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- ArticleQuitkin F, Rifkin A, Kane J, Ramos-Lorenzi JR, Klein DF.Am J Psychiatry. 1978 May;135(5):570-2.Relapse rates of the first 35 unipolar and bipolar II manic-depressive patients who entered the controlled phase of a continuing evaluation of the prophylactic value of lithium alone or in combination with imipramine were analyzed. Lithium had a prophylactic effect in unipolar patients and possibly in bipolar II patients. Imipramine did not have a prophylactic effect in either group of patients.