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  • Book
    James E. Barrett, Clive P. Page, Martin C. Michel, editors.
    Summary: Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.

    Contents:
    Intro
    Preface
    Contents
    Part I: A Century of Advances in Pharmacology
    Perspectives of Pharmacology over the Past 100 Years
    1 Introduction
    2 The Emergence of Pharmacology in Germany: Rudolf Buchheim
    2.1 Schmiedebergś Contribution to the Development of Pharmacology
    3 The Spread of Pharmacology
    3.1 Otto Krayer and the Origins of Behavioral Pharmacology
    4 Pharmacology Through 100 Years and a Future Perspective
    5 Conclusions
    References
    Emergent Concepts of Receptor Pharmacology
    1 Introduction
    2 Shots in the Dark: Null Methods in Pharmacology 1.2 Signalling in Health and Malignant Disease
    1.3 Tumour Microenvironment and Host Immunity
    2 Introduction
    2.1 History
    2.2 Roles for Systemic Therapies
    2.3 Cytotoxic Drugs
    Box 1 Summary of Broad Classes of Cytotoxic Drugs
    2.4 Targeted Therapies
    2.5 Immunotherapy
    3 Clinical Trials in Oncology
    3.1 Phase 1 Trials
    3.2 Phase 2 Trials
    3.3 Phase 3 Trials
    4 Rationally Designed Therapies
    Box 2 Targets for Anticancer Therapies: Examples of Approved and Investigational Drugs
    4.1 Ligands as a Target
    4.1.1 Oestrogen
    4.1.2 Androgen
    4.2 Targeting Receptors 3 Recombinant Systems Redefine Receptor Pharmacology
    4 Binding Gives Way to Functional Experiments
    5 Understanding Agonism: The Black/Leff Operational Model
    6 The Shift from Orthosteric to Allosteric Drug Action
    7 The Move from Parsimonious Models to Dynamic Models of Receptor Conformation
    8 Allosteric Probe Dependence: Biased Receptor Signaling
    9 Structure: Receptors Show Themselves
    10 Genetics and Computer Science Impact Pharmacology
    11 Conclusion
    References
    The Evolving Landscape of Cancer Therapeutics
    1 Biology of Cancer
    1.1 Cancer as a Genetic Disease 4.2.1 Vascular Endothelial Growth Factor (VEGF) and Its Receptors
    4.2.2 Epidermal Growth Factor Receptor
    4.2.3 HER2
    4.2.4 CD20
    4.3 Other Targets
    4.4 Targeting the T-Cell
    4.4.1 Checkpoint Inhibition
    4.4.2 Adoptive T-Cell Therapy
    5 Nuclear Medicine Therapies
    5.1 Radio-Iodine in Thyroid Cancer
    5.2 Somatostatin Analogues
    5.3 Radium-223
    5.4 PSMA Ligand: Lutetium
    6 Pharmacogenetics, Pharmacogenomics and Patient Selection for Treatment
    6.1 Lung Cancer and EGFR Mutations
    6.2 BRCA1, BRCA2 Mutation and PARP Inhibition
    6.3 Prediction of Toxicity 7 Resistance Mechanisms
    7.1 CML BCR-ABL Mutations and Resistance to Imatinib
    7.2 Molecular Markers of Resistance to EGFR Inhibition
    7.2.1 Multiple Targets
    7.2.2 Irreversible Binding
    7.3 ALK Resistance
    8 Cancer Drug Discovery and Preclinical Development
    9 Current Issues in the Development of Drugs in Oncology
    9.1 Improving the Odds of Success of Phase 3 Trials
    9.2 Regulation of Cancer Drug Development
    10 Conclusion and Future Perspectives
    References
    Monoclonal Antibodies: Past, Present and Future
    1 Introduction
    2 Background.
    Digital Access Springer 2019
  • Article
    Haltia M, Tarkkanen A, Vaheri A, Paetau A, Kaakinen K, Erkkilä H.
    Br J Ophthalmol. 1978 Jun;62(6):356-60.
    A 14-year-old boy had an acute attack of measles while on cytotoxic chemotherapy for a testicular neoplasm. Two months later a fatal measles encephalopathy developed, verified by histological, ultrastructural, and immunofluorescent studies. Ophthalmoscopy showed progression of flat depigmented areas of the retina as well as prominent lesions mimicking central serous retinopathy or retinitis. Histopathological studies showed focal retinal necroses with invasion of pigment-laden macrophages into the retina. There were no inflammatory cell infiltrations in the choroid. The presence of structures with the morphological and antigenic properties of measles virus in the affected areas of the retina was shown by electron microsocpy and indirect immunofluorescence. With the increase of immunosuppressive therapy for various purposes the incidence of opportunistic measles virus infections is likely to rise. In the clinical management of such complications ophthalmological examination may prove very helpful.
    Digital Access Access Options