -- Probability distributions, hypothesis testing and Bayesian methods.

This book presents cutting-edge research on the use of physical and mathematical formalisms to model and quantitatively analyze biological phenomena ranging from microscopic to macroscopic systems. The systems discussed in this compilation cover protein folding pathways, gene regulation in prostate cancer, quorum sensing in bacteria to mathematical and physical descriptions to analyze anomalous diffusion in patchy environments and the physical mechanisms that drive active motion in large sets of particles, both fundamental descriptions that can be applied to different phenomena in biology. All chapters are written by well-known experts on their respective research fields with a vast amount of scientific discussion and references in order the interested reader can pursue a further reading. Given these features, we consider Quantitative Models for Microscopic to Macroscopic Biological Macromolecules and Tissues as an excellent and up-to-date resource and reference for advanced undergraduate students, graduate students and junior researchers interested in the latest developments at the intersection of physics, mathematics, molecular biology, and computational sciences. Such research field, without hesitation, is one of the most interesting, challenging and active of this century and the next.

Rationale for Quantitative MRI of the Human Spinal Cord and Clinical Applications -- Inflammatory Demyelinating Diseases -- Traumatic Spinal Cord Injury: Acute Spinal Cord Injury and Prognosis -- Traumatic Spinal Cord Injury: Chronic Spinal Cord Injury and Recovery -- Array Coils -- Bo Inhomogeneity and Shimming -- Susceptibility Artifacts -- Ultra-High Field Spinal Cord Imaging -- Diffusion-Weighted Imaging of the Spinal Cord -- Q-Space Imaging -- Advanced Methods to Study White Matter Microstructure -- Magnetization Transfer -- T₂ Relaxation -- Atrophy -- Spinal Cord fMRI -- Physiological Noise Modeling and Analysis for Spinal Cord fMRI -- Mapping the Vasculature of the Spinal Cord --Single Voxel MR Spectroscopy in the Spinal Cord: Technical Challenges and Clinical Applications -- Annex: Anatomy of the Spinal Cord.

Twenty years of qPCR: A mature technology? -- Minimum information necessary for quantitative real-time PCR experiments -- Selection of reliable reference genes for RT-qPCR analysis -- Introduction to digital PCR -- mRNA and microRNA purity and integrity: The key to success in expression profiling -- Mediator probe PCR: Detection of real-time PCR by label-free probes and a universal fluorogenic reporter -- Absolute quantification of viral DNA: The quest for perfection -- A multiplex real-time PCR-platform integrated into automated extraction method for the rapid detection and measurement of oncogenic HPV type-specific viral DNA load from cervical samples -- Real-time PCR detection of mycoplasma pneumoniae in the diagnosis of community-acquired pneumonia -- A sensible technique to detect mollicutes impurities in human cells cultured in GMP condition -- Real-time quantification assay to monitor BCR-ABL1 transcripts in chronic myeloid leukemia -- A reliable assay for rapidly defining transplacental metastasis using quantitative PCR -- Circulating cell-free DNA in cancer -- Gene expression analysis by qPCR in clinical kidney transplantation -- Posttranscriptional regulatory networks: From expression profiling to integrative analysis of mRNA and microRNA data -- Clinical applications using digital PCR -- Developing noninvasive diagnosis for single-gene disorders: the role of digital PCR.

Due to parallel advances in signal processing and computer hardware in the last 15 years, quantitative ultrasound techniques have reached maturity, allowing for the construction of quantitative maps or images of soft tissues. This book will focus on 5 modern research topics related to quantitative ultrasound of soft tissues: - Spectral-based methods for tissue characterization, tissue typing, cancer detection, etc.; - Envelope statistics analysis as a means of quantifying and imaging tissue properties; - Ultrasound elastography for quantifying elastic properties of tissues (several clinical ultrasound scanners now display elastography images); - Scanning acoustic microscopy for forming images of mechanical properties of soft tissues with micron resolution (desktop size scanners are now available); and - Ultrasound computer tomography for breast cancer imaging (new ultrasound tomography systems have been developed and are currently under evaluation clinically).

