BookPaolo Sbraccia, Nicholas Finer, editors.
Summary: This book presents the latest advances in our understanding of the pathophysiologic basis that induces the chronic positive energy balance necessary to progressively store excessive amounts of fat mass. It highlights the clinical complications of obesity, while also focusing on the major scientific advances that have highlighted the role of genetics, adipose tissue endocrinology and the environment in the mechanisms and causes of obesity. Particular attention is given to the consequences of obesity, including an ever -increasing number of other diseases such as type 2 diabetes, cardiovascular diseases and cancer, as well as conditions such as arthropathy, asthma, non-alcoholic liver disease, and dementia. Increasingly recognized uniting causes highlight the role of systemic, local and paracrine actions of adipocytokines in causing inflammation. As we come to better understand how hypothalamic control of energy balance is influenced by endocrine signaling from the gut and adipose tissue, it paves the way for new therapeutic targets and a resurgence of pharmacological and surgical approaches to treatment. Written by respected experts in the field, this volume is intended as a major reference source for endocrinologists, nutritionists, basic and clinical scientists alike.
Contents:
Epidemiology
Genetics
Epigenetics and fetal programming
Neuroendocrinology of energy balance
The adipose organ
Role of gut hormones
Pathogenesis
Environmental factors: pollutants, viruses food
Food, metabolism and longevity
The microbiota and energy balance
Eating disorders
Clinical assessment of the patient with overweight or obesity
Obesity and NAFLD
Obesity and type 2 diabetes
Obesity and hypertension
Obesity and dyslipidemia
Obesity and obstructive sleep apnoea syndrome
Impact of obesity on cardiovascular disease
Obesity and psychiatry
Obesity in Children
Dietary treatment
Physical exercise
Cognitive and behavioral approaches
Pharmacological approaches
Surgical approaches
An integrated view of treatment options.