Books

1. Collection and handling of blood 2. Reference ranges and normal values 3. Basic haematological techniques 4. Preparation and staining methods for blood and bone marrow films 5. Blood cell morphology in health and disease 6. Supplementary techniques including blood parasite diagnosis 7. Bone marrow biopsy 8. Molecular and cytogenetic analysis 9. Iron deficiency anaemia and iron overload 10. Investigation of megaloblastic anaemia: cobalamin, folate and metabolite status 11. Laboratory methods used in the investigation of the haemolytic anaemias 12. Investigation of the hereditary haemolytic anaemias: membrane and enzyme abnormalities 13. Acquired haemolytic anaemias 14. Investigation of variant haemoglobins and thalassemias 15. Erythrocyte and leucocyte cytochemistry 16. Immunophenotyping by flow cytometry 17. Diagnostic radioisotopies in haematology 18. Investigation of haemostasis 19. Investigation of a thrombotic tehdency 20. Laboratory control of anticoagulant, thrombolytic and antiplatelet therapy 21. Blood cell antigens and antibodies: erythrocytes, platelets, and neutrophils 22. Laboratory aspects of blood transfusion 23. Approach to the diagnosis and classification of blood cell disorders 24. Laboratory organisation, management and safety 25. Quality assurance 26. Haematology in under-resourced laboratories 27. Appendix

The series “Clinical Approaches and Procedures in Cosmetic Dermatology” intends to be a practical guide in Cosmetic Dermatology. Procedures in cosmetic dermatology are very popular and useful in medicine, indicated to complement topical and oral treatments not only for photodamaged skin but also for other dermatosis such as acne, rosacea, scars, etc. Also, full-face treatments using peelings, lasers, fillers and toxins are increasingly being used, successfully substituting or postponing the need for plastic surgeries. Altogether, these techniques not only provide immediate results but also help patients to sustain long-term benefits, both preventing/treating dermatological diseases and maintaining a healthy and youthful skin. Throughout this series, different treatments in Cosmetic Dermatology will be discussed in detail covering the use of many pharmacological groups of cosmeceuticals, the new advances in nutraceuticals and emerging technologies and procedures. This volume, entitled “Daily Routine in Cosmetic Dermatology” will be an important tool for aesthetic doctors, practicing dermatologists, plastic surgeons, and all other physicians interested in the field of aesthetic medicine. It discloses in detail the semiology and general treatments in cosmetic dermatology, providing the state-of-the-art regarding patients' evaluation, photoprotection, nutraceuticals and cosmeceuticals and special prescriptions. Also check the other volumes: Volume II - Chemical and Physical Peelings Volume III - Lasers, Lights and Other Technologies Volume IV - Botulinum Toxins, Fillers and Related Substances.

"Considered the "bible" of rhinoplasty, this two-volume set presents the work of recognized pioneers in the field who provide comprehensive coverage of primary and secondary rhinoplasty. From basic fundamentals and anatomy to the latest refinements and advances in technique, the book includes comprehensive case analyses to facilitate clinical decision making supplying rhinoplasty surgeons with all the tools needed for achieving superb results. Featuring ten new chapters and numerous color images, this third edition is supplemented with six DVDs containing videos of operative procedures"--Provided by publisher.

This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the "danger/injury model" is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.

This book is a continuance of the topic: "DAMPs in Human Diseases", the basics of which were described in a first volume by the same author. This second volume presents our current understanding of the impact of sterile stress/injury-induced innate immune responses on the etiopathogenesis of human diseases by focusing on those diseases that are pathogenetically dominated by DAMPs, i.e., on polytrauma, various solid organ injuries (brain, lung, kidney, liver), atherosclerosis, and cerebro-cardiovascular diseases. Our growing understanding of the pathogenetic function of activating DAMPs and suppressive DAMPs ("SAMPs") is used as a point of departure to explore how these molecules can be used as biomarkers to extend and improve current diagnostic and prognostic modalities. Moreover, this new knowledge about the pathogenetic function of DAMPs and SAMPs is taken as a sound and plausible reason for discussing their implications for present and future treatment of the diseases addressed here. In this context, the focus is on the potential of DAMPs as future therapeutic targets and SAMPs as future therapeutics, applied in strict compliance with safety precautions, as also recommended in this work. The book is intended for professionals from all medical and paramedical disciplines who are interested in applying innovative data from inflammation and immunity research to clinical practice. The readership will include practitioners and clinicians working in the broad field of acute and chronic inflammatory/fibrotic diseases, in particular, traumatologists and intensivists; neurologists and neurosurgeons; cardiologists and cardiac surgeons; pulmonologists and thoracic surgeons; vascular surgeons; nephrologists; gastroenterologists and hepatologists; and pharmacists. Also available: Damage-Associated Molecular Patterns in Human Diseases - Vol. 1: Injury-Induced Innate Immune Responses.

This book describes current, evidence-based guidelines for damage control interventions across the field of trauma care with the aim of enabling clinicians to apply them to best effect in daily clinical practice. Emphasis is placed on the need for trauma surgeons and their teams to recognize that optimal damage control in severely traumatized patients depends upon the combination of immediate assessment, resuscitation, and correct surgical management. The book opens by examining the evolution of damage control and the very significant impact that military damage control interventions have had on civilian emergency health care through improvements as simple as bandaging and tourniquets. Damage control measures in different specialties, including neurosurgery, orthopedics, vascular surgery, cardiothoracic surgery, anesthesia, and critical care, are then covered in detail. Readers will also find helpful information on a range of other important topics, such as the role of pre-hospital care providers, damage control within the emergency department, adjuncts of damage control, and damage control in austere environments. This book is a 'must read' for all clinicians in the trauma field.

This book provides a comprehensive overview of damage control resuscitation (DCR), an evidence-based approach to the resuscitation of patients with severe life-threatening hemorrhage (LTH). It focuses on both civilian and military applications as DCR is utilized in civilian trauma situations as well as combat casualty care settings. The book covers the history of fluid resuscitation for bleeding, epidemiology of severe traumatic injuries, prediction of life-threatening hemorrhage, pathophysiology and diagnosis of blood failure, and permissive hypotension. Chapters provide in-depth detail on hemostatic resuscitation principles, dried plasma, dried platelet surrogates, and recent developments in frozen red blood cells and oxygen carriers. The book also discusses how DCR principles can be used in a variety of situations such as when there are large numbers of patients with hemorrhagic lesions, non-trauma scenarios, and on distinct populations such as children. Finally, it concludes with a discussion of training and education methods for the implementation of DCR and remote DCR principles as well as learning healthcare system principles to facilitate the implementation of DCR and ultimately improve outcomes for patients with life-threatening hemorrhage. Damage Control Resuscitation: Identification and Treatment of Life-Threatening Hemorrhage is an essential resource for physicians and related professionals, residents, nurses and medical students in emergency medicine, anesthesia, surgery, and critical care, as well as civilian and military EMS providers.

Historical perspectives on the art and science of blood culture -- Conventional blood culture methods -- Lysis-centrifugation methods of blood culture -- Bactec blood culture systems -- The bioMerieux BacT/alert: automation at last in the black box -- TREK blood culture systems -- Molecular methods for detection of pathogens directly from blood specimens -- Pediatric blood cultures -- Epidemiology of bloodstream infections -- Best practices in blood cultures -- Processing positive cultures -- Fungal and mycobacterial blood cultures -- The bacterial blood microbiota/microbiome -- Postmortem blood culture.

Data is revolutionizing the healthcare industry. With more data available than ever before, and applying the right analytics you can spur growth. Benefits extend to patients, providers, and board members, and the technology can make centralized patient management a reality. Despite the potential for growth, many in the industry and government are questioning the value of data in health care, wondering if it's worth the investment. This book tackles the issue and proves why BI is not only worth it, but necessary for industry advancement. Madsen challenges the notion that data has little value in healthcare, and shows how BI can ease regulatory reporting pressures and streamline the entire system as it evolves. She illustrates how a data-driven organization is created, and how it can transform the industry. -- Edited summary from book.

Focusing on the interpretation of data commonly available to anesthesiologists, this book presents a data point, followed by discussion in a question and answer format. Covering EKG's, X-Rays, MRI's, graphs, paper recordings, blood gas results, laboratory results, patient case histories and more, Data Interpretation in Anesthesia provides an enhanced and stimulating learning format for residents in training and practitioners alike.

Reproducibility and robustness -- Choosing a research problem -- Basics of data and data distribution -- Experimental design: measures, validity, sampling, bias, randomization, power -- Experimental design: design strategies and controls -- Power estimation -- The data cleansing and analysis pipeline -- Topics to consider when analyzing data -- Null hypothesis statistical testing and the t-Test -- The "new statistics" and Bayesian inference -- ANOVA -- Non parametric tests -- Correlation and other concepts you should know -- How to record and report your experiments -- Data sharing and reuse -- The revolution in scientific publishing.

Dense module enumeration in biological networks / Koji Tsuda and Elisabeth Georgii -- Discovering interacting domains and motifs in protein-protein interactions / Willy Hugo, Wing-Kin Sung, and See-Kiong Ng -- Global alignment of protein-protein interaction networks / Misael Mongiovì and Roded Sharan -- Structure learning for Bayesian networks as models of biological networks / Antti Larjo, Ilya Shmulevich, and Harri Lähdesmäki -- Supervised inference of gene regulatory networks from positive and unlabeled examples / Fantine Mordelet and Jean-Philippe Vert -- Mining regulatory network connections by ranking transcription factor target genes using time series expression data / Antti Honkela, Magnus Rattray, and Neil D. Lawrence -- Identifying pathways of coordinated gene expression / Timothy Hancock, Ichigaku Takigawa, and Hiroshi Mamitsuka -- Mining frequent subtrees in glycan data using the rings glycan miner tool / Kiyoko Flora Aoki-Kinoshita -- Chemogenomic approaches to infer drug-target interaction networks / Yoshihiro Yamanishi -- Localization prediction and structure-based in silico analysis of bacterial proteins : with emphasis on outer membrane proteins / Kenichiro Imai, Sikander Hayat, Noriyuki Sakiyama, Naoya Fujita, Kentaro Tomii, Arne Elofsson, and Paul Horton -- Analysis strategy of protein-protein interaction networks / Zhenjun Hu -- Data mining in the MetaCyc family of pathway databases / Peter D. Karp, Suzanne Paley, and Tomer Altman -- Gene set/pathway enrichment analysis / Jui-Hung Hung -- Construction of functional linkage gene networks by data integration / Bolan Linghu, Eric A. Franzosa, and Yu Xia -- Genome-wide association studies / Tun-Hsiang Yang, Mark Kon, and Charles DeLisi -- Viral genome analysis and knowledge management / Carla Kuiken, Hyejin Yoon, Werner Abfalterer, Brian Gaschen, Chienchi Lo, and Bette Korber -- Molecular network analysis of diseases and drugs in KEGG / Minoru Kanehisa.

Actigraphy pattern analysis for outpatient monitoring / Elies Fuster-Garcia ... [et al.] -- Definition of loss functions for learning from imbalanced data to minimize evaluation metrics / Juan Miguel Garcia-Gómez and Salvador Tortajada -- Audit method suited for DSS in clinical environment / Javier Vicente -- Incremental logistic regression for customizing automatic diagnostic models / Salvador Tortajada, Montserrat Robles, and Juan Miguel Garcia-Gómez -- Using process mining for automatic support of clinical pathways design / Carlos Fernandez-Llatas ... [et al.] -- Analyzing complex patients' temporal histories : new frontiers in temporal data mining / Lucia Sacchi, Arianna Dagliati, and Riccardo Bellazzi -- Snow system : a decentralized medical data processing system / Johan Gustav Bellika, Torje Starbo Henriksen, and Kassaye Yitbarek Yigzaw -- Data mining for pulsing the emotion on the web / Jose Enrique Borras- Morell -- Introduction on health recommender systems / C. L. Sanchez-Bocanegra, F. Sanchez-Laguna, and J. L. Sevillano -- Cloud computing for context-aware enhanced m-health services / Carlos Fernandez-Llatas ... [et al.] -- Analysis of speech-based measures for detecting and monitoring alzheimer's disease / A. Khodabakhsh and C. Demiroglu -- Applying data mining for the analysis of breast cancer data / Der-Ming Liou and Wei-Pin Chang -- Mining data when technology is applied to support patients and professional on the control of chronic diseases : the experience of the METABO platform for diabetes management / Giuseppe Fico ... [et al.] -- Data analysis in cardiac arrhythmias / Miguel Rodrigo ... [et al.] -- Knowledge-based personal health system to empower outpatients of diabetes mellitus by means of P4 medicine / Adrián Bresó ... [et al.] -- Serious games for elderly continuous monitoring / Lenin-G. Lemus-Zúñiga ... [et al.].

Part one. Data sources -- part two. Analysis and enrichment -- part three. Applications to polypharmacology -- part four. system biology approaches.

I. R and data mining -- II. Case studies.

1. R -- 2. R data, part 1: vectors -- 3. R data, part 2: more complicated structures -- 4. R data, part 3: text and factors -- 5. Writing functions and scripts -- 6. Getting data into and out of R -- 7. Data handling in practice -- 8. Extended exercise -- A. Hints and pseudocode -- Bibliography -- Index.

What if you sliced data and found a huge problem or opportunity? Data did its job, but now it needs a storyteller. The way insights are communicated could reverse or increase the trajectory of data. The actions you ask others to take today can change your future data. But getting others to move forward with those actions only happens when someone communicates well. Learn effective ways to turn your data into narratives that blend the power of language, numbers, and graphics. This book is not about visualizing data, there are plenty of books covering that. Instead, you'll learn how to transform numbers into narratives to drive action, and help communicate data in a way that creates outcomes both inside and outside your own organization.

This book allows readers to gain an in-depth understanding of the role of real-world data in pharmacoepidemiology, and highlights the strengths and limitations of the respective databases with regard to pharmacoepidemiological research. Over the past decade, the increasing use of real-world data in pharmacoepidemiological research has been accompanied by a growing recognition of the value of real-world evidence in clinical and regulatory decision-making. Electronic healthcare databases allow analyses of drug and vaccine utilization in routine care after approval, as well as investigations of their comparative effectiveness and safety. They are especially useful for the identification of rare risks and rare drug exposures over long periods of time, and as such sustainably extend the basis for drug safety research. This book provides an introduction to the role of real-world data in pharmacoepidemiological research and the main developments in the last 15 years. It also offers a comprehensive overview of the general classification characteristics of databases, together with their strengths and limitations, and a detailed description of 21 individual databases, written by professionals who work with or maintain them.

Fundamentals of medicine. Clinical decision making -- Clinical therapeutics and good prescribing -- Clinical genetics -- Clinical immunology -- Population health and epidemiology -- Principles of infectious disease -- Emergency and critical care medicine. Poisoning -- Envenomation -- Environmental medicine -- Acute medicine and critical illness -- Clinical medicine. Infectious diseases -- HIV infection and AIDS -- Sexually transmitted infections -- Clinical biochemistry and metabolic medicine -- Nephrology and urology -- Cardiology -- Respiratory medicine -- Endocrinology -- Nutritional factors in disease -- Diabetes mellitus -- Gastroenterology -- Hepatology -- Haematology and transfusion medicine -- Rheumatology and bone disease -- Neurology -- Stroke medicine -- Medical ophthalmology -- Medical psychiatry -- Dermatology -- Maternal medicine -- Adolescent and transition medicine -- Ageing and disease -- Oncology -- Pain and palliative care -- Laboratory reference ranges.

1. Clinical decision-making / N Cooper and AL Cracknell -- 2. Clinical therapeutics and good prescribing / SRJ Maxwell -- 3. Clinical genetics / K Tatton-Brown -- 4. Clinical immunology / SL Johnston -- 5. Population health and epidemiology / H Campbell and DA McAllister -- 6. Principles of infectious disease / JAT Sandoe and DH Dockrell -- 7. Oncology / S Clive and M Stares -- 8. Pain and palliative care / LA Colvin and M Fallon -- 9. Acute medicine and critical illness / VR Tallentire and MJ MacMahon -- 10. Poisoning / SHL Thomas -- 11. Envenomation / J White -- 12. Medicine in austere environments / AC Baker -- 13. Infectious disease / DH Dockrell, S Sundar and BJ Angus -- 14. HIV infection and AIDS / G Maartens -- 15. Sexually transmitted infections / DJ Clutterbuck -- 16. Cardiology / DE Newby and NR Grubb -- 17. Respiratory medicine / IJ Clifton and DAB Ellames -- 18. Nephrology and urology / B Conway, PJ Phelan and GD Stewart -- 19. Clinical biochemistry and metabolic medicine / A Mather, DR Sullivan and E Miller-Hodges -- 20. Endocrinology / JDC Newell-Price and FW Gibb -- 21. Diabetes mellitus / JR Petrie and JG Boyle -- 22. Nutritional factors in disease / AG ShandShand and MEJ Lean -- 23. Gastroenterology / A Rej, TS Chew and DS Sanders -- 24. Hepatology / MJ Williams and TT Gordon-Walker -- 25. Haematology and transfusion medicine / HG Watson, DJ Culligan and LM Manson -- 26. Rheumatology and bone disease / GPR Clunie and SH Ralston -- 27. Dermatology / SH Ibbotson -- 28. Neurology / DPJ Hunt and MD Connor -- 29. Stroke medicine / W Whiteley and R Woodfield -- 30. Medical ophthalmology / JA Olson -- 31. Medical psychiatry / RM Steel and SM Lawrie -- 32. Maternal medicine / L Mackillop and FEM Neuberger -- 33. Adolescent and transition medicine / RJ Mann -- 34. Ageing and disease / TJ Quinn -- 35. Laboratory reference ranges / SJ Jenks.