"The current text explores leadership within the context of a new understanding of complex adaptive systems and complex responsive processes. The leader is seen through a new lens of relational leadership in a way that emphasizes numerous skill sets for managing increasingly complex and diverse healthcare delivery systems in an era of constant movement and change. Rather than focus on the mechanics of operations and function, this text emphasizes the characteristics and role of the complexity leader through both describing the context of complexity and the application of the role as a leader of these complex systems. A revision of the text is needed to share the new science created supporting high levels of interdisciplinary team work as provide strategies for leaders to further advance their skills in leading complex, interdisciplinary teams. The most outstanding feature of this book is that it has an exceptionally unique focus that specifically addresses postindustrial, complex and highly mobile organizational systems and emphasizes the characteristics, elements, and role of leaders in guiding individuals and teams through effectively navigating work in these essentially new models. Quantum Leadership also integrates the essential requirements for Quality Matters certification of online courses that are used in many colleges and universities. Many more of the faculty and students using this textbook are in DNP programs and others are in leadership masters programs. These programs are contending with providing leadership within the context of a shifting healthcare landscape, the PPACA and increasing emphasis on trans disciplinary and value-based processes"--Publisher's description

What is a quasispecies?- Historical origins and current scope -- The nucleation of semantic information in prebiotic matter -- Evolution of RNA-based networks -- Quasispecies on fitness landscapes -- Mathematical models of quasispecies theory and exact results for the dynamics -- Theoretical Models of Generalized Quasispecies -- Theories of lethal mutagenesis: from error catastrophe to lethal defection -- Estimating fitness of viral quasispecies from next-generation sequencing data -- Getting to know viral evolutionary strategies: Towards the next generation of quasispecies models -- Cooperative Interaction within RNA Virus Mutant Spectra -- Arenavirus Quasispecies And Their Biological Implications -- Models of viral population dynamics -- Fidelity variants and RNA quasispecies -- Antiviral strategies based on lethal mutagenesis and error threshold.

As the first neurological hospital in the world, founded in 1859, the National Hospital, Queen Square, and its affiliated Institute of Neurology remain leading neurological centres providing exceptional clinical services, teaching and research. Illustrated by over 100 historical images and much unpublished archival material, this book provides a comprehensive history of the National Hospital, the Institute, and their staff. It relates the ups and downs of the Hospital and Institute in war and peacetime, their financial struggles, many personality conflicts, efforts to remain independent and to maintain neurological dominance, academic and clinical contributions, issues relating to specialisation and subspecialisation and relations between disciplines, and the changing roles of the Hospital and Institute. The history is told from varying perspectives against the backdrop of the evolution of British clinical neuroscience, the special position of London medicine, and the influence of world wars, and is set in the context of modern British social history.

"In this book, personal accounts mingle with factual information and sensitive analysis to provide a snapshot of the joys and concerns of lesbian, gay, bisexual, transgender, queer, intersex, and asexual adolescents"-- Provided by publisher.

This original fourteen chapter book is a brief, slightly autobiographic tale of medical oncologists, surgeons, radiation oncologists, and breast cancer patients in a well-established cancer center in Texas, who pursued the goal of cure for breast cancer. The evolution of improved outcomes in the treatment of microscopic metastatic breast cancer is also the story of the development of adjuvant chemotherapy for post-operative breast disease. The adjuvant therapy of breast cancer came about with the realization that this malignancy, when diagnosed in most patients, had spread beyond the confines of the primary cancer.

"Ace the echocardiography boards with this unique review tool! Questions, Tricks, and Tips for the Echocardiography Boards provides one-of-a-kind assistance directly from those who have recently passed the exam - including hundreds of questions and video clips that mimic what you're likely to encounter. The Second Edition also incorporates valuable feedback from Dr. Sorrell's recent fellows, ensuring complete, up-to-date coverage of the information you need to know to perform at your best on the exam"-- Provided by publisher.

