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  • Book
    [edited by] Brendan C. Stack, Jr., MD, CACS, FACE, Professor, ... Show More Department of Otolaryngology - Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, Mauricio A. Moreno, MD, Associate Professor, Director Head & Neck Division, Department of Otolaryngology - Head and Neck Surgery, Little Rock, Arkansas.
    Summary: "Neck dissection is a surgical procedure to remove cancerous lymph nodes, on patients diagnosed with cancer of the mouth, tongue, thyroid gland, or other areas of the throat or neck. There are three main types of neck dissection: Radical - all tissue on the side of the neck from the jawbone to the collarbone is removed. The muscle, nerve, salivary gland, and major blood vessel in this area are removed. Modified - all lymph nodes are removed. More neck tissue is spared. Selective - fewer lymph nodes have to be removed. The muscle, nerve, and blood vessel in the neck may also be saved. Neck Dissection will be an authoritative text edited by two distinguished surgeons, covering fundamentals of the various dissection types and which approach to use depending on patient clinical findings. The print text will be supplemented with surgical videos"-- Provided by publisher.
    Digital Access
    Provider
    Version
    Thieme-Connect
    2019
    Thieme MedOne Otolaryngology
    2019
  • Article
    Hecht SS, LaVoie E, Mazzarese R, Amin S, Bedenko V, Hoffmann D.
    Cancer Res. 1978 Jul;38(7):2191-4.
    The metabolic activation of the environmental carcinogen 5-methylchrysene was studied by combining high-pressure liquid chromatographic analysis of metabolites formed in vitro with assays of these metabolites for mutagenic activity toward Salmonella typhimurium. Metabolites were formed by incubation of 5-methylchrysene with the 9000 x g supernatant from Aroclor-treated rat livers. With the use of reverse-phase columns, the metabolites were resolved into nine peaks, A to I. Each peak was collected and tested for mutagenicity with activiation. Significant mutagenic activity was observed primarily in peak E and to a lesser extent in peak D. None of the other metabolites showed significant mutagenic activity. The major mutagenic metabolite (peak E) was identified as 1,2-dihydro-1,2-dihydroxy-5-methylchrysene (7.0% from 5-methylchrysene); Peak D was 7,8-dihydro-7,8-dihydroxy-5-methylchrysene (2.6% from 5-methylchrysene). Other metabolites included 9,10-dihydro-9,10-dihydroxy-5-methylchrysene, 9-hydroxy-5-methylchrysene, 7-hydroxy-5-methylchrysene, 1-hydroxy-5-methylchrysene, and 5-hydroxymethylchrysene. These results indicate that 1,2-dihydro-1,2-dihydroxy-5-methylchrysene is a major proximate mutagen of 5-methylchrysene.
    Digital Access Access Options