Davis's Drug Guide for Nurses®, Sixteenth Edition delivers all of the information you need to administer medications safely across the lifespan -- well-organized monographs for hundreds of generic and thousands of trade-name drugs. -- Provided by publisher.

"Davis's Drug Guide for Nurses provides comprehensive, up-to-date drug information in well-organized, nursing-focused monographs. It also includes extensive supplemental material in 16 appendices, thoroughly addresses the issue of safe medication administration, and educates the reader about 50 different therapeutic classes of drugs. In this 17th edition, we have continued the tradition of focusing on safe medication administration by including Medication Safety Tools and even more information about health care's most vulnerable patients: children, the elderly, pregnant women, and breast feeding mothers. Look for more Pedi, Geri, OB, and Lactation headings throughout the monographs"-- Provided by publisher.

This powerful history describes the daily progression of the Ebola outbreak that swept across West Africa and struck Europe and America from December 2013 to June 2016. A case study on a massive scale, it follows the narratives of numerous patients as well as the journey of physicians and scientists from discovery to action and from tracking to containment. The unfolding story reveals ever-shifting complexities such as the varied paths the infection took from country to country, the multiple responses of community members, and the occurrence of flare-ups when the outbreak was seemingly over. The book's finely-documented present-tense reporting records key facts, events, and observations, including: Routes of Ebola transmission, incubation, symptoms, short- and long-term effects on survivors Early attempts to understand and contain the virus and curb practices contributing to its spread Medical, governmental, and public responses, from local education programs to global efforts Communication and conflict between healthcare workers and communities Social and economic outcomes of Ebola in the affected nations Ebola remains incurable, although a vaccine is now available. For members of the medical community, public health officials, medical historians, scholarly professionals, and interested laypeople, A Day-by-Day Chronicle of the 2013-2016 Ebola Outbreak makes starkly clear what we can learn from these events not only for future outbreaks of Ebola, but also for the emergence of as-yet unknown diseases.

"From Marsha M. Linehan--the developer of dialectical behavior therapy (DBT)--this comprehensive resource provides vital tools for implementing DBT skills training. The teaching notes and reproducible handouts and worksheets used for over two decades by hundreds of thousands of practitioners have been significantly revised and expanded to reflect important research and clinical advances. The book gives complete instructions for orienting individuals with a wide range of problems to DBT and teaching them mindfulness, interpersonal effectiveness, emotion regulation, and distress tolerance skills. Handouts and worksheets are not included in the book; purchasers get access to a Web page where they can download and print all the handouts and worksheets discussed in a convenient 8 1/2" x 11" size"--Provided by publisher.

"This book is a comprehensive guidebook of therapeutic de-escalation techniques for nurses and other healthcare professionals to improve safety in healthcare facilities. Readers will explore the concepts of aggression (including risk factors), de-escalation, and therapeutic communication. They will also learn how to perform mental status assessments, manage and even prevent aggressive behavior, and practice conflict resolution, and--when faced with individuals with depressive disorders, suicidal ideation, and/or self-injurious behavior (SIB)--engage in crisis intervention. Specific therapeutic interventions for difficult behavioral issues associated with schizophrenia, dementia, bipolar disorder, cognitive impairment, anxiety and panic disorders are also covered, as are stress-management techniques to help patients cope, tips for creating a caring and healing environment to stop violence before it starts, and a framework for building a healthcare violence prevention program. Nursing students and healthcare professionals of all educational levels will find this book to be immensely valuable. De-escalation is one of the most valuable skills a healthcare worker can possess. Indeed, all healthcare workers need this vital skill to help ensure their safety in the healthcare environment. It's not uncommon for healthcare professionals to encounter an agitated or aggressive person. How that healthcare worker responds will dictate whether the situation is defused or escalated--perhaps even resulting in physical violence. The goal of this book is to ensure the result is the former--to prevent healthcare violence, and to foster a safe healthcare workplace that benefits all and promotes peace and safety for everyone"-- Provided by publisher.

De-whitening intersectionality: race, intercultural communication, and politics reevaluates how the logic of color-blindness as whiteness evolves amidst current race and intercultural communication research, underscoring that, in order to play well with intersectionality, research scholars must be attentive to its origins and implications.

"From James McBride, author of the National Book Award-winning The Good Lord Bird, comes a wise and witty novel about what happens to the witnesses of a shooting. In September 1969, a fumbling, cranky old church deacon known as Sportcoat shuffles into the courtyard of the Cause Houses housing project in south Brooklyn, pulls a .45 from his pocket, and in front of everybody shoots the project's drug dealer at point-blank range. The reasons for this desperate burst of violence and the consequences that spring from it lie at the heart of Deacon King Kong, James McBride's funny, moving novel and his first since his National Book Award-winning The Good Lord Bird. In Deacon King Kong, McBride brings to vivid life the people affected by the shooting: the victim, the African-American and Latinx residents who witnessed it, the white neighbors, the local cops assigned to investigate, the members of the Five Ends Baptist Church where Sportcoat was deacon, the neighborhood's Italian mobsters, and Sportcoat himself. As the story deepens, it becomes clear that the lives of the characters--caught in the tumultuous swirl of 1960s New York--overlap in unexpected ways. When the truth does emerge, McBride shows us that not all secrets are meant to be hidden, that the best way to grow is to face change without fear, and that the seeds of love lie in hope and compassion. Bringing to these pages both his masterly storytelling skills and his abiding faith in humanity, James McBride has written a novel every bit as involving as The Good Lord Bird and as emotionally honest as The Color of Water. Told with insight and wit, Deacon King Kong demonstrates that love and faith live in all of us"-- Provided by publisher.

Despite advances in health care, infectious microbes continue to be a formidable adversary to scientists and doctors. Vaccines and antibiotics, the mainstays of modern medicine, have not been able to conquer infectious microbes because of their amazing ability to adapt, evolve, and spread to new places. Terrorism aside, one of the greatest dangers from infectious disease we face today is from a massive outbreak of drug-resistant microbes. Deadly Outbreaks recounts the scientific adventures of a special group of intrepid individuals who investigate these outbreaks around the world and figure out how to stop them. Part homicide detective, part physician, these medical investigators must view the problem from every angle, exhausting every possible source of contamination. Any data gathered in the field must be stripped of human sorrows and carefully analyzed into hard statistics. -- Jacket.

This book guides healthcare professionals, hospital administrators, and medical interpreters in the United States (and internationally) in ways to better communicate with Deaf and Hard of Hearing (D/HH) patients and sign language interpreters in healthcare settings. It also provides an overview of the healthcare communication issues with healthcare professionals and D/HH patients, and the advantages and disadvantages of using in-person interpreters vs. video remote interpreting (VRI).

Deafness explores the neuronal consequences of being deaf on the peripheral and the central nervous system as well as on cognition and learning, viewed from the standpoint of genetics, neuroanatomy and neurophysiology, molecular biology, systems neuroscience, and cognitive neuroscience.

This thought-provoking volume defines child abuse and neglect as a public health crisis, both in terms of injuries and mental health problems and as a link to poverty and other negative social outcomes. The author identifies key factors contributing to this situation—in particular juvenile ageism, the pervasive othering of children and youth—coupled with the assumption of parental competence until severe abuse or neglect proves otherwise. The book’s practical answers to these complex issues involve recognizing and balancing the rights of parents and children, and responding to the diverse needs of new, competent, and dysfunctional families. To this end, a comprehensive prevention model is outlined, featuring primary, secondary, and tertiary interventions.

"Justyce McAllister is a good kid, an honor student, and always there to help a friend--but none of that matters to the police officer who just put him in handcuffs. Despite leaving his rough neighborhood behind, he can't escape the scorn of his former peers or the ridicule of his new classmates. Justyce looks to the teachings of Dr. Martin Luther King Jr. for answers. But do they hold up anymore? He starts a journal to Dr. King to find out. Then comes the day Justyce goes driving with his best friend, Manny, windows rolled down, music turned up--way up, sparking the fury of a white off-duty cop beside them. Words fly. Shots are fired. Justyce and Manny are caught in the crosshairs. In the media fallout, it's Justyce who is under attack."--Amazon.com.

This book presents principal controversies over the determination of death by neurologic criteria ("brain death"). The editors and authors are exceedingly well-versed in this subject and are on the forefront of the current debates. The content is divided in the following disciplinary: philosophical (conceptual), medical, scientific, legal, religious, and ethical/social. Many of the topics feature pro-con debates, allowing readers to consider the merits of the arguments and decide their own position. The work is targeted to clinicians and nurses who treat critically ill and dying patients, organ donation personnel, ethicists and philosophers who write on end-of-life issues, and lawyers and legislative/public policy professionals who draft laws on death determination. It identifies and debates the essential controversies currently raging in academic and public policy circles over the medical adequacy, scientific validity, and conceptual coherence of death determination by neurologic criteria. Whether a professional or a student, the reader will be given a comprehensive course in the most pressing controversies and areas of consensus in the determination of death by neurologic criteria.

This book examines the mechanisms and functions of tonic immobility, the so-called death feigning behavior, or thanatosis, or animal hypnosis. The chapters cover the neurophysiological and experimental studies on insects, the functional significance of death-feigning, examination of the freezing and immobility behavior in insects through environment, physiology, genetics, and responses to ultrasound and vibration. It also covers tonic immobility and freezing behavior in fish from the perspective of vertebrates study. Tonic immobility is an interesting behavior that occurs reflexively in various animals under physical restraint by predators. The physiological mechanism of thanatosis was extensively investigated during 1960-1980. Researchers have proposed hypotheses to explain the mechanism underlying tonic immobility in vertebrates; local inhibition of the central nervous system, acceleration of the limbic system, abnormal control of the autonomic nervous system. On the other hand, the peripheral and central mechanisms of tonic immobility were intensely investigated at a behavioral and a neuronal level in stick insects and crickets. In the 1970s, behavioral ecology has shed light on the aspect of an ultimate factor for tonic immobility. Ethologists and ecologists challenged this matter in the laboratory and natural habitats, and have collected evidence for its functional roles using mainly insects such as beetles, moths, locusts. More recently, studies of tonic immobility in humans are drawing attention, as clinicians are trying to explain the defencelessness of rape victims from the viewpoint of animal hypnosis. This timely publication provides an understanding of the past and present research of the mechanisms and functions of tonic immobility. This book is intended for researchers and undergraduate/ graduate students in the field of zoology including physiology, ethology, ecology, and human behavior. It will also appeal to the public audience who has an interest in animal behavior, including human behavior.

"In Death Interrupted, ICU doctor Blair Bigham shares his first-hand experiences of how medicine has complicated the way we die and offers a road map for dying in the modern era. Doctors today can call on previously unimaginable technologies to help keep our bodies alive. In this new era, most organs can be kept from dying almost indefinitely by machines. But this unprecedented shift in end-of-life care has created a major crisis. In the widening grey zone between life and death, doctors fight with doctors, families feel pressured to make tough decisions about their loved ones, and lawyers are left to argue life-and-death cases in the courts. Meanwhile, intensive care patients are caught in purgatory, attached to machines and unable to speak for themselves. In Death Interrupted, Dr. Blair Bigham seeks to help readers understand the options facing them at the end of their lives. Through conversations with end-of-life professionals--including ethicists, social workers, and nurses and doctors who practise palliative care--and observations from his own time working in ambulances, emergency rooms, and the ICU, Bigham exposes the tensions inherent in this new era of dying and answers the tough questions facing us all. Because now, for the first time in human history, we may be able to choose how our own story ends."-- Provided by publisher.

"The true story of the war on cancer from one of its generals In The Death of Cancer, Dr. Vincent T. DeVita Jr.--former director of the National Cancer Institute, former physician-in-chief at Memorial Sloan Kettering, director of the Yale Cancer Center, former president of the American Cancer Society, and developer of the first successful chemotherapy treatment for Hodgkin's lymphoma, which first demonstrated that advanced cancers of a major organ system in adults could be cured by chemotherapy--provides a personal history of one of the greatest science stories of our time, covering our fight against cancer from a man who's seen it all. But this is more than a history; it's also a work of advocacy. Despite declining mortality rates, DeVita argues, America's cancer patients are being shortchanged by timid doctors, misguided national agendas, and compromised bureaucracies. He gives readers an eye-opening look at the strengths and weaknesses of America's most prestigious cancer centers, showing how patients can use this information to their advantage. Though we're rapidly approaching total victory over cancer, he contends, we need to do more to synthesize our progress and help doctors put it into practice. This is an ambitious book about a life-or-death subject, a vital entry into the cancer literature genre. With historical depth and authenticity, DeVita brings important information to readers about what cancer is, how best to fight it, and what we still have to learn"-- Provided by publisher.

1. A pragmatic method -- 2. A pragmatic framework of values and principles: the beginning -- 3. Defining and valuing properties and individuals -- 4. What harm does death do to the decedent? -- 5. How should we feel about our own death? -- 6. How should we feel about another's death? -- 7. Is there a duty to die? -- 8. A duty to suicide -- Index.

This is the first book entirely dedicated to exploring issues associated with the nature of neuroethics. It reflects on some of the underlying assumptions in neuroethics, and the implications of those assumptions with respect to training and education programs, research activities, policy engagement, public discourse, teaching, ethics consultation and mentoring, to name but a few areas of interest. Internationally respected and emerging leaders in the area have taken up the pen to express and debate their views about the development, focus and future of neuroethics. They share their analyses and make recommendations regarding how neuroscience could more effectively explore and tackle its philosophical, ethical, and societal implications.

This contributed volume is the first of a series that introduces safe, feasible, and practical decellularization and recellularization techniques for tissue and organ reconstruction. We have put special emphasis on the research areas most likely to develop well-engineered scaffolds for tissue and organ engineering, while presenting easily applicable bench-to-bedside approaches highlighting the latest technical innovations in the field. This book includes both a fundamental discussion for a broad understanding of the basis of tissue repair and substitution, as well as chapters written by world renowned specialists from 20 countries providing deeper discussions and analysis of related sub disciplines. Within these pages, the reader will find state-of-the-art protocols and current clinical challenges in cell and tissue biology, including accurate and comprehensive information on extracellular matrices, natural biomaterials, tissue dynamics, morphogenesis, stem cells, cellular fate progressions, cell and tissue properties for in-vitro and in-vivo applications. This comprehensive and carefully organized treatise provides a clear framework for graduate students and postdoctoral researchers new to the field, but also for researchers and practitioners looking to expand their knowledge on tissue and organ reconstruction.

Current economic, demographic, and environmental shifts are presenting major challenges to health care systems around the world. In response, decentralization--the transfer of control from central to local authorities--is emerging as a successful means of meeting these challenges and reducing inequities of care. But as with health care itself, one size does not fit all, and care systems must be responsive to global reality as well as local demand. Decentralizing Health Services explores a variety of applications of decentralization to health care delivery in both the developing and developed worlds. Outfitted with principles, blueprints, and examples, this ambitious text clearly sets out the potential role of decentralized care as a major player in public health. Its models of service delivery illustrate care that is effective, inclusive, flexible, and in tune with the current era of preventive and evidence-based healthcare. Contributors point out opportunities, caveats, and controversies as they: Clarify the relationships among decentralization, politics, and policy Differentiate between political, fiscal, and administrative decentralization in health care systems. Consider public/private partnerships in health systems. Explain how the effects of decentralization can be evaluated. Present the newest data on the health outcomes of decentralization. Explore some challenges and global issues of health systems in the 21st century. And each chapter features learning goals, discussion questions, activities, and recommendations for further reading. Heralding changes poised to revolutionize care, Decentralizing Health Services will broaden the horizons of researchers and administrators in health services, health economics, and health policy.

This book adopts a novel approach: procedures: instead of discussing the diagnostic categories of neurological syndromes, it focuses on the symptoms of common neurological presentations (especially in the emergency room or on the ward), and the diagnostic hypotheses that can be validated or rejected case by case as a result. Each chapter covers one of the main symptoms of emergencies in neurology from transient consciousness disturbances to focal deficits, acute muscular disorders, respiratory insufficiency in neurological disorders, headaches, delirium, seizures and epileptic status, para-and tetraplegia, and head trauma, to acute functional disorders and includes tables and figures to allow readers to gain a quick and easy, yet comprehensive overview of the topic. The book guides readers through various scenarios generated by the onset of symptoms, the clinical tools for differential diagnostics, and the principles of acute and post-acute phase therapy, managed by decision algorithms supported by the most recent scientific evidence. The resulting precedural profile created through the collaboration of over 80 specialists in neurology or other disciplines makes this text a valuable tool for neurologists, neurology residents and allied professionals in their daily clinical practice, as well as medical students.

This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields.This volume explores interdisciplinary research on decision making taking a neural and behavioural approach *Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research *Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered *All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist.

In the past decade there has been a worldwide evolution in evidence-based medicine that focuses on real-world Comparative Effectiveness Research (CER) to compare the effects of one medical treatment versus another in real world settings. While most of this burgeoning literature has focused on research findings, data and methods, Howard Birnbaum and Paul Greenberg (both of Analysis Group) have edited a book that provides a practical guide to decision making using the results of analysis and interpretation of CER. Decision Making in a World of Comparative Effectiveness contains chapters by senior industry executives, key opinion leaders, accomplished researchers, and leading attorneys involved in resolving disputes in the life sciences industry. The book is aimed at 'users' and 'decision makers' involved in the life sciences industry rather than those doing the actual research. This book appeals to those who commission CER within the life sciences industry (pharmaceutical, biologic, and device manufactures), government (both public and private payers), as well as decision makers of all levels, both in the US and globally.