This book provides a practical and comprehensive review of pain medicine in a clear and easy to apply question-answer format. Divided by topic, the book includes Q&As on Pain Basics, Psychology, Common Pain Syndromes, Medications, Pain Management in Special Populations and Interventional Pain. It is intended as a guide for residents and fellows and is written in such a manner to provide instantaneous feedback on correct answer choice and explanation for self-evaluation while preparing for written board examinations. Questions and Answers in Pain Medicine: A Guide to Board Exams fulfills the need for a resource that is similar to the Accreditation Council for Graduate Medical Education (ACGME) board examination in the US as well as international equivalents. It utilizes a fully Q&A approach which is how many students prefer to study. Written by a physician who has recently passed the ACGME written board exam and the founder of a pain management fellowship program for nearly 20 years, the authors provide valuable insight for successfully undertaking board examinations in pain medicine. .

"This is the first book developed specifically for the Final FFICM structured oral examination. It is written by two senior trainees who have recently passed the exam and is edited by a consultant intensivist with a special interest in education. The book is designed in the style of the SOE, and provides model answers which include summaries of the relevant evidence to guide trainees in their preparation for the exam. The 91 topics and questions therein are drawn from previous exam sittings, and are expanded further to ensure each topic is covered in detail. This text is a valuable revision aid to those studying for the Final FFICM, and will also prove useful to trainees revising for the Final FRCA, as it covers popular ICM topics that often come up in the anaesthetic fellowship exams"--Provided by publisher.

Enhance your knowledge of neonatal-perinatal medicine and/or study for Neonatal-Perinatal Medicine board certification with this new study guide from the editors of NeoReviews.

"Quick Answers: Pharmacy provides concise, practical, expert information on the pharmacotherapy of common disorders. It is designed for quick and easy access to the drug therapy information you need for decision making in the clinical setting."--Preface

"Quick Answers: Pharmacy provides concise, practical, expert information on the pharmacotherapy of common disorders. It is designed for quick and easy access to the drug therapy information you need for decision making in the clinical setting."--Preface

Intro -- Preface -- Contents -- About the Authors -- Chapter 1: Anaphylaxis: Definition, History, and Epidemiology -- 1.1 Definition of Anaphylaxis -- 1.2 History -- 1.3 Epidemiology of Anaphylaxis -- References -- Chapter 2: The Aetiology of Anaphylaxis -- 2.1 Food Allergy -- 2.1.1 Background -- 2.1.2 Definition of Food Allergy -- 2.1.3 Epidemiology -- 2.1.3.1 Sex- and Age-Related Demographics -- 2.1.4 Aetiology -- 2.1.4.1 IgE Antibody-Mediated Responses -- 2.1.4.2 Cell-Mediated Responses -- 2.1.5 Symptoms of Food Allergy -- 2.1.6 Food Allergy Triggers -- 2.1.7 Diagnosing Food Allergies 2.1.8 Characteristics of Food Allergens -- 2.1.9 Risk Factors -- 2.1.10 Management and Treatment -- 2.1.10.1 Investigational Therapeutic Interventions for Food Allergy -- 2.1.10.2 Patient Education -- Preparation -- Avoidance of Allergens -- 2.1.11 Anaphylaxis -- 2.1.12 Food Allergy Action Plan -- 2.1.13 Prognosis -- 2.2 Drug Allergy -- 2.2.1 Definition of Drug Allergy -- 2.2.2 Classification of Drug Allergy -- 2.2.3 Epidemiology -- 2.2.4 Drug Allergy and Anaphylaxis -- 2.2.5 Risk Factors for Drug Allergy -- 2.2.5.1 Drug-Related Factors -- 2.2.5.2 Factors Related to the Host 2.2.6 Genetics of Drug Allergy -- 2.2.7 History and Physical Examination -- 2.2.8 Diagnostic Tests -- 2.2.9 Specific Drugs and Biologic Agents and Drug Allergy -- 2.2.9.1 Antimicrobials -- 2.2.9.2 Insulin and Oral Antidiabetic Drugs -- 2.2.9.3 Cancer Chemotherapeutic Agents -- 2.2.9.4 Medications for Patients with HIV Infections and AIDS -- 2.2.9.5 Medications for Autoimmune Diseases -- 2.2.9.6 Perioperative Agents and Blood Products -- 2.2.9.7 Opiates -- 2.2.9.8 Corticosteroids -- 2.2.9.9 Heparin -- 2.2.9.10 Local Anaesthetics -- 2.2.9.11 Radio-Contrast Media -- 2.2.9.12 Biologic Modifiers 2.3 Venom Allergy -- 2.3.1 Background -- 2.3.2 Pathophysiology -- 2.3.3 Epidemiology -- 2.3.4 Symptoms -- 2.3.4.1 Local Reactions -- 2.3.4.2 Generalised Reactions -- 2.3.5 Diagnosis -- 2.3.6 Prognosis -- 2.3.7 Treatment -- 2.3.7.1 Emergency Department Care -- Epinephrine (Adrenalin, Bronitin, EpiPen) -- Bronchodilators -- Salbutamol (Ventolin) -- Antihistamines -- Systemic Corticosteroids -- Anti-tetanus Immunoglobulin -- 2.3.7.2 Desensitisation (Immunotherapy) -- Mechanism of immunotherapy -- 2.4 Allergic Rhinitis, Asthma, and Anaphylaxis -- 2.4.1 Background -- 2.4.2 Asthma and Anaphylaxis 2.4.2.1 Pathophysiology -- Inflammation Occurring Within Airways -- Discontinuous Blockage of Air Entry and Exit -- Overreactive Bronchi -- 2.4.2.2 Aetiology -- 2.4.2.3 Manifestations of an Acute Episode -- Mild Episodes -- Moderate Severity -- High Severity -- Pre-respiratory Arrest -- 2.4.2.4 Symptoms of an Asthma Emergency -- 2.4.2.5 Incidence of Anaphylactic Shock in Asthma -- 2.4.3 Allergic Rhinitis and Anaphylaxis -- 2.4.3.1 Pathophysiology -- 2.4.3.2 Symptoms and Chronicity -- 2.4.3.3 Trigger Factors -- 2.4.3.4 Comorbid Conditions -- 2.4.3.5 Mortality/Morbidity

