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  • Book
    Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter ; with problems by John Wilson, Tim Hunt.
    Summary: "As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts. As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced. Protein structures better illustrate structure-function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing open-ended questions highlighting "What We Don't Know," introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text. Thought-provoking end-of-chapter questions have been expanded to all chapters, including questions on developmental biology, tissues and stem cells, the immune system, and pathogens."-- Provided by publisher.

    Contents:
    Cells and genomes
    Cell chemistry and bioenergetics
    Proteins
    DNA, chromosomes, and genomes
    DNA replication, repair, and recombination
    How cells read the genome: from DNA to protein
    Control of gene expression
    Analyzing cells, molecules, and systems
    Visualizing cells
    Membrane structure
    Membrane transport of small molecules and the electrical properties of membranes
    Intracellular compartments and protein sorting
    Intracellular membrane traffic
    Energy conversion: mitochondria and chloroplasts
    Cell signaling
    The cytoskeleton
    The cell cycle
    Cell death
    Cell junctions and the extracellular matrix
    Cancer
    Development of multicellular organisms
    Stem cells and tissue renewal
    Pathogens and infection
    The innate and adaptive immune systems.
    Print
    Location
    Version
    Call Number
    Items
    Course Reserves: Request at Lane Information Desk
    2015
    QH581.2 .M64 2015
    1
  • Article
    Martin WJ, Taylor JC.
    Am Rev Respir Dis. 1979 Aug;120(2):411-9.
    The interaction of serum alpha 1-antitrypsin with leukocyte elastolytic activity was examined in 71 patients with chronic obstructive pulmonary disease and 46 normal subjects. Residual elastolytic activity was present despite adequate amounts of alpha1-antitrypsin in 33 of the 71 patients compared to 6 of the 46 normal control subjects (P less than 0.001). This elastolytic activity was completely abolished by a specific human leukocyte elastase inhibitor. A crossover study designed to detect the source of this abnormal activity revealed that the plasma fraction containing alpha 1-antitrypsin was responsible for inadequate inhibition in 30 of the 39 cases. The residual elastolytic activity from a given patient did not correlate with the serum alpha 1-antitrypsin concentration, alpha 1-antitrypsin phenotype, or history of smoking. Our data suggest that the abnormal interaction of alhpa 1-antitrypsin with leukocyte elastolytic activity is an important additional variable in the gensis of chronic obstructive pulmonary disease.
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