"Written by neurologists for neurologists, Decision-Making in Adult Neurology provides practical guidance when encountering patients whose clinical presentation is unfamiliar or complex, or whose treatment path is not completely certain. This useful handbook is filled with diagnostic and treatment algorithms that encourage you to think systematically and follow a logical sequence through the steps necessary for efficient and effective decision-making"--Publisher's description.

Section 1 Introduction Emergency Critical Care -- Robert Rodriguez Section 2 Hemodynamic Monitoring Tissue Oxygenation and Cardiac Output -- Catherine S. Reid, Geoffrey K. Lighthall Non-Invasive Hemodynamic Monitoring -- Chad Myers Arterial Blood Pressure Monitoring -- Vidya Rao, John E. Arbo The Central Venous and Pulmonary Artery Catheter -- Carlos Brun, Geoffrey K. Lighthall Section 3 Critical Care Ultrasonography Principles of Critical Care Ultrasonography -- Philips Perera, Laleh Gharahbaghian, Thomas Mailhot, Sarah Williams, Diku P. Mandavia Pulmonary Ultrasonography -- Feras Khan, Anne-Sophie Beraud Section 4 Pulmonary Critical Care Respiratory Failure and Mechanical Ventilation -- John-Emile Kenny, Stephan J. Ruoss Ventilation Strategies in COPD, Asthma, and Pulmonary Arterial Hypertension -- Jey Chung, Paul Mohabir, Stephen J.-

The book covers various scenarios when errors, biases and systemic barriers prevail in emergency medicine, discusses their impact, and then offers solutions to mitigate their undesired outcomes. The process of clinical reasoning in emergency medicine is a complex exercise in cognition, judgment and problem-solving that is prone to mistakes. The book presents various cases written by a team of emergency specialists and trainees in an engaging format that is helpful for the practicing and teaching emergency doctor and trainees. The book discusses 51 different types of biases and errors with clinical cases, and knowledge of strategies to mitigate them concept known as cognitive debiasing that has the potential to reduce diagnostic error, and therefore, morbidity and mortality. It aims to help the readers during assessment of patients in the emergency department. Each chapter includes 4 cases illustrating the bias, error or barrier discussed, followed by a potential solution. This book helps in polishing the thinking and behavior of the readers so to potentially enhance their clinical competence in emergency department.

Section I: Introduction to perioperative patient care. Role of the perioperative medical consultant -- Preoperative testing -- Anesthesia for nonanesthesiologists -- Perioperative medication management -- Perioperative management of anticoagulants -- Section II: Prophylaxis. Prevention of venous thromboembolism -- Prevention of surgical site infections -- Prevention of infective endocarditis -- Section III: Preoperative evaluation and perioperative management: co-existing diseases and special populations. Cardiac risk calculators -- Ischemic heart disease -- Congestive heart failure -- Valvular heart disease -- Arrhythmias, conduction system disorders, and cardiovascular implant electronic devices -- Hypertension -- Pulmonary disease -- Sleep apnea and airway management -- Pulmonary hypertension -- Diabetes mellitus -- Thyroid disease -- Adrenal disease (including pheochromocytoma) -- Anemia and transfusion medicine -- Coagulation disorders -- Human immunodeficiency virus (HIV) -- Chronic kidney disease -- Liver disease -- Cerebrovascular disease -- Seizure disorder, parkinson's disease, and myasthenia gravis -- Rheumatoid arthritis, lupus, and other systemic autoimmune diseases -- The obese patient -- The cancer patient -- Surgery and the older adult -- Enhanced recovery programs -- Substance use disorder -- Section IV: Common postoperative problems. Fever -- Hypertension and hypotension -- Myocardial injury after noncardiac surgery (MINS) -- Atrial fibrillation -- Pneumonia and respiratory failure -- Deep venous thrombosis and pulmonary embolism -- Acute kidney injury -- Delirium -- Pain management.

"Decision Making in Spinal Care, 2nd Edition presents current management strategies for the most common spine problems, including trauma injuries, metabolic and degenerative diseases, and spinal deformities. Each chapter opens with a concise introduction to the topic and discussion of the classification of the injury, condition, or management approach. The authors then describe the diagnostic workup of the patient, the treatment options available, the likely outcome, and possible complications. Chapters also include useful decision making algorithms"--Provided by publisher.

This guide brings thought leaders and master clinicians together to share their wisdom and expertise regarding clinical decisions surrounding unilateral and bilateral vocal fold paralysis. Designed as a what- to-do and why as opposed to a how-to guide, the authors detail the reasoning process from work up, through intervention, to post-treatment decision making. The text is organized around decision points in the management of vocal fold paralysis such as decisions in regard to timing, intervention, implants, reinnervation, drugs, voice therapy, and post-operative care. Individual chapters focus on specific steps in the process of evaluation and treatment, explore the decisions that can and should be made, and provide answers and direction for the reader. Authors explain the issues around the decision point and use their considerable experience to offer their opinion and as well as the thought process behind it. Decision Making in Vocal Fold Paralysis will be a useful guide for practitioners that deal with vocal fold paralysis, including otolaryngologists, general surgeons, neurologists, speech language pathologists, primary care physicians, and oncologists.

This open access book provides a theoretical framework and case studies on decision science for regional sustainability by integrating the natural and social sciences. The cases discussed include solution-oriented transdisciplinary studies on the environment, disasters, health, governance and human cooperation. Based on these case studies and comprehensive reviews of relevant works, including lessons learned from past failures for predictable surprises and successes in adaptive co-management, the book provides the reader with new perspectives on how we can co-design collaborative projects with various conflicts of interest and how we can transform our society for a sustainable future. The book makes a valuable contribution to the global research initiative Future Earth, promoting transdisciplinary studies to bridge the gap between science and society in knowledge generation processes and supporting efforts to achieve the UN's Sustainable Development Goals (SDGs). Compared to other publications on transdisciplinary studies, this book is unique in that evolutionary biology is used as an integrator for various areas related to human decision-making, and approaches social changes as processes of adaptive learning and evolution. Given its scope, the book is highly recommended to all readers seeking an integrated overview of human decision-making in the context of social transformation.

The book examines an integrated approach for addressing decisions about the location of healthcare facilities. Supported by Geographic Information Systems (GIS) and Multi-Criteria Decision Analysis (MCDA), the approach provides comprehensive information on territory, taking into account the spatial dimensions. Due to the multiple criteria involved, site selection for urban facilities is a crucial topic in planning decision processes, especially for healthcare facilities. Healthcare provision policies generally fail to address the distribution of facilities within cities, entrusting decisions to various stakeholders. Moreover current evaluation tools focus on the intrinsic performances of healthcare structures, disregarding the extrinsic characteristics, namely those related to the location. Starting with a cross-disciplinary literature review, the book describes a multi-methodological approach for decision-making regarding the location of healthcare facilities, and presents an innovative evaluation tool that simultaneously considers functional, locational, environmental and economic issues, providing a comprehensive overview of the areas under investigation.

A look at the recent oncology literature or a search of one of the common databases reveals a steadily increasing number of nomograms and other prognostic models, some of which are also available in the form of web-based tools. These models may predict the risk of relapse, lymphatic spread of a given malignancy, toxicity, survival, et cetera Pathology information, gene signatures, and clinical data may all be used to compute the models. This trend reflects increasingly individualized treatment concepts and also the need for approaches that achieve a favorable balance between effectiveness and side-effects. Moreover, optimal resource utilization requires prognostic knowledge, for example to avoid lengthy and aggressive treatment courses in patients with a short survival expectation. In order to avoid misuse, it is important to understand the limits and caveats of prognostic and predictive models. This book provides a comprehensive overview of such decision tools for radiation oncology, stratified by disease site, which will enable readers to make informed choices in daily clinical practice and to critically follow the future development of new tools in the field.

Instead of following the Magna Charta Universitatum, the declaration of the principles of knowledge signed in 1988 in Bologna, the academic approach pursued in Europe and the other continents over the past 30 years has strictly employed a utilitarian model of higher education. This jeopardizes academic freedom, shared governance and tenure, the three pillars of the long-established model of universities. Scientific conformism and fragmentation, educational bias and authoritarianism are the major drawbacks, together with a poor readiness to meet the emerging challenges in the labor market and technology. In this book, Renzo Rosso presents a new model for countering these developments, e.g. by establishing novel democratic rules for university governance. The Slow University paradigm positions culture and education as essential tools for the long-term survival of humankind.

This book provides a concise overview of cardiac electrophysiology for cardiologists who are not electrophysiologists and for allied cardiovascular professionals, cardiology registrars and fellows who are new to the field. It familiarises them with the main procedures performed in the electrophysiology laboratory. Emphasis is placed on helping the reader develop a core understanding of how data is collected and interpreted in the electrophysiology laboratory, and how this is used to guide ablation for the commonest arrhythmias including AV nodal re-entry tachycardia, accessory pathways, atrial fibrillation and ventricular arrhythmias. Decoding Cardiac Electrophysiology: Understanding the Techniques and Defining the Jargon will translate some of the technical terminology and data frequently used by electrophysiologists into terms and concepts familiar to the wider cardiovascular community. This includes the interpretation of electrograms and 3D electro-anatomical maps of common arrhythmias. Accordingly, it offers a valuable resource for all non-electrophysiologists seeking a guide to the topic and for electrophysiology trainees establishing their core knowledge and skills in the field. The aim is that this should be the first book anyone new to the field should choose to read.

This book provides an interdisciplinary analysis of UK African Diaspora health seekers and their sustained health inequalities in the health market. It translates their often-silenced voices into a decolonial praxis, where their experiences illuminate the hidden factors that have blighted change in health outcomes for these communities. The book excavates and breaks down the nature of these hidden factors, as historical patterns of behaviour that comprise whiteness over the longue duree. Using the lenses of decolonial and critical race studies, the book places whiteness within an ethical and moral framework in order to examine the hidden factors behind health inequalities. The book also looks at intersectionality and discusses whether it is actually fit for purpose as an analytical framework for discussing the health seeking behaviours of both Black men and Black women in relation to their unequal access to the health market. Faye Bruce is Chair of the Caribbean and African Health Network (CAHN) and a Senior Lecturer and Nursing MPH Global Public Health lead, Co-Investigator Nursing and Racism, Non-Executive Director Northern Care Alliance, UK. Ornette D Clennon is Director of Research and Head of MaCTRI (MEaP Academy Community Training & Research Institute), Manchester, UK. Ornette is also Visiting Professor, UFAM (Federal University of the Amazon).

"The history of serious mental illness (SMI) is grim, from a cultural as well as a treatment perspective. The conditions of individuals with psychotic disorders have swung, like a pendulum, from institutional neglect to community neglect and back again over the past several hundred years. At the core of treatment failure is a failure in mental health policy and funding, with the result usually framed as the degree of human institutionalization in jails, prisons and asylums. In the middle of the 19th century, institutions designed to deliver moral treatment were considered the humane answer to care properly for the SMI population. By the mid- 20th century, those same, now overcrowded, institutions were blamed for the horrible conditions of mistreatment of individuals with SMI. Now, as we approach the middle of the 21st century, deinstitutionalization (the answer to the cruel asylums) is purportedly at fault for homelessness, lack of treatment, and criminalization. As the pendulum swings, we are hearing cries to "bring back" the asylums"-- Provided by publisher.

Introduction to deep brain stimulation: history, techniques and ethical considerations -- Customized platform-based stereotactic DBS lead placement technique (FHC STarFix, Medtronic Nexframe, and Robotic System Placement) -- Microelectrod Recording Methods -- Intraoperative imaging-based lead implementation -- Lesioning methods for movement disorders -- Computational modeling and tractography for DBS targeting -- Closed-loop stimulation methods: current practice and future promise -- Parkinson's disease application -- Essential tremor application -- Deep brain stimulation for dystonia- clinical review and surgical considerations -- Deep brain stimulation for obsessive compulsive disorder -- Deep brain stimulation in major depression -- Deep brain stimulation in Tourette Syndrome -- Deep brain stimulation for emerging psychiatric indications -- Intraoperative research druing deep brain stimulation surgery -- Deep brain stimulation: techniques and practices for pediatrics indications -- Establishing a deep brain stimulation practice.

Chronic electrical stimulation of the brain has become a standard surgical therapy for Parkinson's disease, with many studies demonstrating excellent outcomes without any serious complications. Recently this surgical intervention has also been applied to various other neurological diseases, such as involuntary movement disorders, intractable pain, and psychological conditions including depression and obsessive-compulsive disorder. This comprehensive, up-to-date textbook will meet the needs of all who wish to learn more about the application of deep brain stimulation and will provide a sound basis for safe and accurate surgery. The book comprises two main parts, the first of which presents relevant anatomical and functional background information on the basal ganglia, thalamus, and other brain structures as well as on the mechanism of brain stimulation. The second part describes clinical studies on deep brain stimulation, covering results in a range of movement disorders and psychiatric diseases and also important aspects of instrumentation and technique. The authors are outstanding scientists and experts in the field from across the world. This book will be welcomed by all young neurosurgeons, neurologists, psychiatrists, and other medical staff who are interested in electrical stimulation of the brain for the treatment of neurological disorders.

Principles of DBS electronics -- Principles of electrophysiology -- Controlling the flow of electrical charges -- DBS safety -- Nervous system responses to DBS -- DBS effects on motor control -- Pathophysiological mechanisms -- Approaches to programming -- Clinical assessments -- Approach to subthalamic nucleus -- Approach to globus pallidus internal -- Approach to thalamic DBS -- Algorithm for selecting electrode configurations and stimulation parameters -- Helpful programming hints -- Oscillator basics -- Discrete neural oscillators.

The purpose of this edited volume is to provide a comprehensive overview on the fundamentals of deep learning, introduce the widely-used learning architectures and algorithms, present its latest theoretical progress, discuss the most popular deep learning platforms and data sets, and describe how many deep learning methodologies have brought great breakthroughs in various applications of text, image, video, speech and audio processing. Deep learning (DL) has been widely considered as the next generation of machine learning methodology. DL attracts much attention and also achieves great success in pattern recognition, computer vision, data mining, and knowledge discovery due to its great capability in learning high-level abstract features from vast amount of data. This new book will not only attempt to provide a general roadmap or guidance to the current deep learning methodologies, but also present the challenges and envision new perspectives which may lead to further breakthroughs in this field. This book will serve as a useful reference for senior (undergraduate or graduate) students in computer science, statistics, electrical engineering, as well as others interested in studying or exploring the potential of exploiting deep learning algorithms. It will also be of special interest to researchers in the area of AI, pattern recognition, machine learning and related areas, alongside engineers interested in applying deep learning models in existing or new practical applications.

This book presents cutting-edge research and applications of deep learning in a broad range of medical imaging scenarios, such as computer-aided diagnosis, image segmentation, tissue recognition and classification, and other areas of medical and healthcare problems. Each of its chapters covers a topic in depth, ranging from medical image synthesis and techniques for muskuloskeletal analysis to diagnostic tools for breast lesions on digital mammograms and glaucoma on retinal fundus images. It also provides an overview of deep learning in medical image analysis and highlights issues and challenges encountered by researchers and clinicians, surveying and discussing practical approaches in general and in the context of specific problems. Academics, clinical and industry researchers, as well as young researchers and graduate students in medical imaging, computer-aided-diagnosis, biomedical engineering and computer vision will find this book a great reference and very useful learning resource.

"Despite having access to more resources than ever, our doctors are overloaded with demands for their time and expertise. In Deep Medicine, leading physician Eric Topol shows how artificial intelligence can help. Natural-language processing can record our doctor's notes, make sense of our medical histories, and read more deeply into the scientific literature than any human ever could. Deep-learning algorithms -- applied to wearable sensors, genomic information, blood work, scans, and all of our medical data -- can create bespoke treatment plans. And virtual medical assistants, powered by personalized AI, can provide us with coaching to promote our health, shape our diet, and even prevent illness. Bust most importantly, by freeing physicians from the tasks that interfere with human connection, AI will give doctors the gift of time -- to restore the care in healthcare. Innovative, provocative, and hopeful, Deep Medicine shows us how the awesome power of AI can make medicine better, and reveals the paradox that machines can make humans healthier -- and more human"--Provided by publisher.

Introduction to high-throughput sequencing experiments : design and bioinformatics analysis / Rachelly Normand and Itai Yanai -- Compressing resequencing data with GReEn / Armando J. Pinho, Diogo Pratas, and Sara P. Garcia -- On the accuracy of short read mapping / Peter Menzel ... [et al.] -- Statistical modeling of coverage in high-throughput data / David Golan and Saharon Rosset -- Assembly algorithms for deep sequencing data : basics and pitfalls / Nitzan Kol and Noam Shomron -- Short read mapping for exome sequencing / Xueya Zhou ... [et al.] -- Profiling short tandem repeats from short reads / Melissa Gymrek and Yaniv Erlich -- Exome sequencing analysis : a guide to disease variant detection / Ofer Isakov, Marie Perrone, and Noam Shomron -- Identifying RNA editing sites in miRNAs by deep sequencing / Shahar Alon and Eli Eisenberg -- Identifying differential alternative splicing events from RNA sequencing data using RNASeq-MATS / Juw Won Park ... [et al.] -- Optimizing detection of transcription factor-binding sites in ChIP-seq experiments / Aleksi Kallio and Laura L. Elo -- Statistical analysis of ChIP-seq data with MOSAiCS / Guannan Sun ... [et al.] -- Detection of reverse transcriptase termination sites using cDNA ligation and massive parallel sequencing / Lukasz J. Kielpinski ... [et al.].