Immunology: A Quick Guide -- Clinical Features of Contact Dermatitis -- Patch Testing: Essentials -- Patch Testing with Own Products -- Allergic Contact Dermatitis: Clinical Relevance and Exposure Assessment of Allergens -- Irritant Contact Dermatitis: Diagnosis and Risk Factors -- Photoreactions and Testing -- Protein Contact Dermatitis and Testing -- Occupational Contact Dermatitis -- Contact Allergy in Children -- Main Allergen Groups: Metals -- Fragrances -- Preservatives. Allergens in Various Products: Textiles and Hair Dyes -- Dental Materials -- Shoes/Gloves -- Glues -- Metalworking Fluids -- Plants -- Cosmetics -- Workers Protection: Gloves, Creams -- Overview of Allergens.

This quick guide demonstrates the value of dermoscopy before, during, and after the treatment of a wide variety of vascular and other skin lesions with laser and/or intense pulsed light (IPL). The coverage includes the treatment of benign pigmented pathologies, melanocytic nevi, seborrheic dermatoses, solar lentigines, telangiectasias, flat angiomas, port-wine scars, other vascular pathologies, keloids and hypertrophic scars, acne and post-traumatic scars, and tattoos. Practically oriented information is also supplied on the dermoscopic technique, the principles of use of lasers and IPL in dermatology, laser-tissue interactions, and types of laser. This will help the reader to comprehend the importance of lasers and IPL in clinical practice and provide excellent preparation for the use of dermoscopy to visualize the targets to be hit with laser or IPL. The inclusion of more than 100 color photos stored before, during, and after dermoscopy-aided laser or IPL treatment documents the results that can be achieved even in pathologies that were very difficult to cure until several years ago.

This brand-new book offers a reference guide to understanding and applying the rules for properly conducting clinical trials to meet the international quality standard - Good Clinical Practice - provided by the International Conference on Harmonization (ICH). The work offers an updated perspective on the clinical research landscape within the context of the clinical trial regulatory frameworks in Europe and the USA. In addition to providing a historical review and a detailed definition of GPC regulations, it includes step-by-step explanations of all the requirements that researchers should bear in mind when designing and performing new trials. Further topics covered include: ethics of clinical research; the drug development process and evolution of regulations; investigator and sponsor responsibilities; and clinical trial protocols. Written by clinicians for clinicians, the book represents a valuable read also for researchers, pharmacists and all professionals involved in applications to the ethic committees, whose approval is required for new clinical studies.

