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  • Book
    Lucio Miele, Spyros Artavanis-Tsakonas, editors.
    Summary: The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis, tumor-stroma interaction and anti-cancer immune responses. A number of observations have revealed that Notch even plays a role in the renewal of cancer stem cells and tumor initiating cells, which are thought to be a major cause of resistance to treatment. Targeting Notch in Cancer will provide researchers, oncologists, pharmacologists and students with a detailed understanding of the intricate cross-talk between Notch and other pathways of therapeutic interest so to better design rational drug combinations for specific diseases and disease subsets. Divided into two parts, Part I describes in detail what we know about the genetics, molecular biology, biochemistry and structural biology of Notch, as well as the role of Notch in such processes as angiogenesis and immune surveillance. Without insights gained from these basic studies, rational targeting of Notch in human disease would be impossible. Part II describes the role of Notch and ongoing experimental therapeutic efforts in the most important subtypes of human cancers, organized in a clinically oriented fashion by organs and systems affected.

    Contents:
    Structural Biology of Notch Signaling
    Non-Canonical Notch Signaling
    Dual Function of Notch Signaling in Cancer
    Oncogene and Tumorsuppressor
    Out on the Fringe: Modulation of Notch Signaling by Glycosylation
    Notch signaling: A pivot regulator of adaptive and innate immunity
    Notch in Ovarian Cancer
    Notch Signaling in Graft-versus-Host Disease
    Notch Signaling in T-Cell Acute Lymphoblastic Leukemia and Other Hematologic Malignancies
    The Role of Notch in Breast Cancer
    Notch in Lung Cancer
    Notch Signaling in Pediatric Soft tissue Sarcoma
    Notch Ligands in Hematopoietic Stem Cell production
    Notch Signaling in the normal intestine and intestinal Cancer
    Notch Signaling in Estrogen-Dependent Cancers
    Index.
    Digital Access Springer 2018
  • Article
    Abney ER, Cooper MD, Kearney JF, Lawton AR, Parkhouse RM.
    J Immunol. 1978 Jun;120(6):2041-9.
    Paired immunofluorescent staining with antibodies specific for the major isotypes of mouse immunoglobulin was used to study the ontogenetic expression of diversity of cell surface immunoglobulin. The first B lymphocytes to emerge, derived from cytoplasmic IgM+ precursors, express sIgM exclusively. Between birth and 3 days of age separate populations of sIgM+ B lymphocyte acquire a second isotype: sIgD, one of the subclasses of sIgG, or sIgA. At 3 days, all splenic B lymphocytes that bear sIg or sIgA also express sIgM, but virtually none stain for sIgD. By 7 days, a substantial porportion of sIgG+ or sIgA+ lymphocytes in spleen and most of those in lymph node express both sIgM ans sIgD. Anti-mu antibody treatment from birth prevented development of B lymphocytes expressing any isotype. These observations suggest that the immature sIgM+ B lymphocyte is the pivotal cell in the generation of the different sublines of B cells and that sIgD ig or IgA. The frequency of lymphocytes bearing only sIgG or sIgA is higher in old than in young mice, suggesting that sIgD and sIgM may be lost after stimulation by antigens. The occurrence of a nearly identical distribution of sIg isotypes on B lymphocytes from athymic, pathogen-free mice suggests that primary expression of isotype diversity does not require T cells.
    Digital Access Access Options