A pioneering physician reveals how childhood stress leads to lifelong health problems and what we can do to break the cycle. For anyone who has faced a difficult childhood, or who cares about the millions of children who do, the innovative and acclaimed health interventions outlined in this book will represent vitally important hope for change.

Designed and written by a team of clinically established academics, this is a unique book that is an excellent manual for physicians practicing pain medicine or treating pain in neurosurgery, orthopedic, neurology, or family practice clinics. As a practical resource, this book is written to be more accessible to the reader and is designed to be more clinically-focused and useful in day-to-day practice. This 102 chapter volume is divided into seven separate sections: Anatomy and Physiology of Pain, Psychology of Pain, Pharmacological Treatment of Pain, Interventional Treatment of Pain, Adjuvant Therapies for Pain and Suggested Reading. The calculated organization of this book is supplemented by key photos, drawings and a self-assessment of four key questions at the end of each chapter, thus making it an indispensable, pragmatic resource that will benefit anyone working in the pain management field. Deer's Treatment of Pain: An Illustrated Guide for Practitioners contains pearls for improving knowledge and improving one's practice as a physician.

This first volume of a two-volume set describes general aspects, such as the historical view on the topic, the role of information distribution and preparedness of health-care systems and preparedness in emergency cases. Part two describes and discusseses in detail the pathogens and toxins that are potentially used for biological attacks. As such, the book is a valuable resource for faculties engaged in molecular biology, genetic engineering, neurology, biodefense, biosafety & biosecurity, virology, and infectious disease programs, as well as professional medical research organizations.

This second volume of a two-volume set focuses on specific pathogens and their mechanisms of pathogenesis as well as diagnostics, therapeutics and various strategies in the event of biological attacks. This multidisciplinary book appeals to readers from various fields, including biodefense, biosafety & biosecurity, virology, neurology, molecular biology and genetic engineering, as well as infectious disease specialists. Further, the work is of interest to basic science and applied science research scholars and experts working in the area of high-consequence or select agent virology.

This first volume of the book covers 150 important words and phrases encountered in cardiovascular, respiratory and renal physiology, elaborating the concepts, principles and common themes around these words. It offers students a quiver of arrows to direct their thinking accurately in order to understand targeted processes in physiology. Physiology teachers also find this 'definitive' physiology text useful in their lectures and tutorial classes to elaborate on homeostatic mechanisms in physiology. With any increase in physiological knowledge, there will be new words and terms that describe new mechanisms, and definitions of key words in core physiology are essential points of reference since they provide the foundational word pillars needed to understand physiology texts. This book is a valuable companion to the Springer series "Physiology-Question Based Learning (Pq-BL)" by the author. Both the questions and words for learning physiology well have been selected from the successful annual Physiology Quiz International event that is chaired and designed by the author.

Prevention Science: An Epidemiological Approach -- Individual Physical, Cognitive, and Emotional Vulnerability Across the Life Course: Benchmarks and Developmental Challenges -- Benchmarks, Developmental Challenges, and Risks During the Prenatal and Infancy Period -- Childhood and the Entry into Adolescence: A Pivotal Period in Health-Related Behaviors and Prevention -- Adolescence and Early Adulthood -- Stressors and Vulnerabilities in Middle and Old Age: Opportunities for Prevention -- Environmental Influences and Implications for Intervention Development -- Family -- School Influences on Child and Youth Development -- Peer Networks -- Risk and Resilience Processes in Single-Mother Families: An Interactionist Perspective -- Environmental Influences: The Workplace and Mental Health-Models, Vulnerability Factors, and Interventions -- An Integrated Prevention Science Model: A Conceptual Foundation for Prevention Research -- Design of Prevention Interventions -- Implementation Science and the Effective Delivery of Evidence-Based Prevention -- Factors Affecting Implementation: Cultural Adaptation and Training -- Measuring Fidelity -- Research Design -- Translating the Intervention Approach into an Appropriate Research Design: The Next-Generation Adaptive Designs for Effectiveness and Implementation Research -- The Epidemiologic Case-Crossover and Case-Control Approaches in Prevention Research -- The Use of Simulation Models in Public Health with Applications to Substance Abuse and Obesity Problems -- Meta-analysis in Prevention Science -- Mixed Methods Research Design for Prevention Science: Methods, Critiques, and Recommendations -- Analytic Methods -- Latent Class Analysis in Prevention Science -- Discrete-Time Survival Analysis in Prevention Science -- Using Mediation and Moderation Analyses to Enhance Prevention Research -- Advances in Missing Data Models and Fidelity Issues of Implementing These Methods in Prevention Science -- Cost Analysis and Policy -- Economic Analysis and Policy Studies: Special Challenges in the Prevention Sciences -- Strengthening Prevention Science to Ensure Effectiveness of Intervention in Practice: Setting up an International Agenda.

Segmentation of anatomical structures in medical image data is an essential task in clinical practice. Dagmar Kainmueller introduces methods for accurate fully automatic segmentation of anatomical structures in 3D medical image data. The author's core methodological contribution is a novel deformation model that overcomes limitations of state-of-the-art Deformable Surface approaches, hence allowing for accurate segmentation of tip- and ridge-shaped features of anatomical structures. As for practical contributions, she proposes application-specific segmentation pipelines for a range of anatomical structures, together with thorough evaluations of segmentation accuracy on clinical image data. As compared to related work, these fully automatic pipelines allow for highly accurate segmentation of benchmark image data. Contents Deformable Meshes for Accurate Automatic Segmentation Omnidirectional Displacements for Deformable Surfaces (ODDS) Coupled Deformable Surfaces for Multi-object Segmentation From Surface Mesh Deformations to Volume Deformations Segmentation of Anatomical Structures in Medical Image Data Target Groups Academics and practitioners in the fields of computer science, medical imaging, and automatic segmentation. The Author Dagmar Kainmueller works as a research scientist at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, with a focus on bio image analysis. The Editor The series Aktuelle Forschung Medizintechnik - Latest Research in Medical Engineering is edited by Thorsten M. Buzug.

"With rapid advancement in technology and materials in total knee arthroplasty (TKA), long-term survival and function of the total knee is now more and more dependent on restoring accurate limb alignment, precise component position and optimum soft-tissue balance. Proper technique is key to ensuring this and is all the more crucial and challenging to achieve in arthritic knees with severe and complex deformities. Correction of such knee deformities forms an important part of TKA for orthopedic surgeons working in both emerging and developed nations. Deformity Correction in Total Knee Arthroplasty fills the void that exists in treating severe and complex knee deformities and the use of computer-navigation in TKA. It covers the principles of deformity correction and soft-tissue balancing in primary TKA in an illustrative, step-wise and algorithmic fashion. Starting with the initial key step of preoperative planning, this book goes on to specifically describe how to deal with different types of deformities encountered in patients who undergo TKA - varus, valgus, flexion, hypertension, rotational and extra-articular deformities - as well as the stiff knee, the unstable knee, osteotomies in primary TKA and postoperative pain management and rehabilitation. This focused how-to manual includes plentiful images and clear, concise text from authors who have performed thousands of TKAs, making it a must-have reference for any surgeon unfamiliar or frequently confronted with this type of procedure."--Publisher's website.

The authors present anatomical, biomechanical, and clinical basic knowledge relevant to degenerative diseases of the surgical spine and describe how to choose the approach, implant, and surgical technique in detail. Numerous figures illustrate the decision-making process and surgical techniques step-by-step. The book also contains key points about implant safety and possible complications as well as an outlook to the future of cervical spine surgery. Degenerative Diseases of the Cervical Spine is aimed at spinal surgeons (neurosurgeons and orthopaedic surgeons), physical therapists, general practitioners, and rehabilitation physicians, worldwide.

Diagnosis -- History taking and the medical record -- The screening physical examination -- Vital signs, anthropometric data, and pain -- Non-regional systems and diseases -- The skin and nails -- The head and neck -- The chest : chest wall, pulmonary, and cardiovascular systems; the breasts -- Abdomen, perineum, anus, and rectosigmoid -- The urinary system -- The female genitalia and reproductive system -- Male genitalia and reproductive system -- The spine, pelvis and extremities -- The nervous system -- The mental status, psychiatric, and social evaluations -- The preoperative evaluation -- Principles of diagnostic testing -- Common laboratory tests.

"DeGowin's Diagnostic Examination describes the techniques for obtaining a complete history and performing a thorough physical exam, links symptoms and signs with the pathophysiology of disease, presents an approach to differential diagnosis, based upon the pathophysiology of disease, which can be efficiently tested in the laboratory, and does all of this in a format that can be used as a quick point-of-care reference and as a text to study the principles and practice of history taking and physical examination"-- Provided by publisher.

Thoroughly updated to reflect today's recent advances in adult and pediatric endocrinology, DeGroot’s Endocrinology, 8th Edition, remains the comprehensive, international reference of choice for today’s endocrinologists and fellows. A full peer review of the previous edition, conducted by a largely new group of renowned editors, was used to update this trusted, two-volume resource. In-depth coverage of both basic and clinical aspects of endocrinology and up-to-date information on the treatment and management of endocrine disorders are provided by a diverse group of expert contributors from six continents. A full-color format and helpful algorithms summarize clinical decision-making and practical approaches to patient management.

Introduction -- Overview of the nervous system -- The neurologic history -- The general physical examination -- General outline of the neurologic examination -- Gross and microscopic anatomy of the cerebral hemispheres -- Functions of the central cortex and regional cerebral diagnosis -- The mental status examination -- Disorders of speech and language -- Agnosia, apraxia, and related disorders of higher cortical function -- An overview of brainstem and cranial nerve anatomy -- The olfactory nerve -- The optic nerve -- The ocular motor nerves -- The trigeminal nerve -- The facial nerve -- The acoustic (vestibulocochlear) nerve -- The glossopharyngeal and vagus nerves -- The spinal accessory nerve -- The hypoglossal nerve -- Brainstem and multiple cranial nerve syndromes -- Overview of the motor system -- The motor unit level -- The spinal cord level -- The corticospinal (pyramidal) level -- The extrapyramidal level -- Motor strength and power -- Muscle tone -- Muscle volume and contour -- Abnormalities of movement -- Overview of the sensory system -- The exteroceptive sensations -- The proprioceptive sensations -- The interoceptive, or visceral, sensations -- Cerebral sensory functions -- Sensory localization -- Introduction to the reflexes -- The deep tendon or muscle stretch reflexes -- The superficial (cutaneous) reflexes -- Pathologic reflexes -- Postural and righting reflexes -- Associated movements -- Cerebellar function -- Gait and station -- The autonomic nervous system -- Peripheral neuroanatomy and focal neuropathies -- Neck and back pain -- Other musculoskeletal disorders -- The blood supply of the brain -- The ventricular system and the cerebrospinal fluid -- The examination in coma -- Miscellaneous neurologic signs -- Diagnostic reasoning and neurologic differential diagnosis.

"DeJong's The Neurological Examination offers practitioners and residents of Neurology an in-depth discussion of neurologic exams. This definitive source on neurologic examination techniques integrates details of both neuroanatomy and diagnosis in an easy-to-read and clinically-focused format. Anatomical and exam illustrations help ensure proper technique. Also included are illustrative case studies with tables to summarize differentials and clinical findings"--Provided by publisher.

"Indispensable for both surgeons and sports medicine physicians, DeLee, Drez, & Miller's Orthopaedic Sports Medicine: Principles and Practice, 5th Edition, remains your go-to reference for all surgical, medical, rehabilitation and injury prevention aspects related to athletic injuries and chronic conditions. Authored by Mark D. Miller, MD and Stephen R. Thompson, MD, this 2-volume core resource provides detailed, up-to-date coverage of medical disorders that routinely interfere with athletic performance and return to play, providing the clinically focused information you need when managing athletes at any level"--Publisher's description.

Defining organs at risk is a crucial task for radiation oncologists when aiming to optimize the benefit of radiation therapy, with delivery of the maximum dose to the tumor volume while sparing healthy tissues. This book will prove an invaluable guide to the delineation of organs at risk of toxicity in patients undergoing radiotherapy. The first and second sections address the anatomy of organs at risk, discuss the pathophysiology of radiation-induced damage, and present dose constraints and methods for target volume delineation. The third section is devoted to the radiological anatomy of organs at risk as seen on typical radiotherapy planning CT scans, with a view to assisting the radiation oncologist to recognize and delineate these organs for each anatomical region head and neck, mediastinum, abdomen, and pelvis. The book is intended both for young radiation oncologists still in training and for their senior colleagues wishing to reduce intra-institutional variations in practice and thereby to standardize the definition of clinical target volumes.

This text provides a comprehensive, state-of-the-art overview of acute brain dysfunction in the critically ill. The book covers the basic pathophysiology of delirium, epidemiology, risk factors, outcomes associated with delirium, prevention and treatment of delirium, and challenges and techniques for improving delirium awareness. Written by experts in the field, Delirium: Acute Brain Dysfunction in the Critically Ill is a valuable resource for clinicians and practitioners that will help guide patient management and stimulate investigative efforts in this field.

Clinical evaluation -- Assessment of human muscle function -- Electrodiagnostic evaluation of the peripheral nervous system -- Human walking -- Imaging techniques -- Diagnostic ultrasound -- Functional evaluation and management of self-care and other activities of daily living -- Disability determination in relation to work -- The international classification of functioning, disability, and health -- Systematically assessing and improving the quality of pysical medicine and rehabilitation -- Epidemiology of disability in the United States and internationally: implications for policy and practice -- Psychological aspects of rehabilitation -- Speech, language, swallowing, and auditory rehabilitation -- Vocational rehabilitation, independent living, and consumerism -- Important to measure aspects of participation and environmental factors in medical rehabilitation -- Ethical issues in rehabilitation medicine -- International aspects of the practice of physical medicine and rehabilitation -- Stroke rehabilitation -- Traumatic brain injury -- Multiple sclerosis -- Comprehensive rehabilitation of Parkinson disease and movement disorders -- Rehabilitation of spinal cord injury -- Motor neuron disease -- Peripheral neuropathy -- Myopathy -- Disorders of the cervical spine -- Rehabilitation of lumbar spine disorders: an evidence-based clinical practice approach -- Idiopathic scoliosis -- Disorders of the upper limbs -- Disorders of the lower limbs -- The prevention, treatment, and rehabilitation of osteoporosis -- Rheumatic diseases -- Cardiac rehabilitation -- Rehabilitation of the patient with respiratory dysfunction -- Burns -- Rehabilitation for patients with cancer diagnoses -- Amputations and vascular diseases -- Physical inactivity: physiologic impairments and related clinical conditions -- Chronic pain -- Spasticity -- Sports medicine -- Paralympic sports -- Physical activity for people with disabilities -- Performing arts medicine -- Rehabilitation of children with disabilities and adults with childhood-onset disabling conditions -- Health for women with disabilities -- Geriatric rehabilitation -- The role of PM&R in disaster relief -- Exercise -- Acquatic rehabilitation -- The physical agents -- Pharmacotherapy of disability -- Joint and spinal injection procedures -- Electrical stimulation (therapeutic and functional) -- Assistive technology -- Upper and lower limb prosthetics -- Orthotics for the lower and upper limb and spine -- Wheelchairs -- Integrative medicine in PM&R -- Evidence-based practice in rehabilitation (including clinical trials) -- Neural repair and plasticity -- Rehabilitation robotics.

This textbook is an evidenced-based course for interdisciplinary healthcare professionals for improving resilience and reducing stress and burnout. This curriculum improves patient-centered care by providing training in compassion and attention. It is a structured skills-based manual complete with resources for full implementation and dissemination of this evidence-based course. This textbook addresses the gaps existing in other mindfulness-based interventions. It is a unique manual that can be followed in a linear fashion or can be used modularly to suit the needs of specific settings. The curriculum contains didactic content and specific examples of practices; hence, it is easily adaptable for use by groups and classes of various sizes and structure. The authors have conducted several research studies with findings to support its use to prevent and treat burnout. Results demonstrate the curriculums feasibility and acceptability in healthcare professionals and students as well as efficacy in stress and burnout reduction with increases in dispositional mindfulness.

"This book is based on the principle and belief that all healthcare professionals-regardless of discipline, level of education, or role within the healthcare system-have a role in caring for individuals with disability. As such, they need a basic understanding of the issue of disability to provide appropriate, optimal, and sensitive healthcare to those with disability. These issues and more are addressed in the chapters of this book. It is intended to provide information to nurses, nursing students, and other healthcare professionals to enable them to communicate with and provide quality healthcare to individuals with disability"-- Provided by publisher

This in-depth book addresses a key void in the literature surrounding the Internet of Things (IoT) and health. By systematically evaluating the benefits of mobile, wireless, and sensor-based IoT technologies when used in health and wellness contexts, the book sheds light on the next frontier for healthcare delivery. These technologies generate data with significant potential to enable superior care delivery, self-empowerment, and wellness management. Collecting valuable insights and recommendations in one accessible volume, chapter authors identify key areas in health and wellness where IoT can be used, highlighting the benefits, barriers, and facilitators of these technologies as well as suggesting areas for improvement in current policy and regulations. Four overarching themes provide a suitable setting to examine the critical insights presented in the 31 chapters: Mobile- and sensor-based solutions Opportunities to incorporate critical aspects of analytics to provide superior insights and thus support better decision-making Critical issues around aspects of IoT in healthcare contexts Applications of portals in healthcare contexts A comprehensive overview that introduces the critical issues regarding the role of IoT technologies for health, Delivering Superior Health and Wellness Management with IoT and Analytics paves the way for scholars, practitioners, students, and other stakeholders to understand how to substantially improve health and wellness management on a global scale.