This book is intended to provide a quick guide to the field of pediatric retina. It has been long accepted that retinal disorders in children differ from those in adults. Although there are plenty of published books on retinal diseases, most of them only cover adult retinal disorders. Therefore, information on pediatric retinal diseases is urgently needed. The book combines comprehensive information with rich illustrations to offer readers an in-depth understanding of the two main themes: retinopathy of prematurity (ROP) and other pediatric vitreoretinal disorders. World-renowned pediatric retina experts share their insights and research findings in areas such as ROP, familiar exudative vitreoretinopathy, Coats disease, retinoblastoma, congenital x-linked retinoschisis and hereditary retinal diseases. Topics concerning modern and future medicine such as tele-screening for ROP, E-learning for ROP, and deep learning for ROP are also included. Designed to help readers understand the contents as quickly as possible, the book includes many useful tips and pearls, as well as easy-to-follow figures. It covers the majority of pediatric retinal diseases and offers essential information on their diagnosis and management. In addition, relevant and up-to-date references are provided for those who want to explore the topics in more depth. As such, the book offers an excellent reference guide to caring for these young patients.

Medical and psychiatric history -- Physical exam -- Laboratory testing and studies -- Suicide risk assessment -- Agitation -- Anxiety -- Catatonia -- Depression -- Mania -- Psychosis -- Adrenal crisis/adrenal insufficiency -- Chronic pain -- Delirium -- Dementia -- Encephalitis -- Head injury -- Hepatic encephalopathy -- Hypercalcemia -- Hypercortisolism (Cushing's syndrome) -- Hypoglycemia -- Hyponatremia -- Hypothyroidism -- Myxedema coma -- Non-epileptic seizures -- Seizures -- Thyrotoxicosis -- Wernicke-Korsakoff Syndrome -- Acute intoxication : general principles -- Phenethylamines intoxication (amphetamines, methamphetamine, cathinones, and "designer amphetamines") -- Cocaine intoxication -- Ethanol (alcohol) intoxication -- GHB, GBL intoxication -- Inhalant (alkyl nitrates, nitrous oxide, hydrocarbons) intoxication AKA : poppers -- MDMA (Ecstasy, Molly) intoxication -- Opiates, opioids intoxication -- Psychedelic drug (LSD, PCP, hallucinogenic mushrooms) intoxication -- Acute withdrawal : general principles -- Alcohol withdrawal -- Amphetamine withdrawal -- Barbiturate withdrawal -- Benzodiazepine withdrawal -- Cannabis withdrawal -- Cocaine withdrawal -- Opiate/opioid withdrawal -- Antidepressant discontinuation syndrome -- Anti-muscarinic toxicity -- Common medications which may mimic psychiatric symptoms -- Lithium toxicity -- Neuroleptic malignant syndrome -- Salicylate toxicity -- Serotonin syndrome -- Neuropsychiatric complications of steroids -- Valproic acid toxicity.

This book covers essential information necessary in diagnosing and treating pediatric patients in the emergency room. Emergencies require quick and precise decision making that does not allow for extended reading or fact-checking to ensure all factors are considered. This pocket guide addresses that need by placing vital clinical management and algorithms into a quick and simple guidebook that can be accessed within moments from a scrub pocket or white coat. It is an easy, quick access reference that can be used for those facts that are absolutely essential, but are often difficult to remember. Color images and flow charts allow doctors to grasp the essentials quickly, while more detailed explanations are included alongside for trainees. Quick Hits for Pediatric Emergency Medicine uses tips, caveats, drug dosing, and pearls to assist the provider who may not be familiar with all of the unique nuances of the pediatric population. This is ideal for emergency department physicians, nurses, and trainees including students, residents, and fellows.

For important information you need to know, but can't remember, turn to QUICK HITS IN EMERGENCY MEDICINE. This practical, short compendium contains the key decision-rules, clinical values, mnemonics, and dosages that you need at your finger tips in the ED. It covers everything from acute coronary syndrome and ACLS, to electrolyte equations and hyperkalemia, to ventilator settings by disease to Wellen's syndrome. Information on each topic is limited to a single page and presented in easily digested formats such as tables, algorithms, bulleted lists, and clinical illustrations.

