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  • Book
    David H. Barlow [and six others].
    Summary: This patient workbook is designed to be applicable to all anxiety and unipolar mood disorders, as well as other disorders with strong emotional components, such as many somatoform and dissociative disorders. It covers the Unified Protocol (UP), which capitalises on the contributions made by cognitive-behavioural theorists by distilling and incorporating the common principles of CBT present in all evidenced based protocols for specific emotional disorders, as well as drawing on the field of emotion science for insights into deficits in emotion regulation.
    Digital Access Oxford 2011
  • Article
    Porter P, Parry SH, Allen WD.
    Ciba Found Symp. 1977 Apr 26-28(46):55-75.
    The impact of bacterial colonization on the alimentary tract in early life is reflected in gross changes in morphology. Subsequent health, if not survival, may largely be determined by a continuum of local intestinal immune mechanisms and it is essential for antibody development during the neonatal period to compensate adequately for declining passive maternal antibody. Consequent upon the development of the gut microflora the lamina becomes infiltrated with immunocytes in which the dominant immunoglobulins produced are IgM and IgA. Both immunoglobulins are transported across the epithelium by a process involving membrane-bound vesicles. Germ-free and fistulated pigs and calves are shown to be able to respond to oral immunization with Escherichia coli O somatic antigens during the first week of life. Resistance to infection with enteropathogenic E. coli was significantly enhanced, along with other parameters of nutrition and performance. However, in the young chick, although the intestinal response to infection with E. coli was similar to that in the mammal, no response to E. coli O antigens could be determined on oral administration in germ-free or local intestinal applications in fistulated birds. In the mammalian intestine secretory antibodies participate in the control of pathogenic E. coli by blocking adhesion to the mucosal epithelium, interfering with the elaboration of surface antigens, inhibiting toxins, and facilitating rapid elimination from the alimentary tract by agglutination and bacteriostasis. In consequence fewer enteropathogens are excreted into the environment, an important feature in modern intensive systems of animal production.
    Digital Access Access Options