Diagnosis and differential diagnosis of dementia / Richard Camicioli -- Rapidly progressive dementia and its mimics / Amy May Lin Quek and Andrew McKeon -- Young onset dementia : how much diagnostic testing is enough? / Anahita Adeli and Keith A. Josephs -- An approach to the problem of normal pressure hydrocephalus / Norman Relkin -- Depression : cause or complication of cognitive decline? / David Mansoor, Sahana Misra, and Linda Ganzini -- Mild cognitive impairment / Ranjan Duara, David A. Loewenstein, Clinton Wright, Elizabeth Crocco, and Daniel Varon -- After the diagnosis : continuing neurologic care of the outpatient with dementia / Anne M. Lipton -- Using psychotropic medications to manage problem behaviors in dementia / Lucy Y. Wang and Murray A. Raskind -- Palliative care in advanced dementias / Ira Byock and Cory Ingram -- Ethical, legal, and social issues in dementia / Amy Y. Tsou and Jason Karlawish -- Assessing outcomes in dementia car / Joel Mack, Amie Peterson, and Joseph Quinn -- Primary prevention of dementia / Joseph Quinn.

With contributions from experienced dementia practitioners and care researchers, this book examines the impact of culture and ethnicity on the experience of dementia and on the provision of support and services, both in general terms and in relation to specific minority ethnic communities. Drawing together evidence-based research and expert practitioners' experiences, this book highlights the ways that dementia care services will need to develop in order to ensure that provision is culturally appropriate for an increasingly diverse older population. The book examines cultural issues in terms of assessment and engagement with people with dementia, challenges for care homes, and issues for supporting families from diverse ethnic backgrounds in relation to planning end of life care and bereavement. First-hand accounts of living with dementia from a range of cultural and ethnic backgrounds give unique perspectives into different attitudes to dementia and dementia care. The contributors also examine recent policy and strategy on dementia care and the implications for working with culture and ethnicity. This comprehensive and timely book is essential reading for dementia care practitioners, researchers and policy makers.

This book is designed to guide all physicians in long-term care, in-, and outpatient settings who work with elders with co-current dementia and medical comorbidities. Chapters cover a wide range of challenging topics, including epidemiological data, evaluation and management techniques to optimize physical and cognitive function in patients with dementia, safety measures, and nonpharmacologic measures to support cognition. Chapters also discuss the unique aspects of managing the most common chronic diseases and the management of musculoskeletal pain in elders with dementia. Except for the introductory chapter, each chapter will include a case vignette to highlight some of the primary challenges of management of the particular chronic disease/condition in elders with dementia, making this an accessible and highly practical tool for medical professionals of all backgrounds. Written by experts in the field, Dementia and Chronic Disease is an excellent resource for all medical professionals treating patients with dementia, including geriatricians, family medicine physicians, social workers, nurses, hospitalists, and all others.

This unique title offers a novel exploration into the world of advance directives for patients with dementia. Based on real life ethics consultations the expert author has undertaken, the cases depict fascinating and challenging moral issues arising in a variety of healthcare facilities. The dynamics of the interdisciplinary health care teams of these patients, along with the dynamics of the families who are grappling to best serve their loved ones, are outlined and assessed; and the role each player's personal histories have on the ethical issues and their resolution in real life are explored. Following each case study, the author applies a range of concepts introduced in the beginning of the book to the relevant case study, thus integrating theory with a case-based approach. A user-friendly question-and-answer format provides a thought provoking and accessible learning experience for readers. Dementia and the Advance Directive: Lessons from the Bedside tackles complicated and realistic healthcare scenarios and offers an invaluable addition to the literature on advance directives. .

This book provides an overview of the demographic, clinical, and psychosocial context of dementia care. With its focus on patient and family perspectives, this book describes evidence-based approaches towards prevention, detection, and treatment of dementia that is like any other book. The text presents memory clinics, care management, home-based interventions, palliative care, family caregiver programs, specific to dementia care. Additionally, the text examines strategies to support transitions to acute care and long-term care. The text also places a special emphasis on measures of quality, cultural sensitivity, and implications for health care policy. Written by experts in the field, Dementia Care: An Evidence-Based Approach is an excellent resource for clinicians, students, healthcare administrators, and policymakers who aim to improve the quality of life of both the person with dementia and their informal caregiver.

This concise, pragmatic, pocket-sized book addresses neurological contributions to the diagnosis and management of dementia through a longitudinal examination of the work undertaken in a dedicated neurological dementia clinic. It covers the use of cognitive and non-cognitive screening instruments and their diagnostic utility and the use of other diagnostic investigations: neuroimaging, neurophysiology and neuropathology. The diagnostic mix is discussed in terms of both neuropsychological syndromes and neurological diagnoses, as is the use of conventional treatments for dementia and the impact of national directives (e.g. NICE, National Dementia Strategy) on day-to-day clinical practice. Dementia in Clinical Practice: A Neurological Perspective, Second Edition is an illustrated, practical resource for medical professionals involved in the assessment and management of dementia patients. It is of particular benefit to neurologists, psychiatrists, geriatricians, primary care practitioners and those working in the fields of neuropsychology, psychology, occupational therapy, speech and language therapy and nursing.

This expanded, updated third edition summarizes the pragmatic diagnostic accuracy studies of neurological signs and cognitive and non-cognitive screening instruments undertaken in the author's clinic in the context of day-to-day practice involving patients with cognitive disorders including dementia. A new chapter devoted to comparing and combining instruments is included, and illustrative case studies have been included where relevant. Dementia in Clinical Practice: A Neurological Perspective, Third Edition is a practical resource for medical professionals involved in the assessment and management of patients with dementia and cognitive disorders. It may be of particular interest to neurologists, psychiatrists, geriatricians, primary care practitioners and those working with patients with cognitive impairment in the fields of neuropsychology, psychology, occupational therapy, speech and language therapy and nursing.

Written by leading international experts, this book discusses the latest advances in the field of dementia in nursing homes. The topics and findings covered are based on their survey and on a scientific literature review. Dementia is spreading worldwide, placing a growing burden on healthcare systems and caregivers, as well as those affected. With increasing and complex care needs, nursing home admission is often necessary. Globally, over half of nursing home residents suffer from dementia. The book provides essential information on the most important issues in dementia in nursing homes today, including meaningful activities, patient-/person-centered care, psychosocial interventions, challenging behavior, inclusion and support of family members, pain, staff training and education, communication, polypharmacy, quality of life, end-of-life care and advanced care planning, depression, delirium, multidisciplinary approaches, physical restraints and care dependency. Each topic is covered by an international expert in dementia. As such, the book will appeal to professional nurses, nursing scientists, nursing students, other healthcare professionals, and to a broad readership, and will provide a valuable resource for those working in nursing homes, as well as researchers in the field. - Publisher.

"Preface: We all see dementia as a challenge. Indeed, many are frightened by the very prospect of it. This is not unreasonable, because more of us throughout the world are getting it as we live longer. And it's a serious and sometimes devastating condition. The biology and psychology of dementia, its medical and behavioural management, are all dealt with elsewhere. In this book we want to pause to reflect on other aspects of dementia because, as we shall argue, despite everything else about it, dementia is also a way of seeing more clearly the human condition. In the face of a threat to our lives and to our standing as persons with relationships and a sense of dignity and worth, we would argue that it's quite natural to ponder on some of the deeper aspects of our being in, or engagement with, the world. These ponderings are pertinent to us all, not just to those of us who will get or are already living with dementia"-- Provided by publisher.

Part I. Introduction -- 1. History and latest concept of DLB -- 2. Epidemiology of DLB -- Part II. Biological Aspects -- 3. Neuropathology of DLB -- 4. Biochemistry of DLB -- 5. Molecular biology of DLB -- Part III. Clinical Aspects -- 6. Clinical diagnostic criteria of DLB -- 7. Cognitive impairments of DLB -- 8. BPSD in DLB -- 9. Parkinson symptoms of DLB -- 10. Autonomic symptoms of DLB -- Part IV. Biological Markers -- 11. CT, MRI, SPECT and PET in DLB -- 12. DaT Scan in DLB -- 13. MIBG myocardial scintigraphy in DLB -- 14. Alpha-synuclein in cerebrospinal fluid -- 15. Electroencephalography in DLB -- 16. Ventilatory response to hypercapnia -- Part V. Treatment -- 17. Pharmacotherapy in DLB -- 18. Kampo medicine in DLB.

Examination of the face and head -- A brief review of clinical neuroanatomy -- Examination of vision -- Examination of the peripheral ocular motor system -- Examination of the central ocular motor systems -- Examination of the motor cranial nerves V, VII, IX, X, XI, and XII -- Examination of the somatic motor system (Excluding cranial nerves) -- Examination for cerebellar dysfunction -- Examination of the special senses -- Examination of the general somatosensory system -- The patient's mental status and higher cerebral functions -- Examination of the patient who has a disorder of consciousness -- Ancillary neurodiagnostic procedures--lumbar puncture and neuroimaging -- Clinical and laboratory tests to distinguish conversion disorder (Functional neurologic symptom disorder) from organic disease -- A synopsis of the neurologic investigation and a formulary of neurodiagnosis

Chapter 1. Introduction / Herb Smaltz -- chapter 2. Healthcare and the big data V's / Prashant Natarajan -- chapter 3. Big data : how to get started / John Frenzel -- chapter 4. Big data : challenges / John Frenzel -- chapter 5. Best practices : separating myth from reality / Prashant Natarajan -- chapter 6. Big data advanced topics / John Frenzel and Herb Smaltz -- chapter 7. Applied machine learning for healthcare / Prashant Natarajan and Bob Rogers -- Introduction to case studies / Prashant Natarajan -- Penn medicine : precision medicine and big data / Brian Wells -- Ascension : our advanced analytics journey / Tony Byram -- University of Texas MD Anderson : streaming analytics / John Frenzel -- US health insurance organization : financial reporting analytics with big data / Marc Perlman, Larry Manno, and Shalin Saini -- CIAPM : California Initiative to Advance Precision Medicine / Elizabeth -- University of California San Francisco : AI for imaging of neurological emergencies / Pratik Mukherjee -- BayCare health system : actionable, agile analytics using data variety / Apparsamy (Balaji) Balaji -- Arterys : deep learning for medical imaging / Carla Leibowitz -- Big data technical glossary / Shalin Saini.

This book is a concise introduction to the field of interventional radiology (IR), designed to help medical students and residents understand the fundamental concepts related to image-guided interventional procedures and determine the appropriate use of imaging modalities in the treatment of various disorders. It covers the history of interventional radiology; radiation safety; equipment; medications; and techniques such as biopsy and drainage, vascular access, embolization, and tumor ablation. The book also describes the indications, patient preparation, post-procedure care, and complications for the most common interventional radiology procedures. This second edition is fully updated throughout with the latest guidelines and recommendations. Specific updates include: the role of IR outpatient clinics and patient-centered care, prostatic artery embolization, Y90 embolization, embolization for joint disease, the role artificial intelligence plays in IR, and a new chapter on structured reporting in IR. Designed for students and trainees, chapters include key points or "tips and tricks" and review questions. This is an ideal guide for medical students and trainees interested in pursuing interventional radiology.

Dengue Virus Growth, Purification and Fluorescent Labeling -- Isolation and Titration of Dengue Viruses by the Mosquito Inoculation Technique -- Measuring Antibody Neutralization of Dengue Virus (DENV) Using a Flow Cytometry-Based Technique -- Dengue Virus Purification and Sample Preparation for Cryo-Electron Microscopy -- Development of a Multiplex Bead-Based Assay to Monitor Dengue Virus Seroconversion -- Pseudo-Infectious Reporter Virus Particles for Measuring Antibody-Mediated Neutralization and Enhancement of Dengue Virus Infection -- Cell-Based Flavivirus Infection (CFI) Assay for the Evaluation of Dengue Antiviral Candidates Using High Content Imaging -- Development and Application of Dengue Virus Reverse Genetic Systems -- DENV4 Renilla Luciferase Reporter Replicons -- Targeted Mutagenesis of Dengue Virus Type 2 replicon RNA by Yeast in vivo Recombination -- Identification of Dengue-Specific Human Antibody Fragments Using Phage Display -- Next Generation Whole Genome Sequencing of Dengue Virus -- MPGAfold in Dengue Secondary Structure Prediction -- Insights into Secondary and Tertiary Interactions of Dengue Virus RNA by SHAPE -- Use of Small Angle X-Ray Scattering to Investigate the Structure and Function of Dengue Virus NS3 and NS5 -- Identification of Dengue RNA Binding Proteins Using RNA Chromatography and Quantitative Mass Spectrometry -- Analysis of Affinity of Dengue Virus Protein Interaction Using BIAcore -- Functional Genomics Approach for the Identification of Human Host Factors Supporting Dengue Viral Propagation -- Investigating Dengue Virus Non-Structural Protein 5 (NS5) Nuclear Import -- Small Molecule Inhibitor Discovery for Dengue Virus Protease Using High Throughput Screening -- Construction of Dengue Virus Protease Expression Plasmid and in vitro Protease Assay for Screening Antiviral Inhibitors -- Construction of Plasmid, Bacterial Expression, Purification, and Assay of Dengue Virus Type 2 NS5 Methyltransferase -- Animal Models in Dengue -- Evaluation of Dengue Antiviral Candidates In Vivo in Mouse Model.

Dengue : transmission, diagnosis and surveillance / James Whitehorn & Jeremy Farrar -- Biomarkers for dengue : prospects and challenges / Sophie Yacoub, Annette Fox, Nguyen Van Kinh, Gavin Screaton & Heiman Wertheim -- Dengue diagnosis : commercially available kits and laboratory support / Monique da Rocha Queiroz Lima, Rita Maria Ribeiro Nogueira & Flávia Barreto dos Santos -- Lessons learned from dengue : focus on Taiwan / Tzong-Shiann Ho, Chiou-Feng Lin, Ching-Chuan Liu, Trai-Ming Yeh, Robert Anderson & Yee-Shin Lin -- Dengue and international travel / Silvia Odolini, Alberto Matteelli & Francesco Castelli -- Intraepidemic increases in dengue disease severity : applying lessons on surveillance & transmission / Scott B. Halstead -- Prospects for controlling dengue spread : vaccines and vector control / Monica A. McArthur, Marcelo B. Sztein & Robert Edelman -- Ask the experts : surveillance of global dengue distribution / Jane Messina, Oliver Brady, Simon Hay, Jeremy Farrar & James Whitehorn -- Multiple choice questions : answers.

"This contributed volume contains 25 chapters from leading international scientists working on dengue and Zika viruses, who came together in Praia do Tofo in Mozambique to discuss the latest developments in the fields of epidemiology, pathogenesis, structural virology, immunology, antiviral drug discovery and development, vaccine efficacy, and mosquito control programs. The meeting venue offered an opportunity to discuss current research on these flaviviruses in an idyllic setting, and also to develop first-hand appreciation of the issues in infectious diseases facing developing countries and of the research gaps in Africa. For readers, who should include basic and clinical researchers in the field and public health professionals, the chapters are organized to provide a comprehensive overview of the various topics in current dengue and Zika virus research. A unique feature of the proceedings of this meeting is the inclusion of the discussions that took place following presentations. These have been transcribed and appended to the end of the relevant chapters, and they form the "salt in the soup" of this book."-- Provided by publisher.

This concise manual offers best practice guidance on dental treatment of pediatric patients with special health care needs (CSHCN). The straightforward approaches described will enable clinicians to deliver high-quality, patient-centered care to children with intellectual and developmental disabilities. Readers will find up-to-date information on case-based treatment planning, alternative caries management strategies, the use of behavioral and pharmacological interventions to facilitate delivery of quality treatment, and a team approach to care. Practical clinical tips are provided on how to achieve and maintain oral health, including good oral hygiene and nutrition. A systematic framework for patient assessment and interaction with medical colleagues will assist readers in understanding when dental protocols must be altered. Other important topics include techniques for effective communication with CSHCN, behavioral strategies to improve treatment acceptance, the role of occupational therapy techniques, the sensory adapted dental environment, and the use protective stabilization.

This book is an evidence-based update on recent most significant advances in dental ceramics, specifically related to the relationships between composition, microstructure and mechanical behavior. Readers will find an introduction to the chemistry of dental ceramics as well as information about the technological progress and practical requirements restorative materials need to satisfy for long-lasting structural integrity. The book uses mechanistic approaches to address failure mechanisms from controlled experiments thus providing the tools for the application of sound research methodologies in the field. It is targeted for researcher and dentists interested in the field of dental ceramic materials and fracture mechanics.

This book provides comprehensive and updated knowledge about dental digital photography. The first part of this book focuses on the fundamental theory of photography, how to select photographic equipment and the basic applications of digital photography in various aspect in dentistry. It is not only helpful to get more clearly understanding of the concept and methods of dental digital photography, but also instructive for dentist to apply photography during their daily treatment. The second part of the book summaries the different category of digital images. It describes the post-processing methods of the images and the "digital smile design(DSD)" basic process, which highlight the instructive aspects for clinical work. In the Chapter named 'cosmetic dental treatment based on digital photography', comprehensive cosmetic cases are provided; Appendix contains a variety of dental photography standards.