This book provides easy to follow guidance on how to manage emergency situations and common problems in obstetric anesthesia. The book provides different anesthetic recipes for obstetric procedures and describes challenges that will be encountered on a day-to-day basis. There are trouble-shooting chapters and what to do lists for frequent dilemmas. The book covers obstetric-specific resuscitation and medical emergencies seen on the labor ward. Antenatal and postpartum complications relating to anesthesia are covered as well as issues that may arise during follow up of patients who have had neuraxial anesthesia during delivery. Quick Hits in Obstetric Anesthesia should be used as a cognitive aid for emergency cases and as a decision-making tool for urgent management plans. It is a guide to common problems and provides core knowledge to facilitate anesthesia care on labor wards for all grades of anesthetist.

Written for pathologists-in-training, this volume provides high-yield, at-a-glance summaries in a format that is easy to use. Rather than focus on organ-based histologic criteria, the text aids pathologic diagnosis, emphasizing immunohistochemistry, tumor syndromes, etc.

Neurologic system -- Cardiovascular system -- Pulmonary system -- Gastrointestinal and urinary systems -- Renal system -- Endocrine system -- Hematologic and immune systems -- Drugs, doses, tables -- Labs -- Imaging -- Miscellaneous.

For immediate, on-the-unit answers to ICU questions, get the must-have pocket guide: the fully updated "Quick Reference to Critical Care, 6th Edition". Covering a broad range of critical care topics, each chapter is divided by body system and alphabetically organized, addressing disease processes, disorders, medications and titration, tests, lab results, formulas, ICU equipment and treatment strategies and goals. Information provided is based on current, evidence-based procedures and stabilization practices. This classic, concise quick reference offers crucial guidance on numerous processes and procedures. -- From publisher's description.

This book focuses on quinoa, providing background information on its history, summarizing recent genetic and genomic advances, and offering directions for future research. Meeting the caloric and nutritional demands of our growing population will not only require increases in overall food production, but also the development of new crops that can be grown sustainably in agricultural environments that are increasingly susceptible to degradation. Quinoa is an ancient crop native to the Andean region of South America that has recently gained international attention because its seeds are high in protein, particularly in essential amino acids. Quinoa is also highly tolerant of abiotic stresses, including drought, frost and salinity. For these reasons, quinoa has the potential to help address issues of food security - a potential that was recognized when the United Nations declared 2013 the International Year of Quinoa. However, more effort is needed to improve quinoa agronomically and to understand the mechanisms of its abiotic stress tolerance; the recent development of genetic and genomic tools, including a reference genome sequence, will now help accelerate research in these areas.

This classic, coauthored by New York Times columnist and pediatrician Dr. Perri Klass, has been fully revised and updated to reflect the recent significant changes in the recognition and care of children whose development doesn't go as expected. It includes new information about therapeutic interventions, managing co-morbidities, and getting support for children with developmental differences at school. Additional information covers community resources, initiatives at hospitals, clinics, and even theme parks, that make life easier for children with developmental differences and their families. The authors also offer a stronger focus on self-care for parents in this new edition, with the pediatrician's perspective of supporting families as they go through the diagnostic process over time.

This book delves into the biotechnological applications of Quorum sensing (QS)- a peculiar gene-regulatory process of some microorganisms. Quorum Sensing allows a large bacterial population to work together in a coordinated manner to carry out metabolic activities, which individual bacterium cannot. The different chapters describe how, associating bioremediation process with energy generation is an economical proposal, for reducing pollution and managing biowastes. The book discusses how QS can be exploited for biotechnological applications in generating bioproducts, bioenergy, bioremediation, biosensors, health and agricultural activities. It further highlights how QS is becoming an integral part of synthetic biology for genetic circuits for producing: (i) novel products, (ii) biosensors, (iii) bioactive molecules, etc. The book is divided into different sections for a clear understanding of the applicability of QS in, the Environment, Energy, Agriculture and Health sectors.