This book is a comprehensive guide to pediatric dental fear/anxiety (DFA) and phobia that will provide practitioners with a full understanding of the etiology, prevalence, assessment, and management of these conditions. The coping styles of children when under stress are explored, with discussion of their relevance to the assessment visit and treatment allocation. Practical treatment techniques are comprehensively covered, from non-pharmacological behavioral strategies relevant for children with no or mild DFA to those approaches more appropriate for children with severe DFA/phobia. The importance of the use of language and communication skills to build rapport and allay anxiety is explored. Relaxation and hypnosis techniques are described, with guidance on how to introduce these to patients and their parents/carers. Techniques that help children cope when receiving injections are detailed, including systematic needle desensitization; these provide practitioners with options to help resolve DFA and phobia regarding needles. Intravenous sedation, including the challenge of cannulation, is covered comprehensively. Furthermore, cognitive behavioral therapy is presented, with suggestion of practical self-help material when appropriate. The closing chapter looks to the future, discussing the barriers to and the changes required for the creation of more child-centered DFA services.

This book examines the current state of knowledge on why implant failures occur, makes specific recommendations for prevention of failure, and emphasizes the role that maintenance plays in increasing the probability of success. Current recommendations for the treatment of ailing implants are also reviewed. Prevention begins with appropriate patient selection and treatment planning, correct implant placement, and effective prosthetic rehabilitation. All of these aspects are thoroughly discussed. The specifics of maintenance therapy for patients with dental implants are then addressed, bearing in mind that patients on a regular maintenance schedule following completion of active therapy have fewer implant complications. Readers will find information on the frequency of visits as well as step-by-step guidance for a routine visit. In addition, current concepts regarding the etiology of implant failure are covered, with explanation of their potential implications for maintenance care. The book will be an ideal aid and reference source for all clinicians wishing to stay abreast of the latest knowledge and developments in the field of dental implant diagnosis, maintenance, and therapeutic intervention.

This book is an ideal reference guide for clinicians seeking to improve their decision making and treatment outcomes when placing dental implants in medically compromised patients, in whom conditions for osseointegration and soft tissue healing may be unfavorable. Up-to-date information is provided on the potential impacts of a wide variety of diseases and disorders on dental implant treatment and the factors that need to be considered when deciding on the feasibility of such treatment. More specifically, for each condition possible disease-related changes in the oral environment are explained and key treatment issues are identified, including surgical and prosthodontic aspects and pharmacological considerations. The book will help general dentists, periodontists, and oral surgeons to reduce the risk of treatment failure and complications and to ensure that the implant therapy is successful in achieving excellent quality of life and functional benefits, thereby improving patient satisfaction.

This book will serve as a one-stop, reference manual to understand the basic concepts of dental implant design, the related microbiome, research models and current concepts as well as futuristic perspectives in implant surface modification. The manual-like design including colorful illustrations and important critical questions will help researchers and advanced students in understanding the contemporary status and in designing studies for innovative treatments of dental implant infections. Considering the microbiome of dental implant related environment in health and disease is imperative to design strategies to good practice and prevention of infections around implants. This monograph will serve as a single reference material which links the interdisciplinary aspect of the dental implants covering material sciences, engineering and biological aspects, thus effectively bridging the gap between engineering and oral health sciences.

Patient evaluation and risk assessment -- Cardiovascular disease -- Pulmonary disease -- Gastrointestinal disease -- Genitourinary disease -- Endocrine and metabolic disease -- Immunologic disease -- Hematologic and oncologic disease -- Neurologic, behavioral, and psychiatric disorders.

Dental Evolution -- Tooth development -- Dental Pulp is a Connective Tissue -- Dental Pulp Stem Cells (DPSC) -- Isolation methods of DPSC -- Characterization of DPSC -- Reprogramming of DPSC to induced pluripotent stem cells (iPSC) -- Immunomodulatory effects of DPSC -- Dental Pulp is a Complex Adaptive System.

This book is designed to enable dentists to understand various aspects of dental sleep medicine, and to recognize the signs and symptoms of sleep disorders in their patients. It discusses potential negative impact of a sleep disorder on oral and systemic health, and shows how to collaborate with others in order to implement appropriate patient management. The first part of the book concentrated on the scientific background of sleep medicine in connection to dentistry covering the physiology of sleep, classifications of sleep disorders, their diagnosis as well as medical and dental comorbidities. The second part of the book is dedicated to clinical applications like CPAP therapy, oral appliance therapy, surgical procedures and adjunct therapies. Last, the future of dental sleep medicine is discussed. Each chapter is written by specialized researchers and clinicians in the field making the book a useful guide for dental clinicians all around the world.

This book presents up-to-date information on promising indications for ultrasound in contemporary periodontics and implant therapy with the aim of assisting researchers and dental practitioners to use this novel imaging modality to advance research and patient care. Readers will find clear guidance on the application of ultrasound for evaluation of periodontal and peri-implant tissues. The mechanism of ultrasound imaging is explained in detail and compared to other imaging modalities. Furthermore, the role of ultrasound in the planning and execution of implant surgery and the assessment of implant stability is discussed. The book closes by considering the potential dental applications of functional ultrasound and volumetric ultrasound. This book will potentially be of high values for dental surgeons, periodontists, general dentists, orthodontists, dental hygienists, dental assistants, dental researchers and other practitioners, etc.

"The revised and updated second edition of The Dentist's Drug and Prescription Guide offers a practical and quick reference to medications commonly prescribed in dental practice. With contributions from experts on the topic, this comprehensive book takes an accessible question-and-answer format, providing answers to common questions dentists ask about drugs. The most updated information on drugs is presented throughout, including the current antibiotic prophylaxis guidelines and newer osteoporosis drugs. A new section describes how to manage patients on medications, and includes new chapters on the important topics of opioid prescribing and abuse and pain management. Alternative effective medications for opioids are discussed in detail. Putting all the prescription and drug information needed in daily dental practice at your fingertips, The Dentist's Drug and Prescription Guide is an essential reference for practicing dental clinicians and dental hygienists. Written for both general and specialist dentists and dental hygienists, the revised second edition of The Dentist's Drug and Prescription Guide is a must-have reference for the most current information available on medications used in the dental profession"-- Provided by publisher.

This volume provides an eloquent review of the anatomy and physiology of phonation, the work-up of patients with voice disorders, basic evaluation of wind instrument performance and dysfunction, and a full description of the most common skeletal and non-skeletal dentofacial anomalies, including their means of diagnosis and treatment. This is followed by a comprehensive review of literature on the vocal and acoustic features of affected patients, as well as the special considerations in wind instrumentalists. The effect of orthodontic therapy/orthognathic surgery on voice, associated upper airway changes, and wind instruments performance is emphasized. The information provided in this book will heighten the patients', therapists', teachers' and physicians' awareness of the vocal characteristics and wind instrumentalists concerns often associated with these conditions. Dentofacial Anomalies: Implications for Voice and Wind Instrument Performance is addressed to otolaryngologists, laryngologists, speech-language pathologists, voice teachers, professional voice users, wind instrumentalists, instrument teachers, arts medicine physicians, physical therapists, orthodontists and other dentists, as well as members of the general public who are concerned about their voices and or wind instrument playing.

1. The Principles of Dependability -- 2. System Safety Assessment -- 3. Fault Tree Analysis -- 4. Failure Modes and Effects Analysis -- 5. Machine Learning Methods with Applications to Diagnosis -- 6. Byzantine Medical Problems: Decision Making with Misleading, Imperfect Information -- 7. Process Driven Methods in Diagnosis and Treatment -- 8. Toyota Production System -- 9. Reliance Implementation Methods Applied to a Kaizen Project -- 10. Knowledge & Culture.

This book provides a reference and contextual basis for depression, burnout and suicide among oncology and other medical professionals. Oncology as a medical subspecialty is at a unique apex of this crisis. While the same pressures in medicine certainly apply to oncologists, oncology is particularly stressful as a changing field with diverse patient and societal expectations for outcomes. In addition to experiencing the stress of caring for patients that could succumb to their cancer diagnoses, these professionals are regularly confronted with an onslaught of new medical information and a landscape that is changing at a breakneck pace. These are just a few factors involved in the increasing rates of burnout among oncologists as well as other medcial professionals. By addressing a gap in identifying mental health problems among health care professionals, this book sheds light on mental health problems and suicide among physicians. Importantly, this book is a call to action of the professional and administrative organizations to work on improving mental health of physicians. Anxiety and depression affect not only the individual doctor but also patient care. Given the increasing attention to these issues along with limited yet applicable data regarding how to address these issues, the text aims to bring the latest data face to face with consensus opinion and can be used to ultimately enhance oncologic and psychiatric practices. Written by experts in the field, Depression, Burnout and Suicide in Physicians: Insights from Oncology and Other Medical Professions aims to significantly increase awareness and contribute to understanding the necessity of preventive measures on individual, family, and care givers levels.

In this unique title, the full range of chronic respiratory conditions and their association with psychiatric comorbidities are explored and targeted management options are outlined. Indeed recent studies indicate a far higher prevalence of depression and anxiety in patients afflicted with chronic respiratory conditions than in patients with other chronic disorders. Unlike other publications in the field of pulmonary disease, Depression and Anxiety in Patients with Chronic Respiratory Diseases details this significant correlation. The book is comprehensive in scope, covering such topics as depression and anxiety across the age spectrum, diagnostic tools for anxiety and depression, anxiety and depression in COPD patients, depression and anxiety in adult patients with asthma, and end-stage lung disease and lung transplantation, among others. In this novel work, the volume Editors enlist a team of renowned experts in the fields of respiratory and psychiatric disorders to combine a thorough synthesis of the literature with targeted, practical strategies for management. Depression and Anxiety in Patients with Chronic Respiratory Diseases is an invaluable resource for all clinicians who care for patients with chronic and advanced lung diseases.

The relationships between depression and medical illness / Melisa Bui, Michael Mufson, and David Gitlin -- The neurobiology of depression : an integrated systems-level, cellular-molecular and genetic overview / David L. Perez, Mark Eldaief, Jane Epstein, David A. Silbersweig, and Emily Stern -- Assessment of depression in patients with medical illnesses / David J. Wolfe, Jane L. Erb, and Jhilam Biswas -- General considerations in treatment / Jane Erb, David Kroll, Arielle Stanford, Megan Oser and Jhilam Biswas -- Depression and neurologic illness / Laura Safar, John Sullivan, Gaston Baslet, Jessica Harder, Laura Morrissey, Shreya Raj, Kirk Daffner, and David Silbersweig -- Cancer and depression / Fremonta Meyer, Elizabeth Alfson, John Peteet, Rachel Yung, and Ilana Braun -- Depression in cardiovascular disease / Meghan S Kolodziej, Jaya Padmanabhan, Joshua R Leo, and L. Howard Hartley -- Depression and gynecologic conditions / Laura J. Miller, Geena Athappilly, Orit Avni-Barron, Daniela Carusi, and Hadine Joffe -- Depression in obstetrical conditions / Laura J. Miller, Leena Mittal, Audra Robertson, and Lindsay Merrill -- Depression and rheumatological and immune disorders / David S. Kroll, Inder Kalra, Jeffrey N. Katz, Naomi Schmelzer, and Charles Surber -- Depression and infectious diseases / John A.R. Grimaldi, Jessica A. Harder, Megan Oser, and Paul E. Sax -- Dermatologic disease / Sejal B. Shah, Naomi A. Schmelzer, Vivian L. Ecker, and Art Saavedra -- Depression and gastrointestinal disease / Robert J. Boland, Florina Haimovici, Megan Oser, Pamela Mirsky, and Joshua Korzinek -- Depression and endocrine disorder / John A. Fromson, Charles Surber, and Matthew Kim -- Depression in chronic kidney disease, hypertension and nutritional deficiencies / Katy LaLone, Elizabeth Alfson, and David Gitlin -- Depression in pulmonary disease / David J. Wolfe and Hilary J. Goldber -- Depression in the patient with chronic pain / Robert N. Jamison and Ajay D. Wasan -- Depression in sleep disorders / Susan Mackie and John Winkelman -- Depression and substance use disorders / Joji Suzuki -- Depression in medically ill children / Eleni K. Maneta and David R. DeMaso -- Depression in the medically ill older adult / Mark Eldaief, Hongtu Chen, J. Michael Gaziano, and Olivia I. Okereke -- The surgical patient / Meghan S. Kolodziej, David J. Wolfe, Fremonta Meyer, Samata Sharma, and Stanley W. Ashley -- Delivering depression care : services and settings / Jane Erb, Emily Benedetto, James Cartreine, David S. Kroll, Eliza M Park, Sejal B. Shah, and Stuart Pollack.

This book is a comprehensive volume dedicated to dermal absorption and decontamination. Given risks including chemical warfare and accidents with toxic industrial chemicals, studies involving dermal absorption and decontamination are of the utmost importance. Each chapter consists of a systematic review on an important dermal absorption and/or decontamination topic. Chapters address key issues such as the general acceptance of water/ soap and water as the gold standard of dermal decontamination despite the fact that it commonly provides incomplete decontamination and may even result in a "wash-in effect" an increased penetration of contaminant). Decontamination with other substances (e.g. RSDL) is explored, and factors that affect dermal penetration (e.g. anatomical variation) are summarized. All systematic reviews are comprehensive and up-to-date. Dermal Absorption and Decontamination will be useful for many fields and disciplines. Firstly, information on dermal decontamination may be used by governments for military and national defense purposes in the event of chemical warfare. Additionally, this information would be of use to many production companies, whose employees are at risk of an accident with toxic industrial chemicals. Topics covered in the book will also be of use to pharmaceutical companies, especially those exploring transdermal delivery of drugs and is of great relevance to those in the medical field, particularly dermatologists.

The aging process affects every aspect of the body, with the face being one of the first places to show signs. The search for the perfect injectable filler has taken an interesting path with the majority of innovations having been introduced in the last 30 years. The patient-driven demand for safe and effective minimally invasive aesthetic procedures has led to the development of an expanding and competitive market for dermal fillers. The demand for soft tissue augmentation has grown rapidly since its start in 1981 with collagen fillers. Fillers using hyaluronic acid, calcium hydroxyapatite, poly-L-lactic acid, and polymethylmethacrylate provide a wide range of options so that the best cosmetic outcome can be attained. The ability to correct facial rhytides and folds, to augment lips and cheeks, to correct acne scars, and now even to replenish volume loss in the dorsum of the hands is something that many practitioners thought would never be possible. This publication reviews the history of fillers, injection techniques, complications and safety as well as the novel use of fillers and fillers of the future.

"In-depth and detailed knowledge of anatomy, different facial shapes, and ethnic origins is essential to delivering safe, effective, natural, and harmonious aesthetic facial treatment results. Dermal Fillers: Facial Anatomy and Injections Techniques is the culmination of many years of expertise decrypting facial anatomy as it applies to aesthetic enhancement of the face. This visually rich atlas is authored by internationally renowned Brazilian dermatologists André Vieira Braz, an esteemed expert in the use of botulinum toxin, fillers, and lasers; and Thais Sakuma, a distinguished lecturer in the application of botulinum toxin and hyaluronic acid fillers. Nineteen highly practical, concise, and didactic chapters are organized consistently with structured text at the beginning of each chapter. The book encompasses the application of injection techniques for the full spectrum of indications, from softening wrinkles to facial contouring. Important topics include facial assessment, hyaluronic acid science, facial aging, and regional nerve blocks for pain management. Meticulous anatomic descriptions and images depict the relationships between superficial and deeper structures such as vasculature, thereby providing vital knowledge to help clinicians avoid potentially serious complications"-- Provided by publisher.

Skin: Architecture and Function -- Skin Tissue Engineering -- Use of Novel Biomaterial Design and Stem Cell Therapy in Cutaneous Wound Healing -- In Vivo Visualisation of Skin Graft Revascularisation -- The Role of Elastin in Wound Healing and Dermal Substitute Design -- Surface Modi fi cation by Cold Gasplasma: A Method to Optimise the Vascularisation of Biomaterials -- Collagen Matrices with Enhanced Angiogenic and Regenerative Capabilities -- 3D Visualisation of Skin Substitutes -- Wound Coverage Technologies in Burn Care-Established and Novel Approaches -- Collagen Implants in Hernia Repair and Abdominal Wall Surgery -- The Use of Dermal Substitutes in Dermatosurgery -- The Use of Dermal Substitutes in Breast Reconstruction: An Overview -- Reconstruction of the Skin in Posttraumatic Wounds -- Subdermal Tissue Regeneration -- Bioengineering and Analysis of Oral Mucosa Models -- The Use of Dermal Substitutes in Burn Surgery: Acute Phase -- Burn Reconstruction.

This book provides clinicians, clinicians-in-training and researchers with a unique rapid-access educational resource on the spectrum of issues at the intersection of skin and malignancy. In it, there is clinical detail provided on how the skin reveals systemic malignancy via cutaneous metastases, genodermatoses or paraneoplastic dermatoses. At the same time, it reviews pharmacologic treatment of internal malignancy and how this can result in cutaneous adverse reactions; conversely, therapeutics for skin conditions can increase risk for internal malignancy. As arguably the most significant cutaneous malignancy, melanoma receives specific attention for its metastatic potential, current diagnostic advances, and recent therapeutic breakthroughs. Dermato-Oncology Study Guide: Essential Text and Review serves a critical educational need for clinicians caring for patients with systemic malignancy by creating an easy-to-use resource that provides practical tools to recognize skin signs of internal malignancy. Furthermore it helps in anticipating and managing adverse reactions of therapeutics for systemic malignancy, and gives the reader the opportunity to weigh the risks of malignancy of pharmacologic agents for skin disease.

Dermatoanthropology of Ethnic Skin and Hair is a comprehensive text that extensively examines cutaneous disease in persons with skin of color. The breadth of knowledge in this book encompasses the wide scope of dermatologic disease with 26 distinct and unique chapters. It serves as a guide to the diagnosis and treatment of skin disorders for those populations with darker skin types. Vashi and Maibach's Dermatoanthropology of Ethnic Skin and Hair provides an overview of medical, surgical, and cosmetic dermatology in addition to providing an extensive anthropological and basic science background to fully understand skin disorders in persons of color. Topics of discussion include anthropology of skin and hair, biophysical properties of ethnic skin, structure and function of the skin, physiologic pigmentation, mucosal lesions, acne, rosacea, inflammatory disorders, infections, autoimmune disorders, connective tissue disease, hyperpigmentation, hypopigmentation and depigmentation, keloids, scarring, pediatric disease, alopecias, adnexal disorders, common cosmetic concerns and treatments, and cultural considerations.

This extensively updated textbook reviews the ethical issues faced within dermatology. Bringing together practical real-life case scenarios and scholarly analysis, it covers the foundations of bioethics, as well as ethical issues associated with the various roles dermatologists play, including clinician, professional, educator, business person, and scholar. New chapters on the ethics of dermatologic care during pandemics, non-traditional interventions, private equity in dermatology, self-care and improvement, skin cancer screening, maintenance of certification, the ethics of clinical trial design are also included. Dermatoethics: Contemporary Ethics and Professionalism in Dermatology, 2nd Edition creates a dialogue around issues of ethics and professionalism within dermatology and is an essential text for both trainee and practicing dermatologists wishing to immerse themselves in the key questions in the discipline.

Section 1 Dermotology and Oncology 1 Epidemiology and Burden of Disease / Beth N. McLellan, Devika Patel and Mario E. Lacouture -- 2 The History of Supportive Oncodermatology / Yevgeniy Balagula, Steven T. Rosen and Mario E. Lacouture -- 3 Structure and Function of the Integumentary System and the Dermatology Lexicon / Emmy Garber and Amit Garg -- Types of dermatologic reactions / Raed O. Alhusayen, Sandra R. Knowles and Neil H. Shear -- 5 Grading Dermatologic Adverse Events on Clinical Trials using CTCAE v4.0 / Alice Chen, Asha Acharya and Ann Setser -- 6 Psychosocial Issues in Oncology: Clinical management of psychosocial distress, health-related quality of life and special considerations in dermatologic oncology / Lynne I. Wagner and David Cella -- 7 Dermatopathology / Molly A. Hinshaw and James L. Troy -- Section 2 8 Cancer-Related Dermatologic Disorders pareneoplastic, Inherited Cancer Syndrome, and Environmental Carcinogen-related Dermatoses / Cindy England Owen and Jeffrey P. Callen -- Section 3 Dermatologic Conditions During Cancer Therapy 9 Oral Mucosal Complications of Cancer Therapy / Stephen T. Sonis -- 10 Hair Disorders Associated with Anticancer Agents / Caroline Yeager and Elise A. Olsen -- 11 Nail Abnormalities in Oncology Practice / Robert Baran, Bernard Fouilloux and Caroline Robert -- 12 Pruritus / Tejesh Patel and Gil Yosipovitch -- 13 Management Options for Hot Flashes in Cancer Patients / Amanda R. Moraska and Charles L. Loprinzi -- Section 4 Skin toxicities due to chemotherapy 14 Alkylating agents / Elisabeth Livingstone, Lisa Zimmer, Larissa Schottler, Dirk Schadendorf -- 15 Antimetabolite Reactions / Emily Y. Chu and Heidi H. Kong -- 16 Topoisomerase-interacting agents / Tomas Skacel, Roger von Moos and Reinhard Dummer -- 17 Epidermal Growth Factor Receptor Inhibitor Reactions / Yevgeniy Balagula and Mario E. Lacouture -- 18 Small Molecule Kinase Inhibitors / Caroline Robert, Vincent Sibaud and Christine Mateus -- 19 Antimicrotubule agents / Claus Garbe -- 20 Histone Deacetylase Inhibitors, Proteasome inhibitors, Demethylating Agents, Arsenicals Retinoids / Najla Al-Dawsari, Shannon C. Trotter and Francine Foss -- 21 Miscellaneous Reactions / Katharina C. Kaehler, Christine B. Boers-Doets, Mario E. Lacouture and Axel Hauschild -- 22 Skin toxicities due to Biotherapy / Kathryn T. Ciccolini, Katherina C. Kaehler, Mario E. Lacouture and Axel Hauschild -- 23 Monoclonal antibodies / Caroline Robert -- 24 Endocrine Agents / Katherine Szyfelbein Masterpol, Maura Dickler and Mario Lacouture -- 25 Agents for the management of hematologic reactions / Mee-young Lee and Caroline C. Kim -- 26 Radiation-Induced Skin Reactions / Rebecca Wong and Zahra Kassam -- 27 Hematopoietic Stem Cell Transplantation and Graft Versus Host Disease / Stephanie Hu and Jonathan Cotliar -- 28 Extravasation Reactions / Seppo W. Langer -- 29 Topical Anticancer Therapies / Patricia L. Myskowski -- 30 Life-threatening (Serious) Dermatologic Adverse Events / Milan J. Anadkat -- 31 Dermatologic infections / Yevgeniy Balagula, Mario E. Lacouture and James I. Ito Section 5 Late Cutaneous Events from Cancer Treatments -- 32 Late Dermatologic Conditions / Jennifer Namchoi Section 6 Dermatologic Practice in Oncology 33 Management Algorithms for Dermatologic Adverse Events / Alyx Rosen, Iris Amitay-Laish and Mario E. Lacouture -- 34 Dermatological therapeutics and formulations / Judy H. Borovicka, Jennifer R.S. Gordon, Ann Cameron Haley, Nicole E. Larson and Dennis P. West 35 Dermatological Techniques and Procedures / Robert Eilers Jr., Kishwer S. Nehal and Erica H. Lee -- 36 Appearance-Related Concerns in the Cancer Patient / Amy J. Derick.

I: Fundamentals -- II: Surgical procedures for diagnosis, therapy, and reconstruction -- III: Regional approaches to reconstruction -- IV: Surgical approaches by disease state -- V: Cosmetic dermatologic surgery -- VI: Management of cosmetic conditions.

This book is a comprehensive introduction to ultrasonography of the skin, nails, and scalp as it relates to the assessment and diagnosis of dermatologic diseases. It provides a concise understanding of the diagnosis of dermatologic conditions through extensive high-resolution gray scale and color Doppler ultrasound images and presents classical correlations of clinical dermatologic lesions with sonographic and histologic findings.

Life span and life course approaches to dermatological disease / Ryff, C.D. -- Key concepts in the life course approach in medicine : allostatic load and cumulative life course impairment / Offidani, E.; Tomba, E.; Linder, M.D. -- Mathematical modeling in life course research / Barban, N.; Linder, M.D. -- Life course impairment and quality of life over time / Sampogna, F. -- Concept of major life-changing decisions in life course research / Bhatti, Z.U.; Salek, S.; Finlay, A.Y. -- Setting up a life course questionnaire / Sampogna, F. -- Cumulative life course impairment in chronic wounds / Augustin, M. -- Cumulative life course impairment : evidence for psoriasis / Mattei, P.L.; Corey, K.C.; Kimball, A.B. -- Cumulative life impairment by epidermolysis bullosa / Fine, J.-D. -- Cumulative life course impairment in vitiligo / Krüger, C.; Schallreuter, K.U. -- Cumulative life course impairment in melanoma and nonmelanoma skin cancer / Piaserico, S. -- Cumulative life course impairment : identifying patients at risk / Augustin, M. -- Cumulative life course impairment in dermatological diseases other than psoriasis : an overview / Ibler, K.S.; Jemec, G.B.E. -- Cumulative life course impairment across cultures and medical systems / Lima, X.T. -- Patients' narratives / Foulkes, A.C.; Warren, R.B.

Genodermatoses / Erin L. Reese -- Metabolic disorders / Davida A. Kornreich -- Hepatitis viruses / Ivy I. Norris and Cindy England Owen -- Human immunodeficiency virus / Caroline Y. Winslow and Francisco A. Kerdel -- Rheumatologic conditions / Kseniya Golubets, Dan Ilkovitch, and Lisa M. Grandinetti -- Xerosis / Connie M. Wu, Annie M. Wu, Jenna Lester, and Leslie Robinson-Bostom -- Pruritus in chronic kidney disease / Ehsan Azimi, Ethan A. Lerner, and Sarina B. Elmariah -- Dyschromias in renal disease / Mwatsveruka N. Munhutu and Rebat M. Halder -- Calcinosis cutis / Mitalee P. Christman and Daniela Kroshinsky -- Calciphylaxis / Julio C. Sartori-Valinotti and Mark Davis -- Acquired perforating disorders / Mieke L.F. Flour and Dirk R.J. Kuypers -- Nephrogenic systemic fibrosis / Avery LaChance, Ali K. Abu-Alfa, and Shawn E. Cowper -- Blistering disorders (Porphyria cutanea tarda and Pseudoporphyria) / Christine A. DeWitt, Kara M. Trapp, and Melissa A. Muszynski -- Nail diseases among renal patients / Avner Shemer, Nicole Sakka, and C. Ralph Daniel III -- Alopecias / Kimberly Scott Salkey -- Uremic frost / Kristie Lynn Slivka Delaney, Edgar V. Lerma, and Julia R. Nunley -- Infections in the kidney transplant recipient / James D. Russell and Calvin O. McCall -- Cutaneous malignancies / Melina B. Chu, Brandon T. Beal, and Ian A. Maher -- Miscellaneous drug related adverse effects / Punam H. Patel and Krista L. Donohoe -- Drug dosing in patients with chronic kidney disease and dermatological diseases / Ali J. Olyaei and Edgar V. Lerma.

Contents. - pt. 1. A study of health manpower resources, 1963-1970.

Basic principles of dermatology -- Anatomy and physiology -- Skin development and maintenance -- Molecular biology -- Immunology -- Cutaneous neurophysiology -- Pruritus and dysesthesia -- Psychocutaneous diseases -- Psoriasis -- Other papulosquamous disorders -- Erythroderma -- Lichen planus and lichenoid dermatoses -- Atopic dermatitis -- Other eczematous eruptions -- Allergic contact dermatitis -- Irritant contact dermatitis -- Occupational dermatoses -- Dermatoses due to plants -- Urticaria and angioedema -- Figurate erythemas -- Erythema multiforme, stevens-johnson syndrome, and toxic epidermal necrolysis -- Drug reactions -- Purpura : mechanisms and differential diagnosis -- Cutaneous manifestations of microvascular occlusion syndromes -- Cutaneous vasculitis -- Eosinophil-associated dermatoses -- Neutrophilic dermatoses -- Pregnancy dermatoses -- The biology of the basement membrane -- Pemphigus -- Pemphigoid group -- Dermatitis herpetiformis and linear IgA bullous dermatosis -- Epidermolysis bullosa -- Other vesiculobullous diseases -- Vesiculopustular and erosive disorders in newborns and infants -- Structure and function of eccrine, apocrine and sebaceous glands -- Acne vulgaris -- Rosacea and related disorders -- Folliculitis and other follicular disorders -- Diseases of the eccrine and apocrine sweat glands -- Autoantibodies encountered in patients with autoimmune connective tissue diseases -- Lupus erythematosus -- Dermatomyositis -- Systemic sclerosis (scleroderma) and related disorders -- Morphea and lichen sclerosus -- Other rheumatologic disorders and autoinflammatory diseases -- Mucinoses -- Amyloidosis -- Deposition diseases -- Porphyria -- Calcifying and ossifying disorders of the skin -- Nutritional diseases -- Graft-versus-host disease -- Dermatologic manifestations in patients with systemic disease -- Basic principles of genetics -- Genetic basis of cutaneous diseases -- Biology of keratinocytes -- Ichthyoses, erythrokeratodermas, and related disorders -- Palmoplantar keratodermas -- Darier disease and Hailey-Hailey disease -- Primary immunodeficiencies -- Neurofibromatosis and tuberous sclerosis complex -- Mosaicism and linear lesions -- Other genodermatoses -- Developmental anomalies -- Melanocyte biology -- Vitiligo and other disorders of hypopigmentation -- Disorders of hyperpigmentation -- Biology of hair and nails -- Alopecias -- Hypertrichosis and hirsutism -- Nail disorders -- Oral disease -- Anogenital (non-venereal) disease -- Bacterial diseases -- Mycobacterial infections -- Rickettsial diseases -- Fungal diseases -- Cutaneous manifestations of HIV infection -- Human papillomaviruses -- Human herpesviruses -- Other viral diseases -- Sexually transmitted infections -- Protozoa and worms -- Infestations -- Bites and stings -- Ultraviolet radiation -- Photodermatologic disorders -- Environmental and sports-related skin diseases -- Signs of drug abuse -- Skin signs of abuse -- Histiocytoses -- Xanthomas -- Non-infectious granulomas -- Foreign body reactions -- Biology of the extracellular matrix -- Perforating diseases -- Heritable disorders of connective tissue -- Dermal hypertrophies -- Atrophies of connective tissue -- Panniculitis -- Lipodystrophies -- Vascular biology -- Infantile hemangiomas -- Vascular malformations -- Ulcers -- Other vascular disorders -- Principles of tumor biology and pathogenesis of BCCS and SCCS -- Actinic keratosis, basal cell carcinoma, and squamous cell carcinoma -- Benign epidermal tumors and proliferations -- Cysts -- Adnexal neoplasms -- Benign melanocytic neoplasms -- Melanoma -- Vascular neoplasms and neoplastic-like proliferations -- Neural and neuroendocrine neoplasms (other than neurofibromatosis) -- Fibrous and fibrohistiocytic proliferations of the skin and tendons -- Smooth muscle, adipose and cartilage neoplasms -- Mastocytosis -- B-cell lymphomas of the skin -- Cutaneous T-cell lymphoma -- Other lymphoproliferative and myeloproliferative diseases -- Cutaneous metastases -- Public health and dermatology -- Skin barrier and transdermal drug delivery -- Glucocorticoids -- Retinoids -- Antimicrobial drugs -- Systemic immunomodulators -- Other topical medications -- Other systemic drugs -- Drug interactions -- Sunscreens and photoprotection -- Complementary and alternative medicine -- Ultraviolet therapy -- Photodynamic therapy -- Lasers and other energy-based technologies - principles and skin interactions -- Lasers and other energy-based therapies -- Cryosurgery -- Radiotherapy -- Electrosurgery -- Biology of wound healing -- Surgical anatomy of the head and neck -- Anesthesia -- Wound closure materials and instruments -- Dressings -- Biopsy techniques and basic excisions -- Flaps -- Grafts -- Nail surgery -- Mohs micrographic surgery -- Surgical complications and optimizing outcomes -- Evaluation of beauty and the aging face -- Cosmetics and cosmeceuticals -- Chemical and mechanical skin resurfacing -- Phlebology and treatment of leg veins -- Body contouring : liposuction and non-invasive modalities -- Hair restoration -- Injectable soft tissue augmentation -- Botulinum toxin.

"Dermatology: An Illustrated Colour Text is an ideal resource for today's medical student, hospital resident, specialty registrar in dermatology or internal medicine, specialist nurse or family doctor. It presents the subject as a series of two page 'learning units', each covering important aspects of clinical dermatology. These units use an unsurpassed collection of colour clinical photographs of all major dermatological conditions, concise yet comprehensive text and Key Point boxes to aid quick access to information and examination preparation. They incorporate summaries of the essential skin biology and associated basic sciences that underpin clinical practice, as well as advice on established and emerging dermatological treatments. Guidance is also given to dermatological emergencies, and to the most useful online resources for updates and further reference. Building on previous success, this seventh edition has been fully revised throughout"--Publisher's description.

A fully-illustrated, note-packed volume of information, Dermatology: Illustrated Study Guide and Comprehensive Board Review fulfills a real need for a single study guide for the Dermatology Board Exam. Written by a previous Chief Resident of Dermatology at the University of Illinois at Chicago Medical Center, the text focuses on presenting comprehensive information in an easy-to-understand, easy-to-remember format. The second edition of this incredibly popular book includes updated coverage of new medications, new entities, and over 300 additional full-color clinical and histological images. Following the layout of the successful first edition, even more tips, short lists, and tables, including mnemonics and memory tricks to mentally organize information fill every inch of this book - a must-have for any dermatologist and dermatology resident.

This book reviews the dermatological manifestations of Diabetes Mellitus, including a broad spectrum of conditions since the dysfunction of the cutaneous barrier, going through cutaneous infections in diabetics, dermatoses associated to Diabetes and manifestations related to Diabetes treatment. Moreover, the book comprises the latest concepts regarding epidemiology, classification, diagnosis and treatment of Diabetes Mellitus, insulin resistance and metabolic syndrome, including useful tools for the management of patients with diabetes. It explains why skin conditions have such a great impact on the quality of life of these patients, particularly the subset of patients with diabetic foot syndrome. Dermatology and Diabetes discusses all these dermatologic conditions and provides a roundup of the current guidelines in diabetic patients. Taking into account the critical differential diagnostic information and therapeutic options, the book is an important reference for clinical dermatologist and all health care professionals involved.

This atlas, containing more than 300 color photos, focuses on those dermatologic conditions that are most common in ethnic skin or skin of color. It includes succinct explanations of each disease process, describes clinical findings, and presents key information on diagnosis and treatment. Individual chapters are devoted to pigmentary disorders, follicular disorders, hair and scalp disorders, eczemas, papulosquamous disorders, granulomatous disorders, connective tissue diseases, infectious diseases, scarring disorders, cutaneous neoplasms, photodermatoses and drug eruptions. The fact that this atlas covers skin disorders that affect patients of all ethnic backgrounds ensures that it will be of worldwide relevance. It will serve as a valuable reference for dermatologists and a range of other health care providers.

Dermatology Essentials, edited by world authorities Drs. Jean L. Bolognia, Julie V. Schaffer, Karynne O. Duncan, and Christine J. Ko, provides the quick answers you need on every important aspect of dermatology and guidance on their application in your day-to-day practice. Derived from the renowned authoritative reference work Dermatology, 3rd Edition, this on-the-go reference distills the essential information needed to quickly diagnose and manage a wide range of dermatologic disorders-without the need for any additional resources. Review or refresh your knowledge of the fundamentals and diagnostic approaches of skin disease with unique introductory chapters providing the basic principles of dermatology, bedside diagnostics, and clinical approach to a fever and rash - extremely helpful for the beginner. Visualize more of the conditions you see in practice with over 1,500 clinical images, illustrations, and schematics. Avoid diagnostic pitfalls using practical tables, intuitive artworks, and logical algorithms. Find answers fast with a highly user-friendly, "easy-in-easy-out" format and a wealth of tables and schematics for instant visual comprehension. Expedite decision making with easily recognizable DDx and Rx sections to provide rapid direct reference to the expert guidance and treatment recommendations. Downloadable worksheets are also available. Make the most of electronic functionality with access to the complete contents online and in various ebook formats - making it easy to teach impromptu on a tablet in the clinic, or conduct more formal lecturing.

Dermatology clinics are extremely fast-paced, and while the internet is useful, online resources can slow clinics down as it can often take lengthy amounts of time to obtain meaningful information. Recognizing this problem, Dr. Vashi has developed, over the course of several years, a practical guide targeted towards practicing dermatologists, resident physicians, medical students, family practitioners, nurse practitioners, and physician assistants. The Dermatology Handbook provides clinical information and quick solutions to common problems typically faced by dermatologists in a user-friendly and meaningful way. Designed to fit into a coat pocket, the content is presented as bulleted lists, along with tables and algorithms to allow busy clinicians to find the information they need rapidly. Featuring fill in the blank pages for users to personalize, this handbook is at once both comprehensive and succinct. Chapters include sections on the most common dermatologic complaints, differential diagnoses, laboratory techniques, dermoscopy, dermatologic emergencies, commonly used medications, pediatrics, surgery basics, and cosmetic pearls. Drug tables, guidelines, and algorithms for history taking and treatment approach also work to provide the reader with efficient usability.

This book provides a reference guide in the field of dermatology, presenting and discussing its interface with public health. Dermatological diseases are extremely common in populations around the globe, and the systematization of knowledge about these dermatoses and their relationships with different epidemiological factors may help us to understand the challenges that governments and private institutions face and must try to overcome in order to improve global health. Undergraduate and graduate students, dermatologists and general practitioners who study and / or work in the area will find scientific support in this book, which is intended as a reference work for dermatological practice and public health. The book has ten sections addressing carefully selected topics, including: 1. concepts in dermatoepidemiology and the international strategies in programs of Public Health; 2-6. the most significant skin diseases (including dermatology in tro pical medicine); 7. diseases that are not primarily dermatological, but have a high impact on public health and may have skin and mucosal manifestations; 8. a number of emerging issues in dermatology in public health; 9. clinical approaches (diagnosis and management) to common dermatological symptoms and 10. multidisciplinary approaches in dermatology. The editors have brought together authors with extensive experience in their respective fields in order to provide a reference book for those involved in or with an interest in the relationship between dermatology and public health.

This book addresses the maldistribution of health care between people in dense cities and more rural areas. This proactive resource provides solutions that will motivate dermatologists to make a difference, including free rural clinics and incentives to attract dermatologists to the aforementioned areas. Comprehensive yet concise, the book encompasses not only the logistics of the healthcare issues, including location, incentive, and set up of facility but includes insight into the effectiveness of teledermatology, a practice more commonly utilized due to the COVID-19 Pandemic. Additionally, chapters examine the relationship between economic viability and quality of care, as well as government incentives and political action to mitigate this issue. Unique and timely, Dermatology in Rural Settings is an invaluable resource for dermatologists, resident dermatologists, and academic physicians interested in rural and urban health.

Inflammatory disease of the dermis and epidermis / Maxwell A. Fung -- Panniculitis / Maxwell A. Fung -- Infectious diseases of the skin / Helen M. Chen, Anca G. Prundeanu Croitoru, Stefanie Hu, Hideko Kamino, Marcia Ramos-e-Silva, Klaus J. Busam -- Cutaneous vasculitis / Rami N. Al-Rohil, J. Andrew Carlson -- Blistering skin diseases / Jacqueline M. Junkins-Hopkins, Klaus J. Busam -- Mucinoses, deposition disorders, and connective tissue alterations / Franco Rongioletti, Jacqueline Granese, Jacqueline Junkins-Hopkins, Luis Requena -- Non-neoplastic disorders of pigmentation / Ravi Ubriani, Loren E. Clarke, Michael E. Ming -- Non-neoplastic disorders of hair / Klaus Sellheyer, Wilma F. Bergfeld -- Cysts and sinuses / Douglas R. Fullen -- Tumors of the epidermis / Angela J. Wyatt, Klaus J. Busam -- Adnexal tumors / Victor G. Prieto, Christopher R. Shea, Julide Tok Celebi, Klaus J. Busam -- Melanocytic proliferations / Klaus J. Busam -- Soft tissue tumors and tumor-like reactions / Darya Buehler, Steven D. Billings -- Hematopoietic neoplasms / Jacqueline M. Junkins-Hopkins, Patricia L. Myskowski, Melissa P. Pulitzer -- Histiocytic proliferative disorders / Bijal Amin, Melissa P. Pulitzer, Klaus J. Busam -- Cutaneous neuroendocrine (Merkel cell) carcinoma / Bijal Amin, Klaus J. Busam -- Cutaneous metastases / Richard A. Scolyer, John F. Thompson, Annabelle Mahar, Rajmohan Murali -- Neoplastic and non-neoplastic disorders of the nail apparatus / Beth S. Ruben -- Neoplastic and non-neoplastic disorders of the conjunctiva and eyelid / Jasmine Francis, Klaus J. Busam, Brian Marr -- Evaluations of sections from Mohs surgery / Kishwer S. Nehal, Marie Tudisco, Klaus J. Busam.

"Offering a unique combination of expert online lectures, vast image collections both in print and online, and an easy-to-use print atlas, Dermatopathology, 3rd Edition, helps you master the complexities of this challenging and fast-changing subspecialty. Dr. Elston and his colleagues make dermatopathology easier to understand, leading you to efficient, accurate diagnoses of the most important common dermatologic findings seen in practice"--Publisher's description.

This updated second edition provides a structured and highly illustrated guide to dermatopathology. It focuses on the most common dermatopathological diagnoses and presents their clinical, histological, and differential diagnostic features of the diseases. New chapters cover various inflammatory diseases such as interstitial granulomatous dermatitis and filler reactions as well as cutaneous neoplasms such as digital papillary adenocarcinoma. Dermatopathology aims to help readers to rapidly identify patterns and specific diagnostic features. The book is relevant to both practicing and trainee dermatologists and pathologists.

With a unique combination of targeted online lectures, vast online image collections, and an easy-to-follow supporting atlas, Dr. Elston's highly acclaimed "dermatopathology made easier" approach presents a unique way to master the foundations of this complex dermatology sub-specialty, guiding you through the diagnosis of the most important and common dermatologic pathology findings seen in practice. Effortlessly find all the information you need to know about each topic thanks to a highly user-friendly full-color format and a consistent chapter template

Elements of Cutaneous Embryology, Anatomy, and Biochemistry -- Classification of Cutaneous Lesions -- Hereditary Lesions -- Malformative Lesions -- Inflammatory Cutaneous Lesions -- Proliferative Cutaneous Lesions -- Miscellaneous Cutaneous Lesions.

With significant progress as new techniques to evaluate the pathology of the skin, this book satisfies the need to provide practical clinical information and concise criteria for pathologic diagnosis for pathologists and dermatologists looking for an up-to-date resource. This superb visual reference provides detailed instruction of the experience of both diagnostic pathology and clinical dermatology. Dermatopathology: Clinicopathological Correlations is a comprehensive but concise visual reference that contains specific features on the various clinical findings and histologic findings of skin diseases. It emphasizes criteria for diagnosis to help the trainee pathologist or dermatologist decipher the most important features and make clinical decisions quickly and effectively.

Shape on low power -- Gestalt : rash/inflammatory -- Cell type -- Top-down -- Color : blue -- Color : pink.

Dermatopathology A-Z is intended to serve as an easily accessible tool for diagnostic criteria and images of all entities that might be encountered. This comprehensive book is designed to help a novice in the field quickly learn diagnostic criteria and memorize the images, while more experienced dermatopathologists or surgical pathologists can quickly refresh their visual memory by reviewing images of two cases of a particular disease. Alphabetically organized, this image-heavy text provides visual aid and succint pathological description on nearly 600 different diseases.

This book offers a unique checklist methodology for learning how to use dermosocpy to diagnose benign and malignant pigmented and non-pigmented skin lesions. Each high-quality, full-color clinical and dermoscopic image is presented with short history.

This atlas presents dermoscopic-histopathological correlations of dermatologic and pathological presentations seen in the Asian subcontinent. The disorders have been explained with the help of state of the art clinical, dermoscopic and pathological figures of various entities in skin of color. The format has been kept simple and easy to understand which is deciphered through dermoscopic and histopathological correlation. This title also emphasizes on atypical presentations and rare dermoscopic features with the help of thorough description covering clinical and pathological manifestations, diagnosis, and differential diagnosis. Written for dermatologists, dermato-pathologists, dermoscopists and residents of dermatology, this atlas is a detailed visual guide to effectively evaluate and diagnose various skin disorders.

"Dermoscopy: The Essentials presents the practical guidance you need to master this highly effective, more economical, and less invasive alternative to biopsy. Drs. Peter Soyer, Giuseppe Argenziano, Rainer Hofmann-Wellenhof, and Iris Zalaudek explain all aspects of performing dermoscopy and interpreting results. With approximately 30% new clinical and dermoscopic images, valuable pearls and checklists, and online access to the fully searchable and downloadable text, you'll have everything you need to diagnose earlier and more accurately"--Publisher's description.

Dermoscopy from A to Z -- Comprehensive dermoscopy criteria review -- Benign and malignant melanocytic lesions -- Benign and malignant non-melanocytic lesions -- Dermoscopy in general dermatology / Aimilios Lallas -- Trichoscopy/hair / Antonella Tosti.

pt. I. Introduction -- Basic statistical concepts -- Basic design considerations -- Randomization and blinding -- pt. II. Designs and their classifications -- Designs for clinical trials -- Designs for cancer clinical trials -- Classification of clinical trials -- pt. III. Analysis of clinical data -- Analysis of continuous data -- Analysis of categorical data -- Censored data and interim analysis -- Sample size determination -- pt. IV. Issues in evaluation -- Issues in efficacy evaluation -- Safety assessment -- pt. V. Recent development -- Biomarkers and targeted clinical trials -- Trials for evaluating accuracy of diagnostic devices -- Statistical methods in translational medicine -- Adaptive clinical trial designs -- Traditional Chinese medicine -- pt. VI. Conduct of clinical trials -- Preparation and implementation of a clinical protocol -- Data management of a clinical trial.

Design and Development of New Nanocarriers focuses on the design and development of new nanocarriers used in pharmaceutical applications that have emerged in recent years. In particular, the pharmaceutical uses of microfluidic techniques, supramolecular design of nanocapsules, smart hydrogels, polymeric micelles, exosomes and metal nanoparticles are discussed in detail. Written by a diverse group of international researchers, this book is a valuable reference resource for those working in both biomaterials science and the pharmaceutical industry.

This book outlines the approach to comprehensive men's health deployed at three of the most successful American men's health centers. It demonstrates the ways in which multidisciplinary care allows patients to easily access their doctors via coordination of care, same day add-on visits, and streamlining of office logistics such as sharing of charts, reports, and results. Guiding readers in establishing an evidence-based, multidisciplinary approach to the management of male patients of all ages, this volume shows how prevention, rapid intervention, cost efficiency, and coordinated care are at the forefront of a health center's care strategy. The authors of this volume are thought leaders in the disciplines of cardiology, gastroenterology, dermatology, psychiatry, and preventative medicine. Design and Implementation of the Modern Men's Health Center: A Multidisciplinary Approach enables urologists, medical subspecialists, and surgical subspecialists to both manage basic patient issues and also to understand how multidisciplinary care enables the success of a men's health center.

Adopting a unique approach, this book provides a thorough, one-stop introduction to nanoscience and self-assembly of nanomaterials composed of such materials as metals, metal oxides, metal sulphides, polymers, and biopolymers. Clearly divided into three sections covering the main aspects of nanoscience, the first part deals with the basic principles of nanoscale science. Alongside essential approaches and forces, this section also covers thermodynamics, phase transitions, and applications to biological systems. The second and third parts then go on to provide a detailed description of the synthesis of inorganic and organic nanoparticles, respectively. With its interdisciplinary content of importance to many different branches of nanoscience, this is essential reading for material scientists, physicists, biophysical chemists, chemical engineers, and biotechnologists alike.

Design of Nanostructures for Versatile Therapeutic Applications focuses on antimicrobial, antioxidant and nutraceutical applications of nanostructured materials. Many books discuss these subjects, but not from a pharmaceutical point-of-view. This book covers novel approaches related to the modulation of microbial biofilms, antimicrobial therapy and encapsulate polyphenols as antioxidants. Written by an internationally diverse group of academics, this book is an important reference resource for researchers, both in biomaterials science and the pharmaceutical industry.

Identifies and presents a variety of contemporary technologies to support older adults' abilities to perform everyday activities. Efforts of industry, laboratories, and learning institutions are documented under four major categories: social connections, independent self care, healthy home and active lifestyle. The book contains well-documented and illustrative recent examples of designed technologies--ranging from wearable devices, to mobile applications, to assistive robots-- on the broad areas of design and computation, including industrial design, interaction design, graphic design, human-computer interaction, software engineering, and artificial intelligence.

Defining the functional equivalence of wild-type and chemically engineered G protein-coupled receptors / Elisa Alvarez-Curto and Graeme Milligan -- Design and analysis of an arrestin-biased DREADD / Ken-ichiro Nakajima ... [et al.] -- Regulation of gene transcription following stimulation of Gαq-coupled designer receptors / Oliver G. Rössler and Gerald Thiel -- Chemogenetic deconstruction of feeding circuits / Michael Krashes -- Dissecting neuronal circuits involved in olfactory-mediated behaviors / Alexia Nunez-Parra ... [et al ] -- Use of DREADDs (Designer Receptors Exclusively Activated by Designer Receptors) in transgenic mouse behavioral models / Daniela Cassataro and Lucas Sjulson -- Pharmacogenetic dissection of neural mechanisms underlying the regulation of sleep-wakefulness using DREADDs / Michihiro Mieda and Takeshi Sakurai -- DREADD'ed addiction : using designer receptors to delineate neural circuits underlying drug-seeking behaviors / Sunila G. Nair, Denis Smirnov, and John F. Neumaier -- DREADDs in Drosophila melanogaster / Charles D. Nichols and Jaime Becnel.

"This book provides a practical guide to planning, tabulating, formulating, and implementing clinical research, in an easy-to-use, readable presentation"--Provided by publisher.

"For over 30 years, this title sets the standard as a practical guide for physicians, nurses, pharmacists and other practitioners involved in all forms of clinical and public health research. It presents the epidemiologic concepts in a reader-friendly way and suggests common sense approaches to the challenging judgments involved in designing, funding and implementing a study. Translated in many languages over the years, it is a manual for clinical research in it various flavors: clinical trials, observational epidemiology, translated science, patient-oriented research. Epidemiologic- terms and principles, presented advanced conceptual material in a practical and reader friendly way and suggested common sense approaches to many judgments involved in designing a study"-- Provided by publisher.

This book presents a comprehensive study covering the design and application of microwave sensors for glucose concentration detection, with a special focus on glucose concentration tracking in watery and biological solutions. This book is based on the idea that changes in the glucose concentration provoke variations in the dielectric permittivity of the medium. Sensors whose electrical response is sensitive to the dielectric permittivity of the surrounding media should be able to perform as glucose concentration trackers. At first, this book offers an in-depth study of the dielectric permittivity of waterglucose solutions at concentrations relevant for diabetes purposes; in turn, it presents guidelines for designing suitable microwave resonators, which are then tested in both waterglucose solutions and multi-component human blood plasma solutions for their detection ability and sensitivities. Finally, a portable version is developed and tested on a large number of individuals in a real clinical scenario. All in all, the book reports on a comprehensive study on glucose monitoring devices based on microwave sensors. It covers in depth the theoretical background, provides extensive design guidelines to maximize sensitivity, and validates a portable device for applications in clinical settings. .

"Clear, polished, and stimulating presentations are as important to the scientific profession as they are to business, yet most scientists never receive formal training in the creation, delivery, and evaluation of such material." ... "Designing Science Presentations provides visually intensive guidance at every step-from the construction of original figures to the presentation and delivery of those figures in papers, slideshows, posters, and websites." --Excerpts from publisher's description.